公开(公告)号：US20240254267A1

公开(公告)日：2024-08-01

申请号：US18280649

申请日：2021-03-01

申请人： Renosis, Inc.

发明人： Gerrit Klaerner ,  Eric F. Connor ,  Randi K. Gbur ,  Matthew J. Kade ,  Paul H. Kierstead ,  Kalpesh N. Biyani ,  Son H. Nguyen ,  Scott M. Tabakman

IPC分类号： C08F226/02 ,  A61K31/785

CPC分类号： C08F226/02 ,  A61K31/785

摘要： Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain crosslinked amine polymers and may be used, for example, to treat diseases or other metabolic conditions in which removal of a target species from the gastrointestinal tract would provide physiological benefits.

公开(公告)号：US11986555B2

公开(公告)日：2024-05-21

申请号：US17678178

申请日：2022-02-23

申请人： Cosette Pharmaceuticals, Inc.

发明人： Tommy L. Chau

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K31/785 ,  A61P3/06

CPC分类号： A61K9/0056 ,  A61K9/145 ,  A61K31/785 ,  A61P3/06

摘要： A chewable pharmaceutical product comprises a matrix comprising: a binder, a bulking agent, a lubricant, a humectant, an emulsifier, and optionally a flavoring, wherein the binder comprises one or more maltitol syrups, which are present in the pharmaceutical product in an amount in the range of 60-70% by weight; and colesevelam hydrochloride.

公开(公告)号：US20240118294A1

公开(公告)日：2024-04-11

申请号：US18543588

申请日：2023-12-18

申请人： Quest Diagnostics Investments LLC

发明人： Karin O. Thomassian

IPC分类号： G01N33/94 ,  A61K31/785 ,  H01J49/00

CPC分类号： G01N33/94 ,  A61K31/785 ,  G01N33/9493 ,  H01J49/0036 ,  G01N2560/00

摘要： A method for determining an amount of teriflunomide in a sample by mass spectrometry includes adding an internal standard to the sample, subjecting the sample to solid phase extraction, purifying the sample by high turbulence liquid chromatography, ionizing the sample to produce one or more teriflunomide ions detectable by mass spectrometry, determining the amount of the one or more teriflunomide ions by mass spectrometry, and using the amount of the one or more ions determined to further determine the amount of teriflunomide in the sample.

公开(公告)号：US20240108607A1

公开(公告)日：2024-04-04

申请号：US18112423

申请日：2023-02-21

申请人： FUJIFILM Corporation

发明人： Hirofumi FUKUNAGA ,  Sachiko SHINJO ,  Daisuke NAKAGAWA ,  Shinichiro SEKINE ,  Takayuki YAMAKAWA

IPC分类号： A61K31/4375 ,  A61K31/145 ,  A61K31/223 ,  A61K31/27 ,  A61K31/395 ,  A61K31/555 ,  A61K31/785 ,  A61K51/00 ,  C07B59/00 ,  C07D255/02 ,  C07D257/02 ,  C07D471/04 ,  C07D487/00 ,  C07F1/08 ,  C07F5/00

CPC分类号： A61K31/4375 ,  A61K31/145 ,  A61K31/223 ,  A61K31/27 ,  A61K31/395 ,  A61K31/555 ,  A61K31/785 ,  A61K51/00 ,  C07B59/00 ,  C07D255/02 ,  C07D257/02 ,  C07D471/04 ,  C07D487/00 ,  C07F1/08 ,  C07F5/00

摘要： A compound represented by Formula [3] or a salt thereof and a method of making the






in the formula, L3 represents a group represented by Formula [2c]










wherein R3c, R4c, R5c and R6c are the same as or different from each other and represent a hydrogen atom or a C1-6 alkyl group; p3 represents an integer of 1 to 3; q3 represents an integer of 0 to 3; and r3 represents an integer of 1 to 6; A1 represents any one of the groups represented by Formulae [4] to [9],










wherein * represents a binding position; and R7 represents a carboxyl-protecting group; and m represents an integer of 1 to 3.

公开(公告)号：US20240066052A1

公开(公告)日：2024-02-29

申请号：US17898897

申请日：2022-08-30

申请人： Ethicon, Inc.

发明人： Salim A. Ghodbane ,  Sridevi Dhanaraj ,  Brian Aitken

IPC分类号： A61K31/787 ,  A61K31/785 ,  A61K47/22 ,  A61P11/00

CPC分类号： A61K31/787 ,  A61K31/785 ,  A61K47/22 ,  A61P11/00

摘要： The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.

公开(公告)号：US20240066010A1

公开(公告)日：2024-02-29

申请号：US18117899

申请日：2023-03-06

申请人： Salix Pharmaceuticals, Ltd.

发明人： William Forbes

IPC分类号： A61K31/437 ,  A61K31/08 ,  A61K31/352 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/606 ,  A61K31/7016 ,  A61K31/785 ,  A61K38/14 ,  A61K38/31 ,  A61K45/06

CPC分类号： A61K31/437 ,  A61K31/08 ,  A61K31/352 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/606 ,  A61K31/7016 ,  A61K31/785 ,  A61K38/14 ,  A61K38/31 ,  A61K45/06

摘要： The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin.

