公开(公告)号：US20240350708A1

公开(公告)日：2024-10-24

申请号：US17997439

申请日：2021-05-20

申请人： UNIV PARIS XIII PARIS-NORD VILLETANEUSE ,  UNIVERSITE PARIS CITE ,  OST DEVELOPPEMENT ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ETAT FRANCAIS REPRESENTE PAR LA DIRECTION CENTRALE DU SERVICE DE SANTE DES ARMÉES

发明人： Didier LUTOMSKI ,  Geraldine ROHMAN ,  Sylvie CHANGOTADE ,  Jean-Marc COLLOMBET ,  Sophie FRASCA ,  Hubert GUIBOURT ,  Credson LANGUEH ,  Anne CONSALUS

IPC分类号： A61L27/36 ,  A61F2/28 ,  A61F2/30 ,  A61L27/18 ,  A61L27/44 ,  A61L27/56

CPC分类号： A61L27/3608 ,  A61F2/3094 ,  A61L27/18 ,  A61L27/44 ,  A61L27/56 ,  A61F2002/2835 ,  A61F2002/30784

摘要： The present invention relates to a porous bone substitution material for bone repair, in particular the repair of a cavitary bone defect and/or the repair of a segmental bone defect.

公开(公告)号：US20240343859A1

公开(公告)日：2024-10-17

申请号：US18628340

申请日：2024-04-05

申请人： University of Rhode Island Board of Trustees ,  Yale University

发明人： Matthew Kiesewetter ,  Kassie Picard ,  Jinal Pothupitiya ,  W. Mark Saltzman

IPC分类号： C08G63/08 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58

CPC分类号： C08G63/08 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58

摘要： Embodiments of the present invention comprises one or more of an article composed of a copolymer, a copolymer made from a process, and a process for the preparation of a copolymer composition by metal free enzyme ring-opening polymerization of a monomer composition comprising i) an ethylene brassylate monomer; ii) a 1-4 dioxan-2-one (DO); iii) lipase B from Candida antarctica (Novozyme® 435) and at an elevated temperature, processing the monomer reactants i) and ii) to a copolymer via ring-opening polymerization under solvent-free conditions and a nitrogen atmosphere in the absence of a metal and the presence of the lipase to produce a random EB-co-DO copolymer.

公开(公告)号：US20240335219A1

公开(公告)日：2024-10-10

申请号：US18745396

申请日：2024-06-17

申请人： Bone Solutions, Inc.

发明人： Frankie Morris ,  Drew Diaz ,  Brandon Roller

IPC分类号： A61B17/86 ,  A61F2/30 ,  A61F2/44 ,  A61L27/04 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56

CPC分类号： A61B17/866 ,  A61F2/30771 ,  A61F2/3094 ,  A61F2/447 ,  A61L27/047 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61F2002/30827 ,  A61F2002/30985 ,  A61F2310/00023 ,  A61F2310/00041 ,  A61F2310/00359 ,  A61L2300/102 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2430/02 ,  A61L2430/24 ,  A61L2430/38

摘要： The present disclosure provides a bone-implantable device and methods of use. The bone-implantable device comprises a body having an exterior surface, wherein a portion of the exterior surface includes a cured osteostimulative material comprising MgO.

公开(公告)号：US20240301179A1

公开(公告)日：2024-09-12

申请号：US18591870

申请日：2024-02-29

申请人： Boston Scientific Scimed, Inc.

发明人： Yen-Hao Hsu ,  Cristian Parisi ,  Joseph Thomas Delaney, JR.

IPC分类号： C08L5/08 ,  A61K9/06 ,  A61K47/36 ,  A61L27/18 ,  A61L27/20 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  C08J3/075

CPC分类号： C08L5/08 ,  A61K9/06 ,  A61K47/36 ,  A61L27/18 ,  A61L27/20 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  C08J3/075 ,  C08J2305/08 ,  C08L2201/06 ,  C08L2203/02 ,  C08L2312/00

摘要： In some aspects, the present disclosure pertains to radiopaque crosslinked hydrogel compositions that comprise a crosslinked reaction product of (a) a polyamino iodinated compound and (b) a reactive polymer that comprises a plurality of reactive groups that are reactive with the amino groups of the polyamino iodinated compound. In other aspects, the present disclosure pertains to systems for forming a hydrogel composition that comprise (a) a polyamino iodinated compound and (b) a reactive polymer that comprises a plurality of reactive groups that are reactive with the amino groups of the polyamino iodinated compound. In further aspects, the present disclosure pertains to methods of treatment using such systems.

公开(公告)号：US20240294872A1

公开(公告)日：2024-09-05

申请号：US18574264

申请日：2022-06-23

申请人： FREIE UNIVERSITÄT BERLIN

发明人： Heidemarie WEINHART ,  Daniel STÖBENER ,  Matthias PEISER

IPC分类号： C12N5/0784 ,  A61L27/18 ,  C08G65/331 ,  C09D171/02

CPC分类号： C12N5/0639 ,  A61L27/18 ,  C08G65/3318 ,  C09D171/02 ,  C12N2533/30

摘要： It is provided a method for activating dendritic cells in vitro, comprising the following steps: a) providing a substrate, wherein a surface of the substrate comprises at least one poly(glycidyl ether) derivative according to general formula (i); b) contacting the substrate with a dendritic cell in an isosmotic aqueous solution or buffer.

