公开(公告)号：US12077495B2

公开(公告)日：2024-09-03

申请号：US16965343

申请日：2019-02-01

申请人： Københavns Universitet ,  Otago Innovation Ltd

发明人： Anders Bue Klein ,  Andrew Neil Clarkson ,  Joshua Macdonald Houlton ,  Ulrike Leurs ,  Rasmus Prætorius Clausen ,  Bente Frølund ,  Petrine Wellendorph

IPC分类号： C07C69/757 ,  A61P25/00 ,  C07C59/54 ,  C07C59/56 ,  C07C69/732

CPC分类号： C07C69/757 ,  A61P25/00 ,  C07C59/54 ,  C07C59/56 ,  C07C69/732

摘要： The invention relates to a compound according to formula I wherein when R5 is H, and R1 and R2 form a ring system, then said compound is selected from the following compounds of formula II or formula IV or when R2 is H, and R1 and R5 form a ring system, then said compound has formula III.

公开(公告)号：US11760715B2

公开(公告)日：2023-09-19

申请号：US16081738

申请日：2017-03-03

申请人： Universite de Moncton

发明人： Mohamed Touaibia ,  Marc Edgar Surette

IPC分类号： C07C69/732 ,  C07C69/736 ,  C07C69/65 ,  C07C69/94 ,  C07D319/18 ,  C07C235/34 ,  C07C69/618 ,  C07C69/734

CPC分类号： C07C69/732 ,  C07C69/618 ,  C07C69/65 ,  C07C69/734 ,  C07C69/736 ,  C07C69/94 ,  C07C235/34 ,  C07D319/18

摘要： The present invention relates to modulators of lipoxygenase and/or cyclooxygenase enzyme. The present invention also provides compositions comprising such modulators, and methods therewith for treating lipoxygenase receptor mediated diseases.

公开(公告)号：US11649203B2

公开(公告)日：2023-05-16

申请号：US16984850

申请日：2020-08-04

申请人： Rutgers, The State University of New Jersey

发明人： Durgadas Bolikal ,  Joachim B. Kohn

IPC分类号： C07C69/732 ,  C08G64/10 ,  C07C69/734 ,  C07C233/51 ,  C07C69/84 ,  C08G64/38 ,  A61L31/18 ,  A61L31/14 ,  A61L31/16 ,  A61L31/06 ,  C08G64/06 ,  C08G64/12 ,  C07C69/40 ,  C07C233/47 ,  C07C69/736 ,  C07C69/36

CPC分类号： C07C69/732 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L31/18 ,  C07C69/36 ,  C07C69/40 ,  C07C69/734 ,  C07C69/736 ,  C07C69/84 ,  C07C233/47 ,  C07C233/51 ,  C08G64/06 ,  C08G64/10 ,  C08G64/12 ,  C08G64/38 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/416 ,  A61L2300/604 ,  A61L31/06 ,  C08L69/00

摘要： Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula






These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.

公开(公告)号：US20220281801A1

公开(公告)日：2022-09-08

申请号：US17750383

申请日：2022-05-22

申请人： Evonik Röhm GmbH

发明人： Patrik Hartmann ,  Marita Kaufmann ,  Steffen Krill ,  Thorben Schütz ,  Marcel Treskow ,  Andrea Wittkowski

IPC分类号： C07C69/732

摘要： The present invention describes storage-stable glycerol (meth)acrylate carboxylic esters and a method for preparing these esters.

公开(公告)号：US11414372B2

公开(公告)日：2022-08-16

申请号：US16252915

申请日：2019-01-21

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： John Ralph ,  Steven D Karlen ,  Fachuang Lu ,  Dharshana Padmakshan

IPC分类号： C07C69/00 ,  C07C69/73 ,  C07C69/007 ,  C07C69/16 ,  C07C69/732 ,  C07C69/734 ,  C07C69/84 ,  C07C69/86 ,  C07C69/92 ,  G01N33/50

摘要： Methods of detecting and, optionally, determining a level of incorporation of monolignol ester conjugates into lignin. The methods include derivatizing lignin to acylate at least a portion of free phenolic and aliphatic hydroxyls and to halogenate at least a portion of benzylic alcohols present in the lignin to yield derivatized lignin, treating the derivatized lignin with a reducing agent to cleave at least a portion of the derivatized lignin to yield lignin cleavage products, acetylating at least a portion of free hydroxyl groups in the lignin cleavage products with a labeled acetylation agent to yield labeled lignin fragments, and detecting the labeled lignin fragments.

公开(公告)号：US11332433B2

公开(公告)日：2022-05-17

申请号：US16938238

申请日：2020-07-24

申请人： CHIROGATE INTERNATIONAL INC.

