公开(公告)号：US10080735B2

公开(公告)日：2018-09-25

申请号：US15712269

申请日：2017-09-22

申请人： OLATEC THERAPEUTICS LLC

发明人： Joseph St. Laurent

IPC分类号： A01N37/34 ,  A61K31/275 ,  A61K9/00 ,  A61K9/06 ,  A61K47/10 ,  C07C317/28

CPC分类号： A61K31/275 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/06 ,  A61K47/10 ,  C07C317/28

摘要： The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.

公开(公告)号：US20180230097A1

公开(公告)日：2018-08-16

申请号：US15577102

申请日：2016-05-26

申请人： LUPIN LIMITED

发明人： Palash SANPHUI ,  Ananda Pundlik SAPDHARE ,  Arunkumar Digambar PATIL ,  Hemraj Mahadeorao LANDE ,  Gurvinder Pal SINGH ,  Purna Chandra RAY ,  Nandu Bahan BHISE ,  Girij Pal SINGH ,  Mithun Dasharath SURWASE ,  Shantanu Gokuldas VARADE ,  Govind Dnyanoba AUSEKAR ,  Radhakrishna Bhikaji SHIVDAVKAR

IPC分类号： C07D209/48

CPC分类号： C07D209/48 ,  C07B2200/07 ,  C07C315/04 ,  C07C317/28

摘要： The present invention provides an improved process for preparation of an intermediate of apremilast. The present invention also provides an improved process for preparation of apremilast. This invention also provides novel polymorphs of apremilast. The present invention also provides pharmaceutical compositions of novel polymorphs of apremilast. This invention also provides a process for preparation of novel polymorphs of apremilast, which are cost-effective, robust, and viable at plant scale.

公开(公告)号：US20180180992A1

公开(公告)日：2018-06-28

申请号：US15854244

申请日：2017-12-26

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Masaaki Kotake ,  Keiichi Masunaga ,  Satoshi Watanabe ,  Masaki Ohashi

IPC分类号： G03F7/004 ,  C07C381/12

CPC分类号： G03F7/004 ,  C07C317/04 ,  C07C317/28 ,  C07C381/12 ,  G03F7/0045 ,  G03F7/033 ,  G03F7/0392 ,  G03F7/0395 ,  G03F7/0397 ,  G03F7/2059 ,  G03F7/322

摘要： A positive resist composition comprising a polymer adapted to be decomposed under the action of acid to increase its solubility in alkaline developer and a sulfonium compound of formula (A) has a high resolution. When the resist composition is processed by lithography, a pattern with minimal LER can be formed.

公开(公告)号：US10003102B2

公开(公告)日：2018-06-19

申请号：US14705819

申请日：2015-05-06

申请人： SAMSUNG SDI CO., LTD.

发明人： Erang Cho ,  Duckhyun Kim ,  Moonsung Kim ,  Jeonghye Lee ,  Woocheol Shin

IPC分类号： H01M10/0567 ,  H01M6/16 ,  C07C317/28 ,  C07D333/24 ,  C07D213/57 ,  H01M10/052

CPC分类号： H01M10/0567 ,  C07C317/28 ,  C07C2601/08 ,  C07D213/57 ,  C07D333/24 ,  H01M6/168 ,  H01M10/052 ,  H01M2300/0025

摘要： An electrolyte additive for a lithium battery, an electrolyte including the electrolyte additive, and a lithium battery including the electrolyte additive are disclosed. The electrolyte additive for a lithium battery includes a sulfonylmethylisocyanide-based compound. The electrolyte additive including the sulfonylmethylisocyanide-based compound may form a protective layer having improved high-temperature stability on positive and negative electrodes of a lithium battery, thereby improving the safety of the lithium battery.

公开(公告)号：US20180030063A1

公开(公告)日：2018-02-01

申请号：US15683189

申请日：2017-08-22

申请人： Alkermes Pharma Ireland Limited

发明人： Tarek A. Zeidan ,  Scott Duncan ,  Christopher P. Hencken ,  Thomas Andrew Wynn ,  Carlos N. Sanrame

IPC分类号： C07D491/113 ,  C07C229/18 ,  C07C317/18 ,  C07C317/28 ,  C07D207/408 ,  C07D211/92 ,  C07D295/088 ,  C07C229/12 ,  C07D207/12 ,  C07D207/40 ,  A61K31/4015

CPC分类号： C07D491/113 ,  A61K31/4015 ,  C07C229/12 ,  C07C229/18 ,  C07C317/18 ,  C07C317/28 ,  C07D207/12 ,  C07D207/40 ,  C07D207/408 ,  C07D211/92 ,  C07D295/088

摘要： The present invention provides compounds of formula (I), wherein: R1 is unsubstituted C1-C6 alkyl; La is substituted or unsubstituted C1-C6 alkyl linker, substituted or unsubstituted C3-C10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; and R2 and R3 are each, independently, H, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C6-C10 aryl; or alternatively, R2 and R3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S. The invention also provides pharmaceutical compositions and methods for treating neurological diseases, such as multiple sclerosis.

公开(公告)号：US20170369426A1

公开(公告)日：2017-12-28

申请号：US15615276

申请日：2017-06-06

申请人： Achaogen, Inc.

