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公开(公告)号：US20250032453A1
公开(公告)日：2025-01-30
申请号：US18891536
申请日：2024-09-20
Inventor： John R. Falck , Michal L. Schwartzman , Victor Garcia
IPC: A61K31/41 , A61K31/197 , A61K31/201 , A61K47/54 , A61P13/12 , C07C59/42 , C07C233/49 , C07C247/12 , C07D257/04 , C07D257/06 , C07K14/72 , C40B30/04 , C40B40/04 , G01N33/92
Abstract: The present invention concerns compounds and their use to treat cardiovascular disease, renal disease, thrombic disease, stroke, metabolic syndrome, cell proliferation, and ischemic cardiovascular disorders. Compounds of the present invention display significant potency as antagonists of 20-hydroxyeicosatetraenoic acid (20-HETE), and function as anti-hypertensive, anti-inflammatory, or anti-growth agents.
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公开(公告)号：US20240409487A1
公开(公告)日：2024-12-12
申请号：US18537355
申请日：2023-12-12
Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College , University of Southern California
Inventor： Nicolas G. Bazan , Nicos A. Petasis
IPC: C07C57/03 , A61K31/202 , A61K31/232 , A61P25/28 , A61P29/00 , C07C59/42 , C07C69/587 , C07C69/732 , C07F9/10
Abstract: This disclosure provides compounds, pharmaceutical compositions, and methods of use for the prevention and treatment of inflammatory diseases or degenerative diseases including neurodegenerative diseases. Embodiments of the present disclosure provide compounds related to very long chain polyunsaturated fatty acids, pharmaceutical compositions containing the provided compounds, and methods of treating a subject with a condition or disease using provided compounds or pharmaceutical compositions.
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公开(公告)号：US11690825B2
公开(公告)日：2023-07-04
申请号：US16083404
申请日：2017-03-08
Inventor： John R. Falck , Michal L. Schwartzman , Victor Garcia
IPC: A61K31/201 , C07C59/42 , A61K31/41 , A61K47/54 , A61P13/12 , A61K31/197 , C07C233/49 , C07C247/12 , C07D257/06 , C40B40/04 , C07K14/72 , C40B30/04 , G01N33/92 , C07D257/04
CPC classification number: A61K31/41 , A61K31/197 , A61K31/201 , A61K47/542 , A61P13/12 , C07C59/42 , C07C233/49 , C07C247/12 , C07D257/04 , C07D257/06 , C07K14/723 , C40B30/04 , C40B40/04 , G01N33/92 , G01N2333/705 , G01N2500/00
Abstract: The present invention concerns compounds and their use to treat cardiovascular disease, renal disease, thrombic disease, stroke, metabolic syndrome, cell proliferation, and ischemic cardiovascular disorders. Compounds of the present invention display significant potency as antagonists of 20-hydroxyeicosatetraenoic acid (20-HETE), and function as anti-hypertensive, anti-inflammatory, or anti-growth agents.
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公开(公告)号：US20200179521A1
公开(公告)日：2020-06-11
申请号：US16535754
申请日：2019-08-08
Applicant: Thetis Pharmaceuticals LLC
Inventor： Frank C Sciavolino , Gary Mathias , Michael C. Van Zandt , Gunnar Erik Jagdmann, JR. , Jessica J. Dworak
IPC: A61K47/54 , A61P1/00 , A61K45/06 , A61K38/03 , A61K31/232 , A61K31/202 , A61P1/04 , A61P29/00 , A61P1/12 , A61P1/06 , A61K47/62 , C07C237/22 , C07C237/12 , C07C229/26 , C07C59/42
Abstract: The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.
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公开(公告)号：US20200030291A1
公开(公告)日：2020-01-30
申请号：US16083404
申请日：2017-03-08
Inventor： John R. Falck , Miehal L. Schwartzman , Victor Garcia
IPC: A61K31/41 , C07C59/42 , C07C247/12 , C07C233/49 , C07D257/02 , A61K31/201 , A61K31/197 , A61K47/54 , A61P13/12
Abstract: The present invention concerns compounds and their use to treat cardiovascular disease, renal disease, thrombic disease, stroke, metabolic syndrome, cell proliferation, and ischemic cardiovascular disorders. Compounds of the present invention display significant potency as antagonists of 20-hydroxyeicosatetraenoic acid (20-HETE), and function as anti-hypertensive, anti-inflammatory, or anti-growth agents.
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Patent Agency Ranking
公开(公告)号：US20190031590A1
公开(公告)日：2019-01-31
申请号：US16151268
申请日：2018-10-03
Applicant: Apeel Technology, Inc.
