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公开(公告)号：US11246884B2
公开(公告)日：2022-02-15
申请号：US16244746
申请日：2019-01-10
IPC分类号： A61K31/785 , A61K49/04
摘要： Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
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公开(公告)号：US20220002478A1
公开(公告)日：2022-01-06
申请号：US17475914
申请日：2021-09-15
发明人： Joachim B. Kohn , Durgadas Bolikal
IPC分类号： C08G63/64 , A61L31/06 , A61L31/16 , C07C69/36 , C07C69/40 , C07C69/732 , C07C69/736 , C07C69/96 , A61K47/34 , C07C59/52 , C07C59/68 , C08G67/00 , A61L31/14 , A61L31/18 , C07C233/47 , C08G63/66
摘要： The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.
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3.发明申请公开(公告)号：US20190292312A1
公开(公告)日：2019-09-26
申请号：US16439232
申请日：2019-06-12
IPC分类号： C08G63/08 , C08G64/16 , C08G63/64 , A61L31/14 , A61L31/18 , C08G64/02 , C08G63/19 , C08G63/91 , A61L31/16 , A61L31/06
摘要： The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.
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公开(公告)号：US10329379B2
公开(公告)日：2019-06-25
申请号：US14454073
申请日：2014-08-07
IPC分类号： C08G63/08 , C08G63/19 , C08G64/16 , A61L31/06 , A61L31/16 , C08G63/91 , C08G64/02 , C08G63/64 , A61L31/14 , A61L31/18 , C08G79/025 , C08G79/04
摘要： The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogs, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.
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公开(公告)号：US20190185624A1
公开(公告)日：2019-06-20
申请号：US16240091
申请日：2019-01-04
发明人： Joachim B. Kohn , Durgadas Bolikal
CPC分类号： C08G69/44 , A61L24/046 , A61L27/18 , A61L31/06 , C08G69/08
摘要： The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.
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6.发明授权Polymeric biomaterials derived from phenolic monomers and their medical uses 有权衍生自酚类单体的聚合物生物材料及其医疗用途公开(公告)号：US09416090B2
公开(公告)日：2016-08-16
申请号：US13757752
申请日：2013-02-02
发明人： Joachim B. Kohn , Durgadas Bolikal
IPC分类号： C08G63/02 , C08G63/06 , A61K47/30 , C07C59/52 , A61K47/34 , C07C59/68 , C08G67/00 , C07C69/36 , C07C69/40 , C07C69/732 , C07C69/736 , C07C69/96 , C08G63/64 , A61L31/06 , A61L31/16
CPC分类号： C08G63/64 , A61K47/34 , A61L31/06 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/41 , A61L2300/412 , A61L2300/416 , C07C59/52 , C07C59/68 , C07C69/36 , C07C69/40 , C07C69/732 , C07C69/736 , C07C69/96 , C07C233/47 , C08G63/66 , C08G67/00 , C08G2230/00
摘要： The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogs, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.
摘要翻译： 本发明提供新类型的酚化合物，包括衍生自酪醇和类似物的那些，其可用作制备生物相容性聚合物的单体，以及由这些单体酚化合物制备的生物相容性聚合物，包括新的可生物降解和/或生物可再吸收的聚合物。 具有增强的生物可再生性和加工性的这些生物相容性聚合物或聚合物组合物可用于各种医疗应用，例如在医疗装置和控制释放治疗制剂中。 本发明还提供了制备这些单体酚化合物和生物相容性聚合物的方法。
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公开(公告)号：US20160177028A1
公开(公告)日：2016-06-23
申请号：US14983801
申请日：2015-12-30
发明人： Durgadas Bolikal , Joachim B. Kohn
CPC分类号： C08G64/10 , A61K49/0442 , C07C69/84 , C08G63/64 , C08G81/00
摘要： Disclosed are monomeric compounds which may be polymerized to form novel biodegradable and bioresorbable polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radioopacity and are useful for medical device applications and controlled release therapeutic formulations.
摘要翻译： 公开了可以聚合以形成新的可生物降解和生物可再吸收的聚合物和共聚物的单体化合物。 这些聚合物和共聚物虽然不限于此，但可适用于放射性能力，并且可用于医疗器械应用和控制释放治疗剂型。
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公开(公告)号：US20140255335A1
公开(公告)日：2014-09-11
申请号：US14197679
申请日：2014-03-05
IPC分类号： A61K31/785
CPC分类号： A61K31/785 , A61K49/0442
摘要： Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
摘要翻译： 优选的实施方案涉及固有的不透射线的，生物相容的，生物可再吸收的聚合物颗粒的组合物和使用它们来栓塞体腔的方法。
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公开(公告)号：US11649203B2
公开(公告)日：2023-05-16
申请号：US16984850
申请日：2020-08-04
发明人： Durgadas Bolikal , Joachim B. Kohn
IPC分类号： C07C69/732 , C08G64/10 , C07C69/734 , C07C233/51 , C07C69/84 , C08G64/38 , A61L31/18 , A61L31/14 , A61L31/16 , A61L31/06 , C08G64/06 , C08G64/12 , C07C69/40 , C07C233/47 , C07C69/736 , C07C69/36
CPC分类号： C07C69/732 , A61L31/06 , A61L31/148 , A61L31/16 , A61L31/18 , C07C69/36 , C07C69/40 , C07C69/734 , C07C69/736 , C07C69/84 , C07C233/47 , C07C233/51 , C08G64/06 , C08G64/10 , C08G64/12 , C08G64/38 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/604 , A61L31/06 , C08L69/00
摘要： Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula
These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.-
公开(公告)号：US11118011B2
公开(公告)日：2021-09-14
申请号：US16240091
申请日：2019-01-04
发明人： Joachim B. Kohn , Durgadas Bolikal
摘要： The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.
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