公开(公告)号：US20240045307A1

公开(公告)日：2024-02-08

申请号：US18378217

申请日：2023-10-10

申请人： Lightwave Logic, Inc.

发明人： Cory Pecinovsky ,  Barry Johnson ,  Ginelle Ramann

IPC分类号： G02F1/361 ,  C07D487/00 ,  G02F1/00

CPC分类号： G02F1/3617 ,  C07D487/00 ,  G02F1/0018 ,  G02F1/3612

摘要： Nonlinear optical chromophores having one or more diamondoid groups covalently attached to the chromophore, methods of making nonlinear optical chromophores, their use in thin films and electro-optical devices containing such nonlinear optical chromophores and thin films comprising the same.

公开(公告)号：US20220251086A1

公开(公告)日：2022-08-11

申请号：US17666850

申请日：2022-02-08

申请人： Idemitsu Kosan Co.,Ltd.

发明人： Heinz WOLLEB ,  Michelle GROARKE ,  Masato MITANI ,  Natalia CHEBOTAREVA

IPC分类号： C07D487/00 ,  H01L51/00 ,  C07D498/04 ,  C07D513/04

摘要： Specific compounds represented by formula (1), a material for an organic electroluminescence device comprising said specific compound, an organic electroluminescence device comprising said specific compound, an electronic equipment comprising said organic electroluminescence device and the use of said compounds in an organic electroluminescence device.

公开(公告)号：US11247998B2

公开(公告)日：2022-02-15

申请号：US16632973

申请日：2018-07-26

申请人： JIANGSU HENGRUI MEDICINE CO., LTD. ,  SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.

发明人： Xin Li ,  Wei He ,  Yang Chen ,  Feng He ,  Weikang Tao

IPC分类号： C07D241/36 ,  C07D487/00 ,  A61K31/495 ,  C07D487/04 ,  A61P31/12 ,  A61K31/4985

摘要： The present invention relates to a piperazine heteroaryl derivative, a preparation method therefor and the use of same in medicine. In particular, the present invention relates to the piperazine heteroaryl derivative as shown in the general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and the use of same as a capsid protein inhibitor, in particular in the prevention and/or treatment of diseases such as hepatitis B, influenza, herpes, AIDS, etc. The definitions of each group in the general formula (I) are the same as those defined in the description.

公开(公告)号：US20220024927A1

公开(公告)日：2022-01-27

申请号：US17315910

申请日：2021-05-10

申请人： SAMSUNG SDI CO., LTD.

发明人： Chang Ju SHIN ,  Dong Wan RYU ,  Jongwoo WON ,  Dongkyu RYU ,  Hanill LEE ,  Jinseok JANG ,  Sung-Hyun JUNG ,  Ho Kuk JUNG

IPC分类号： C07D487/00 ,  C07D493/00 ,  C07D495/00 ,  H01L51/00

摘要： A compound for an organic optoelectronic device, a composition for an organic optoelectronic device, an organic optoelectronic device, and a display device, the compound being represented by Chemical Formula 1:

公开(公告)号：US10190160B2

公开(公告)日：2019-01-29

申请号：US14466208

申请日：2014-08-22

申请人： Children's Medical Center Corporation ,  The Technical University of Denmark ,  Dana-Farber Cancer Institute, Inc. ,  The Brigham and Women's Hospital, Inc.

发明人： Zoltan Szallasi ,  Nicolai Juul Birkbak ,  Aron Eklund ,  Daniel Silver ,  Zhigang Wang ,  Andrea Richardson

IPC分类号： C12Q1/6886 ,  C12P19/34 ,  A61K38/00 ,  C07D487/00 ,  C12Q1/6874

摘要： The present invention is based, in part, on the identification of novel methods for defining predictive biomarkers of response to anti-cancer drugs.

公开(公告)号：US10085968B2

公开(公告)日：2018-10-02

申请号：US14950834

申请日：2015-11-24

申请人： Sunovion Pharmaceuticals, Inc. ,  PGI Drug Discovery LLC

发明人： Liming Shao ,  John Emmerson Campbell ,  Michael Charles Hewitt ,  Una Campbell ,  Taleen G. Hanania

IPC分类号： C07D233/00 ,  C07D403/02 ,  C07D403/14 ,  C07D231/00 ,  C07D487/02 ,  C07D487/00 ,  C07D405/00 ,  C07D409/00 ,  C07D495/02 ,  A61K31/415 ,  A61K31/40 ,  C07D277/22 ,  A61K31/381 ,  C07D277/60 ,  C07D333/54 ,  C07D333/76 ,  C07D333/78 ,  C07D495/04 ,  C07D495/20 ,  A61K31/435 ,  A61K31/55 ,  A61K45/06

摘要： Provided herein are multicyclic compounds of formula (IVa), shown below, wherein R1, R2, R3, R4, R5, R6, R7, m, and n are defined herein elsewhere, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

公开(公告)号：US10022378B2

公开(公告)日：2018-07-17

申请号：US15594796

申请日：2017-05-15

申请人： Emory University

发明人： Christina Gavegnano ,  Raymond F. Schinazi

IPC分类号： A61K31/70 ,  A61K31/66 ,  A61K31/535 ,  A61K31/519 ,  C07F9/02 ,  C07D487/00 ,  A61K45/06 ,  A61K31/536 ,  A61K31/52 ,  A61K31/513 ,  A61K31/4045 ,  A61K31/7072

摘要： Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations of these JAK inhibitors and additional antiretroviral compounds, such as NRTI, NNRTI, integrase inhibitors, entry inhibitors, protease inhibitors, and the like, are also disclosed. In one embodiment, the combinations include a combination of adenine, cytosine, thymidine, and guanine nucleoside antiviral agents, optionally in further combination with at least one additional antiviral agent that works via a different mechanism than a nucleoside analog. This combination has the potential to eliminate the presence of HIV in an infected patient.

公开(公告)号：US09902728B2

公开(公告)日：2018-02-27

申请号：US14982127

申请日：2015-12-29

申请人： Forma Therapeutics, Inc.

发明人： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  Darby Rye Schmidt ,  David Joseph Guerin ,  Justin A. Caravella ,  R. Bruce Diebold ,  Anna Ericsson ,  David R. Lancia, Jr.

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07D519/00

摘要： The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.

公开(公告)号：US09902721B2

公开(公告)日：2018-02-27

申请号：US15121432

申请日：2015-02-27

申请人： Cancer Research Technology Limited

发明人： Hannah Woodward ,  Paolo Innocenti ,  Sebastien Naud ,  Julian Blagg ,  Swen Hoelder

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D471/00 ,  C07D487/00 ,  C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D519/00

摘要： The present invention relates to compounds of formula I: wherein R1, R2, R3 and R4 are all as defined herein. The compounds of the present invention are known to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases either directly or indirectly via interaction with the Mps1 kinase itself. In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

公开(公告)号：US09902702B2

公开(公告)日：2018-02-27

申请号：US14797414

申请日：2015-07-13

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Vladimir Ladziata ,  Peter W. Glunz ,  Zilun Hu ,  Yufeng Wang

IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  C07D237/26 ,  C07D487/00 ,  C07D237/32 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D413/12 ,  C07D471/04 ,  C07D513/04 ,  C07D487/04 ,  C07D405/14 ,  C07D471/10 ,  C07D413/14 ,  C07D403/08 ,  C07D519/00

CPC分类号： C07D237/32 ,  C07D403/08 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.