Inventor： Ronald C. Bakus, II , Louis Perez , Camille Mol , James Rogers , Gabriel Rodriguez
IPC: C07C51/09 , A23L3/3454 , C09D167/00 , C09D5/00 , C07C67/03 , C07C51/367 , A23B7/16 , C07C51/36 , C07C51/00 , C08G63/06 , C07C67/08 , C09D167/04 , C08G63/00 , C07C59/105 , C07C53/126 , C07C59/01 , C07C69/24 , C07C69/675 , C07C69/58 , C07C69/732 , C07C69/533 , C07C57/12 , C07C57/03 , C07C59/42 , C07C69/587
CPC classification number: A23B7/16 , A23L3/3454 , A23V2002/00 , B01D11/0284 , C07C29/132 , C07C29/17 , C07C51/00 , C07C51/09 , C07C51/36 , C07C51/367 , C07C51/377 , C07C63/00 , C07C67/03 , C07C67/08 , C07C67/475 , C07D303/38 , C08G63/00 , C08G63/06 , C09D5/00 , C09D167/00 , C09D167/04 , C07C59/105 , C07C53/126 , C07C59/01 , C07C69/24 , C07C69/675 , C07C69/58 , C07C69/732 , C07C69/533 , C07C57/12 , C07C57/03 , C07C59/42 , C07C69/587
Abstract: Described herein are methods of preparing cutin-derived monomers, oligomers, or combinations thereof from cutin-containing plant matter. The methods can include heating the cutin-derived plant matter in a solvent at elevated temperature and pressure. In some preferred embodiments, the methods can be carried out without the use of additional acidic or basic species.
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公开(公告)号：US10017453B2
公开(公告)日：2018-07-10
申请号：US14543638
申请日：2014-11-17
Applicant: Dignity Sciences Limited
Inventor： Mehar Manku , David Coughlan , Bill Downes
IPC: C07C59/42 , C07C229/26 , C07D295/027 , C07C215/10 , C07C241/04
CPC classification number: C07C59/42 , C07C215/10 , C07C229/26 , C07C241/04 , C07D295/027
Abstract: The present disclosure provides pharmaceutically acceptable stable salt forms of 15-lipoxygenase products, such as 15-HETrE lysine salt, compositions comprising same and methods of making and using same.
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公开(公告)号：US20170320841A1
公开(公告)日：2017-11-09
申请号：US15437206
申请日：2017-02-20
Applicant: The Brigham And Women's Hospital, Inc.
Inventor： Charles N. SERHAN , Rong YANG
IPC: C07D303/38 , C07C69/732 , C07C59/58 , C07C59/42 , A61Q19/08 , A23K20/158 , A61Q5/00 , A61K31/202 , A61K8/49 , A61K8/37 , A61K8/365 , C07D303/12 , A61Q19/00
CPC classification number: C07D303/38 , A23K20/158 , A61K8/365 , A61K8/37 , A61K8/4973 , A61K31/202 , A61Q5/006 , A61Q19/00 , A61Q19/08 , C07C59/42 , C07C59/58 , C07C69/732 , C07D303/12 , Y02P20/55
Abstract: The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogues, their preparation, isolation, identification, purification and uses thereof.
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公开(公告)号：US09611240B2
公开(公告)日：2017-04-04
申请号：US14557230
申请日：2014-12-01
Applicant: The Brigham and Women's Hospital, Inc.
Inventor： Charles N. Serhan , Rong Yang
IPC: A23K20/158 , A61K31/202 , A61K8/37 , A61K8/49 , A61Q19/08 , A61Q5/00 , C07C59/42 , C07C69/732 , C07D303/12 , C07D303/38 , A61K8/365
CPC classification number: C07D303/38 , A23K20/158 , A61K8/365 , A61K8/37 , A61K8/4973 , A61K31/202 , A61Q5/006 , A61Q19/00 , A61Q19/08 , C07C59/42 , C07C59/58 , C07C69/732 , C07D303/12 , Y02P20/55
Abstract: The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
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公开(公告)号：US09611239B2
公开(公告)日：2017-04-04
申请号：US14557212
申请日：2014-12-01
Applicant: The Brigham and Women's Hospital, Inc.
Inventor： Charles N. Serhan , Rong Yang
IPC: A23K20/158 , A61K31/202 , A61K8/365 , A61K8/37 , A61K8/49 , A61Q19/08 , A61Q5/00 , C07C59/42 , C07C69/732 , C07D303/12 , C07D303/38
CPC classification number: C07D303/38 , A23K20/158 , A61K8/365 , A61K8/37 , A61K8/4973 , A61K31/202 , A61Q5/006 , A61Q19/00 , A61Q19/08 , C07C59/42 , C07C59/58 , C07C69/732 , C07D303/12 , Y02P20/55
Abstract: The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogues, their preparation, isolation, identification, purification and uses thereof.
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