公开(公告)号：US20250024752A1

公开(公告)日：2025-01-16

申请号：US18827468

申请日：2024-09-06

Applicant: FUJIFILM Corporaton

Inventor： Masaki MORITA ,  Saika IZUMI ,  Yasunori YONEKUTA

IPC: H10K85/60 ,  C07D237/26 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D495/14 ,  C07D513/04 ,  C07D519/00 ,  H10K30/30

Abstract: An object of the present invention is to provide a photoelectric conversion element which has excellent manufacturing suitability, an imaging element, an optical sensor, and a compound. A photoelectric conversion element according to the present invention including in the following order, a conductive film, a photoelectric conversion film, and a transparent conductive film, in which the photoelectric conversion film contains a compound represented by Formula (1).

公开(公告)号：US20240091371A1

公开(公告)日：2024-03-21

申请号：US18497645

申请日：2023-10-30

Applicant: Tagworks Pharmaceuticals B.V.

Inventor： Marc Stefan ROBILLARD ,  Hendricus Marie JANSSEN ,  Wolter TEN HOEVE ,  Ronny Mathieu VERSTEEGEN ,  Raffaella ROSSIN

IPC: A61K47/68 ,  A61K31/435 ,  A61K31/444 ,  A61K31/704 ,  A61K38/05 ,  A61K39/395 ,  A61K47/22 ,  A61K47/54 ,  B82Y5/00 ,  C07C33/16 ,  C07D237/26 ,  C07D257/08

CPC classification number: A61K47/6803 ,  A61K31/435 ,  A61K31/444 ,  A61K31/704 ,  A61K38/05 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/22 ,  A61K47/545 ,  A61K47/555 ,  A61K47/558 ,  A61K47/6897 ,  B82Y5/00 ,  C07C33/16 ,  C07D237/26 ,  C07D257/08 ,  Y02A50/30

Abstract: The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.

公开(公告)号：US11718642B2

公开(公告)日：2023-08-08

申请号：US16961097

申请日：2019-01-11

Applicant: Sage Therapeutics, Inc.

Inventor： Albert Jean Robichaud ,  Francesco G. Salituro ,  Maria Jesus Blanco-Pillado ,  Daniel La ,  Boyd L. Harrison

IPC: A61K31/352 ,  A61K31/382 ,  A61K31/385 ,  A61K31/39 ,  A61K31/435 ,  A61K31/498 ,  A61K31/502 ,  A61K31/517 ,  A61K31/53 ,  A61K31/536 ,  A61K31/415 ,  C07D221/08 ,  C07D237/26 ,  C07D239/70 ,  C07D241/36 ,  C07D253/08 ,  C07D265/02 ,  C07D265/12 ,  C07D265/34 ,  C07D279/02 ,  C07D279/08 ,  C07D279/14 ,  C07D291/08 ,  C07D311/78 ,  C07D319/02 ,  C07D319/08 ,  C07D319/14 ,  C07D323/04 ,  C07D327/06 ,  C07D327/10 ,  C07D335/04 ,  C07D339/08 ,  C07D341/00 ,  C07D401/06 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D411/14 ,  C07D413/14 ,  C07D417/14 ,  C07D419/14 ,  C07J73/00

CPC classification number: C07J73/003

Abstract: Provided herein is a compound of Formula (I-I), or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I-I), and methods of using the compounds, e.g. in the treatment of CNS-related disorders.

公开(公告)号：US11530352B2

公开(公告)日：2022-12-20

申请号：US16316996

申请日：2017-10-02

Applicant: ILLUMINA, INC.

Inventor： Ali Asadi ,  Jian-Sen Li

IPC: G01N21/00 ,  C09K11/07 ,  C07D209/62 ,  G07C3/14 ,  C07D237/26 ,  G01N21/64 ,  C07D471/04 ,  G01N21/31

Abstract: Provided herein are processes for preparing fluorescent 1-cyano-2-substituted isoindole compounds or N-substituted phthalazinium compounds, comprising reacting an aromatic dialdehyde or aromatic aldehyde-ketone compound with a material that contains primary amino or hydrazine groups, and assaying methods involving the processes thereof.

公开(公告)号：US11119095B2

公开(公告)日：2021-09-14

申请号：US15766333

申请日：2016-09-26

Applicant: TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Shinichi Sato ,  Hiroyuki Nakamura ,  Hirofumi Nakano

IPC: G01N33/573 ,  G01N33/533 ,  G01N33/542 ,  C07D237/32 ,  C12Q1/42 ,  C12Q1/48 ,  G01N33/50 ,  C07D237/26

Abstract: Provided is a method for measuring tyrosine phosphatase and tyrosine kinase activity, as a high-sensitivity measuring method, which is suitable for high throughput and which uses a compound represented by general formula (I) (in the formula, A represents a conjugated ring; L represents a linker or the like having a labeling substance at an end; R1 represents a hydrogen atom or the like; and R2 and R3 each represent a hydrogen atom, an alkyl group or the like).

公开(公告)号：US10821208B2

公开(公告)日：2020-11-03

申请号：US15301466

申请日：2015-04-06

Applicant: President and Fellows of Harvard College

Inventor： Rajiv Desai ,  Neel Satish Joshi ,  David J. Mooney ,  Sandeep T. Koshy ,  Alexander G. Stafford

IPC: A61L27/52 ,  C07D237/26 ,  A61L27/20 ,  A61L27/54 ,  C08B37/00 ,  A61L27/26 ,  A61L27/22 ,  A61L27/38 ,  C07K14/78

Abstract: The present disclosure provides click-crosslinked hydrogels and methods of use.

