公开(公告)号：US20240327707A1

公开(公告)日：2024-10-03

申请号：US18741022

申请日：2024-06-12

申请人： Iowa State University Research Foundation, Inc.

发明人： Brent Shanks ,  George A. Kraus ,  William Bradley ,  Jiajie Huo ,  Kyle Podolak

IPC分类号： C09K15/30 ,  C07D213/70 ,  C07D233/84 ,  C07D235/28 ,  C07D249/12 ,  C07D277/36 ,  C07D285/125 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C09D5/08

CPC分类号： C09K15/30 ,  C07D213/70 ,  C07D233/84 ,  C07D235/28 ,  C07D249/12 ,  C07D277/36 ,  C07D285/125 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C09D5/086

摘要： A heteroaryl-thio-substituted pyrone compound that is a heteroaryl-thio-substituted pyrone or a heteroaryl-thio-substituted coumarin. In various embodiments, the heteroaryl-thio-substituted pyrone compound or a reaction product thereof is a metal corrosion inhibitor.

公开(公告)号：US20240262796A1

公开(公告)日：2024-08-08

申请号：US18620876

申请日：2024-03-28

申请人： STINGINN LLC

发明人： GLEN N BARBER

IPC分类号： C07D249/12 ,  C07D271/06 ,  C07D401/04 ,  C07D401/14 ,  C07D417/12

CPC分类号： C07D249/12 ,  C07D271/06 ,  C07D401/04 ,  C07D401/14 ,  C07D417/12

摘要： In an embodiment of the present invention, compounds of the present application or pharmaceutically acceptable salts thereof are capable of interacting with and activating the stimulator of interferon genes (STING) protein. In an embodiment of the present invention, pharmaceutical compositions and methods involving such compounds as STING modulators are additionally provided herein.

公开(公告)号：US12012392B2

公开(公告)日：2024-06-18

申请号：US16761993

申请日：2018-11-09

申请人： Inflazome Limited

发明人： Matthew Cooper ,  David Miller ,  Angus Macleod ,  Stephen Thom ,  Stephen St-Gallay ,  Jonathan Shannon ,  Ian Strutt

IPC分类号： C07D401/06 ,  A61P29/00 ,  C07D231/18 ,  C07D233/84 ,  C07D249/04 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06

CPC分类号： C07D401/06 ,  A61P29/00 ,  C07D231/18 ,  C07D233/84 ,  C07D249/04 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06

摘要： The present invention relates to sulfonylureas and sulfonylthioureas comprising as-membered nitrogen-containing heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is substituted with at least one group containing an oxygen atom, and wherein said oxygen atom is attached to the heteroaryl ring via at least two other atoms. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

公开(公告)号：US11912671B1

公开(公告)日：2024-02-27

申请号：US18382834

申请日：2023-10-23

申请人： KING FAISAL UNIVERSITY

发明人： Mai Mostafa Khalaf Ali ,  Hany Mohamed Abd El-Lateef Ahmed ,  Antar Ahmed Abdelhamid Ahmed ,  Amer A. Amer

IPC分类号： A61P31/10 ,  A61K31/4196 ,  A61P31/04 ,  C07D249/12

CPC分类号： C07D249/12 ,  A61P31/04 ,  A61P31/10

摘要： An ethyl 3-(5-(3-fluorophenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)propanoate compound, its synthesis, and its use as an antimicrobial agent.

公开(公告)号：US20230391734A1

公开(公告)日：2023-12-07

申请号：US18206005

申请日：2023-06-05

申请人： Neuropore Therapies, Inc.

发明人： Wolfgang J. WRASIDLO ,  Emily M. STOCKING ,  Srinivasa Reddy NATALA ,  Diana Luz PRICE

IPC分类号： C07D249/12 ,  A61P25/28 ,  A61K9/10 ,  A61P3/00 ,  C07D243/10 ,  A61K31/18

CPC分类号： C07D249/12 ,  A61P25/28 ,  A61K9/10 ,  A61P3/00 ,  C07D243/10 ,  A61K31/18

摘要： The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.

公开(公告)号：US20230365524A1

公开(公告)日：2023-11-16

申请号：US18137281

申请日：2023-04-20

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft ,  The Broad Institute, Inc. ,  President and Fellows of Harvard College ,  The General Hospital Corporation

发明人： Stefan Nikolaus GRADL ,  Duy NGUYEN ,  Knut EIS ,  Judith GÜNTHER ,  Timo STELLFELD ,  Andreas JANZER ,  Sven CHRISTIAN ,  Thomas MÜLLER ,  Sherif El SHEIKH ,  Han Jie ZHOU ,  Changjia ZHAO ,  David B. SYKES ,  Steven James FERRARA ,  Kery LIU ,  Michael KRÖBER ,  Claudia MERZ ,  Michael NIEHUES ,  Martina SCHÄFER ,  Katja ZIMMERMANN ,  Carl Friedrich NISING

