公开(公告)号：US20240416007A1

公开(公告)日：2024-12-19

申请号：US18816619

申请日：2024-08-27

Applicant: Warsaw Orthopedic, Inc.

Inventor： Gretchen Selders ,  Ian Dunkley

IPC: A61L27/46 ,  A61L27/10 ,  A61L27/12 ,  A61L27/24 ,  A61L27/36 ,  A61L27/56

Abstract: A uniformly hydrated composition is provided and methods of making the uniformly hydrated composition. The method comprises providing a plurality of lyophilized porous macroparticles in a chamber, the plurality of lyophilized porous macroparticles each having an average diameter from about 0.1 mm to about 10 mm and comprising ceramic material and polymer; and mixing each of the plurality of lyophilized porous macroparticles with a fluid in the chamber to uniformly hydrate each of the plurality of lyophilized porous macroparticles to form a uniformly hydrated composition. Hydratable compositions are also provided.

公开(公告)号：US20240374791A1

公开(公告)日：2024-11-14

申请号：US18292355

申请日：2022-07-29

Applicant: PROMIMIC AB

Inventor： Per Kjellin ,  Line Vikingsson ,  Hoda Fathali ,  Gunnar Simonarson ,  Oscar Davidsson

IPC: A61L27/46 ,  A61L27/06 ,  A61L27/28 ,  A61L27/56 ,  A61L27/58 ,  B82Y5/00 ,  B82Y40/00 ,  C01B25/32

Abstract: Porous hydrophilic composites for use in promoting bone growth are disclosed, along with methods for their preparation. The composites comprise a porous biodegradable polymer matrix, and nanosized calcium phosphate (CaP) homogeneously dispersed throughout the polymer matrix. The CaP has a specific surface area in the range of about 180 to about 380 m2/g.

公开(公告)号：US20240335592A1

公开(公告)日：2024-10-10

申请号：US18743016

申请日：2024-06-13

Applicant: Vanderbilt University

Inventor： Scott A. Guelcher ,  Sichang Lu ,  Madison A.P. McGough ,  Katarzyna J. Zienkiewicz

IPC: A61L27/48 ,  A61L27/10 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C04B26/16 ,  C04B111/00 ,  C08G18/10 ,  C08G18/38 ,  C08G18/48 ,  C08G18/77 ,  C08G18/80

CPC classification number: A61L27/48 ,  A61L27/10 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C04B26/16 ,  C08G18/10 ,  C08G18/3868 ,  C08G18/4833 ,  C08G18/771 ,  C08G18/8061 ,  A01K2207/20 ,  A61L2300/404 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/02 ,  C04B2111/00836

Abstract: A hybrid composite and method for producing a polymer network are provided. The hybrid composite includes nanocrystalline hydroxyapatite (nHA) and polyurethane. The method for producing a polymer network includes reacting nanocrystalline hydroxyapatite (nHA) particles with lysine derived triisocyanate (LTI) to form a nHA/LTI hybrid prepolymer and reacting the prepolymer with a thioketal (TK) diol to form a nHA/poly(thioketal urethane) (PTKUR) hybrid polymer network.

公开(公告)号：US20240335586A1

公开(公告)日：2024-10-10

申请号：US18681443

申请日：2022-08-02

Applicant: Amrita Vishwa Vidyapeetham

Inventor： Binulal Nelson Sathy ,  Shantikumar Nair ,  Niji Nandakumar

IPC: A61L27/26 ,  A61L27/22 ,  A61L27/44 ,  A61L27/46 ,  A61L27/56 ,  D01D5/00

CPC classification number: A61L27/26 ,  A61L27/222 ,  A61L27/227 ,  A61L27/446 ,  A61L27/46 ,  A61L27/56 ,  D01D5/0038 ,  A61L2300/252

Abstract: The present invention discloses a highly stretchable matrix, comprising mesh of lattice structures of microfibrillar filaments, having pore size enlargeable up to 8 times by moving the microfibrillar filaments perpendicular to the longitudinal axis of the microfibrillar filaments without losing its integrity. The invention also pertains to a method of preparing said highly stretchable matrix comprising the steps of: electrostatic spinning of the polymeric solution as microfibers, creating an air-flow at the inter-phase of microfibers to completely eliminate the solvent from the surface of the microfibers bundles to avoid inter-fibrillar bonding after collection and dispersing the microfibers in a direction perpendicular to the longitudinal axis of the fibers, 6-12 times the original width using a dispersion unit to obtain a stretch responsive fibrillar matrix.

