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公开(公告)号：US20240358899A1
公开(公告)日：2024-10-31
申请号：US18515020
申请日：2023-11-20
申请人： 206 Ortho, Inc.
CPC分类号： A61L31/128 , A61L31/026 , A61L31/06 , A61L31/148 , C08J5/10 , A61L2430/02 , C08J2367/04 , C08J2375/04
摘要： An elongated composite for an implant comprising: one or more composite elements includes a core region including a plurality of fibrous bundles, (which are preferably braided, woven, bound, interlaced and/or interlocked by bias fiber elements) wherein the core region of the composite elements includes a polymerizable material or polymeric material which fills gaps between the fibrous bundles, (preferably wherein the each of the one or more composite elements has a second region including a polymeric covering formed of a polymerizable material or a polymeric material); and a covering over the one or more composite elements, preferably wherein the covering provides one or more functional features to the composite.
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公开(公告)号：US20240358889A1
公开(公告)日：2024-10-31
申请号：US18766738
申请日：2024-07-09
CPC分类号： A61L27/20 , A61L27/227 , A61L27/52 , A61L2430/02
摘要： Methods and compositions employing hybrid hydrogels formed of high molecular weight hyaluronic acid and a plurality of self-assembled peptides in inducing bone regeneration are provided.
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3.发明公开公开(公告)号：US20240358417A1
公开(公告)日：2024-10-31
申请号：US18770157
申请日：2024-07-11
申请人： MediCarbone, Inc.
发明人： Ravichandran Kollarigowda , Krishna Kolan , Neda Saadatmanesh , Hamid Saadatmanesh , Abiraman Srinivasan
IPC分类号： A61B17/72 , A61B17/56 , A61B17/68 , A61B17/88 , A61L15/12 , A61L15/14 , A61L27/12 , A61L27/16
CPC分类号： A61B17/7258 , A61B17/68 , A61B17/8805 , A61B17/8836 , A61B17/8858 , A61L15/125 , A61L15/14 , A61L27/12 , A61L27/16 , A61B2017/564 , A61B2017/568 , A61L2400/06 , A61L2430/02
摘要： A photocurable device injection system for creating in situ polymerization via light or free-radical to enable fractured bone fixation. The system comprises a photosensitive polymeric resin sensitive to light, temperature, oxygen, enzymes, or a combination thereof. The photosensitive polymeric resin may be configured to cure at room temperature or physiological temperature with a light source. The photosensitive polymeric resin may be configured to depolymerize with ultrasonication, sonication, or a combination thereof. The system further comprises an implantable 3-dimensional biocompatible pouch comprising an optical light guide. The system further comprises one or more micro-sized ultrasonication probes configured to contact a three-dimensional pouch by one or more openings. The one or more probes may be configured to enable polymer outflow.
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公开(公告)号：US20240335219A1
公开(公告)日：2024-10-10
申请号：US18745396
申请日：2024-06-17
申请人： Bone Solutions, Inc.
发明人： Frankie Morris , Drew Diaz , Brandon Roller
IPC分类号： A61B17/86 , A61F2/30 , A61F2/44 , A61L27/04 , A61L27/06 , A61L27/12 , A61L27/18 , A61L27/54 , A61L27/56
CPC分类号： A61B17/866 , A61F2/30771 , A61F2/3094 , A61F2/447 , A61L27/047 , A61L27/06 , A61L27/12 , A61L27/18 , A61L27/54 , A61L27/56 , A61F2002/30827 , A61F2002/30985 , A61F2310/00023 , A61F2310/00041 , A61F2310/00359 , A61L2300/102 , A61L2300/112 , A61L2300/412 , A61L2430/02 , A61L2430/24 , A61L2430/38
摘要： The present disclosure provides a bone-implantable device and methods of use. The bone-implantable device comprises a body having an exterior surface, wherein a portion of the exterior surface includes a cured osteostimulative material comprising MgO.
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公开(公告)号：US12109327B2
公开(公告)日：2024-10-08
申请号：US17401542
申请日：2021-08-13
CPC分类号： A61L27/365 , A61L27/22 , B33Y10/00 , B33Y70/00 , B33Y80/00 , C12N5/0654 , A61L2430/02 , C12N2506/1353 , C12N2513/00 , C12N2533/50
摘要： The present disclosure relates generally to an osteo-tissue graft capable of promoting bone tissue growth and regeneration, comprising at least one self-assemble peptide and mesenchymal stem cells (MSCs) in accordance with the present invention and a method of preparing such an osteo-tissue graft. The grafts are suitable for treatment of bone disorder or damages through tissue engineering, cellular replacement therapies as well as other applications.
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公开(公告)号：US12109326B2
公开(公告)日：2024-10-08
申请号：US16638113
申请日：2018-08-10
申请人： Theracell, LLC
CPC分类号： A61L27/3608 , A61B17/686 , A61F2/0811 , A61B17/7001 , A61L2430/02 , A61L2430/10
摘要： Compositions and methods thereof include bone fibers made from cortical bone in which a plurality of bone fibers are made into shapes that are used to augment fixation of orthopedic implants and screws. Sheets of bone fibers may be used as an interface between bone and tissue, tendons, and/or ligaments. Cylindrical shaped implants that may be placed in drilled holes in bone prior to screw placement to enhance fixation of the screw. The physical presence of the fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the screw and hence fixation. The bone fiber compositions may be in the form of a cylinder or a tube. A delivery system and methods of use are also provided.
