公开(公告)号：US20230174457A1

公开(公告)日：2023-06-08

申请号：US17940585

申请日：2022-09-08

Applicant: Iowa State University Research Foundation, Inc.

Inventor： Joel R. Coats ,  Edmund J. Norris ,  James Scott Klimavicz

IPC: C07C69/75 ,  A01N37/06 ,  A01N37/08 ,  A01N37/10 ,  A01N43/16 ,  C07D311/16 ,  C07D333/24 ,  C07D307/68 ,  C07D333/38 ,  A01N43/30 ,  C07D305/06 ,  C07C69/74 ,  A01N49/00 ,  C07D305/08 ,  C07C69/24 ,  C07C69/07 ,  C07C69/618 ,  C07C69/533 ,  C07C255/19 ,  C07C69/63 ,  C07C69/587 ,  A01N37/02 ,  A01N43/08 ,  A01N43/10 ,  A01N53/00 ,  C07C67/08 ,  C07C69/04 ,  C07C69/22 ,  C07C69/612 ,  C07C69/635 ,  C07C69/757 ,  C07C69/76 ,  C07C205/43 ,  C07D333/40

CPC classification number: C07C69/75 ,  A01N37/06 ,  A01N37/08 ,  A01N37/10 ,  A01N43/16 ,  C07D311/16 ,  C07D333/24 ,  C07D307/68 ,  C07D333/38 ,  A01N43/30 ,  C07D305/06 ,  C07C69/74 ,  A01N49/00 ,  C07D305/08 ,  C07C69/24 ,  C07C69/07 ,  C07C69/618 ,  C07C69/533 ,  C07C255/19 ,  C07C69/63 ,  C07C69/587 ,  A01N37/02 ,  A01N43/08 ,  A01N43/10 ,  A01N53/00 ,  C07C67/08 ,  C07C69/04 ,  C07C69/22 ,  C07C69/612 ,  C07C69/635 ,  C07C69/757 ,  C07C69/76 ,  C07C205/43 ,  C07D333/40 ,  C07C2601/08 ,  C07C2602/42 ,  C07C2601/02 ,  C07C2601/16 ,  C07C2601/04 ,  C07C2601/14

Abstract: The present invention relates to monoterpenoid and phenylpropanoid containing derivative compounds, methods of making the compounds, compositions comprising the compounds, and methods of repelling pests using the compounds and/or compositions.

公开(公告)号：US20190106380A1

公开(公告)日：2019-04-11

申请号：US15520989

申请日：2015-10-21

Applicant: Council of Scientific & Industrial Research

Inventor： Asish Kumar Bhattacharya ,  Eswar Kumar Aratikatla ,  Kumkum Srivastava ,  Ashan Manhas

IPC: C07C233/73 ,  C07C233/22 ,  C07C231/02 ,  C07C233/18 ,  C07C69/618 ,  C07C67/08 ,  C07D317/60 ,  A61P33/06

CPC classification number: C07C233/73 ,  A61P33/06 ,  C07B2200/09 ,  C07C67/08 ,  C07C69/612 ,  C07C69/618 ,  C07C69/92 ,  C07C231/02 ,  C07C233/18 ,  C07C233/22 ,  C07D317/60 ,  C07F7/1804

Abstract: The present invention discloses anti-malarial compound of formula (I) Formula (I) wherein, X is selected from O or NH; R1, R2, R3, R4 and R5 is selected from H or OMe or CH3, —CH2—O—CH2— or —CH═CH—CH═CH—; Y is selected from O or NH and R6, R7 is selected from the following compounds: or pharmaceutically acceptable salts thereof, process for preparation and a pharmaceutical composition containing the same.

公开(公告)号：US20180037840A1

公开(公告)日：2018-02-08

申请号：US15670891

申请日：2017-08-07

Applicant: Rutgers, The State University of New Jersey ,  ExxonMobil Research and Engineering Company

Inventor： Kathryn Uhrich ,  Jonathan Faig ,  Yingyue Zhang ,  Shuji Luo ,  Man Kit Ng ,  Alan Schilowitz ,  Anne Marie Shough

IPC: C10M169/04 ,  C10M129/95 ,  C07C69/533 ,  C07C69/02 ,  C07C69/612 ,  C07C69/708 ,  C10M105/00 ,  C10M129/72

CPC classification number: C10M169/04 ,  C07C69/02 ,  C07C69/533 ,  C07C69/612 ,  C07C69/708 ,  C10M105/00 ,  C10M129/42 ,  C10M129/72 ,  C10M129/76 ,  C10M129/95 ,  C10M2203/003 ,  C10M2207/123 ,  C10M2207/124 ,  C10M2207/127 ,  C10M2207/128 ,  C10M2207/282 ,  C10M2207/284 ,  C10M2207/288 ,  C10N2230/06 ,  C10N2230/54 ,  C10N2240/10

Abstract: Certain embodiments of the invention provide a lubricating oil composition comprising a lubricating oil base stock and a compound of formula (I): or a salt thereof, wherein R1, R2, R3 and R4 have any of the values defined in the specification, as well as methods of use thereof.

