公开(公告)号：US20200069846A1

公开(公告)日：2020-03-05

申请号：US16515819

申请日：2019-07-18

Applicant: The Johns Hopkins University

Inventor： Russell Martin ,  Hai-Quan Mao ,  Sashank Reddy ,  Kevin Colbert

IPC: A61L27/56 ,  A61L27/48 ,  A61L27/54

Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

公开(公告)号：US10463768B2

公开(公告)日：2019-11-05

申请号：US15432606

申请日：2017-02-14

Applicant: The Johns Hopkins University

Inventor： Xuesong Jiang ,  Sashank Reddy ,  Gerald Brandacher ,  Hai-Quan Mao ,  Justin Sacks ,  Xiaowei Li ,  Kevin Feng ,  Russell Martin ,  Georgia C. Yalanis ,  Ji Suk Choi

IPC: A61L27/52 ,  A61L27/16 ,  A61L27/36 ,  A61L27/18 ,  A61L27/56 ,  A61L27/24 ,  A61L27/58 ,  A61L27/48

Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

公开(公告)号：US20180050130A1

公开(公告)日：2018-02-22

申请号：US15432606

申请日：2017-02-14

Applicant: The Johns Hopkins University

Inventor： Xuesong Jiang ,  Sashank Reddy ,  Gerald Brandacher ,  Hai-Quan Mao ,  Justin Sacks ,  Xiaowei Li ,  Kevin Feng ,  Russell Martin ,  George C. Yalanis ,  Ji Suk Choi

IPC: A61L27/52 ,  A61L27/36 ,  A61L27/24 ,  A61L27/56

CPC classification number: A61L27/52 ,  A61L27/16 ,  A61L27/18 ,  A61L27/24 ,  A61L27/3633 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L2400/06 ,  A61L2430/06 ,  A61L2430/34 ,  C08L5/08 ,  C08L67/04

Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

公开(公告)号：US20230293776A1

公开(公告)日：2023-09-21

申请号：US18200526

申请日：2023-05-22

Applicant: The Johns Hopkins University

Inventor： Xuesong Jiang ,  Sashank Reddy ,  Gerald Brandacher ,  Hai-Quan Mao ,  Justin Sacks ,  Xiaowei Li ,  Kevin Feng ,  Russell Martin ,  Georgia C. Yalanis ,  Ji Suk Choi

IPC: A61L27/52 ,  A61L27/16 ,  A61L27/24 ,  A61L27/36 ,  A61L27/56 ,  A61L27/58 ,  A61L27/18

CPC classification number: A61L27/52 ,  A61L27/16 ,  A61L27/24 ,  A61L27/3633 ,  A61L27/56 ,  A61L27/58 ,  A61L27/18 ,  A61L2430/06 ,  A61L2430/34 ,  A61L27/48

Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

公开(公告)号：US20200030496A1

公开(公告)日：2020-01-30

申请号：US16515946

申请日：2019-07-18

Applicant: The Johns Hopkins University

Inventor： Sashank Reddy ,  Russell Martin ,  Xiaowei Li ,  Calvin Chang ,  Kevin Colbert ,  Hai-Quan Mao

IPC: A61L27/58 ,  A61L27/54 ,  A61L27/20 ,  A61L27/18 ,  A61L27/44 ,  A61L27/52 ,  A61L27/38 ,  A61M5/19

Abstract: A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

公开(公告)号：US20180243481A1

公开(公告)日：2018-08-30

申请号：US15753274

申请日：2016-08-17

Applicant: The Johns Hopkins University

Inventor： Russell Martin ,  Sashank Reddy ,  Justin Sacks ,  Xiaowei Li ,  Brian Honewee Cho ,  Hai-quan Mao

IPC: A61L27/48 ,  A61F2/00 ,  A61F2/12 ,  A61L27/52 ,  A61L27/58 ,  A61L27/36 ,  A61L27/56 ,  A61L27/54

CPC classification number: A61L27/48 ,  A61F2/0063 ,  A61F2/12 ,  A61F2210/0061 ,  A61F2250/0067 ,  A61L27/3633 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/129 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/64 ,  A61L2430/04 ,  A61L2430/34 ,  C08L5/08 ,  C08L89/00 ,  C08L67/04

Abstract: The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.