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公开(公告)号：US20240307592A1
公开(公告)日：2024-09-19
申请号：US18034455
申请日：2021-10-29
申请人： Spiderwort Inc.
发明人： Ryan Hickey , Kama Szereszewski , Andrew E. Pelling , Paula Cristina de Sousa Faria Tischer , Anna CANTO , Joshua SALAMUN , Matthew LOURENCO
IPC分类号： A61L27/52 , A23L29/262 , A23L31/00 , A23P30/40 , A61L27/20 , A61L27/38 , A61L27/54 , A61L27/56 , C08L5/14
CPC分类号： A61L27/52 , A23L29/262 , A23L31/00 , A23P30/40 , A61L27/20 , A61L27/383 , A61L27/54 , A61L27/56 , C08L5/14 , A61L2300/402 , A61L2400/06 , A61L2430/02 , A61L2430/34 , A61L2430/38
摘要： Provided herein are aerogels and foams including: single structural cells and/or groups of structural cells derived from a plant or fungal tissue, the single structural cells having a decellularized 3D structure lacking cellular materials and nucleic acids of plant or fungal tissue; the single structural cells and/or groups of structural cells being distributed within a carrier derived from a dehydrated, lyophilized, or freeze-dried hydrogel. Also provided herein are methods for preparing aerogels or foams, including steps of: providing a decellularized plant or fungal tissue; obtaining single structural cells and/or groups of structural cells from the decellularized plant or fungal tissue by performing mercerization; mixing or distributing the single structural cells and/or groups of structural cells in a hydrogel, to provide a mixture; and dehydrating, lyophilizing, or freeze-drying the mixture to provide the aerogel or foam. Related methods and uses are also provided.
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公开(公告)号：US12076462B2
公开(公告)日：2024-09-03
申请号：US17018708
申请日：2020-09-11
发明人： Gretchen Selders , Ian Dunkley
CPC分类号： A61L27/46 , A61L27/10 , A61L27/12 , A61L27/24 , A61L27/3608 , A61L27/362 , A61L27/365 , A61L27/56 , A61L2400/06 , A61L2430/02
摘要： A uniformly hydrated composition is provided and methods of making the uniformly hydrated composition. The method comprises providing a plurality of lyophilized porous macroparticles in a chamber, the plurality of lyophilized porous macroparticles each having an average diameter from about 0.1 mm to about 10 mm and comprising ceramic material and polymer; and mixing each of the plurality of lyophilized porous macroparticles with a fluid in the chamber to uniformly hydrate each of the plurality of lyophilized porous macroparticles to form a uniformly hydrated composition. Hydratable compositions are also provided.
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公开(公告)号：US20240277846A1
公开(公告)日：2024-08-22
申请号：US18409423
申请日：2024-01-10
发明人： Heemin KANG , Woo-Young JANG
CPC分类号： A61K41/00 , A61K33/26 , A61K47/549 , A61L27/042 , A61L27/12 , A61L27/54 , A61P19/00 , A61L2300/232 , A61L2300/412 , A61L2430/02
摘要： A magnetic biomolecule-metal ion self-assembly complex for treatment includes an iron ion; and at least one ligand, wherein the ligand and the iron ion are reversibly self-assembled with each other or self-disassembled from each other, wherein the ligand and the iron ion are self-assembled with each other via a first bond to form a self-assembly, wherein the self-assembling is performed by at least one of the metal ion and the ligand, wherein the self-assembly includes a plural of self-assemblies, wherein the self-assemblies adjacent to each other self-bind to each other via a second bond to form the self-assembly complex. The magnetic biomolecule-metal ion self-assembly complex is effectively used for cancer treatment, osteoarthritis treatment, and bone defect treatment.
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10.发明授权公开(公告)号：US12064352B2
公开(公告)日：2024-08-20
申请号：US18321083
申请日：2023-05-22
申请人： ALPS HOLDING LLC
CPC分类号： A61F2/30771 , A61F2/3859 , A61F2/389 , A61F2/4081 , A61F2/4202 , A61F2/4261 , A61F2/442 , A61L27/06 , A61L27/18 , A61F2/2803 , A61F2002/30069 , A61F2002/30224 , A61F2002/30326 , A61F2002/30383 , A61F2002/30896 , A61F2002/3093 , A61F2002/3863 , A61F2002/4205 , A61F2002/4207 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00293 , A61F2310/00359 , A61L2430/02 , A61L2430/38
摘要： Hard-tissue implants are provided that include a bulk implant, a face, pillars, slots, and at least one support member. The pillars are for contacting a hard tissue. The slots are to be occupied by the hard tissue. The at least one support member is for contacting the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1. Methods of making and using hard-tissue implants are also provided.
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