公开(公告)号：US12076464B2

公开(公告)日：2024-09-03

申请号：US17072166

申请日：2020-10-16

申请人： The Texas A&M University System

发明人： Duncan Maitland ,  Corey Bishop ,  Shreedevi Arun Kumar

IPC分类号： A61L27/56 ,  A61L27/18 ,  A61L27/54 ,  C08G18/32 ,  C08G18/34 ,  C08G18/38 ,  C08G18/73 ,  C08G101/00

CPC分类号： A61L27/56 ,  A61L27/18 ,  A61L27/54 ,  C08G18/3206 ,  C08G18/341 ,  C08G18/3825 ,  C08G18/73 ,  A61L2300/626 ,  A61L2300/802 ,  A61L2400/16 ,  C08G2101/00 ,  C08G2280/00

摘要： Tumor resection is commonly practiced to prevent the progression of cancer. However, there are post-surgery concerns including the formation of a void that can allow cancer cells to escape at the surgery site, which increases the risk of metastasis. To counter this challenge, an embodiment includes a polyurethane-based shape memory foam as a tissue void-filling device that can also release anti-cancer drugs. Such foams may activate at body temperature and become malleable. Such properties may enable the foam to be shaped to precisely seal the tissue void and then serve as a drug-eluting device. Based on the drug composition with poly vinyl alcohol (PVA), the drug release profile from the foam may be altered depending on the application.

公开(公告)号：US12064352B2

公开(公告)日：2024-08-20

申请号：US18321083

申请日：2023-05-22

申请人： ALPS HOLDING LLC

发明人： George J. Picha ,  Grant Wesley Phillips ,  Rachel Smith ,  James Price ,  Gregory Causey

IPC分类号： A61F2/40 ,  A61F2/30 ,  A61F2/38 ,  A61F2/42 ,  A61F2/44 ,  A61L27/06 ,  A61L27/18 ,  A61F2/28

CPC分类号： A61F2/30771 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/4081 ,  A61F2/4202 ,  A61F2/4261 ,  A61F2/442 ,  A61L27/06 ,  A61L27/18 ,  A61F2/2803 ,  A61F2002/30069 ,  A61F2002/30224 ,  A61F2002/30326 ,  A61F2002/30383 ,  A61F2002/30896 ,  A61F2002/3093 ,  A61F2002/3863 ,  A61F2002/4205 ,  A61F2002/4207 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00293 ,  A61F2310/00359 ,  A61L2430/02 ,  A61L2430/38

摘要： Hard-tissue implants are provided that include a bulk implant, a face, pillars, slots, and at least one support member. The pillars are for contacting a hard tissue. The slots are to be occupied by the hard tissue. The at least one support member is for contacting the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1. Methods of making and using hard-tissue implants are also provided.

公开(公告)号：US12064340B2

公开(公告)日：2024-08-20

申请号：US17900168

申请日：2022-08-31

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  GEORGIA TECH RESEARCH CORPORATION

发明人： David Zopf ,  Scott J. Hollister

IPC分类号： A61F2/18 ,  A61L27/18 ,  A61L27/38 ,  A61L27/56 ,  A61M27/00 ,  A61F2/00

CPC分类号： A61F2/186 ,  A61L27/18 ,  A61L27/3839 ,  A61L27/56 ,  A61M27/00 ,  A61F2002/0081 ,  A61F2240/002 ,  A61F2250/0067

摘要： A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.

公开(公告)号：US20240269351A1

公开(公告)日：2024-08-15

申请号：US18237744

申请日：2023-08-24

申请人： The Johns Hopkins University

发明人： Sashank Reddy ,  Russell Martin ,  Xiaowei Li ,  Calvin Chang ,  Kevin Colbert ,  Hai-Quan Mao

IPC分类号： A61L27/58 ,  A61L27/18 ,  A61L27/20 ,  A61L27/38 ,  A61L27/44 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61M5/19 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L27/20 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3895 ,  A61L27/44 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61M5/19 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/622 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/34 ,  A61M2202/08 ,  A61M2202/09 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

摘要： A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

公开(公告)号：US20240261086A1

公开(公告)日：2024-08-08

申请号：US18434530

申请日：2024-02-06

申请人： Cannuflow, Inc.

发明人： Theodore R. Kucklick

IPC分类号： A61F2/08 ,  A61F2/00 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54

CPC分类号： A61F2/0811 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  A61F2002/0081 ,  A61F2002/0852 ,  A61F2002/0888 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2240/001 ,  A61L2430/10

摘要： A biological patch or construct used in tissue engineering for tendon repair. The patch system includes a scaffold connected to at least one fastener via a suture. The patch is delivered to a torn tendon via a delivery cannula and left over a torn tendon to assist in repair of the tendon.