公开(公告)号：US12103916B2

公开(公告)日：2024-10-01

申请号：US15836675

申请日：2017-12-08

申请人： University of Kentucky Research Foundation

发明人： Sylvie Garneau-Tsodikova ,  Sanjib K Shrestha ,  Atefeh Garzan ,  Nishad Thamban Chandrika

IPC分类号： C07D249/08 ,  A01N33/08 ,  A01N43/60 ,  A01N43/653 ,  A01N43/84 ,  A01N47/12 ,  A61P31/10 ,  C07C217/08 ,  C07C271/16 ,  C07D295/03 ,  C07D403/06 ,  C07D405/06

CPC分类号： C07D249/08 ,  A01N33/08 ,  A01N43/60 ,  A01N43/653 ,  A01N43/84 ,  A01N47/12 ,  A61P31/10 ,  C07C217/08 ,  C07C271/16 ,  C07D295/03 ,  C07D403/06 ,  C07D405/06

摘要： Compounds and compositions having antifungal activity, and methods of using the antifungal compounds and compositions, are described for use in treating fungal infections.

公开(公告)号：US20240262851A1

公开(公告)日：2024-08-08

申请号：US18338750

申请日：2023-06-21

申请人： Quantum-Si Incorporated

发明人： David N. Kamber ,  Haidong Huang ,  Andrzej Wilczynski ,  Saketh Gudipati

IPC分类号： C07F9/24 ,  C07C233/60 ,  C07C271/16 ,  C07F9/6571

CPC分类号： C07F9/2408 ,  C07C233/60 ,  C07C271/16 ,  C07F9/657154 ,  C07C2601/02

摘要： Provided herein are cyclopropene phosphoramidites, which can be coupled to oligonucleotides to form cyclopropene-functionalized oligonucleotides. Also provided herein are methods of preparing cyclopropene phosphoramidites. Further provided herein are methods of functionalizing oligonucleotides by reaction with tetrazines, providing oligonucleotide cycloadduct products.

公开(公告)号：US12043636B2

公开(公告)日：2024-07-23

申请号：US16950901

申请日：2020-11-17

申请人： Covestro Deutschland AG

发明人： Thomas Rölle ,  Horst Berneth ,  Dennis Hönel ,  Friedrich-Karl Bruder ,  Jürgen Kintrup

IPC分类号： C07F5/02 ,  C07C211/63 ,  C07C211/64 ,  C07C217/08 ,  C07C219/10 ,  C07C219/28 ,  C07C219/30 ,  C07C271/12 ,  C07C271/16 ,  C07C271/20 ,  C07C271/24 ,  C07C271/28 ,  C07D213/20 ,  C07D233/02 ,  C07D233/58 ,  C07D247/00 ,  C07D295/037 ,  C07D309/34 ,  C07D335/02 ,  C07D347/00 ,  C07D413/06 ,  C07F5/04 ,  C07F9/54 ,  G03F7/00

CPC分类号： C07F5/027 ,  C07C211/63 ,  C07C211/64 ,  C07C217/08 ,  C07C219/10 ,  C07C219/28 ,  C07C219/30 ,  C07C271/12 ,  C07C271/16 ,  C07C271/20 ,  C07C271/24 ,  C07C271/28 ,  C07D213/20 ,  C07D233/02 ,  C07D233/58 ,  C07D247/00 ,  C07D295/037 ,  C07D309/34 ,  C07D335/02 ,  C07D347/00 ,  C07D413/06 ,  C07F5/04 ,  C07F9/54 ,  C07F9/5407 ,  C07F9/5442 ,  G03F7/001 ,  C07C2601/14

摘要： The invention relates to a process for preparing triaryl organo borates proceeding from organoboronic esters in the presence of an n-valent cation 1/n Kn+, comprising the anhydrous workup of the reaction mixture and the use of the triaryl organoborates obtained as co-initiator in photopolymer formulations, holographic media and holograms.

公开(公告)号：US20230320995A1

公开(公告)日：2023-10-12

申请号：US18296363

申请日：2023-04-05

申请人： CAPSTAN THERAPEUTICS, INC.

发明人： Priya Prakash KARMALI ,  Steven TANIS

IPC分类号： A61K9/51 ,  C07D295/088 ,  C07D211/46 ,  C07C271/16 ,  C07C275/14 ,  A61K31/7105

CPC分类号： A61K9/5123 ,  C07D295/088 ,  C07D211/46 ,  C07C271/16 ,  C07C275/14 ,  A61K31/7105

摘要： Ionizable cationic lipids, methods for synthesizing them, as well as intermediates useful in synthesis of these lipids and methods of synthesizing the intermediates are disclosed. The ionizable cationic lipids are useful as a component of lipid nanoparticles (LNP), which in turn can be used for the delivery of nucleic acids into cells in vivo or ex vivo. LNP compositions are also disclosed, including LNP comprising a functionalized lipid to enable conjugation of a binding moiety, and targeted LNP (tLNP), that is a LNP in which a binding moiety has been conjugated to the functionalized lipid and can serve as a targeting moiety to direct the tLNP to a desired tissue or cell type.

