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    Method for producing polyol esters
    6.
    发明授权
    Method for producing polyol esters 有权
    多元醇酯的制造方法

    公开(公告)号：US09388115B2

    公开(公告)日：2016-07-12

    申请号：US15008498

    申请日：2016-01-28

    申请人： Oxea GmbH

    发明人： Guido D. Frey ,  Tonia Weber ,  Jörg Arnold ,  Thorsten Kreickmann ,  Heinz Strutz

    IPC分类号： C07C67/08

    CPC分类号： C07C67/08 ,  C07C69/28

    摘要： A process for preparing polyol esters by reacting polyols with linear or branched aliphatic monocarboxylic acids having 3 to 20 carbon atoms, is characterized in that a mixture of the starting compounds is allowed to react in the presence of a Lewis acid containing at least one element of groups 4 to 14 of the periodic table of the elements as a catalyst and in the presence of an adsorbent with removal of the water formed, and then the crude ester obtained is aftertreated by adding a further adsorbent which is an acidic activated carbon having a pH of 1 to 6.5.

    摘要翻译： 多元醇与碳原子数为3〜20的直链或支链脂族一元羧酸反应制备多元醇酯的方法，其特征在于使起始化合物的混合物在含有至少一种元素的路易斯酸 作为催化剂的元素周期表的4至14族，并且在除去所形成的水的吸附剂存在下，然后通过加入另外的吸附剂进行后处理，所述吸附剂是具有pH的酸性活性炭 为1〜6.5。

    3-ACYLOXYMETHYL-3-BUTENYL CARBOXYLATE COMPOUND AND METHOD FOR PRODUCING 4-ALKYL-3-METHYLENEBUTYL CARBOXYLATE
    7.
    发明申请
    3-ACYLOXYMETHYL-3-BUTENYL CARBOXYLATE COMPOUND AND METHOD FOR PRODUCING 4-ALKYL-3-METHYLENEBUTYL CARBOXYLATE 有权
    3-乙酰甲基-3-丁烯基羧酸酯化合物及其制备方法4-甲基-3-甲基戊酸羧酸酯

    公开(公告)号：US20160185707A1

    公开(公告)日：2016-06-30

    申请号：US14974104

    申请日：2015-12-18

    申请人： Shin-Etsu Chemical Co., Ltd.

    发明人： Takeshi Kinsho ,  Naoki Ishibashi ,  Yusuke Nagae

    IPC分类号： C07C67/297 ,  C07C69/02 ,  C07C69/34

    CPC分类号： C07C67/297 ,  C07C67/11 ,  C07C67/293 ,  C07C69/003 ,  C07C69/02 ,  C07C69/28 ,  C07C69/34 ,  C07C69/24

    摘要： Provided is a simple, selective and efficient method for producing 4-alkyl-3-methylenebutyl carboxylates such as 7-methyl-3-methylene-7-octenyl propionate. More specifically provided is a method for producing a 4-alkyl-3-methylenebutyl carboxylate compound, the method comprising a diacyloxylation step of subjecting a 4-halo-2-halomethyl-1-butene compound (6) to diacyloxylation to obtain a 3-acyloxymethyl-3-butenyl carboxylate compound (3), and a coupling step of subjecting the 3-acyloxymethyl-3-butenyl carboxylate compound (3) to a coupling reaction with an organometallic reagent (4) to obtain the 4-alkyl-3-methylenebutyl carboxylate compound (5).

    摘要翻译： 提供了一种用于制备4-烷基-3-亚甲基丁基羧酸酯如7-甲基-3-亚甲基-7-辛烯基丙酸酯的简单，选择性和有效的方法。 更具体地提供了制备4-烷基-3-亚甲基丁基羧酸酯化合物的方法，该方法包括使4-卤代-2-甲基-1-丁烯化合物（6）进行二酰氧基化得到3- 酰氧基甲基-3-丁烯基羧酸酯化合物（3），以及使3-酰氧基甲基-3-丁烯基羧酸酯化合物（3）与有机金属试剂（4）进行偶联反应的偶联工序，得到4-烷基-3- 亚甲基丁基羧酸酯化合物（5）。

    Method of treating ocular disorders with compounds found in Harderian gland secretions
    8.
    发明授权
    Method of treating ocular disorders with compounds found in Harderian gland secretions 有权
    用Harderian腺分泌物中发现的化合物治疗眼部疾病的方法

    公开(公告)号：US09289494B2

    公开(公告)日：2016-03-22

    申请号：US14523264

    申请日：2014-10-24

    申请人： RestorTears, LLC

    发明人： Daniel M. Albert ,  Arthur S. Polans

    IPC分类号： A61K45/06

    CPC分类号： C07C69/708 ,  A61K9/0048 ,  A61K31/22 ,  A61K31/225 ,  A61K45/06 ,  C07C69/28 ,  C07C69/593

    摘要： The present invention is directed to pharmaceutical compositions comprising compounds found in Harderian gland secretions, a method of treating dry eye in a human comprising ophthalmically administering an effective amount of a compound, e.g. a lipid compound, found in Harderian gland secretions, pharmaceutical compositions comprising said lipid compounds, as identified by characteristic chemical data and mass spectra of said lipid compounds, said lipid compound in essentially pure form, and an ophthalmic vehicle comprising a therapeutic agent and a compound present in the secretions of the Harderian gland, e.g. a lipid compound, found in the secretions of the Harderian gland, e.g. a rabbit Harderian gland.

    摘要翻译： 本发明涉及包含在哈氏胃分泌物中发现的化合物的药物组合物，一种治疗人类的干眼症的方法，包括眼睛施用有效量的化合物，例如， 在Harderian腺分泌物中发现的脂质化合物，包含所述脂质化合物的药物组合物，通过所述脂质化合物的特征化学数据和质谱鉴定，所述脂质化合物基本上是纯的形式，以及包含治疗剂和化合物 存在于哈德氏腺的分泌物中，例如 在Harderian腺的分泌物中发现的脂质化合物，例如 一只兔子哈德氏腺。

    Method for producing polyol esters
    9.
    发明授权
    Method for producing polyol esters 有权

    公开(公告)号：US09284253B2

    公开(公告)日：2016-03-15

    申请号：US14427742

    申请日：2013-08-10

    申请人： Oxea GmbH

    发明人： Guido D. Frey ,  Tonia Weber ,  Jörg Arnold ,  Thorsten Kreickmann ,  Heinz Strutz

    IPC分类号： C07C67/08

    CPC分类号： C07C67/08 ,  C07C69/28

    摘要： A process for preparing polyol esters by reacting polyols with linear or branched aliphatic monocarboxylic acids having 3 to 20 carbon atoms, is characterized in that a mixture of the starting compounds is allowed to react in the presence of a Lewis acid containing at least one element of groups 4 to 14 of the periodic table of the elements as a catalyst and in the presence of an adsorbent with removal of the water formed, and then the crude ester obtained is aftertreated by adding a further adsorbent which is an acidic activated carbon having a pH of 1 to 6.5.