IPC分类号： C07D401/12 ,  A61P35/00 ,  C07D405/12 ,  C07D413/12 ,  C07D249/12 ,  C07D403/12 ,  A61K45/06

CPC分类号： C07D401/12 ,  A61P35/00 ,  C07D405/12 ,  C07D413/12 ,  C07D249/12 ,  C07D403/12 ,  A61K45/06

摘要： The present invention provides triazolone compounds of general formula (I):




in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

公开(公告)号：US11814358B2

公开(公告)日：2023-11-14

申请号：US17401269

申请日：2021-08-12

申请人： UPL LIMITED

发明人： Vic Prasad ,  Tinker McBrayer ,  Leandro Alves ,  Luiz Campos ,  Raj Arora ,  Raj Tiwari

IPC分类号： C07D249/12

CPC分类号： C07D249/12

摘要： The present invention relates to an improved process for the preparation of 4-amino-N-tert-butyl-4,5-dihydro-3-isopropyl-5-oxo-1H-1,2,4-triazole-1-carboxamide (Amicarbazone). The present invention more particularly relates to an improved process for the preparation of 4-amino-N-tert-butyl-4,5-dihydro-3-isopropyl-5-oxo-1H-1,2,4-triazole-1-carboxamide (Amicarbazone) by coupling of 4-Amino-2,4-dihydro-5-(1-methylethyl)-3H-1,2,4-triazol-3-one (TAZ) and poor quality tert-Butyl isocyanate (TBIC) with purity less than or equal to 98%, preferably less than or equal to 85%.

公开(公告)号：US11760732B2

公开(公告)日：2023-09-19

申请号：US17979869

申请日：2022-11-03

申请人： UPL LTD

发明人： Digish Manubhai Panchal ,  Rakesh Bhikubhai Patel

IPC分类号： C07D249/12

CPC分类号： C07D249/12

摘要： Described herein is an environmentally friendly process for preparing pure sulfentrazone having tank-mix compatibility which includes treating sulfentrazone with a base and isolating the pure sulfentrazone with an acid. Compositions containing the pure sulfentrazone are also included.

公开(公告)号：US20230286913A1

公开(公告)日：2023-09-14

申请号：US18182234

申请日：2023-03-10

申请人： Gacter Inc.

发明人： Wenxin Qi

IPC分类号： C07C335/04 ,  C07D231/12 ,  C07D271/06 ,  C07D277/36 ,  C07D249/12 ,  C07D257/04 ,  C07D211/54 ,  C07D237/18 ,  C07D239/38 ,  C07D241/18 ,  C07D251/38 ,  C07D473/00 ,  C07D473/36 ,  C07D213/643 ,  C07D401/12 ,  C07D231/56 ,  C07D471/04 ,  C07D209/44 ,  C07D209/34 ,  C07D235/08 ,  C07D249/18 ,  C07D401/06 ,  C07D403/12 ,  C07C255/34 ,  C07C211/10 ,  C07D313/14 ,  C07D313/20 ,  C07D313/00 ,  C07D313/08 ,  C07D307/81 ,  C07D311/60

CPC分类号： C07C335/04 ,  C07D231/12 ,  C07D271/06 ,  C07D277/36 ,  C07D249/12 ,  C07D257/04 ,  C07D211/54 ,  C07D237/18 ,  C07D239/38 ,  C07D241/18 ,  C07D251/38 ,  C07D473/00 ,  C07D473/36 ,  C07D213/643 ,  C07D401/12 ,  C07D231/56 ,  C07D471/04 ,  C07D209/44 ,  C07D209/34 ,  C07D235/08 ,  C07D249/18 ,  C07D401/06 ,  C07D403/12 ,  C07C255/34 ,  C07C211/10 ,  C07D313/14 ,  C07D313/20 ,  C07D313/00 ,  C07D313/08 ,  C07D307/81 ,  C07D311/60

摘要： The present invention provides NOS inhibitors such as iNOS inhibitors, or a pharmaceutically acceptable salt, ester, prodrug, complex, solvate, hydrate, or isomer thereof, in any crystalline form or in amorphous form. The inhibitors include 1,1 or 1,2 substituted-ethyl carbamimido thioates, cyclic compounds substituted with a carbamimidoyl sulfanylethylphenyl group and a carbamimidoylsulfanyl group, compounds substituted with a carbamimidoyl sulfanylethyl phenylmethyl group, bis-carbamimidoylsulfanylethyl substituted compounds, 2-propoxypyridine derivatives, alkylamine or heteroalkylamine derivatives, n-aminoethyl n-phenyl amine derivatives, and saturated heterocyclic fused benzene derivatives. Pharmaceutical products comprising the NOS inhibitors such as iNOS inhibitors and the applications thereof in prophylaxis and/or treatment of inflammatory diseases, and proliferative diseases such as cancer including gastro-intestinal, colorectal, gynecological, pancreatic, head and neck, esophageal, breast, lung, and central nervous system tumors, among others, are also provided.

公开(公告)号：US20230219902A1

公开(公告)日：2023-07-13

申请号：US18000939

申请日：2021-06-10

申请人： MEDSHINE DISCOVERY INC.

发明人： Jianfei WANG ,  Yang ZHANG ,  Shuhui CHEN

IPC分类号： C07D249/12

CPC分类号： C07D249/12

摘要： Disclosed is a method for preparing a chlorinated compound, and specifically disclosed is a method for preparing a compound represented by formula (I).