公开(公告)号：US09828331B2

公开(公告)日：2017-11-28

申请号：US14593164

申请日：2015-01-09

Applicant: KINDEX PHARMACEUTICALS, INC.

Inventor： Veera Konda ,  Jan Urban ,  Anuradha Desai ,  Clinton J. Dahlberg ,  Brian J. Carroll

IPC: C07C225/14 ,  A61K31/122 ,  A61K31/135 ,  C07C59/90 ,  C07C69/02 ,  C07C69/22 ,  C07C69/614 ,  C07C69/78 ,  C07C69/96 ,  C07C69/28 ,  C07C69/612 ,  C07C49/707 ,  C07C49/743 ,  C07C251/42

CPC classification number: C07C225/14 ,  A61K31/122 ,  A61K31/135 ,  C07C49/707 ,  C07C49/743 ,  C07C59/90 ,  C07C69/02 ,  C07C69/22 ,  C07C69/28 ,  C07C69/612 ,  C07C69/614 ,  C07C69/78 ,  C07C69/96 ,  C07C251/42 ,  C07C2601/08 ,  C07C2601/10

Abstract: The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPARγ modulation such as diabetes.

公开(公告)号：US20170305844A9

公开(公告)日：2017-10-26

申请号：US15374491

申请日：2016-12-09

Applicant: Huntsman Petrochemical LLC

Inventor： George A. Smith ,  Daniel R. Weaver ,  Zheng Chai

IPC: C07C303/32 ,  C07C67/08 ,  C07C67/31 ,  C07C67/343

CPC classification number: C07C303/32 ,  C07C67/08 ,  C07C67/31 ,  C07C67/343 ,  C07C69/612 ,  C07C309/58 ,  C08K5/10 ,  C08K5/42

Abstract: A surface active agent comprising an arylated methyl ester of a fatty acid, or mixture of fatty acids, derived from biodiesel or a triglyceride source is disclosed. The fatty acid mixture is condensed to methyl esters and alkylated with aromatic substituents under Friedel-Crafts conditions. The alkylated methyl esters may be alkoxylated using a catalyst derived from fatty acids, alkaline earth salts, and strong acids. The resulting nonionic surfactant may also be sulfonated to produce one class of anionic surfactants. The alkylated methyl esters may also be directly sulfonated to produce another class of anionic surfactants.

公开(公告)号：US20170275241A1

公开(公告)日：2017-09-28

申请号：US15129313

申请日：2015-02-03

Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

Inventor： Takashi OHSHIMA ,  Ryo YAZAKI ,  Chika FUJIMOTO ,  Rikiya HORIKAWA

IPC: C07C213/06 ,  C07C269/06 ,  C07C231/02 ,  C07B41/12 ,  B01J23/745 ,  C07C67/03

CPC classification number: C07C213/06 ,  B01J23/745 ,  B01J31/22 ,  C07B41/12 ,  C07B2200/07 ,  C07C67/03 ,  C07C67/08 ,  C07C231/02 ,  C07C269/06 ,  C07C2601/14 ,  C07C2603/74 ,  C07D211/22 ,  C07D211/46 ,  C07C69/78 ,  C07C69/612 ,  C07C69/618 ,  C07C69/34 ,  C07C233/65 ,  C07C233/75 ,  C07C233/11 ,  C07C271/22 ,  C07C219/14 ,  C07C219/24 ,  C07C219/34

Abstract: Provided is a catalyst for transesterification reactions, which contains an iron salen complex. Also provided is a method for producing an ester compound, which is characterized by carrying out a transesterification reaction between a starting material ester and a starting material alcohol with use of the catalyst.

公开(公告)号：US20170183596A1

公开(公告)日：2017-06-29

申请号：US15384471

申请日：2016-12-20

Applicant: ExxonMobil Research and Engineering Company

Inventor： Man Kit Ng ,  Halou Oumar-Mahamat ,  Hong Cheng ,  David A. Blain

IPC: C10M105/34

CPC classification number: C10M105/34 ,  C07C69/24 ,  C07C69/612 ,  C07C69/614 ,  C07C69/734 ,  C07C69/78 ,  C10M111/02 ,  C10M129/70 ,  C10M129/95 ,  C10M2203/024 ,  C10M2207/281 ,  C10M2207/2815 ,  C10M2207/284 ,  C10M2207/2845 ,  C10N2220/022 ,  C10N2230/02 ,  C10N2230/04 ,  C10N2230/06 ,  C10N2230/08 ,  C10N2230/10 ,  C10N2230/74 ,  C10N2240/04 ,  C10N2240/10

Abstract: A composition including one or more aromatic alkanoate monoester compounds represented by the formulae (I) and (II) as defined herein. The composition has a viscosity (Kv100) from about 1 cSt to about 10 cSt at 100° C. as determined by ASTM D445, a viscosity index (VI) from about −100 to about 300 as determined by ASTM D2270, and a Noack volatility of no greater than 50 percent as determined by ASTM D5800. A process for producing the composition, a lubricating oil base stock and lubricating oil containing the composition, and a method for improving one or more of thermal and oxidative stability, solubility and dispersancy of polar additives, deposit control and traction control in a lubricating oil by using as the lubricating oil a formulated oil containing the composition.

