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公开(公告)号：US20220332699A1
公开(公告)日：2022-10-20
申请号：US17613870
申请日：2020-05-24
Applicant: SAGE THERAPEUTICS, INC.
Inventor： Allen Taylor Hopper , Steven Mischke , Daniel La
IPC: C07D401/14 , C07D405/14 , C07D413/14
Abstract: Described herein are compounds that act as CYP46A1 inhibitors, compositions comprising these compounds, and methods of their use into treating neurodegenerative diseases and the like, or a pharmaceutically active salt thereof. The present invention relates to compounds represented by the formula wherein each symbol is as defined in the specification, or a pharmaceutically active salt thereof.
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公开(公告)号：US20220315621A1
公开(公告)日：2022-10-06
申请号：US16955736
申请日：2018-12-21
Applicant: Sage Therapeutics, Inc.
Inventor： Albert Jean Robichaud , Francesco G. Salituro , Maria Jesus Blanco-Pillado , Daniel La , Boyd L. Harrison
Abstract: Provided herein is a compound of Formula (I-I) or a pharmaceutically acceptable salt thereof, wherein t, R7, R3, R9, R6a, R6b, R11a, R11b, R15a, R15b, R16a, R16b, R17a, R17b, R18a, R18b, R19a, R19b, R5a, R5b, R8 and R13 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I-I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
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公开(公告)号：US20210147468A1
公开(公告)日：2021-05-20
申请号：US16943649
申请日：2020-07-30
Applicant: Sage Therapeutics, Inc.
Inventor： Francesco G. Salituro , Albert Jean Robichaud , Gabriel Martinez Botella , Boyd L. Harrison , Andrew Griffin , Daniel La
IPC: C07J9/00
Abstract: Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3 and R6, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
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公开(公告)号：US20230085354A1
公开(公告)日：2023-03-16
申请号：US17620303
申请日：2020-06-29
Applicant: SAGE THERAPEUTICS, INC.
Inventor： Albert Jean Robichaud , Francesco G. Salituro , Maria Jesus Blanco-Pillado , Daniel La , Boyd L. Harrison , Marshall Lee Morningstar
Abstract: Provided herein is a compound of Formula (1-I): or a pharmaceutically acceptable salt thereof, wherein R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R11a, R11b, R16a, R16b, R19, R18, X, q, r, s, t, u, and n are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (1-I) and methods of using the compounds, e.g, in the treatment of CNS-related disorders.
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公开(公告)号：US20200002371A1
公开(公告)日：2020-01-02
申请号：US16315250
申请日：2017-07-07
Applicant: Sage Therapeutics, Inc.
Inventor： Francesco G. Salituro , Albert Jean Robichaud , Gabriel Martinez Botella , Boyd L. Harrison , Andrew Griffin , Daniel La
IPC: C07J9/00
Abstract: Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, and R6, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
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Patent Agency Ranking
公开(公告)号：US20240300995A1
公开(公告)日：2024-09-12
申请号：US18430056
申请日：2024-02-01
Applicant: Sage Therapeutics, Inc.
Inventor： Francesco G. Salituro , Albert Jean Robichaud , Gabriel Martinez Botella , Andrew Griffin , Boyd L. Harrison , Daniel La
CPC classification number: C07J31/006 , C07J9/005
Abstract: Compounds are provided according to Formula (A):
and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1A, R1B, n, R2A, R2B, R3, and R4 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.-
公开(公告)号：US11926646B2
公开(公告)日：2024-03-12
申请号：US17476153
申请日：2021-09-15
Applicant: Sage Therapeutics, Inc.
Inventor： Francesco G. Salituro , Albert Jean Robichaud , Gabriel Martinez Botella , Andrew Griffin , Boyd L. Harrison , Daniel La
CPC classification number: C07J31/006 , C07J9/005
Abstract: Compounds are provided according to Formula (A):
and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1A, R1B, n, R2A, R2B, R3, and R4 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.-
公开(公告)号：US11149056B2
公开(公告)日：2021-10-19
申请号：US16338315
申请日：2017-09-30
Applicant: Sage Therapeutics, Inc.
Inventor： Francesco G. Salituro , Albert Jean Robichaud , Gabriel Martinez Botella , Andrew Griffin , Boyd L. Harrison , Daniel La
Abstract: Compounds are provided according to Formula (A): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1A, R1b, n, R2A, R2b, R3, and R4 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
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公开(公告)号：US20230312522A1
公开(公告)日：2023-10-05
申请号：US18201885
申请日：2023-05-25
Applicant: Sage Therapeutics, Inc.
Inventor： Steven Mischke , Allen Taylor Hopper , Daniel La , Maria-Jesus Blanco-Pillado
IPC: C07D401/14 , C07D405/14 , C07D471/04 , C07D417/14
CPC classification number: C07D401/14 , C07D405/14 , C07D471/04 , C07D417/14
Abstract: Described herein are compounds that act as CYP46A1 inhibitors, compositions comprising these compounds, and methods for their use in treating neurodegenerative diseases and the like, or a pharmaceutically acceptable salt thereof.
The present disclosure relates to compounds represented by the formula
wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.-
公开(公告)号：US20220081465A1
公开(公告)日：2022-03-17
申请号：US17476153
申请日：2021-09-15
Applicant: Sage Therapeutics, Inc.
Inventor： Francesco G. Salituro , Albert Jean Robichaud , Gabriel Martinez Botella , Andrew Griffin , Boyd L. Harrison , Daniel La
Abstract: Compounds are provided according to Formula (A): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1A, R1B, n, R2A, R2B, R3, and R4 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
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