发明人： Shih-Yi Wei ,  Ming-Kun Hsu ,  Tzyh-Mann Wei

IPC分类号： C07C201/02 ,  C07C203/04 ,  C07C69/732 ,  C07F7/02 ,  A61K31/216

摘要： Processes for preparing latanoprostene bunod and an intermediate prepared from the process. Also latanoprostene bunod compositions having high-purity latanoprostene bunod.

公开(公告)号：US11130974B2

公开(公告)日：2021-09-28

申请号：US16642282

申请日：2018-08-30

申请人： KYOTO UNIVERSITY ,  Noster Inc.

发明人： Jun Ogawa ,  Shigenobu Kishino ,  Kohey Kitao

IPC分类号： C12P7/64 ,  C07C69/732

摘要： The present invention provides a derivative of hydroxylated fatty acid which has a high content of hydroxylated fatty acid, and permits easy ingestion and easy handling, and a production method thereof. The present invention provides a method for producing a homopolymer of hydroxylated fatty acid, including polymerizing the hydroxylated fatty acid by using an enzyme. The homopolymer of hydroxylated fatty acid is stabilized. In addition, a novel, utilizable homopolymer of hydroxylated fatty acid obtained by this production method is also provided.

公开(公告)号：US11065233B2

公开(公告)日：2021-07-20

申请号：US16866900

申请日：2020-05-05

申请人： Recurium IP Holdings, LLC

发明人： Peter Qinhua Huang ,  Deborah Helen Slee ,  Sayee Gajanan Hegde ,  Chad Daniel Hopkins ,  Kevin Duane Bunker ,  Joseph Robert Pinchman ,  Rakesh Kumar Sit

IPC分类号： C07D471/04 ,  A61K31/438 ,  C07C69/738 ,  C07C69/732 ,  C07B59/00 ,  C07C69/757 ,  C07D209/10 ,  A61P5/30 ,  A61P35/00 ,  A61K31/437

摘要： Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described in the disclosure. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions characterized by excessive cellular proliferation, such as breast cancer.

公开(公告)号：US11040934B2

公开(公告)日：2021-06-22

申请号：US16394009

申请日：2019-04-25

申请人： HALDOR TOPSØE A/S

发明人： Esben Taarning ,  Irantzu Sadaba Zubiri ,  Sebastian Meier

IPC分类号： C07C59/42 ,  C07C67/39 ,  C07C51/16 ,  B01J29/70 ,  C07C69/732

摘要： Preparation of 2,5,6-trihydroxy-3-hexenoic acid and 2,5-dihydroxy-3-pentenoic acid and esters thereof from C6 and C5 sugars in the presence of a Lewis Acid material, wherein the yield of the 2,5,6-trihydroxy-3-hexenoic acid or 2,5-dihydroxy-3-pentenoic acid or esters thereof exceeds 15%. The process including the steps of contacting a saccharide composition including one or more C6 and/or C5 saccharide units with a Lewis Acid material; and recovering 2,5,6-trihydroxy-3-hexenoic acid and/or 2,5-dihydroxy-3-pentenoic acid or the esters thereof.

公开(公告)号：US20200308109A1

公开(公告)日：2020-10-01

申请号：US16670264

申请日：2019-10-31

申请人： JAPAN TOBACCO INC.

发明人： Takahisa Motomura ,  Hironobu NAGAMORI ,  Koichi SUZAWA ,  Hirotsugu ITO ,  Toru MORITA ,  Satoru KOBAYASHI ,  Hisashi SHINKAI

IPC分类号： C07D205/04 ,  C07F7/08 ,  A61K31/045 ,  A61K31/05 ,  A61K31/085 ,  A61K31/10 ,  A61K31/121 ,  A61K31/136 ,  A61K31/166 ,  A61K31/167 ,  A61K31/192 ,  A61K31/235 ,  A61K31/277 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/401 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4523 ,  A61K31/5375 ,  C07C35/52 ,  C07C39/42 ,  C07C43/23 ,  C07C43/253 ,  C07C49/83 ,  C07C59/56 ,  C07C59/72 ,  C07C65/17 ,  C07C69/712 ,  C07C69/732 ,  C07C69/76 ,  C07C215/44 ,  C07C215/70 ,  C07C217/20 ,  C07C233/18 ,  C07C233/25 ,  C07C235/42 ,  C07C235/66 ,  C07C255/12 ,  C07C255/53 ,  C07C259/10 ,  C07C271/16 ,  C07C271/30 ,  C07C311/04 ,  C07C317/22 ,  C07D231/12 ,  C07D239/26 ,  C07D249/08 ,  C07D257/04 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D275/02 ,  C07D295/08 ,  C07D295/18 ,  C07D333/22 ,  C07D401/06 ,  C07D403/12 ,  C07D401/12 ,  C07D207/04 ,  C07D211/06 ,  C07D213/30 ,  C07D213/56 ,  C07D295/192

摘要： The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.