公开(公告)号：US20240269351A1

公开(公告)日：2024-08-15

申请号：US18237744

申请日：2023-08-24

Applicant: The Johns Hopkins University

Inventor： Sashank Reddy ,  Russell Martin ,  Xiaowei Li ,  Calvin Chang ,  Kevin Colbert ,  Hai-Quan Mao

IPC: A61L27/58 ,  A61L27/18 ,  A61L27/20 ,  A61L27/38 ,  A61L27/44 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61M5/19 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: A61L27/58 ,  A61L27/18 ,  A61L27/20 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3895 ,  A61L27/44 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61M5/19 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/622 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/34 ,  A61M2202/08 ,  A61M2202/09 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

公开(公告)号：US10052389B2

公开(公告)日：2018-08-21

申请号：US14767784

申请日：2014-02-13

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Ki Hyun Bae ,  Fan Lee

IPC: A61K47/61 ,  A61K47/69 ,  A61K47/48 ,  A61L27/20 ,  A61L27/22 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L31/04 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L15/44 ,  A61L15/60 ,  A61K9/00 ,  A61K47/10 ,  A61K47/36 ,  A61K38/21 ,  A61K38/28 ,  A61K38/38 ,  C08B37/02 ,  C08L5/02 ,  A61K47/60

CPC classification number: A61K47/61 ,  A61K9/0019 ,  A61K9/0024 ,  A61K38/21 ,  A61K38/212 ,  A61K38/28 ,  A61K38/385 ,  A61K47/10 ,  A61K47/36 ,  A61K47/60 ,  A61K47/6903 ,  A61L15/44 ,  A61L15/60 ,  A61L27/20 ,  A61L27/22 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L31/042 ,  A61L31/043 ,  A61L31/129 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/622 ,  A61L2400/06 ,  C08B37/0021 ,  C08L5/02 ,  C08L89/00 ,  C08L5/00 ,  C08L71/02

Abstract: The present disclosure relates to a polymeric system for release of an active agent, comprising a first polymeric phase containing the active agent, the first polymeric phase forming discrete regions of a set size range and being dispersed within a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein. The present disclosure further provides an injectable hydrogel comprising the disclosed polymeric system, a carrier for delivering a biologically active substance or a drug comprising the injectable hydrogel, and a method for producing the disclosed polymeric system.

公开(公告)号：US20180126128A1

公开(公告)日：2018-05-10

申请号：US15866930

申请日：2018-01-10

Applicant: Surmodics, Inc.

Inventor： James Howard Arps ,  Andrew G. Bach

IPC: A61M25/10 ,  A61L29/08 ,  A61L29/04 ,  A61K31/337 ,  A61L29/14 ,  A61L29/16 ,  C08L3/02

CPC classification number: A61M25/1002 ,  A61K31/337 ,  A61L29/041 ,  A61L29/085 ,  A61L29/145 ,  A61L29/148 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/622 ,  A61M25/104 ,  A61M2025/1004 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1075 ,  C08L3/02

Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.

公开(公告)号：US20180085493A1

公开(公告)日：2018-03-29

申请号：US15564101

申请日：2016-04-07

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Chang Hun Lee

IPC: A61L27/44 ,  A61L27/18 ,  A61L27/54 ,  A61L27/38 ,  A61L27/36 ,  A61L27/56 ,  B33Y70/00 ,  B29C64/112 ,  B33Y10/00 ,  B33Y80/00

CPC classification number: A61L27/44 ,  A61L27/18 ,  A61L27/3608 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/622 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/10 ,  A61L2430/38 ,  B29C64/112 ,  B29K2067/04 ,  B29K2995/0056 ,  B29K2995/006 ,  B29L2031/7532 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  C08L67/04

Abstract: Provided herein is a 3D printing system and related compositions, and method of using such, that can produce a polymeric microfiber having embedded microspheres encapsulating an active agent with micron precision and high spatial and temporal resolution. One aspect of the present disclosure provides a method of forming a biocompatible scaffold. Another aspect provides a method of forming a polymeric fiber having a microencapsulated agent distributed in the polymeric fiber. Another aspect provides a composition including a polymeric microfiber produced by 3D printing.

公开(公告)号：US09925087B2

公开(公告)日：2018-03-27

申请号：US13956717

申请日：2013-08-01

Applicant: BRUDER HEALTHCARE COMPANY

Inventor： Mark H. Bruder ,  Aaron N. Ingram

IPC: A61F9/00 ,  A61F13/00 ,  A61F7/02 ,  A61L15/44 ,  A61F7/00

CPC classification number: A61F7/02 ,  A61F13/00021 ,  A61F13/00063 ,  A61F2007/0004 ,  A61F2007/0204 ,  A61F2007/0242 ,  A61F2013/00187 ,  A61L15/44 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/622 ,  A61L2300/626

Abstract: A dressing for treatment of a body part surface of a human or animal patient. The dressing includes a compress with a plurality of loose fill granules contained in an enclosure. The plurality of loose fill granules is configured to deliver moist heat. The dressing also includes antibacterial medication that is activated by the moist heat delivered from the compress and released toward the body part surface. The fill granules substantially retain at least one antimicrobial metal material therein and allow repeated absorption and dissipation of moisture to and from the fill granules.

