公开(公告)号：US20240092753A1

公开(公告)日：2024-03-21

申请号：US18261182

申请日：2022-01-14

申请人： DSM IP Assets B.V.

发明人： Werner BONRATH ,  Jonathan Alan MEDLOCK ,  Marc-André MUELLER ,  Bettina WUESTENBERG

IPC分类号： C07D333/48

CPC分类号： C07D333/48

摘要： The present invention relates to a new process for the production of specific intermediates, which are preferably used in the production of vitamin A, vitamin A acetate, or β-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin.

公开(公告)号：US11912679B2

公开(公告)日：2024-02-27

申请号：US18372771

申请日：2023-09-26

申请人： Astellas Pharma, Inc. ,  Mitobridge, Inc.

发明人： Junko Maeda ,  Ikumi Kuriwaki ,  Kai Kitamura ,  Yumi Yamashita ,  Kenichi Kakefuda ,  Akio Kamikawa ,  Kenji Negoro ,  Wataru Hamaguchi ,  Ryushi Seo ,  Jeffrey Ciavarri

IPC分类号： C07C233/69 ,  C07C233/22 ,  C07C233/81 ,  C07C235/42 ,  C07C237/42 ,  C07C311/13 ,  C07C311/46 ,  C07D205/04 ,  C07D207/12 ,  C07D207/16 ,  C07D207/273 ,  C07D209/08 ,  C07D211/48 ,  C07D211/62 ,  C07D213/56 ,  C07D213/75 ,  C07D231/12 ,  C07D231/40 ,  C07D239/26 ,  C07D279/12 ,  C07D295/155 ,  C07D295/16 ,  C07D295/195 ,  C07D305/08 ,  C07D307/22 ,  C07D309/14 ,  C07D333/48 ,  C07D401/06 ,  C07D403/06 ,  C07D403/10 ,  C07D405/10 ,  C07D487/10

CPC分类号： C07D295/16 ,  C07C233/22 ,  C07C233/69 ,  C07C233/81 ,  C07C235/42 ,  C07C237/42 ,  C07C311/13 ,  C07C311/46 ,  C07D205/04 ,  C07D207/12 ,  C07D207/16 ,  C07D207/273 ,  C07D209/08 ,  C07D211/48 ,  C07D211/62 ,  C07D213/56 ,  C07D213/75 ,  C07D231/12 ,  C07D231/40 ,  C07D239/26 ,  C07D279/12 ,  C07D295/155 ,  C07D295/195 ,  C07D305/08 ,  C07D307/22 ,  C07D309/14 ,  C07D333/48 ,  C07D401/06 ,  C07D403/06 ,  C07D403/10 ,  C07D405/10 ,  C07D487/10

摘要： [Problem] A compound which is useful as a STING inhibitor is provided.
[Means for Solution] The present inventors have found aryl alkynamide derivatives having an inhibitory action on STING. The aryl alkynamide derivatives of the present invention have an inhibitory action on STING and can be used as an agent for treating an autoimmune disease, a neurodegenerative disease, a type I interferonopathy and/or other STING-mediated disease.

公开(公告)号：US20210119255A1

公开(公告)日：2021-04-22

申请号：US17042241

申请日：2019-05-21

申请人： MU IONIC SOLUTIONS CORPORATION ,  SUMITOMO SEIKA CHEMICALS CO., LTD.

发明人： Masahide KONDO ,  Kei SHIMAMOTO

IPC分类号： H01M10/0567 ,  H01M10/0568 ,  H01M10/0525 ,  C07D333/48

摘要： Disclosed is a non-aqueous electrolytic solution for an energy storage device, including a non-aqueous solvent, an electrolyte salt, a first additive consisting of a sulfolane compound represented by the following formula (1), and a second additive which is at least one selected from the group consisting of a cyclic sulfuric ester compound represented by the following formula (2a) and a dinitrile compound represented by the following formula (2b):

公开(公告)号：US10472351B2

公开(公告)日：2019-11-12

申请号：US16008631

申请日：2018-06-14

申请人： Zander Therapeutics, Inc.

发明人： Harry M. Lander ,  David R. Koos

IPC分类号： C07D407/12 ,  C07D333/48 ,  C07D407/04 ,  C07D407/14

摘要： The present technology is directed to modulators of nuclear receptor activity, specifically to the modulation of NR2F6 activity and NR2F6 utilizing compounds, and the immune modulation and modulation of cancer stem cell activity through administration of compounds described herein to animals.

公开(公告)号：US10290812B2

公开(公告)日：2019-05-14

申请号：US14951718

申请日：2015-11-25

申请人： Samsung Electronics Co., Ltd.

