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公开(公告)号：US11672776B2
公开(公告)日：2023-06-13
申请号：US16026979
申请日：2018-07-03
申请人： Nektar Therapeutics
IPC分类号： A61K31/337 , A61K38/00 , A61K31/785 , C08G79/08 , A61K47/60 , A61K31/4745 , C08G65/332 , C08G65/333
CPC分类号： A61K31/337 , A61K31/4745 , A61K31/785 , A61K38/00 , A61K47/60 , C08G65/3328 , C08G65/33344 , C08G79/08
摘要： Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
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公开(公告)号：US20220072010A1
公开(公告)日：2022-03-10
申请号：US17527910
申请日：2021-11-16
申请人： Nektar Therapeutics
IPC分类号： A61K31/573 , C07J41/00 , A61K47/60 , A61K47/59
摘要： The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the corticosteroid not attached to the water-soluble oligomer.
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公开(公告)号：US20180256599A1
公开(公告)日：2018-09-13
申请号：US15788626
申请日：2017-10-19
申请人： Nektar Therapeutics
IPC分类号： A61K31/573 , C07J41/00
CPC分类号： A61K31/573 , A61K47/59 , A61K47/60 , C07J41/0005
摘要： The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the corticosteroid not attached to the water-soluble oligomer.
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公开(公告)号：US09220790B2
公开(公告)日：2015-12-29
申请号：US14591601
申请日：2015-01-07
申请人： NEKTAR THERAPEUTICS
IPC分类号： A61K47/48 , A61P35/00 , C08G65/48 , A61K38/00 , A61K31/785 , C08G79/08 , A61K31/337
CPC分类号： A61K31/337 , A61K31/4745 , A61K31/785 , A61K38/00 , A61K47/60 , C08G65/3328 , C08G65/33344 , C08G79/08
摘要： Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
摘要翻译： 在其它方面，本文提供了包含链烷酸酯 - 连接体，包含这种缀合物的组合物的多臂聚合物缀合物及其制备和施用相关方法。 还提供了使用这种缀合物和相关用途的治疗方法。 以高药物负载效率制备缀合物。
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公开(公告)号：US20150133534A1
公开(公告)日：2015-05-14
申请号：US14591601
申请日：2015-01-07
申请人： NEKTAR THERAPEUTICS
IPC分类号： A61K47/48 , A61K31/337
CPC分类号： A61K31/337 , A61K31/4745 , A61K31/785 , A61K38/00 , A61K47/60 , C08G65/3328 , C08G65/33344 , C08G79/08
摘要： Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
摘要翻译： 在其它方面，本文提供了包含链烷酸酯 - 连接体，包含这种缀合物的组合物的多臂聚合物缀合物及其制备和施用相关方法。 还提供了使用这种缀合物和相关用途的治疗方法。 以高药物负载效率制备缀合物。
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公开(公告)号：US20220235056A1
公开(公告)日：2022-07-28
申请号：US17608582
申请日：2020-05-01
申请人： Nektar Therapeutics
发明人： Neel K. Anand , Natalia Aurrecoechea , Anthony James Brockway , Haiying Cai , Lin Cheng , Bo-Liang Deng , Donogh John Roger O'Mahony , Zhongxu Ren , Wen Zhang
IPC分类号： C07D487/04 , C07D519/00
摘要： The instant disclosure provides novel adenosine receptor antagonist compounds, compositions, methods of making and methods of using. In a further aspect, a method of treating a subject in need thereof, comprising administering a therapeutically effective amount of any one or more of the compounds described herein. In some embodiments, the subject has cancer and the method is a method of treating cancer.
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公开(公告)号：US20190352291A1
公开(公告)日：2019-11-21
申请号：US16529504
申请日：2019-08-01
申请人： Nektar Therapeutics
发明人： Neel K. Anand , Franco J. Duarte , Wen Zhang , Zhongxu Ren
IPC分类号： C07D409/12 , C07D213/61 , C07D213/56 , C07D207/14 , C07D207/12 , C07D241/04 , C07C233/40 , C07D401/12 , C07D207/09 , C07C233/05 , C07D295/125 , C07D205/04 , C07D333/48
摘要： Provided are compounds of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds of Formula I described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.
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公开(公告)号：US10039737B2
公开(公告)日：2018-08-07
申请号：US15296414
申请日：2016-10-18
申请人： Nektar Therapeutics
IPC分类号： A61K31/337 , A61K38/00 , A61K31/785 , C08G79/08 , A61K47/48 , A61K31/4745 , C08G65/332 , C08G65/333
摘要： Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
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公开(公告)号：US20180140712A1
公开(公告)日：2018-05-24
申请号：US15875864
申请日：2018-01-19
申请人： Nektar Therapeutics
发明人： Jennifer Riggs-Sauthier , Wen Zhang
IPC分类号： A61K47/60 , A61K31/165 , C07D235/22
CPC分类号： A61K47/60 , A61K31/165 , C07D235/22
摘要： The invention relates to (among other things) N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides and compositions comprising the same. A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer.
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公开(公告)号：US09815824B2
公开(公告)日：2017-11-14
申请号：US14900039
申请日：2014-06-27
申请人： Nektar Therapeutics
发明人： Neel K. Anand , Franco J. Duarte , Wen Zhang , Zhongxu Ren
IPC分类号： C07D409/12 , C07C233/05 , C07D207/09 , C07D401/12 , C07D295/125 , C07C233/40 , C07C205/04 , C07C333/00 , C07D241/04 , C07D207/12 , C07D207/14 , C07D213/56 , C07D333/48 , C07D213/61 , C07D205/04
CPC分类号： C07D409/12 , C07C233/05 , C07C233/40 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D213/56 , C07D213/61 , C07D241/04 , C07D295/125 , C07D333/48 , C07D401/12
摘要： Provided are compounds of Formula I; and pharmaceutically acceptable salts and solvates thereof. The present disclosure relates to novel compounds and to their use as agonists of the kappa opioid receptor. The disclosure also relates to methods for preparation of the compounds and to pharmaceutical compositions containing such compounds. Kappa opioid agonists that exhibit full agonist properties at the kappa opioid receptor have been widely shown to be efficacious in preclinical models of pain, particularly visceral pain.
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