公开(公告)号：US10155777B2

公开(公告)日：2018-12-18

申请号：US15564540

申请日：2016-04-07

Applicant: Joseph Fox ,  Han Zhang ,  Yinzhi Fang

Inventor： Joseph Fox ,  Han Zhang ,  Yinzhi Fang

IPC: C07F7/08 ,  C07D401/14 ,  C07D223/04 ,  C07D237/26 ,  C07D237/30 ,  C07D257/08 ,  C07C13/24 ,  C07C35/20 ,  C07C49/547 ,  G01N33/58

Abstract: A substituted trans-cycloheptene according to formula (I); wherein: a) Z and L are each selected from the group consisting of SiR1R2, CH2, CHOH, and CHR2; R1 is phenyl or CH3; R2 is phenyl, CH3, (CH2)nCN, or (CH2)nOH, wherein n is an integer from 1 to 5; Ra and Rb are each individually selected from the group consisting of H, OH, and CH3; and Z and L are not both SiR1R2; or b) Z is BocN, L is CH2, Ra is H, and Rb is H; or c) Z is C=0, L is CH2, Ra is H, and Rb is H.

公开(公告)号：US10047040B2

公开(公告)日：2018-08-14

申请号：US15502512

申请日：2015-08-27

Applicant: Elanco Tiergesundheit AG

Inventor： Noelle Gauvry ,  Chouaib Tahtaoui

IPC: C07C311/08 ,  C07F7/08 ,  C07F5/02 ,  C07D295/155 ,  C07D333/24 ,  C07D231/12 ,  C07D213/61 ,  C07D231/56 ,  C07D213/56 ,  C07D239/30 ,  C07D239/26 ,  C07D277/30 ,  C07D213/84 ,  C07D333/28 ,  C07C311/21 ,  C07C311/14 ,  C07D309/06 ,  C07D249/08 ,  C07D277/64 ,  C07D277/60 ,  C07D277/56 ,  C07D285/135 ,  C07D333/78 ,  C07D277/46 ,  C07D277/54 ,  C07D263/50 ,  C07D275/03 ,  C07D317/66 ,  C07D209/08 ,  C07D215/06 ,  C07D487/04 ,  C07D237/26

CPC classification number: C07C311/08 ,  C07C235/56 ,  C07C307/10 ,  C07C311/09 ,  C07C311/10 ,  C07C311/14 ,  C07C311/21 ,  C07C311/29 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/40 ,  C07C2602/42 ,  C07D209/08 ,  C07D213/26 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D213/84 ,  C07D215/06 ,  C07D231/12 ,  C07D231/20 ,  C07D231/56 ,  C07D237/26 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D249/08 ,  C07D249/12 ,  C07D263/50 ,  C07D275/03 ,  C07D277/30 ,  C07D277/46 ,  C07D277/54 ,  C07D277/56 ,  C07D277/60 ,  C07D277/62 ,  C07D277/64 ,  C07D279/12 ,  C07D285/135 ,  C07D295/155 ,  C07D295/185 ,  C07D295/26 ,  C07D309/06 ,  C07D317/66 ,  C07D333/24 ,  C07D333/28 ,  C07D333/78 ,  C07D487/04 ,  C07F5/025 ,  C07F7/081 ,  C07F7/0812

Abstract: The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.

公开(公告)号：US20180127381A1

公开(公告)日：2018-05-10

申请号：US15866429

申请日：2018-01-09

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Xingchun HAN ,  Yongguang WANG ,  Song YANG

IPC: C07D237/26 ,  A61P31/20

CPC classification number: C07D237/26 ,  A61P31/20 ,  C07D471/04

Abstract: The invention provides novel compounds having the general formula: wherein R1 to R6 are as described herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US09893299B2

公开(公告)日：2018-02-13

申请号：US15021027

申请日：2014-08-13

Applicant: Merck Patent GmbH

Inventor： Philipp Stoessel ,  Nils Koenen

IPC: H01L51/00 ,  C09K11/06 ,  H05B33/10 ,  C07D221/16 ,  C07D221/18 ,  C07D221/22 ,  C07D237/26 ,  C07D471/04 ,  C07D471/14 ,  C07D471/22 ,  C07D491/048 ,  C09B57/00 ,  C09B3/14 ,  C09B5/00 ,  C09B5/02 ,  C07D221/20 ,  C07D471/18 ,  C07D491/08 ,  C07D491/147 ,  C09K11/02 ,  H01L51/50

CPC classification number: H01L51/0072 ,  C07D221/16 ,  C07D221/18 ,  C07D221/20 ,  C07D221/22 ,  C07D237/26 ,  C07D471/04 ,  C07D471/14 ,  C07D471/18 ,  C07D471/22 ,  C07D491/048 ,  C07D491/08 ,  C07D491/147 ,  C09B3/14 ,  C09B5/00 ,  C09B5/008 ,  C09B5/028 ,  C09B57/00 ,  C09B57/001 ,  C09K11/02 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1044 ,  C09K2211/1059 ,  C09K2211/1088 ,  H01L51/0067 ,  H01L51/0071 ,  H01L51/0085 ,  H01L51/0087 ,  H01L51/5012 ,  H01L51/5016 ,  H01L51/5072 ,  H05B33/10 ,  Y02E10/549

Abstract: The invention concerns heterocyclic compounds and electronic devices, in particular organic electroluminescent devices, containing these compounds.