公开(公告)号：US09883710B2

公开(公告)日：2018-02-06

申请号：US12855783

申请日：2010-08-13

Applicant: Karine Theberge ,  Isabelle Goudreault ,  Francois Quirion ,  Gerald Perron

Inventor： Karine Theberge ,  Isabelle Goudreault ,  Francois Quirion ,  Gerald Perron

IPC: A41D1/00 ,  A61K8/02 ,  A61K9/70 ,  A61K31/231 ,  A61K8/97 ,  A61K8/92 ,  A61Q19/00 ,  A41D19/00 ,  A43B1/00 ,  A43B17/00 ,  A61K8/55 ,  A61L15/42 ,  A61L15/44 ,  D06M23/08 ,  D06M23/12 ,  A61K9/00 ,  A61K9/16 ,  A61M35/00

CPC classification number: A43B1/0045 ,  A43B17/003 ,  A61K8/0208 ,  A61K8/0241 ,  A61K8/553 ,  A61K9/0014 ,  A61K9/1617 ,  A61K9/70 ,  A61K2800/56 ,  A61L15/42 ,  A61L15/44 ,  A61L2300/602 ,  A61L2300/622 ,  A61L2300/802 ,  A61M35/00 ,  A61Q19/00 ,  D06M23/08 ,  D06M23/12

Abstract: The present invention relates to articles of manufacture having a formulation distributed therein, wherein the formulation comprises an active agent which manifests a desirable property when released from the articles of manufacture. The present invention also relates to methods for manufacturing these articles of manufacture, to vehicles for applying the formulation to these articles of manufacture, and to perception indicators indicating the presence and the amount of formulation comprising an active agent applied to an article of manufacture.

公开(公告)号：US09867781B2

公开(公告)日：2018-01-16

申请号：US13400382

申请日：2012-02-20

Applicant: Daniel G. Anderson ,  Robert S. Langer ,  Tram T. Dang

Inventor： Daniel G. Anderson ,  Robert S. Langer ,  Tram T. Dang

IPC: A61K9/16 ,  A61K9/00 ,  A61K31/573 ,  A61K45/06 ,  A61K35/39 ,  G01N33/50 ,  A61L27/38 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  C12N5/071

CPC classification number: A61K9/1641 ,  A61K9/0019 ,  A61K31/573 ,  A61K35/39 ,  A61K45/06 ,  A61L27/3804 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/622 ,  A61L2300/64 ,  C12N5/0676 ,  C12N2502/1157 ,  C12N2533/40 ,  C12N2533/74 ,  G01N33/5088 ,  A61K2300/00 ,  C08L5/04 ,  C08L5/08

Abstract: A composition containing biocompatible hydrogel encapsulating mammalian cells and anti-inflammatory drugs is disclosed. The encapsulated cells have reduced fibrotic overgrowth after implantation in a subject. The compositions contain a biocompatible hydrogel having encapsulated therein mammalian cells and anti-inflammatory drugs or polymeric particles loaded with anti-inflammatory drugs. The anti-inflammatory drugs are released from the composition after transplantation in an amount effective to inhibit fibrosis of the composition for at least ten days. Methods for identifying and selecting suitable anti-inflammatory drug-loaded particles to prevent fibrosis of encapsulated cells are also described. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

公开(公告)号：US09861154B2

公开(公告)日：2018-01-09

申请号：US12680836

申请日：2009-07-17

Applicant: Karine Theberge ,  Isabelle Goudreault ,  Francois Quirion ,  Gerald Perron

Inventor： Karine Theberge ,  Isabelle Goudreault ,  Francois Quirion ,  Gerald Perron

IPC: A61K8/02 ,  A61K9/14 ,  A61K9/00 ,  A61K31/201 ,  A61P43/00 ,  A61Q90/00 ,  A43B1/00 ,  A43B17/00 ,  A61K8/55 ,  A61L15/42 ,  A61L15/44 ,  A61Q19/00 ,  D06M23/08 ,  D06M23/12 ,  A61K9/16 ,  A61K9/70 ,  A61M35/00

