公开(公告)号：US12121626B2

公开(公告)日：2024-10-22

申请号：US17542473

申请日：2021-12-05

Applicant: Zhejiang University

Inventor： Mingying Yang ,  Fang Lei ,  Yajun Shuai

IPC: A61K38/10 ,  A61L24/00 ,  A61L24/10

CPC classification number: A61L24/108 ,  A61L24/0015 ,  A61L2300/252 ,  A61L2300/418 ,  A61L2400/04

Abstract: The present invention discloses a blood coagulation-promoting silk fibroin-polypeptide electrospun membrane and a preparation method thereof. The electrospun membrane is made by using silkworm silk fibroin as a carrier and adding the polypeptide GPRPPSEHLQIT. It is mainly used for promoting blood coagulation, and is a blood coagulation material that can targetedly bind to human fibrinogen. The preparation method includes the steps of dissolving, filtering, dialyzing, concentrating and freeze-drying silkworm cocoons after degumming to obtain silk fibroin freeze-dried powder. The polypeptide used in the present invention is a polypeptide obtained by self-screening. Compared with other polypeptides, it can specifically targetedly bind to human fibrinogen.

公开(公告)号：US20240299616A1

公开(公告)日：2024-09-12

申请号：US18665926

申请日：2024-05-16

Applicant: ABC IP, LLC

Inventor： Mladen Thomas Strbac

IPC: A61L24/00 ,  A61L24/04 ,  F41A17/48 ,  F41A19/10 ,  F41A19/15 ,  F41A19/24

CPC classification number: A61L24/0036 ,  A61L24/0015 ,  A61L24/043 ,  F41A17/48 ,  F41A19/10 ,  F41A19/15 ,  F41A19/24 ,  A61L2300/252 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2430/36

Abstract: A trigger mechanism that can be used in AR-pattern firearms has a hammer, a trigger member, a disconnector, a locking member, and a “three position” safety selector having safe, standard semi-automatic, and forced reset semi-automatic positions. In the standard semi-automatic position, rearward movement of the bolt carrier causes rearward pivoting of the hammer such that the disconnector hook catches the hammer hook, at which time a user must manually release the trigger member to free the hammer from the disconnector to permit the hammer and trigger member to pivot to the set positions so that the user can pull the trigger member to fire the firearm. In the forced reset semi-automatic position, rearward movement of the bolt carrier causes rearward pivoting of the hammer causing the trigger member to be forced to the set position, the safety selector preventing the disconnector hook from catching the hammer hook, and thereafter when the bolt carrier reaches the substantially in-battery position the user can pull the trigger member to fire the firearm without manually releasing the trigger member. The locking member is pivotable between a first position at which the locking member mechanically blocks the trigger member from moving to the released position and a second position at which the locking member does not mechanically block the trigger member allowing the trigger member to be moved to the released position. The locking member is spring biased toward the first position and moved against the spring bias to the second position by contact from the bolt carrier during forward movement of the bolt carrier as the bolt carrier reaches a substantially in-battery position.

公开(公告)号：US20240277893A1

公开(公告)日：2024-08-22

申请号：US18644676

申请日：2024-04-24

Applicant: UAB Bioremedium

Inventor： Šiurkus Juozas

IPC: A61L26/00

CPC classification number: A61L26/008 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/0076 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/802

Abstract: Stabilized pharmaceutical wound dressing compositions comprising calreticulin protein for use in medical treatment, in particular for topical treatment of acute and chronic wounds, are provided. Pharmaceutical compositions of the present invention comprise calreticulin protein or a functional fragment or derivative thereof and one or more of pharmaceutically acceptable polymeric materials that form hydrogel. More specifically, compositions of present invention can be sprayed onto a wound as a liquid or applied topically in the form of gel. Compositions of the present invention may further comprise serum albumins, preservatives and additional biologically active molecules.

公开(公告)号：US12053561B2

公开(公告)日：2024-08-06

申请号：US17022062

申请日：2020-09-15

Applicant: President and Fellows of Harvard College

Inventor： Rajiv Desai ,  Neel Satish Joshi ,  David J. Mooney ,  Sandeep T. Koshy ,  Alexander Stafford

IPC: A61L27/52 ,  A61L27/20 ,  A61L27/22 ,  A61L27/26 ,  A61L27/38 ,  A61L27/54 ,  C07D237/26 ,  C07K14/78 ,  C08B37/00

CPC classification number: A61L27/52 ,  A61L27/20 ,  A61L27/222 ,  A61L27/26 ,  A61L27/3886 ,  A61L27/54 ,  C07D237/26 ,  C07K14/78 ,  C08B37/0084 ,  A61L2300/22 ,  A61L2300/23 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/258 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2400/18 ,  A61L27/26 ,  C08L5/04 ,  A61L27/26 ,  C08L89/00

Abstract: The present disclosure provides click-crosslinked hydrogels and methods of use.

公开(公告)号：US20240197954A1

公开(公告)日：2024-06-20

申请号：US18390310

申请日：2023-12-20

Applicant: UAB Bioremedium

Inventor： Šiurkus Juozas

IPC: A61L26/00 ,  A61K38/19

CPC classification number: A61L26/0066 ,  A61K38/19 ,  A61L26/0052 ,  A61L26/0076 ,  A61L26/008 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/802

Abstract: Stabilized pharmaceutical wound dressing compositions comprising calreticulin protein for use in medical treatment, in particular for topical treatment of acute and chronic wounds, are provided. Pharmaceutical compositions of the present invention comprise calreticulin protein or a functionally active fragment or derivative thereof and one or more of pharmaceutically acceptable polymeric materials that form hydrogel. More specifically, compositions of present invention can be sprayed onto a wound as a liquid or applied topically in the form of gel. Compositions of the present invention may further comprise serum albumins, preservatives and additional biologically active molecules.