公开(公告)号：US20170101380A1

公开(公告)日：2017-04-13

申请号：US15287023

申请日：2016-10-06

Applicant: Genentech, Inc.

Inventor： Stephan Bachmann ,  Serena Maria Fantasia ,  Francis Gosselin ,  Chong Han ,  Stefan Hildbrand ,  Theresa Humphries ,  Christian Jenny ,  Ngiap-Kie Lim ,  Andrew McClory ,  Christian Moessner ,  Pankaj Rege ,  Scott Savage ,  Haiming Zhang

IPC: C07D231/56 ,  C07C309/73 ,  C07C69/73 ,  C07F5/04 ,  C07D405/04

CPC classification number: C07D231/56 ,  C07C69/612 ,  C07C69/73 ,  C07C69/738 ,  C07C309/73 ,  C07D405/04 ,  C07F5/025 ,  C07F5/04

Abstract: Processes are described for the preparation of estrogen receptor modulating compound, (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid I: and salts thereof, and intermediates useful for the preparation of I.

公开(公告)号：US09598340B2

公开(公告)日：2017-03-21

申请号：US14782402

申请日：2014-04-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： John F. Hartwig ,  Shaozhong Ge ,  Wojciech Chaładaj

IPC: C07F15/00 ,  C07C45/86 ,  C07C49/80 ,  B01J23/44 ,  C07C45/68 ,  B01J31/24 ,  C07B39/00 ,  C07C17/361 ,  C07C41/18 ,  C07C45/00 ,  C07C67/297 ,  C07C67/343 ,  C07C67/42 ,  C07C69/612 ,  C07C69/76 ,  C07C201/12 ,  C07C205/45 ,  C07C221/00 ,  C07C225/22 ,  C07C231/12 ,  C07C269/06 ,  C07C319/20 ,  C07C323/22 ,  C07D213/50 ,  C07D213/56 ,  C07D215/12 ,  C07D215/14 ,  C07D217/18 ,  C07D295/104 ,  C07D317/16 ,  C07D317/26 ,  C07D317/54 ,  C07D333/24 ,  C07F7/08

CPC classification number: C07C45/68 ,  B01J23/44 ,  B01J31/2404 ,  B01J2531/824 ,  C07B39/00 ,  C07C17/361 ,  C07C41/18 ,  C07C45/004 ,  C07C45/86 ,  C07C49/80 ,  C07C67/297 ,  C07C67/343 ,  C07C67/42 ,  C07C69/612 ,  C07C69/76 ,  C07C201/12 ,  C07C205/45 ,  C07C221/00 ,  C07C225/22 ,  C07C231/12 ,  C07C269/06 ,  C07C319/20 ,  C07C323/22 ,  C07D213/50 ,  C07D213/56 ,  C07D215/12 ,  C07D215/14 ,  C07D217/18 ,  C07D295/104 ,  C07D317/16 ,  C07D317/26 ,  C07D317/54 ,  C07D333/24 ,  C07F7/081 ,  C07F7/083 ,  C07F15/006 ,  C07C49/84

Abstract: The coupling of aryl, heteroaryl, and vinyl halides with α,α-difluoroketones or silyl ethers or siylenol ethers of α,α-difluoroketones and α,α-difluoroamides and esters are described. Further derivatization of the coupling products (such as ketone cleavage and Baeyer-Villiger oxidation) is also described.

公开(公告)号：US09340485B2

公开(公告)日：2016-05-17

申请号：US14366965

申请日：2012-12-17

Applicant: Robert Franke ,  Dieter Hess ,  Matthias Beller ,  Ralf Jackstell ,  Daniela Cozzula ,  Ivana Fleischer ,  Reiko Jennerjahn

Inventor： Robert Franke ,  Dieter Hess ,  Matthias Beller ,  Ralf Jackstell ,  Daniela Cozzula ,  Ivana Fleischer ,  Reiko Jennerjahn

IPC: C07D209/48 ,  C07C69/612 ,  C07C69/34 ,  C07C67/38 ,  C07C69/22

CPC classification number: C07C69/22 ,  C07C67/38 ,  C07C69/34 ,  C07C69/612 ,  C07D209/48 ,  C07C69/24

Abstract: The invention provides a process for preparing esters from formates and olefinically unsaturated compounds with catalysts based on palladium compounds. In addition, the invention discloses a polyphasic reaction mixture and nonyl methyl ester mixtures prepared by the process according to the invention.

Abstract translation: 本发明提供了一种由甲酸酯和烯属不饱和化合物与基于钯化合物的催化剂制备酯的方法。 此外，本发明公开了通过根据本发明的方法制备的多相反应混合物和壬基甲基酯混合物。