公开(公告)号：US20230265041A1

公开(公告)日：2023-08-24

申请号：US18114584

申请日：2023-02-27

申请人： Francis Johnson ,  Lorne Johnson

发明人： Francis Johnson ,  Lorne Johnson

IPC分类号： C07C69/738 ,  C07C49/255 ,  C07C225/22 ,  C07C235/78 ,  C07C237/20 ,  C07D213/50 ,  C07C235/80 ,  C12N9/64

CPC分类号： C07C69/738 ,  C07C49/255 ,  C07C225/22 ,  C07C235/78 ,  C07C235/80 ,  C07C237/20 ,  C07D213/50 ,  C12N9/6491 ,  C12Y304/24

摘要： This invention provides a compound having the structure





wherein α, β, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NFK-B activation in a population of cells.

公开(公告)号：US11596716B2

公开(公告)日：2023-03-07

申请号：US17136830

申请日：2020-12-29

申请人： Human BioMolecular Research Institute

发明人： John R Cashman ,  Daniel R Ryan ,  Sigeng Chen

IPC分类号： A61L27/38 ,  A61L27/12 ,  C07D215/44 ,  C07D487/04 ,  A61K31/519 ,  A61K33/42 ,  A61K38/18 ,  A61K31/4706 ,  A61K31/12 ,  A61K45/06 ,  A61K35/28 ,  A61L27/28 ,  A61L27/32 ,  A61L27/42 ,  A61L27/54 ,  A61L27/58 ,  C07C49/248 ,  C07C49/255 ,  C07C225/22 ,  G01N33/50 ,  C07C229/40 ,  C12Q1/6883

摘要： Compositions of small molecules, matrices, and isolated cells including methods of preparation, and methods for differentiation, trans-differentiation, and proliferation of animal cells into the osteoblast cell lineage were described. Examples of osteogenic materials that were administered to cells or co-cultured with cells are represented by compounds of Formula II, IV, and VI independently or preferably in combination with a matrix to afford bone cells. Small molecule-stimulated cells were also combined with a matrix, placed with a cellular adhesive or material carrier and implanted to a site in an animal for bone repair. Matrix pretreated with compounds of Formula II, IV, and VI were also used to cause cells to migrate to the matrix that is of use for therapeutic purposes.

公开(公告)号：US11512042B2

公开(公告)日：2022-11-29

申请号：US15518748

申请日：2016-12-23

申请人： Commonwealth Scientific and Industrial Research Organisation

发明人： Mark York ,  John Ryan

IPC分类号： C07D209/12 ,  C07D403/14 ,  C07D403/10 ,  C07D403/08 ,  A61K31/405 ,  A61K31/404 ,  C07C225/22 ,  A61Q17/04 ,  C09D5/32 ,  A61K8/41 ,  C07C225/16 ,  C07C229/34 ,  C07C229/60 ,  C11D3/30 ,  C07C255/42 ,  C07C235/78 ,  C07C311/37 ,  C08K5/16 ,  C07C255/58 ,  A61K8/70 ,  A61K8/58 ,  C09D7/48 ,  C07D243/12 ,  A61K8/49 ,  C07D233/16 ,  A61K8/46 ,  C07F7/18 ,  C07D209/08 ,  C07D215/06 ,  C07D217/04 ,  C07D295/108 ,  C08K5/17 ,  C08K5/18 ,  C08K5/3412 ,  C08K5/3415 ,  C08K5/3417 ,  C08K5/3432 ,  C08K5/3435 ,  C08K5/3437 ,  C08K5/3442 ,  C08K5/3462 ,  C08K5/3465 ,  C08K5/357 ,  C09D133/12 ,  G02B1/04 ,  G02C7/10 ,  C08K5/00

摘要： The present invention describes compounds and uses thereof in applications relating to absorption of electromagnetic energy. Preferred compounds are double bond-containing compounds capable of absorbing electromagnetic radiation energy and having improved properties.