发明人： Brian D. Patterson ,  Qing Lu ,  James Bradley Aggen ,  Paola Dozzo ,  Ramesh Annasaheb Kasar ,  Martin Sheringham Linsell ,  Timothy Robert Kane ,  Micah James Gliedt ,  Darin James Hildebrandt ,  Glenn A. McEnroe ,  Frederick Cohen

IPC分类号： C07C259/06 ,  C07D333/70 ,  C07C313/04 ,  C07C313/12 ,  C07D213/81 ,  C07D213/79 ,  C07D213/64 ,  C07C323/60 ,  C07C323/42 ,  C07C317/50 ,  C07C317/46 ,  C07C317/28 ,  C07D471/04 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08

CPC分类号： C07C259/06 ,  C07C313/04 ,  C07C313/12 ,  C07C317/28 ,  C07C317/46 ,  C07C317/50 ,  C07C323/42 ,  C07C323/60 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07D213/64 ,  C07D213/79 ,  C07D213/81 ,  C07D333/70 ,  C07D471/04

摘要： Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

公开(公告)号：US09795140B2

公开(公告)日：2017-10-24

申请号：US15092646

申请日：2016-04-07

申请人： Dow AgroSciences LLC

发明人： Timothy P. Martin ,  Joseph D. Eckelbarger ,  Ronald Ross, Jr. ,  Kyle DeKorver ,  Ronald J. Heemstra ,  Daniel I. Knueppel ,  Peter Vednor ,  Ricky Hunter ,  David A. Demeter ,  Tony K. Trullinger ,  Erich Baum ,  Zoltan Benko ,  Nakyen Choy ,  Gary Crouse ,  John F. Daeuble, Sr. ,  Fangzheng Li ,  Jeff Nissen ,  Michelle Riener ,  Tom Sparks ,  Frank Wessels ,  Maurice Yap

IPC分类号： A01N53/00 ,  A01N43/90 ,  C07D207/273 ,  A01N43/82 ,  C07D307/33 ,  C07D277/36 ,  C07D263/26 ,  C07D261/12 ,  C07D333/48 ,  C07D307/52 ,  C07D277/30 ,  C07D213/56 ,  C07C237/22 ,  C07D333/60 ,  C07D233/80 ,  C07D487/04 ,  A01N43/707 ,  A01N43/653 ,  A01N43/60 ,  A01N43/40 ,  A01N41/10 ,  A01N37/34 ,  A01N37/22 ,  C07D253/07 ,  C07D241/20 ,  C07C317/14 ,  C07C233/65 ,  C07C233/63 ,  C07D209/49 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/10 ,  C07D207/452 ,  C07C255/29 ,  C07C255/57 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07C255/46 ,  C07D213/75 ,  C07C255/60 ,  C07C259/10 ,  C07D213/81 ,  C07D213/84 ,  C07D309/14 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D231/12 ,  C07D331/04 ,  C07D231/56 ,  C07D333/36 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07D249/08 ,  C07C331/12 ,  C07D215/38

CPC分类号： A01N53/00 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C237/22 ,  C07C237/42 ,  C07C255/29 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07C271/28 ,  C07C271/66 ,  C07C311/08 ,  C07C311/46 ,  C07C317/14 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/10 ,  C07D207/273 ,  C07D207/452 ,  C07D209/49 ,  C07D213/56 ,  C07D213/75 ,  C07D213/81 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07D215/38 ,  C07D231/12 ,  C07D231/56 ,  C07D233/36 ,  C07D233/80 ,  C07D235/30 ,  C07D241/20 ,  C07D249/08 ,  C07D253/07 ,  C07D261/12 ,  C07D263/26 ,  C07D277/30 ,  C07D277/36 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D307/33 ,  C07D307/52 ,  C07D309/14 ,  C07D331/04 ,  C07D333/36 ,  C07D333/48 ,  C07D333/60 ,  C07D487/04

摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US20170281597A1

公开(公告)日：2017-10-05

申请号：US15629678

申请日：2017-06-21

申请人： Celgene Corporation

发明人： George W. Muller ,  Peter H. Schafer ,  Hon-Wah Man ,  Chuansheng Ge

IPC分类号： A61K31/4035 ,  C07D209/48 ,  C07C317/28 ,  A61K45/06

CPC分类号： A61K31/4035 ,  A61K45/06 ,  C07B2200/07 ,  C07C317/28 ,  C07D209/48 ,  Y02A50/411

摘要： Stereomerically pure (+)-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4.

公开(公告)号：US09775823B2

公开(公告)日：2017-10-03

申请号：US15295370

申请日：2016-10-17

申请人： Alkermes Pharma Ireland Limited

发明人： Tarek A. Zeidan ,  Scott Duncan ,  Christopher P. Hencken ,  Thomas Andrew Wynn ,  Carlos N. Sanrame

IPC分类号： A61K31/225 ,  C07D491/113

CPC分类号： A61K31/225 ,  C07C219/08 ,  C07C229/16 ,  C07C233/18 ,  C07C233/91 ,  C07C317/18 ,  C07C317/28 ,  C07D207/06 ,  C07D207/40 ,  C07D209/52 ,  C07D211/06 ,  C07D211/38 ,  C07D295/088 ,  C07D491/113

摘要： The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

公开(公告)号：US09750714B2

公开(公告)日：2017-09-05

申请号：US15262176

申请日：2016-09-12

申请人： Olatec Therapeutics LLC

发明人： Joseph P. St. Laurent ,  Gerald S. Jones ,  David M. Bresse ,  Scott A. Goodrich

IPC分类号： A61K31/277 ,  C07C315/02 ,  C07C317/28 ,  C07C317/44 ,  C07C319/12 ,  A61K9/00

CPC分类号： A61K31/277 ,  A61K9/0014 ,  A61K9/0053 ,  C07C315/02 ,  C07C317/28 ,  C07C317/44 ,  C07C319/12

摘要： The present invention is directed to a method of treating inflammation or pain. The present invention is also directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method comprises administering to the subject 3, 4-bis-benzylsulfonylbutyronitrile in an amount effective to reduce or eliminate the symptoms of the disease or disorder. Topical administration and oral administration are preferred route of administration.