公开(公告)号：US11911387B2

公开(公告)日：2024-02-27

申请号：US17122072

申请日：2020-12-15

申请人： Boehringer Ingelheim International GmbH

发明人： Thomas Klein ,  Andreas Daiber ,  Odd-Erik Johansen ,  Michael Mark ,  Sanjaykumar Patel ,  Hans-Juergen Woerle

IPC分类号： A61K31/522 ,  C07D473/06 ,  C07D473/12 ,  A61K31/397 ,  A61K31/5377 ,  A61K31/616 ,  A61K31/727 ,  A61K31/785 ,  A61K38/26 ,  A61K38/28 ,  A61K45/06 ,  A61K31/519 ,  A61K31/155 ,  A61K31/4184

CPC分类号： A61K31/522 ,  A61K31/155 ,  A61K31/397 ,  A61K31/4184 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/616 ,  A61K31/727 ,  A61K31/785 ,  A61K38/26 ,  A61K38/28 ,  A61K45/06 ,  C07D473/06 ,  C07D473/12 ,  A61K31/519 ,  A61K2300/00 ,  A61K31/397 ,  A61K2300/00 ,  A61K31/522 ,  A61K2300/00 ,  A61K31/5377 ,  A61K2300/00 ,  A61K31/616 ,  A61K2300/00 ,  A61K31/727 ,  A61K2300/00 ,  A61K31/785 ,  A61K2300/00 ,  A61K38/26 ,  A61K2300/00 ,  A61K38/28 ,  A61K2300/00

摘要： The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.

公开(公告)号：US20240050464A1

公开(公告)日：2024-02-15

申请号：US18372162

申请日：2023-09-25

申请人： Viscera Labs, Inc.

发明人： Stephen TAGLIENTI ,  Steven L. PETRUCCELLI

IPC分类号： A61K31/785 ,  A61K9/28 ,  A61K9/20 ,  A61K45/06

CPC分类号： A61K31/785 ,  A61K9/2886 ,  A61K9/2866 ,  A61K9/2054 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/282 ,  A61K45/06

摘要： In exemplary embodiments, the disclosure provides a Colesevelam Colon Specific Drug Delivery System for use in treatment of, for example pruritus, a disorder related to elevated serum cholesterol concentration, or reducing elevated low-density lipoprotein cholesterol (LDL) concentration in a patient.

公开(公告)号：US11896698B2

公开(公告)日：2024-02-13

申请号：US15763920

申请日：2016-09-30

申请人： RB HEALTH (US) LLC

发明人： Jessica Wilson ,  Sarah Frances de Szalay ,  Elizabeth Bruning ,  Rui Yang

IPC分类号： A61K8/44 ,  A61K8/34 ,  A61K8/365 ,  A61K8/46 ,  A61Q17/00 ,  A61Q19/10 ,  A61K8/45 ,  A61K8/20 ,  A61K31/095 ,  A61K8/86 ,  A61Q19/00 ,  A61K8/39 ,  A61K31/19 ,  A61K31/765 ,  A61K8/04 ,  A61K31/785 ,  A61K31/047 ,  A61K45/06 ,  A61K8/42

CPC分类号： A61K8/442 ,  A61K8/046 ,  A61K8/20 ,  A61K8/345 ,  A61K8/365 ,  A61K8/39 ,  A61K8/42 ,  A61K8/44 ,  A61K8/45 ,  A61K8/463 ,  A61K8/86 ,  A61K31/047 ,  A61K31/095 ,  A61K31/19 ,  A61K31/765 ,  A61K31/785 ,  A61K45/06 ,  A61Q17/005 ,  A61Q19/005 ,  A61Q19/10 ,  A61K2800/75 ,  A61K31/047 ,  A61K2300/00 ,  A61K31/19 ,  A61K2300/00 ,  A61K31/095 ,  A61K2300/00 ,  A61K31/765 ,  A61K2300/00 ,  A61K31/785 ,  A61K2300/00

摘要： A personal wash composition which provides an effective antimicrobial benefit against fungi, gram positive and gram negative bacteria, which composition comprises: a) from 0.1% to 10 wt % betaine surfactant, b) from 0.1% to 5.0 wt % lactic acid, c) from 0.1% to 20 wt % polyhydric C2-C6 alcohol, d) from 0% to 10 wt % alkyl polyethoxy carboxylate of the formula RO(CH2CH2O)kCH2COO−M+ wherein R is a C8-C22 alkyl, k is an integer from 0 to 20, and M is a soluble salt-forming cation, e) from 0% to 10 wt % alkyl polyethoxy amides of the formula RO(CH2CH2O)kCH2CONH2 wherein R is a C8-C22 alkyl, k is an integer from 0 to 20, f) >8 wt % alkyl ether sulphate, g) water, h) a pH of 3.8-4.5, i) 10-20 wt % total surfactant, j) from 0.1 to 10 wt % metal salt.

公开(公告)号：US20230390326A1

公开(公告)日：2023-12-07

申请号：US18250876

申请日：2021-10-27

申请人： SUNGKWANG MEDICAL FOUNDATION ,  CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Kyung-Soon PARK ,  Keun-Hong PARK ,  Seung Hee CHOI ,  Hye Jin KIM ,  Hee Jung AN

IPC分类号： A61K31/785 ,  C12N5/0783 ,  A61P35/00

CPC分类号： A61K31/785 ,  C12N5/0646 ,  A61P35/00 ,  C12N2500/50

摘要： According to a composition including a cationic substance as an active ingredient according to one aspect, the stability of perforin protein is increased to induce the accumulation of intracellular perforin proteins, thereby increasing the activity of immune cells.