专利检索 cpc:"C07D257/04" 第 1 页

1.

发明授权
Triazolones, tetrazolones, and imidazolones, or their salts, and pharmaceutical compositions comprising the same 有权

公开(公告)号：US12110279B2

公开(公告)日：2024-10-08

申请号：US17726323

申请日：2022-04-21

申请人： Yuhan Corporation

发明人： Hee Jae Tak , Eun Kyung Kim , Hyok Jun Cho , Cheol Hee Lim

IPC分类号： C07D405/14 , C07D257/04 , C07D401/04 , C07D401/14 , C07D405/10 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/10 , C07D401/10

CPC分类号： C07D257/04 , C07D401/04 , C07D401/14 , C07D405/10 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/10 , C07D401/10

摘要： The present technology provides triazolones, tetrazolones, and imidazolones, or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and uses thereof. The triazolones, tetrazolones, and imidazolones or their pharmaceutically acceptable salts exhibit inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).

2.

发明授权
Caspase inhibitors and methods of use thereof 有权

公开(公告)号：US12071412B2

公开(公告)日：2024-08-27

申请号：US18104691

申请日：2023-02-01

申请人： NOBO Medicine Inc.

发明人： Alfred P. Spada , Robert J. Temansky , Michael Mueller

IPC分类号： C07D239/42 , A61P29/00 , C07C233/56 , C07D213/75 , C07D215/38 , C07D215/40 , C07D217/24 , C07D239/34 , C07D257/04

CPC分类号： C07D239/42 , A61P29/00 , C07C233/56 , C07D213/75 , C07D215/38 , C07D215/40 , C07D217/24 , C07D239/34 , C07D257/04

摘要： Provided herein are compounds of formula I, compositions comprising the compounds and method of treating various diseases with the compounds and compositions.

3.

发明授权
2-pyrazole anilines and related analogs for inhibiting YAP/TAZ-TEAD 有权

公开(公告)号：US12030866B2

公开(公告)日：2024-07-09

申请号：US18145909

申请日：2022-12-23

申请人： THE KATHOLIEKE UNIVERSITEIT LEUVEN , SpringWorks Therapeutics, Inc. , VIB vzw

发明人： Bart Vanderhoydonck , Arnaud Marchand , Stephen L. Gwaltney , Stéphane Spieser , Wim Smets , Aurélie Candi , Matthias Versele , Georg Halder

IPC分类号： C07D401/10 , C07D213/16 , C07D231/12 , C07D255/02 , C07D257/04 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/08

CPC分类号： C07D401/10 , C07D213/16 , C07D231/12 , C07D255/02 , C07D257/04 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/08 , C07B2200/09

摘要： The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.

4.

发明授权
Inhibitor of indoleamine-2,3-dioxygenase (IDO) 有权

公开(公告)号：US11969425B2

公开(公告)日：2024-04-30

申请号：US18166789

申请日：2023-02-09

申请人： InventisBio LLC

发明人： Xing Dai , Yaolin Wang

IPC分类号： A61K31/505 , A61K31/196 , A61K31/351 , A61K31/382 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/4184 , C07C275/42 , C07D233/88 , C07D239/42 , C07D257/04 , C07D261/14 , C07D309/08 , C07D309/14 , C07D335/02 , C07D413/12

CPC分类号： A61K31/505 , A61K31/196 , A61K31/351 , A61K31/382 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/4184 , C07C275/42 , C07D233/88 , C07D239/42 , C07D257/04 , C07D261/14 , C07D309/08 , C07D309/14 , C07D335/02 , C07D413/12

摘要： The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating a disease associated with IDO, for example, cancer or an infectious disease (e.g., viral or bacterial infectious diseases). Also, provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

5.

发明公开
INHIBITORS OF TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) AND USES THEREOF 审中-公开

公开(公告)号：US20240124406A1

公开(公告)日：2024-04-18

申请号：US18000049

申请日：2021-06-02

申请人： Dana-Farber Cancer Institute, Inc.

