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    MEDICAL TISSUE ADHESIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    1.
    发明申请
    MEDICAL TISSUE ADHESIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 有权

    公开(公告)号：US20250041475A1

    公开(公告)日：2025-02-06

    申请号：US18718575

    申请日：2022-10-27

    Applicant: Beijing Biosis Healing Biological Technology Co., Ltd

    Inventor： Bo ZHAO ,  Pengfei WEI ,  Yiqian HUANG ,  Wei JING

    IPC: A61L24/04 ,  A61L27/26 ,  A61L27/50 ,  C08L71/02 ,  C09J171/02

    Abstract: The present disclosure belongs to the field of biomedical materials, and specifically relates to a medical tissue adhesive, and a preparation method therefor and the use thereof, and a composition and a kit for preparing the medical tissue adhesive. According to the medical tissue adhesive provided by the present disclosure, a three-dimensional net-shaped gel skeleton structure is formed by means of the mutual crosslinking of a polyethylene glycol derivative L a polyethylene glycol derivative H and trilysine. Moreover, the gel skeleton has a crosslinked network density and intermolecular interaction that can be improved, and accordingly has an improved structure bonding strength and mechanical strength. In addition, the medical tissue adhesive has the advantages of a reduced swelling rate, a high biocompatibility and biodegradability, can effectively adhere to tissues and seal wounds, reduces compression on tissues such as nerves, realizes wound sealing, tissue repair and blocking of postoperative liquids such as blood and tissue fluid, and has great clinical significance and wide application prospects.

    BIODEGRADABLE AND BIOCOMPATIBLE MEDICAL PRODUCTS, NAMELY ADHESIVES, SEALANTS, AND HEMOSTATS
    2.
    发明申请
    BIODEGRADABLE AND BIOCOMPATIBLE MEDICAL PRODUCTS, NAMELY ADHESIVES, SEALANTS, AND HEMOSTATS 有权

    公开(公告)号：US20240417609A1

    公开(公告)日：2024-12-19

    申请号：US18814146

    申请日：2024-08-23

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： PHILLIP MESSERSMITH ,  Subhajit Pal ,  Kelsey G. Defrates ,  Jisoo Shin

    IPC: C09J181/04 ,  A61L24/04 ,  C08G75/14 ,  C08G75/26

    Abstract: Adhesive compositions for medical and non-medical uses are provided. The adhesive compositions can include cyclic disulfide monomers, oligomers of reactions between the cyclic disulfides, polymers of the cyclic disulfides, solid articles formed formed from the polymers, and any combination thereof. Methods of making, using, and recycling the adhesive compositions are provided, including use of the adhesive compositions on a variety of substrates that include biological tissue; biomaterials, including synthetics and natural such as bone, wood, and cellulosics; metals and alloys; polymers, plastics, and rubbers; ceramics; composites; and, any combination of these materials. The adhesives can adhere to substrates in a variety of environmental conditions that include ambient atmospheric conditions, wet conditions that include adhering materials underwater, and in a wide variety of temperatures and pressures, such as those temperatures and pressures found in medical environments, including in living tissue, as well as many residential, commercial, industrial, and manufacturing environments.

    Gelation of Highly Entangled Hydrophobic Macromolecular Fluid for Ultra-Strong Underwater In-Situ Fast Adhesion to Artery, Lung, Bone and Skin Tissues
    5.
    发明申请
    Gelation of Highly Entangled Hydrophobic Macromolecular Fluid for Ultra-Strong Underwater In-Situ Fast Adhesion to Artery, Lung, Bone and Skin Tissues 有权

    公开(公告)号：US20240374785A1

    公开(公告)日：2024-11-14

    申请号：US18690078

    申请日：2022-10-26

    Applicant: University of Manitoba

    Inventor： Malcolm Xing

    IPC: A61L26/00 ,  A61L24/00 ,  A61L24/04

    Abstract: Building strong underwater bioadhesion is important for several applications but proved to be an extremely challenging task. In a wet/underwater environment, the water boundary layer hinders interfacial adhesion, which is further undermined by water-induced swelling in bioadhesives. In contrast to current hydrophilic bioadhesives, we here propose an underwater and in-situ applicable hydrophobic adhesive (UIHA). We report polydimethylsiloxane (PDMS) tangled with macromolecular silicone fluid as a dissipation phase to provide strong interface adhesion strength. The silicone fluid repels the surface boundary water layer, overcomes capillary break up in water, and rapidly gelates with PDMS, while a small amount of silane (

    COMPOSITIONS FOR EMBOLIZATION
    6.
    发明公开
    COMPOSITIONS FOR EMBOLIZATION 审中-公开

    公开(公告)号：US20240358885A1

    公开(公告)日：2024-10-31

    申请号：US18292107

    申请日：2022-07-25

    Applicant: IBERHOSPITEX, S.A.

    Inventor： MARIO LÓPEZ MOYA ,  VÍCTOR RAMOS PÉREZ

    IPC: A61L24/04 ,  C08L29/04

    CPC classification number: A61L24/043 ,  C08L29/04 ,  A61L2300/418 ,  A61L2400/06 ,  A61L2430/36

    Abstract: A liquid polymeric composition including: (a) from about 2 to about 20 weight percent of a polymer; (b) from about 5 to about 40 weight percent of a radiopaque molecule with a molecular weight below 2000 g/mol; and (c) from about 40 to about 93 weight percent of a non-physiological solvent or solvent system; wherein (i) the sum of the weight percent of all components in the composition is 100, (ii) the polymer and the radiopaque molecule are not covalently bound and are both dissolved in the non-physiological solvent or solvent system, and (iii) the polymer is soluble in the non-physiological solution and insoluble in a physiological solution at room temperature, and (iv) the liquid polymeric composition is capable of forming, upon contact with physiological conditions, a radiopaque precipitate which maintains at least 50% of its radiopacity during at least 30 minutes and loses at least 50% of its radiopacity in less than 6 months.

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