发明人： Seon-Jeong Lim ,  Takkyun Ro ,  Tadao Yagi ,  Kyung Bae Park ,  Sung Young Yun ,  Yong Wan Jin ,  Chul-Joon Heo

IPC分类号： H01L51/00 ,  H01L27/30 ,  C07D345/00 ,  C07D333/48 ,  C07D421/06 ,  C07D333/36 ,  C07F7/08 ,  C09B23/04 ,  C09B47/00 ,  C09B57/00 ,  H01L51/44 ,  H01L51/42

摘要： A compound for an organic photoelectric device is represented by Chemical Formula 1, and an organic photoelectric device, an image sensor and an electronic device include the same.

公开(公告)号：US20180179166A1

公开(公告)日：2018-06-28

申请号：US15128672

申请日：2015-03-24

申请人： ViroCarb Inc.

发明人： Clifford LINGWOOD ,  Mario HUESCA ,  Raveendra DAYAM ,  Shamshair SINGH

IPC分类号： C07D239/46 ,  C07D239/47 ,  A61P31/18 ,  G01N33/68 ,  C07D253/075 ,  C07D239/60 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D401/14 ,  C07D417/14 ,  C07D333/48 ,  C07D231/06 ,  C07D401/04

CPC分类号： C07D239/46 ,  A61K31/381 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/635 ,  A61P31/18 ,  C07D231/06 ,  C07D239/47 ,  C07D239/60 ,  C07D253/07 ,  C07D253/075 ,  C07D333/24 ,  C07D333/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/14 ,  C12Q1/70 ,  G01N33/6893 ,  G01N2333/162 ,  G01N2500/02 ,  G16B35/00 ,  G16C20/60

摘要： Small molecule inhibitors GP120-mediated HIV infections, methods for identifying the same, and methods and uses employing of these compounds in treatment, inhibition or prevention of HIV infection are provided. The compounds have a structure according to Formula (I), and comprise a pharmacophore functionally corresponding with pharmacophore (I) of FIG. 2.

公开(公告)号：US20180016266A1

公开(公告)日：2018-01-18

申请号：US15719376

申请日：2017-09-28

申请人： Nektar Therapeutics

发明人： Neel K. Anand ,  Franco J. Duarte ,  Wen Zhang ,  Zhongxu Ren

IPC分类号： C07D409/12 ,  C07D333/48 ,  C07D295/125 ,  C07D241/04 ,  C07D213/61 ,  C07D213/56 ,  C07D207/14 ,  C07D207/12 ,  C07D207/09 ,  C07D205/04 ,  C07C233/40 ,  C07D401/12 ,  C07C233/05

CPC分类号： C07D409/12 ,  C07C233/05 ,  C07C233/40 ,  C07D205/04 ,  C07D207/09 ,  C07D207/12 ,  C07D207/14 ,  C07D213/56 ,  C07D213/61 ,  C07D241/04 ,  C07D295/125 ,  C07D333/48 ,  C07D401/12

摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, and R6 are as described herein. The compounds of Formula I are agonists of the kappa opioid receptor and relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

公开(公告)号：US09776963B2

公开(公告)日：2017-10-03

申请号：US13128549

申请日：2009-11-10

申请人： Joseph G. Sodroski ,  Navid Madani ,  Arne Schön ,  Judith M. LaLonde ,  Joel R. Courter ,  Takahiro Soeta ,  Danny Ng ,  Ernesto Freire ,  Amos B. Smith, III ,  Amy M. Princiotto ,  Matthew Le-Khac ,  Wayne A. Hendrickson

发明人： Joseph G. Sodroski ,  Navid Madani ,  Arne Schön ,  Judith M. LaLonde ,  Joel R. Courter ,  Takahiro Soeta ,  Danny Ng ,  Ernesto Freire ,  Amos B. Smith, III ,  Amy M. Princiotto ,  Matthew Le-Khac ,  Wayne A. Hendrickson

IPC分类号： A61K31/397 ,  C07D211/58 ,  C07D205/04 ,  C07D207/09 ,  C07D207/16 ,  C07D207/22 ,  C07D211/26 ,  C07D211/44 ,  C07D211/56 ,  C07D217/14 ,  C07D223/04 ,  C07D231/56 ,  C07D233/64 ,  C07D235/02 ,  C07D235/14 ,  C07D237/32 ,  C07D239/42 ,  C07D239/47 ,  C07D239/90 ,  C07D249/08 ,  C07D265/36 ,  C07D295/13 ,  C07D307/52 ,  C07D317/28 ,  C07D333/20 ,  C07D333/48 ,  C07D401/04 ,  C07D401/06 ,  C07D405/06 ,  C07D409/14 ,  C07D455/02 ,  C07D471/08 ,  C07D473/18 ,  C07D487/04 ,  C07D495/04