公开(公告)号：US12076463B2

公开(公告)日：2024-09-03

申请号：US17849893

申请日：2022-06-27

Applicant: DSM IP Assets B.V. ,  ACADEMISCH ZIEKENHUIS MAASTRICHT

Inventor： Jens Christoph Thies ,  Ruud Jozef Regina Wilhelmus Peters ,  Pieter J. Emans ,  Jacob Koenen

IPC: A61L27/46 ,  A61L27/44 ,  A61L27/54 ,  A61L27/56 ,  C08L75/04

CPC classification number: A61L27/46 ,  A61L27/446 ,  A61L27/54 ,  A61L27/56 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2430/02 ,  C08L75/04

Abstract: The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 μm; providing a dispersion of bioactive ceramic particles of particle size at most 10 μm in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent.

公开(公告)号：US12048779B2

公开(公告)日：2024-07-30

申请号：US17506831

申请日：2021-10-21

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Sarindr Bhumiratana ,  Gordana Vunjak-Novakovic

IPC: A61L27/36 ,  A61F2/30 ,  A61L27/38 ,  A61L27/42 ,  A61L27/46 ,  A61L27/50 ,  A61L27/56

CPC classification number: A61L27/3612 ,  A61F2/30756 ,  A61L27/3608 ,  A61L27/3834 ,  A61L27/425 ,  A61L27/46 ,  A61L27/50 ,  A61L27/56 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2/3094 ,  A61L2400/06 ,  A61L2430/06 ,  A61L2430/10 ,  A61L27/46 ,  C08L89/06

Abstract: Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.

公开(公告)号：US12048633B2

公开(公告)日：2024-07-30

申请号：US17519336

申请日：2021-11-04

Applicant: HAPPE SPINE, LLC

Inventor： Ryan K. Roeder ,  Gabriel L. Converse ,  Stephen M. Smith

IPC: A61F2/44 ,  A61F2/28 ,  A61L27/12 ,  A61L27/18 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  B29C67/20 ,  C08J9/00 ,  C08J9/28 ,  C08J9/36 ,  A61F2/30

CPC classification number: A61F2/4455 ,  A61F2/28 ,  A61F2/4465 ,  A61L27/12 ,  A61L27/18 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  B29C67/202 ,  C08J9/0066 ,  C08J9/28 ,  C08J9/36 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30006 ,  A61F2002/30011 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30065 ,  A61F2002/30225 ,  A61F2002/30235 ,  A61F2002/30622 ,  A61F2002/30904 ,  A61F2002/3092 ,  A61F2002/30957 ,  A61F2/30965 ,  A61F2210/0004 ,  A61F2210/0071 ,  A61F2230/0069 ,  A61F2250/0015 ,  A61F2250/0018 ,  A61F2250/0023 ,  A61F2250/0031

Abstract: A composite material for use, for example, as an orthopedic implant, that includes a porous reinforced composite scaffold that includes a polymer, reinforcement particles distributed throughout the polymer, and a substantially continuously interconnected plurality of pores that are distributed throughout the polymer, each of the pores in the plurality of pores defined by voids interconnected by struts, each pore void having a size within a range from about 10 to 500 nm. The porous reinforced composite scaffold has a scaffold volume that includes a material volume defined by the polymer and the reinforcement particles, and a pore volume defined by the plurality of pores. The reinforcement particles are both embedded within the polymer and exposed on the struts within the pore voids. The polymer may be a polyaryletherketone polymer and the reinforcement particles may be anisometric calcium phosphate particles.

公开(公告)号：US11992581B2

公开(公告)日：2024-05-28

申请号：US16376552

申请日：2019-04-05

Applicant: HISTOGRAFT, LLC

Inventor： Roman Vadimovich Deev ,  Artur Aleksandrovich Isaev ,  Ilya Yadigerovich Bozo ,  Vladimir Sergeevich Komlev

IPC: A61L27/54 ,  A61K48/00 ,  A61L27/12 ,  A61L27/18 ,  A61L27/36 ,  A61L27/46 ,  C12Q1/6834

CPC classification number: A61L27/54 ,  A61K48/00 ,  A61L27/12 ,  A61L27/18 ,  A61L27/3608 ,  A61L27/46 ,  C12Q1/6834 ,  A61L2300/414 ,  A61L2430/02

Abstract: Provided are gene-activated materials comprising a scaffold and at least one nucleic acid molecule which may be chemical bound together or in which the at least one nucleic acid is not bound but coated on a surface of the scaffold. Methods for regenerating bone using these gene-activated materials are also provided.

