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公开(公告)号：US10519128B2
公开(公告)日：2019-12-31
申请号：US16179111
申请日：2018-11-02
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , David R. Lancia, Jr.
IPC分类号： C07D401/06 , C07D239/88 , C07D487/04 , C07D471/04
摘要： The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.
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公开(公告)号：US10513508B2
公开(公告)日：2019-12-24
申请号：US16179061
申请日：2018-11-02
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , David R. Lancia, Jr.
IPC分类号： C07D401/06 , C07D487/04 , C07D239/88 , C07D471/04
摘要： The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.
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公开(公告)号：US10377773B2
公开(公告)日：2019-08-13
申请号：US15907007
申请日：2018-02-27
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell
IPC分类号： C07D487/04 , C07D513/04
摘要： The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.
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公开(公告)号：US09902728B2
公开(公告)日：2018-02-27
申请号：US14982127
申请日：2015-12-29
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , Darby Rye Schmidt , David Joseph Guerin , Justin A. Caravella , R. Bruce Diebold , Anna Ericsson , David R. Lancia, Jr.
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , A61K31/519 , C07D519/00
摘要： The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.
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5.发明申请PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS 有权吡咯和吡唑并嘧啶作为UBIQUITIN特异性蛋白酶7抑制剂公开(公告)号：US20160185785A1
公开(公告)日：2016-06-30
申请号：US14982127
申请日：2015-12-29
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , Darby Rye Schmidt , David Joseph Guerin , Justin A. Caravella , R. Bruce Diebold , Anna Ericsson , David Lancia, JR.
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , A61K31/519 , C07D519/00
摘要： The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.
摘要翻译： 本发明涉及可用于治疗癌症，神经变性疾病，免疫疾病，炎症性疾病，心血管疾病，缺血性疾病，病毒感染和疾病以及细菌感染和疾病的USP7抑制剂的抑制剂，其具有下式：其中m，n， 本文描述了X1，X2，R1-R5，R5'和R6。
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公开(公告)号：US20200087280A1
公开(公告)日：2020-03-19
申请号：US16694500
申请日：2019-11-25
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , David R. Lancia, JR.
IPC分类号： C07D401/06 , C07D239/88 , C07D487/04 , C07D471/04
摘要： The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.
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公开(公告)号：US10508098B2
公开(公告)日：2019-12-17
申请号：US16179099
申请日：2018-11-02
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , David R. Lancia, Jr.
IPC分类号： C07D401/06 , C07D487/04 , C07D471/04 , C07D239/88
摘要： The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.
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公开(公告)号：US20190071423A1
公开(公告)日：2019-03-07
申请号：US16179125
申请日：2018-11-02
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , David R. Lancia, JR.
IPC分类号： C07D401/06 , C07D487/04 , C07D471/04 , C07D239/88
CPC分类号： C07D401/06 , C07D239/88 , C07D471/04 , C07D487/04
摘要： The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.
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公开(公告)号：US10189841B2
公开(公告)日：2019-01-29
申请号：US15355887
申请日：2016-11-18
发明人： Alexandre Joseph Buckmelter , Stephanos Ioannidis , Bruce Follows , Gary Gustafson , Minghua Wang , Justin A. Caravella , Zhongguo Wang , Edward L. Fritzen , Jian Lin
IPC分类号： A61K31/522 , C07D473/00
摘要： The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.
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10.发明申请公开(公告)号：US20180339991A1
公开(公告)日：2018-11-29
申请号：US15988790
申请日：2018-05-24
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, R6, X1, X2, m, and n are described herein.
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