CPC分类号： C07D211/58 ,  C07D205/04 ,  C07D207/09 ,  C07D207/16 ,  C07D207/22 ,  C07D211/26 ,  C07D211/44 ,  C07D211/56 ,  C07D217/14 ,  C07D223/04 ,  C07D231/56 ,  C07D233/64 ,  C07D235/02 ,  C07D235/14 ,  C07D237/32 ,  C07D239/42 ,  C07D239/47 ,  C07D239/90 ,  C07D249/08 ,  C07D265/36 ,  C07D295/13 ,  C07D307/52 ,  C07D317/28 ,  C07D333/20 ,  C07D333/48 ,  C07D401/04 ,  C07D401/06 ,  C07D405/06 ,  C07D409/14 ,  C07D455/02 ,  C07D471/08 ,  C07D473/18 ,  C07D487/04 ,  C07D495/04

摘要： The invention provides for compounds of formula I: wherein Z is absent or (CRARB)nW; each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, haloalkyl, each of which may be optionally substituted; (ii) OH, ORc, NH2, NHRc, NRcRc, SH, S(O)mRc; or (iii) RA and RB together form C(O); W is absent, C(O), C(O)O, C(O)NRcRc, O, S(O)m, or NRcRc; Y is an optionally substituted heterocyclic, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted aryl, or NRXRY; wherein Rx and Ry are each independently H, alkyl or aryl; X1 is selected from the group consisting of halogen, methyl, and hydroxyl; X2 is a halogen; each Rc is independently alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl, each of which may be optionally substituted; m is O, 1, or 2; and n is 1, 2, 3, 4, 5, or 6; and pharmaceutically acceptable salts thereof.

公开(公告)号：US09708287B2

公开(公告)日：2017-07-18

申请号：US14872419

申请日：2015-10-01

申请人： Cayman Chemical Company Incorporated

发明人： Mitchell A. deLong ,  Kalla Lynn Kvalnes ,  Raymond Boissy

IPC分类号： C07D335/02 ,  C07D309/10 ,  A61K8/49 ,  A61K8/69 ,  C07D309/12 ,  A61Q19/02 ,  A61K8/60 ,  C07D215/227 ,  C07D311/94 ,  C07D313/04 ,  C07D313/18 ,  C07D333/32 ,  C07D333/64 ,  C07D493/04 ,  C07H15/203 ,  C07D311/02 ,  C07D215/22 ,  C07D319/12 ,  C07D333/48 ,  C07D307/20 ,  A61K8/33

CPC分类号： C07D335/02 ,  A61K8/33 ,  A61K8/4926 ,  A61K8/4973 ,  A61K8/498 ,  A61K8/4986 ,  A61K8/602 ,  A61K8/69 ,  A61K2800/591 ,  A61Q19/02 ,  C07D215/22 ,  C07D215/227 ,  C07D307/20 ,  C07D309/10 ,  C07D309/12 ,  C07D311/02 ,  C07D311/94 ,  C07D313/04 ,  C07D313/18 ,  C07D319/12 ,  C07D333/32 ,  C07D333/48 ,  C07D333/64 ,  C07D493/04 ,  C07H15/203

摘要： Compounds that function, alone or in combination, as inhibitors of pigmentation for the improvement of mammalian skin are described herein. Specifically, the compounds of the present disclosure, namely chiral, non-racemic compounds, function as pigment formation inhibitors thereof to beautify skin and discourage the production of melanins. One or more products, consumer and otherwise, comprising the chiral, non-racemic compounds are disclosed herein. Methods of employing both the compounds of the present disclosure and the products incorporating the present compounds are also disclosed herein.

公开(公告)号：US20160376250A1

公开(公告)日：2016-12-29

申请号：US14832131

申请日：2015-08-21

申请人： International Business Machines Corporation

发明人： Dylan J. Boday ,  Joseph Kuczynski ,  Timothy C. Mauldin

IPC分类号： C07D333/48 ,  C07C1/32

CPC分类号： B01D53/44 ,  B01D53/346 ,  B01D53/72 ,  B01D53/76 ,  B01D53/82 ,  B01D53/96 ,  B01D2251/508 ,  B01D2253/108 ,  B01D2257/7022 ,  B01D2259/40088 ,  B01D2259/4009 ,  B01D2259/40092 ,  B01J19/24 ,  B01J19/2445 ,  B01J2219/24 ,  C07C1/322 ,  C07C7/17 ,  C07D333/48 ,  C07C11/167

摘要： In an example, a method of butadiene sequestration includes receiving an input stream that includes butadiene. The method includes directing the input stream to a first sulfur dioxide charged zeolite bed for butadiene sequestration via a first chemical reaction of butadiene and sulfur dioxide to form sulfolene.