发明人： Nathanael S. Gray , Tinghu Zhang , Nicholas Paul Kwiatkowski , Mengyang Fan , Jianwei Che , Wenchao Lu

IPC分类号： C07D257/04 , A61P35/00 , C07D213/64 , C07D233/64 , C07D237/08 , C07D239/26 , C07D239/34 , C07D271/10 , C07D277/28 , C07D401/04 , C07D403/04 , C07D405/12 , C07D513/04

CPC分类号： C07D257/04 , A61P35/00 , C07D213/64 , C07D233/64 , C07D237/08 , C07D239/26 , C07D239/34 , C07D271/10 , C07D277/28 , C07D401/04 , C07D403/04 , C07D405/12 , C07D513/04

摘要： Provided herein are compounds of Formula (I″), Formula (I′), Formula (I), Formula (II′), and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are methods, uses, and kits involving the disclosed compounds and pharmaceutical compositions thereof for treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers), inflammatory diseases (e.g., fibrosis), autoimmune diseases (e.g., sclerosis)) in a subject. Provided are methods of inhibiting the activity of a transcription factor (e.g., TEAD, such as TEAD1, TEAD2, TEAD3, TEAD4) and/or inhibiting the transcription of a gene (e.g., a gene controlled or regulated by a transcription factor (e.g., TEAD)) in a subject.

6.

发明公开
REAGENT FOR MASS SPECTROMETRY 审中-公开

公开(公告)号：US20240092742A1

公开(公告)日：2024-03-21

申请号：US18500149

申请日：2023-11-02

申请人： Roche Diagnostics Operations, Inc.

发明人： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Nicole Pirkl

IPC分类号： C07D249/06 , C07D203/04 , C07D249/04 , C07D257/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04

CPC分类号： C07D249/06 , C07D203/04 , C07D249/04 , C07D257/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04 , G01N30/72

摘要： The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

7.

发明授权
Alpha-cinnamide compounds and compositions as HDAC8 inhibitors 有权

公开(公告)号：US11919839B2

公开(公告)日：2024-03-05

申请号：US17238529

申请日：2021-04-23

申请人： Valo Health, Inc.

发明人： Kenneth W. Bair , Nicholas Barczak , Bingsong Han , David R. Lancia, Jr. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Mary-Margaret Zablocki , Xiaozhang Zheng

IPC分类号： C07C259/06 , A61K31/185 , A61K31/277 , A61K31/397 , A61K31/4035 , A61K31/407 , A61K31/417 , A61K31/4184 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/495 , A61K31/5377 , C07D207/10 , C07D207/267 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/46 , C07D211/16 , C07D211/58 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D215/12 , C07D221/20 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D233/68 , C07D235/14 , C07D235/30 , C07D239/20 , C07D239/22 , C07D241/08 , C07D241/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D277/56 , C07D295/155 , C07D295/192 , C07D307/68 , C07D317/68 , C07D333/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D493/08 , C07D495/10 , C07D498/04 , C07D513/10

CPC分类号： C07C259/06 , A61K31/185 , A61K31/277 , A61K31/397 , A61K31/4035 , A61K31/407 , A61K31/417 , A61K31/4184 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/495 , A61K31/5377 , C07D207/10 , C07D207/267 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/46 , C07D211/16 , C07D211/58 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D215/12 , C07D221/20 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D233/68 , C07D235/14 , C07D235/30 , C07D239/20 , C07D239/22 , C07D241/08 , C07D241/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D277/56 , C07D295/155 , C07D295/192 , C07D307/68 , C07D317/68 , C07D333/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D493/08 , C07D495/10 , C07D498/04 , C07D513/10 , Y02A50/30

摘要： The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

8.

发明公开
20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE 审中-公开

公开(公告)号：US20240041831A1

公开(公告)日：2024-02-08

申请号：US18314623

申请日：2023-05-09

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , New York Medical College

发明人： John R. Falck , Michal L. Schwartzman , Victor Garcia

IPC分类号： A61K31/41 , A61K47/54 , A61P13/12 , A61K31/197 , A61K31/201 , C07C59/42 , C07C233/49 , C07C247/12 , C07D257/06 , C40B40/04 , C07K14/72 , C40B30/04 , G01N33/92 , C07D257/04

CPC分类号： A61K31/41 , A61K47/542 , A61P13/12 , A61K31/197 , A61K31/201 , C07C59/42 , C07C233/49 , C07C247/12 , C07D257/06 , C40B40/04 , C07K14/723 , C40B30/04 , G01N33/92 , C07D257/04 , G01N2333/705 , G01N2500/00

摘要： The present invention concerns compounds and their use to treat cardiovascular disease, renal disease, thrombic disease, stroke, metabolic syndrome, cell proliferation, and ischemic cardiovascular disorders. Compounds of the present invention display significant potency as antagonists of 20-hydroxyeicosatetraenoic acid (20-HETE), and function as anti-hypertensive, anti-inflammatory, or anti-growth agents.