公开(公告)号：US20210403415A1

公开(公告)日：2021-12-30

申请号：US17288181

申请日：2019-10-28

申请人： THE TRUSTEES OF INDIANA UNIVERSITY

发明人： Samy MEROUEH ,  Khuchtumur BUM-ERDENE

IPC分类号： C07C229/60 ,  C07C225/22 ,  C07D213/74 ,  C07D333/20 ,  C07D495/04 ,  C07C233/43 ,  C07C233/44

摘要： This invention relates to certain compounds or pharmaceutically acceptable salts thereof, and for the use of the compounds to treat cancer. In another aspect, the disclosure relates to a pharmaceutical composition comprising a compound of Formula (1), Formula (1a), or Formula (1b), or a pharmaceutically acceptable salt thereof, and at least one of a pharmaceutically acceptable carrier, diluent or excipient.

公开(公告)号：US20210363109A1

公开(公告)日：2021-11-25

申请号：US17395433

申请日：2021-08-05

申请人： SPIRIFY PHARMA INC.

发明人： Irving W. WAINER

IPC分类号： C07D233/24 ,  C07C49/753 ,  C07C225/22 ,  C07C311/36 ,  C07C255/46 ,  C07C225/28 ,  C07D207/09 ,  C07D307/14

摘要： Phenyl cyclohexanone based active agents, pharmaceutical preparations containing such active agents, methods of modifying cellular activity by contacting cells with such active agents, and methods of treating various conditions by administering such active agents to a patient are described.

公开(公告)号：US10981860B2

公开(公告)日：2021-04-20

申请号：US16099989

申请日：2017-05-11

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. ,  Medshine Discovery Inc.

发明人： Haiying He ,  Songliang Wu ,  Zhi Luo ,  Jianfeng Mou ,  Fengying Guo ,  Chuan Wang ,  Guoqing Li ,  Minggao Zeng ,  Shuhui Chen

IPC分类号： C07C225/22 ,  C07C225/10 ,  C07C225/18 ,  C07D205/04 ,  C07D207/04 ,  C07D221/22 ,  C07D221/20 ,  C07D221/04 ,  C07D223/04 ,  C07D265/30 ,  C07D267/12 ,  C07D401/06 ,  A61P43/00 ,  C07D409/06 ,  C07D211/62 ,  C07D451/02 ,  A61K31/46 ,  A61K31/445 ,  C07C237/12 ,  C07D211/60 ,  C07D207/06 ,  C07D227/04 ,  C07D239/26 ,  C07D333/10 ,  C07D333/72 ,  C07D413/06

摘要： Disclosed are a class of compounds as a caspase inhibitor, and in particular the compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the use of the compound in treating caspase-related diseases.

公开(公告)号：US20210053905A1

公开(公告)日：2021-02-25

申请号：US16885800

申请日：2020-05-28

申请人： Francis Johnson ,  Lorne Golub

发明人： Francis Johnson ,  Lorne Golub

IPC分类号： C07C69/738 ,  C07C49/255 ,  C07C225/22 ,  C07C235/78 ,  C07C237/20 ,  C07D213/50 ,  C07C235/80 ,  C12N9/64

摘要： This invention provides a compound having the structure wherein α, β, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NFκ-B activation in a population of cells.

公开(公告)号：US10233171B2

公开(公告)日：2019-03-19

申请号：US15442475

申请日：2017-02-24

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Brent R. Stockwell ,  Scott J. Dixon ,  Rachid Skouta

IPC分类号： C07D213/74 ,  A61K31/47 ,  C07D401/12 ,  C07D309/14 ,  C07C255/58 ,  C07D213/80 ,  C07C271/16 ,  C07C271/24 ,  C07C271/28 ,  C07C205/57 ,  C07C205/58 ,  C07C211/50 ,  C07D239/26 ,  C07C229/60 ,  C07C233/54 ,  C07C237/30 ,  C07D295/088 ,  C07D211/58 ,  C07D295/30 ,  C07D213/36 ,  A61K31/245 ,  A61K31/325 ,  A61K31/351 ,  A61K31/4465 ,  A61K31/495 ,  A61K31/5375 ,  A61K45/06 ,  C07C69/78 ,  C07D295/192 ,  A61K31/27 ,  A61K31/44 ,  A61K31/444 ,  A61K31/4468 ,  A61K31/505 ,  A61K31/506 ,  C07C225/22 ,  C07D239/42

摘要： The present invention provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.

