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    Amino Lipid and Preparation Method and Application Thereof
    2.
    发明公开
    Amino Lipid and Preparation Method and Application Thereof 审中-公开

    公开(公告)号：US20230348360A1

    公开(公告)日：2023-11-02

    申请号：US18100596

    申请日：2023-01-24

    申请人： Shenzhen MagicRNA Biotechnology Co., Ltd.

    发明人： Gaofeng ZHA ,  Yuexiao HU ,  Xinghua PENG ,  Wanyin FANG

    IPC分类号： C07C219/08 ,  C07D211/62 ,  A61K47/28

    CPC分类号： C07C219/08 ,  C07D211/62 ,  A61K47/28

    摘要： The disclosure belongs to the technical field of medical chemistry, particularly relates to an amino lipid and their preparation method as well as an application thereof, and provides the ionizable amino lipids with a general formula as shown in Formula (I), or pharmaceutically acceptable salts thereof. The amino lipids of the disclosure can be used for delivering nucleic acids and small molecule drugs. The amino lipid compounds have two ester bonds, which obviously enhance the lysosome escape capability of the ionizable amino lipids, and are favorable for the release of delivery targets of a targeted drug or gene, etc., thus improving the delivery efficiency, and showing the good capability of delivering nucleic acids into cells in the in-vitro and in-vivo delivery study.

    Reducing agent monomer for preparing styrene-acrylic emulsion by oxidation-reduction reaction at room temperature, and synthesis method thereof
    3.
    发明授权
    Reducing agent monomer for preparing styrene-acrylic emulsion by oxidation-reduction reaction at room temperature, and synthesis method thereof 有权

    公开(公告)号：US11377511B2

    公开(公告)日：2022-07-05

    申请号：US17414980

    申请日：2020-12-29

    申请人： CHANGZHOU UNIVERSITY

    发明人： Wenyan Huang ,  Qiujie Sun ,  Bibiao Jiang ,  Xiaoqiang Xue ,  Hongjun Yang ,  Li Jiang ,  Qimin Jiang

    IPC分类号： C08F212/08 ,  C08F220/14 ,  C08F220/18 ,  C07C219/08

    摘要： A reducing agent monomer for preparing a styrene-acrylic emulsion by an oxidation-reduction reaction at room temperature and a synthesis method thereof are disclosed. Maleic anhydride (MAH) and dimethylethanolamine (DMEA) are used as raw materials to synthesize the reducing agent monomer: 4-(2-(dimethylamino)ethoxy)-4-oxobut-2-enoic acid, and the synthesis method involves inexpensive easily-available raw materials, simple synthesis conditions, and easy purification. With the synthesized reducing agent monomer as a reducing agent, potassium persulfate (KPS) as an oxidizing agent, water as a dispersion medium, sodium dodecyl sulfate (SDS) as an emulsifier, and styrene, butyl acrylate (BA), and methylmethacrylate (MMA) as comonomers, free-radical microemulsion polymerization is conducted at room temperature to obtain a styrene-acrylic emulsion. In the synthesis of the styrene-acrylic emulsion, a monomer conversion rate is high, and a styrene-acrylic emulsion with a high molecular weight and a branched structure can be obtained at room temperature.