CPC classification number: A43B1/0045 ,  A43B17/003 ,  A61K8/0208 ,  A61K8/0241 ,  A61K8/553 ,  A61K9/0014 ,  A61K9/1617 ,  A61K9/70 ,  A61K2800/56 ,  A61L15/42 ,  A61L15/44 ,  A61L2300/602 ,  A61L2300/622 ,  A61L2300/802 ,  A61M35/00 ,  A61Q19/00 ,  D06M23/08 ,  D06M23/12

Abstract: The present invention relates to articles of manufacture having a formulation distributed therein, wherein the formulation comprises an active agent which manifests a desirable property when released from the articles of manufacture. The present invention also relates to methods for manufacturing these articles of manufacture, to vehicles for applying the formulation to these articles of manufacture, and to perception indicators indicating the presence and the amount of formulation comprising an active agent applied to an article of manufacture.

公开(公告)号：US09695505B2

公开(公告)日：2017-07-04

申请号：US14969631

申请日：2015-12-15

Applicant: EnBio Ltd.

Inventor： John Gerard O'Donoghue ,  Donncha Haverty

IPC: B05D3/12 ,  B05D1/12 ,  B05D1/34 ,  C23C16/02 ,  A61F2/30 ,  A61L27/04 ,  A61L27/06 ,  A61L27/50 ,  A61L27/54 ,  A61L29/02 ,  A61L29/14 ,  A61L29/16 ,  A61L31/02 ,  A61L31/14 ,  A61L31/16 ,  B24C11/00 ,  B05D7/14 ,  B05D5/06

CPC classification number: C23C16/0227 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2002/30092 ,  A61F2002/30906 ,  A61F2002/30924 ,  A61F2210/0014 ,  A61F2310/00011 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00047 ,  A61F2310/00059 ,  A61F2310/00071 ,  A61F2310/00095 ,  A61F2310/00131 ,  A61F2310/0097 ,  A61F2310/00976 ,  A61L27/04 ,  A61L27/06 ,  A61L27/50 ,  A61L27/54 ,  A61L29/02 ,  A61L29/14 ,  A61L29/16 ,  A61L31/022 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/622 ,  B05D1/12 ,  B05D3/12 ,  B05D5/06 ,  B05D7/14 ,  B24C11/00 ,  B24C11/005

Abstract: Disclosed herein are methods of treating an article surface. The method comprises removing a metal oxide surface from the metal substrate to expose a metal surface; and delivering particles comprising a dopant from at least one fluid jet to the metal surface to impregnate the surface of the article with the dopant. The method also comprises delivering substantially simultaneously a first set of particles comprising a dopant and a second set of particles comprising an abrasive from at least one fluid jet to a surface of an article to impregnate the surface of the article with the dopant.

公开(公告)号：US20170042916A1

公开(公告)日：2017-02-16

申请号：US15335064

申请日：2016-10-26

Applicant: Carl Hilliard ,  William R. Cast

Inventor： Carl Hilliard ,  William R. Cast

IPC: A61K31/695 ,  A61K47/10 ,  A61K47/20 ,  A61K31/56 ,  A61K47/26 ,  A61K45/06 ,  A61K9/00 ,  A61K9/50 ,  A61K38/47

CPC classification number: A61K31/695 ,  A61K9/0014 ,  A61K9/0017 ,  A61K9/0046 ,  A61K9/50 ,  A61K31/10 ,  A61K31/573 ,  A61K31/7004 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61L26/0066 ,  A61L2300/208 ,  A61L2300/404 ,  A61L2300/622 ,  C12Y302/01004 ,  A61K2300/00

Abstract: An antimicrobial composition and methods of use are provided. This antimicrobial composition includes a water-soluble organosilane (3-(trihydroxysilyl) propyldimethyloctadecyl ammonium chloride) and additional adjuvant compounds, including anti-inflammatory medications, antiseptics, transdermal penetrants, nutrients and/or buffers, generally to be applied in liquid form to penetrate and kill biofilms that are infecting living vertebrates. The methods include topically treating an infection by penetrating and disrupting an existing biofilm and killing cells therein and killing any persister cells that, through degrees of dormancy or otherwise, have escaped being killed during the initial application of the antimicrobial composition.

Abstract translation: 提供抗微生物组合物和使用方法。 该抗微生物组合物包括水溶性有机硅烷（3-（三羟基甲硅烷基）丙基二甲基十八烷基氯化铵）和其它助剂化合物，包括抗炎药物，防腐剂，透皮渗透剂，营养物质和/或缓冲剂，通常以液体形式施用以渗透 并杀死感染活的脊椎动物的生物膜。 所述方法包括通过穿透和破坏现有的生物膜并在其中杀死细胞来局部治疗感染，并杀死在抗微生物组合物的初始施用期间通过休眠或其它方式逸出的被杀死的任何持久细胞。