公开(公告)号：US11850328B2

公开(公告)日：2023-12-26

申请号：US16349186

申请日：2017-11-14

Applicant: Northwestern University

Inventor： Guillermo A. Ameer

IPC: A61L27/46 ,  A61K9/00 ,  A61K9/08 ,  A61K47/32 ,  A61L27/18 ,  A61L27/50 ,  C08G63/47 ,  C08G63/91 ,  C08L67/00 ,  C08L101/00 ,  A61L27/16 ,  C08L101/16

CPC classification number: A61L27/46 ,  A61K9/00 ,  A61K9/0024 ,  A61K47/32 ,  A61L27/16 ,  A61L27/18 ,  A61L27/50 ,  C08G63/47 ,  C08G63/914 ,  C08L67/00 ,  C08L101/00 ,  C08L101/16 ,  A61L2300/802 ,  A61L2430/02 ,  A61L27/18 ,  C08L67/00 ,  A61L27/46 ,  C08L67/00

Abstract: Provided herein are thermoresponsive polymer materials and methods of preparation and use thereof. In particular, materials are provided that cure upon exposure to physiologic conditions (e.g., human body temperature) and find use in, for example, orthopedic surgery, bone tissue engineering, and the repair of bone injuries and defects.

公开(公告)号：US11826949B2

公开(公告)日：2023-11-28

申请号：US16328448

申请日：2017-11-14

Applicant: Desktop Metal, Inc.

Inventor： Michael Andrew Gibson ,  Jonah Samuel Myerberg ,  Ricardo Fulop ,  Michael J. Tarkanian ,  Yet-Ming Chiang ,  Jay Tobia ,  Olivia Molnar Lam

IPC: B29C64/124 ,  B29C64/245 ,  B29C64/165 ,  B33Y70/10 ,  C04B35/486 ,  C04B35/626 ,  C04B35/632 ,  C04B35/638 ,  G03F7/00 ,  G03F7/004 ,  A61K6/807 ,  A61K6/818 ,  A61K6/822 ,  A61K6/833 ,  C04B35/01 ,  C04B35/634 ,  B22F1/10 ,  B22F10/12 ,  B22F10/50 ,  A61L27/46 ,  B33Y50/02 ,  B29C64/135 ,  B22F7/04 ,  B28B1/00 ,  B33Y10/00 ,  B22F3/26 ,  B22F7/08 ,  B33Y80/00 ,  B82Y30/00 ,  B82Y40/00 ,  C22C9/06 ,  C22C19/03 ,  B22F12/90 ,  B22F10/64 ,  B22F1/102 ,  G03F7/027 ,  B22F3/10 ,  B29K509/02

CPC classification number: B29C64/124 ,  A61K6/807 ,  A61K6/818 ,  A61K6/822 ,  A61K6/833 ,  A61L27/46 ,  B22F1/10 ,  B22F3/26 ,  B22F7/04 ,  B22F7/08 ,  B22F10/12 ,  B22F10/50 ,  B28B1/001 ,  B29C64/135 ,  B29C64/165 ,  B29C64/245 ,  B33Y10/00 ,  B33Y50/02 ,  B33Y70/10 ,  C04B35/013 ,  C04B35/486 ,  C04B35/6263 ,  C04B35/6264 ,  C04B35/632 ,  C04B35/634 ,  C04B35/638 ,  C04B35/63488 ,  G03F7/0037 ,  G03F7/0047 ,  G03F7/70416 ,  B22F1/102 ,  B22F3/1021 ,  B22F10/64 ,  B22F12/90 ,  B22F2007/042 ,  B22F2998/10 ,  B29K2509/02 ,  B33Y80/00 ,  B82Y30/00 ,  B82Y40/00 ,  C22C9/06 ,  C22C19/03 ,  G03F7/027 ,  B22F2998/10 ,  B22F10/12 ,  B22F3/1021 ,  B22F3/02

Abstract: Systems, methods, components, and materials are disclosed for stereolithographic fabrication of three-dimensional, dense objects. A resin including at least one component of a binder system and dispersed particles can be exposed to an activation light source. The activation light source can cure the at least one component of the binder system to form a green object, which can include the at least one component of the binder system and the particles. A dense object can be formed from the green object by removing the at least one component of the binder system in an extraction process and thermally processing particles to coalesce into the dense object.