公开(公告)号：US20240189486A1

公开(公告)日：2024-06-13

申请号：US18546945

申请日：2022-02-16

Applicant: Université de Bordeaux ,  Centre National de la Recherche Scientifique ,  Institut Polytechnique de Bordeaux ,  Université Paul Sabatier Toulouse III ,  Institut Pasteur

Inventor： Colin BONDUELLE ,  Pierre VERHAEGHE ,  Bruno DUPUY ,  Pedro SALAS-AMBROSIO ,  Antoine TRONNET

IPC: A61L27/54 ,  A61L27/22 ,  C07K7/64 ,  C07K14/00

CPC classification number: A61L27/54 ,  A61L27/22 ,  C07K7/64 ,  C07K14/001 ,  A61L2300/252 ,  A61L2300/404

Abstract: The present invention provides cationic peptoid/N-substituted peptidic copolymers, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful for the treatment of microbial infections.

公开(公告)号：US12005152B2

公开(公告)日：2024-06-11

申请号：US17168780

申请日：2021-02-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang-Heon Kim ,  Seung Ja Oh ,  Ha Eun Chung

IPC: A61L26/00

CPC classification number: A61L26/0033 ,  A61L26/0023 ,  A61L26/008 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/60 ,  A61L27/26 ,  C08L89/06 ,  A61L27/26 ,  C08L5/08

Abstract: The present disclosure relates to a microgel composition comprising collagen and hyaluronic acid and a method of preparing the same. The microgel according to an embodiment is composed of natural biocompatible substances and is non-toxic and has high mechanical stability or long persistence, and thus can be effectively used in a microgel composition, a three-dimensional scaffold composition, and a tissue-engineering scaffold.

公开(公告)号：US20240165297A1

公开(公告)日：2024-05-23

申请号：US18235404

申请日：2023-08-18

Applicant: Philip Neil MacPherson

Inventor： Philip Neil MacPherson

IPC: A61L26/00

CPC classification number: A61L26/0057 ,  A61L26/0023 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2430/02 ,  A61L2430/12 ,  A61L2430/38

Abstract: The present disclosure relates to delivering a biological material to a wounded tissue of a patient by the application of a composition comprising biocompatible modified starch particles modified by carboxylation or hydroxylation of glucose units in the starch. Compositions comprising biocompatible modified starch particles are also provided.

公开(公告)号：US11986561B2

公开(公告)日：2024-05-21

申请号：US17499221

申请日：2021-10-12

Applicant: THE PENN STATE RESEARCH FOUNDATION ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jian Yang ,  Kytai T. Nguyen ,  Zhiwei Xie

IPC: A61L15/22 ,  A61L15/26 ,  A61L15/28 ,  A61L15/42 ,  A61L15/44 ,  A61L15/64 ,  A61L31/04 ,  A61L31/06 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  C08L67/04

CPC classification number: A61L15/225 ,  A61L15/26 ,  A61L15/28 ,  A61L15/425 ,  A61L15/44 ,  A61L15/64 ,  A61L31/042 ,  A61L31/06 ,  A61L31/129 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  C08L67/04 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/414 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2300/624 ,  A61L31/06 ,  C08L71/02 ,  A61L31/042 ,  C08L1/26 ,  A61L31/042 ,  C08L5/08 ,  A61L31/129 ,  C08L67/04 ,  A61L31/129 ,  C08L71/02 ,  A61L31/129 ,  C08L1/26 ,  A61L31/129 ,  C08L5/08 ,  A61L15/28 ,  C08L5/08 ,  A61L15/28 ,  C08L1/26 ,  A61L15/26 ,  C08L71/02

Abstract: In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation.

公开(公告)号：US20240131222A1

公开(公告)日：2024-04-25

申请号：US18483493

申请日：2023-10-08

Applicant: SHANXI JINBO BIO-PHARMACEUTICAL CO., LTD ,  SICHUAN UNIVERSITY

Inventor： Hai LIN ,  He QIU ,  Jing WANG ,  Jian WANG ,  Yang XU ,  Lu SONG ,  Xia YANG ,  Xingdong ZHANG

IPC: A61L27/26 ,  A61L27/52

CPC classification number: A61L27/26 ,  A61L27/52 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/802 ,  A61L2430/34

Abstract: The present invention relates to a transdermal photocuring forming hydrogel with biological activity. The hydrogel can release recombinant collagen with biological activity, the recombinant collagen includes a sequence as shown in SEQ ID No. 1, an amino acid sequence of the recombinant collagen includes N basic repetitive units, and each basic repetitive unit includes n1 of the following characteristic amino acid sequences: “G-Xaa1-Xaa2-G-E-Xaa3”; the 3′ end and the 5′ end of the basic repetitive unit are connected to form the above characteristic amino acid sequence. The recombinant collagen provided by the present invention has relatively obvious integrin binding activity, and has the effects of promoting cell adhesion, proliferation and differentiation. The hydrogel of the present invention has good biocompatibility and stable quality, which can be cured and formed in situ in a transdermal photo-crosslinking manner after injection, with simple, convenient and controllable operation.