公开(公告)号：US20180243480A1

公开(公告)日：2018-08-30

申请号：US15753272

申请日：2016-08-17

Applicant: The Johns Hopkins University

Inventor： Russell Martin ,  Hai-quan Mao ,  Sashank Reddy ,  Justin Sacks ,  Xiaowei Li ,  Brian Honewee Cho

IPC: A61L27/48 ,  A61L27/52 ,  A61L27/38 ,  A61L27/58 ,  A61L27/36 ,  A61L27/56 ,  A61L27/54

CPC classification number: A61L27/48 ,  A61K35/28 ,  A61K38/08 ,  A61K39/395 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/38 ,  A61L27/3834 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  A61L2400/06 ,  A61L2430/34 ,  C12N5/0667 ,  C12N2513/00 ,  C12N2533/30 ,  C12N2533/90

Abstract: The presently disclosed composition and methods are provided for a nanofiber-hydrogel composite containing adipose cell binding moieties. A method for healing a soft tissue defect can include applying an adipose cell-binding composite material to a soft tissue defect in combination with exogenous adipose-derived cells or endogenous cells recruited from the surrounding tissue.

公开(公告)号：US20230405189A1

公开(公告)日：2023-12-21

申请号：US18210003

申请日：2023-06-14

Applicant: The Johns Hopkins University

Inventor： Xuesong Jiang ,  Sashank Reddy ,  Gerald Brandacher ,  Hai-Quan Mao ,  Justin Sacks ,  Xiaowei Li ,  Kevin Feng ,  Russell Martin ,  Georgia C. Yalanis ,  Ji Suk Choi

IPC: A61L27/52 ,  A61L27/16 ,  A61L27/24 ,  A61L27/36 ,  A61L27/56 ,  A61L27/58 ,  A61L27/18

CPC classification number: A61L27/52 ,  A61L27/16 ,  A61L27/24 ,  A61L27/3633 ,  A61L27/48 ,  A61L27/58 ,  A61L27/18 ,  A61L2430/06 ,  A61L2430/34 ,  A61L27/56

Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

公开(公告)号：US11771807B2

公开(公告)日：2023-10-03

申请号：US16515946

申请日：2019-07-18

Applicant: The Johns Hopkins University

Inventor： Sashank Reddy ,  Russell Martin ,  Xiaowei Li ,  Calvin Chang ,  Kevin Colbert ,  Hai-Quan Mao

IPC: A61L27/58 ,  A61L27/54 ,  A61L27/20 ,  A61L27/18 ,  A61L27/44 ,  A61L27/38 ,  A61L27/52 ,  A61M5/19 ,  A61L27/48 ,  A61L27/56 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: A61L27/58 ,  A61L27/18 ,  A61L27/20 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3895 ,  A61L27/44 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61M5/19 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/622 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/34 ,  A61M2202/08 ,  A61M2202/09 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

公开(公告)号：US11707553B2

公开(公告)日：2023-07-25

申请号：US16533375

申请日：2019-08-06

Applicant: The Johns Hopkins University

Inventor： Xuesong Jiang ,  Sashank Reddy ,  Gerald Brandacher ,  Hai-Quan Mao ,  Justin Sacks ,  Xiaowei Li ,  Kevin Feng ,  Russell Martin ,  Georgia C. Yalanis ,  Ji Suk Choi

IPC: A61L27/52 ,  A61L27/16 ,  A61L27/24 ,  A61L27/36 ,  A61L27/56 ,  A61L27/58 ,  A61L27/18 ,  A61L27/48

CPC classification number: A61L27/52 ,  A61L27/16 ,  A61L27/18 ,  A61L27/24 ,  A61L27/3633 ,  A61L27/56 ,  A61L27/58 ,  A61L27/48 ,  A61L2400/06 ,  A61L2430/06 ,  A61L2430/34 ,  A61L27/16 ,  C08L5/08 ,  A61L27/18 ,  C08L67/04

Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.