公开(公告)号：US20220348586A1

公开(公告)日：2022-11-03

申请号：US17765856

申请日：2020-10-02

申请人： CANOPY GROWTH CORPORATION

发明人： SIAWASH AHMAR ,  JUNG YUN KIM ,  PING SHAN LAI ,  JEFFREY ALAN OMEARA ,  QUANG HUY TO ,  PETER MARTIN DOVE

IPC分类号： C07D487/04 ,  C07C235/60 ,  C07C235/58 ,  C07C235/88 ,  C07C235/62 ,  C07C235/64 ,  C07D239/26 ,  C07D261/08 ,  C07D263/32 ,  C07D233/64 ,  C07D213/40 ,  C07D257/04 ,  C07D295/192 ,  C07D295/26 ,  C07D207/16 ,  C07D207/24 ,  C07D209/44 ,  C07D209/08 ,  C07D203/18 ,  C07D205/04 ,  C07C255/29 ,  C07C271/16 ,  C07C271/34 ,  C07C271/48 ,  C07C271/24 ,  C07C233/60 ,  C07C233/18 ,  C07D261/14 ,  C07D271/10

摘要： This disclosure relates to cannabinoid derivatives of Formula (I), wherein R4 or R7 is a carboxamide group, pharmaceutical compositions comprising these compounds and methods of using the cannabinoid derivatives. These compounds are potential cannabinoid receptor inhibitors, including CB1 and CB2 receptors.

公开(公告)号：US11298326B2

公开(公告)日：2022-04-12

申请号：US15560854

申请日：2016-03-24

申请人： Kyowa Kirin Co., Ltd.

发明人： Kentaro Hatanaka ,  Nobuhiro Yagi ,  Takeshi Kuboyama ,  Kaori Yagi ,  Shintaro Hosoe

IPC分类号： A61K9/51 ,  C07C217/28 ,  A61K9/127 ,  C07D223/04 ,  C07C229/12 ,  A61K31/713 ,  A61P29/00 ,  C07C237/22 ,  C07D401/04 ,  A61K9/00 ,  C07D295/088 ,  C07D207/12 ,  A61P35/00 ,  C07D317/28 ,  C07D211/22 ,  C07D207/08 ,  C12N15/11 ,  A61K31/7088 ,  C07C211/63 ,  C07C215/08 ,  C07C219/08 ,  C07C229/06 ,  C07C233/20 ,  C07C237/08 ,  C07C271/16 ,  C07D451/14 ,  C12N15/113

摘要： The present invention provides nucleic acid-containing lipid nanoparticles containing a lipid (lipid A) which has a hydrophilic unit having a single quaternary ammonium group, and three independent, optionally substituted hydrocarbon groups, a lipid derivative or fatty acid derivative of a water-soluble polymer, and a nucleic acid.

公开(公告)号：US20220089800A1

公开(公告)日：2022-03-24

申请号：US17346368

申请日：2021-06-14

申请人： Henkel IP & Holding GmbH

发明人： David Dworak ,  Deirdre Ledwith

IPC分类号： C08F222/22 ,  C08F220/36 ,  C09J4/00 ,  C09J133/14 ,  C09J135/02 ,  C07C271/16

摘要： The present invention relates to (meth)acrylate-functionalized waxes and curable compositions, such as anaerobic adhesive compositions, made therewith.

公开(公告)号：US20210347949A1

公开(公告)日：2021-11-11

申请号：US17382452

申请日：2021-07-22

申请人： Alliance for Sustainable Energy, LLC

发明人： Tao DONG ,  Lieve M.L. LAURENS ,  Philip T. PIENKOS ,  Paris Fabian SPINELLI

IPC分类号： C08G71/04 ,  C07C269/04 ,  C07C271/16 ,  C07C271/20 ,  C07C237/10 ,  C07C237/20 ,  C07C237/22 ,  C07C279/12

摘要： The present disclosure relates to methods for producing polymers and resins, the method including a first reacting of at least a first diamine with a first carbonate-containing compound and a second carbonate-containing compound to produce at least one of the polymer or the resin, where the first reacting is according to each of R1, R2, R3, and R4 include at least one of a hydrogen atom, a methyl group, a saturated hydrocarbon chain, and/or an unsaturated hydrocarbon chain, and R comprises at least one of a carbon atom, a saturated hydrocarbon chain, and/or an unsaturated hydrocarbon chain.

公开(公告)号：US10858317B2

公开(公告)日：2020-12-08

申请号：US16383049

申请日：2019-04-12

申请人： Global Blood Therapeutics, Inc.

发明人： Qing Xu ,  Zhe Li

IPC分类号： C07D207/08 ,  C07C271/16 ,  C07D207/34 ,  C07D211/22 ,  C07D211/60 ,  C07D211/78 ,  C07D213/81 ,  C07D241/04 ,  C07D265/30 ,  C07D279/12 ,  C07D309/08 ,  C07D309/28 ,  C07D333/38 ,  C07D335/02 ,  C07D401/06 ,  C07D211/16 ,  C07D401/12 ,  C07D207/48 ,  C07D403/06

摘要： Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

公开(公告)号：US10689407B2

公开(公告)日：2020-06-23

申请号：US15417924

申请日：2017-01-27

申请人： ACatechol, Inc.

发明人： Byung Jun Ahn ,  Bruce H. Lipshutz ,  Sam L. Nguyen ,  Roscoe Linstadt

IPC分类号： C07F9/12 ,  C09D7/63 ,  C09D5/00 ,  C07C205/43 ,  A61K6/20 ,  A61K6/62 ,  A61K6/65 ,  A61K6/78 ,  B05D3/10 ,  C07C69/01 ,  C07C205/42 ,  C07C235/06 ,  C07C271/16 ,  C07F7/08 ,  B05D3/00 ,  C07C235/20 ,  C07D217/16 ,  C07F9/62 ,  C08K5/13 ,  C08K5/107

摘要： In one embodiment, the present application discloses a photo-cleavable surface binding compound of the Formula I and Formula II: wherein the variables EG, EG1, SP1, SP2, SP3, Ar and BG are as defined herein. In another embodiment, the application discloses a method for forming a coating on a surface of a substrate using the surface binding compound.