公开(公告)号：US20180141030A1

公开(公告)日：2018-05-24

申请号：US15560942

申请日：2016-06-01

申请人： DALHOUSIE UNIVERSITY

发明人： Mark John STRADIOTTO

IPC分类号： B01J31/24 ,  B01J31/28 ,  C07C209/18 ,  C07C209/10 ,  C07C213/02 ,  C07C253/30 ,  C07C221/00 ,  C07F15/04 ,  C07F9/6571 ,  C07J41/00 ,  C07C225/22 ,  C07C217/90 ,  C07C217/92 ,  C07C211/58

CPC分类号： B01J31/2438 ,  B01J31/28 ,  C07C209/10 ,  C07C209/18 ,  C07C211/58 ,  C07C213/02 ,  C07C217/90 ,  C07C217/92 ,  C07C221/00 ,  C07C225/22 ,  C07C253/30 ,  C07F9/657163 ,  C07F15/04 ,  C07F15/045 ,  C07J41/0011 ,  C07C211/45 ,  C07C217/80 ,  C07C255/58 ,  C07C211/52 ,  C07C217/84

摘要： A compound having a chemical formula according to Formula (I) is disclosed where one of Z1, Z2 and Z3 is and one of the Z1, Z2, and Z3 that is bonded to a carbon atom that is adjacent to the carbon atom bonded to is P(AR1)(A′R2). Metal-based catalyst and pre-catalysts, such as nickel-based catalysts and precatalysts, where the metal is complexed to the compound are also disclosed. Methods of forming C(sp2)-N bonds are also disclosed.

公开(公告)号：US09896479B2

公开(公告)日：2018-02-20

申请号：US14853806

申请日：2015-09-14

申请人： Kay M. Brummond

发明人： Kay M. Brummond ,  Laura S. Kocsis ,  Erica Benedetti

IPC分类号： C07K2/00 ,  A61K49/00 ,  C07D295/112 ,  C07C225/22 ,  C07C45/67 ,  C07C315/04 ,  C07F9/40 ,  C07C67/34 ,  G01N21/64 ,  C07C49/792 ,  C07C317/14 ,  C07D209/62 ,  C07C69/757 ,  C07C69/76 ,  C07C49/813 ,  C07F9/50 ,  C07F15/00 ,  C07D307/73 ,  C07C317/44 ,  A61K49/14 ,  C07K1/13

CPC分类号： C07K2/00 ,  A61K49/0021 ,  A61K49/14 ,  C07C45/67 ,  C07C47/55 ,  C07C49/792 ,  C07C49/813 ,  C07C67/34 ,  C07C69/757 ,  C07C69/76 ,  C07C69/78 ,  C07C221/00 ,  C07C225/22 ,  C07C305/00 ,  C07C315/04 ,  C07C317/14 ,  C07C317/44 ,  C07C2603/14 ,  C07D207/06 ,  C07D209/62 ,  C07D211/14 ,  C07D249/06 ,  C07D295/112 ,  C07D307/73 ,  C07D307/87 ,  C07F9/4015 ,  C07F9/4018 ,  C07F9/4021 ,  C07F9/4056 ,  C07F9/4075 ,  C07F9/5022 ,  C07F15/006 ,  C07K1/13 ,  G01N21/64

摘要： Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful properties including liquid crystals and fluorescence properties, such as solvatochromatic fluorescence, with high quantum yields, Stoke's shift, and show emission maxima that are significantly red-shifted.