公开(公告)号：US12084798B2

公开(公告)日：2024-09-10

申请号：US17613560

申请日：2019-06-12

申请人： SAMYANG HOLDINGS CORPORATION

发明人： Hye Sung Yoon ,  Jin Su Kim

IPC分类号： D04H17/12 ,  A61L24/08 ,  A61L31/04 ,  D04H1/44 ,  D04H1/70

CPC分类号： D04H17/12 ,  A61L24/08 ,  A61L31/042 ,  D04H1/44 ,  D04H1/70 ,  D10B2509/022

摘要： The present invention relates to an apparatus for manufacturing a fibrous web, a fibrilla fiber aggregate, or a nonwoven fabric by using a woven fabric, a method for manufacturing a fibrous web, a fibrilla fiber aggregate, or a nonwoven fabric by using the apparatus, and a fibrous web, a fibrilla fiber aggregate, or a nonwoven fabric manufactured by the method, especially, a fibrous web, a fibrilla fiber aggregate, or a nonwoven fabric for use in a hemostatic agent or an anti-adhesive agent.

公开(公告)号：US12070564B2

公开(公告)日：2024-08-27

申请号：US17657895

申请日：2022-04-04

申请人： GYRUS ACMI, INC.

发明人： Judy L. Walish ,  Hui Tang ,  Thomas J. Holman

IPC分类号： A61M27/00 ,  A61F2/04 ,  A61L31/04

CPC分类号： A61M27/008 ,  A61F2/04 ,  A61L31/042 ,  A61F2002/048 ,  A61L2430/22 ,  A61M2210/1085

摘要： A ureteral stent is provided. The stent may include a first section having a first wall defining a first luminal section. The stent may further include a second section having a second wall defining a second luminal section. The second section can be enabled to substantially close at times external pressure is applied to the stent.

公开(公告)号：US20240238486A1

公开(公告)日：2024-07-18

申请号：US18454628

申请日：2023-08-23

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Carnegie Mellon University

发明人： Louis D. Falo, Jr. ,  Geza Erdos ,  O. Burak Ozdoganlar

IPC分类号： A61L31/14 ,  A61L31/04 ,  A61L31/06 ,  A61L31/16 ,  A61M37/00 ,  B23C3/00

CPC分类号： A61L31/148 ,  A61L31/042 ,  A61L31/06 ,  A61L31/16 ,  A61M37/0015 ,  B23C3/00 ,  A61L2300/426 ,  A61L2300/604 ,  A61L2400/06 ,  A61M2037/0053 ,  B23C2215/00 ,  B23C2220/48 ,  B23C2226/00 ,  Y10T409/303752

摘要： A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.

公开(公告)号：US20240226390A9

公开(公告)日：2024-07-11

申请号：US18011616

申请日：2022-06-14

申请人： CNLD CO., LTD. ,  UIF (University Industry Foundation), Yonsei Uneversity

发明人： Sung Joo Hwang ,  Dong Min Kim ,  Ji Eun Kim ,  Yeon Ju Choi ,  Yong Kyung Hwang

IPC分类号： A61L31/04 ,  A61L31/00 ,  A61L31/14

CPC分类号： A61L31/042 ,  A61L31/005 ,  A61L31/14

摘要： Disclosed is an anti-adhesion agent composition which uses a high molecular weight compound having biocompatibility and an oil derived from animals, plants, and minerals so as to improve low viscosity and low strength, which are problems of existing anti-adhesion agents, and prevent adhesion between living tissues. The anti-adhesion composition according to the present disclosure performs a physical barrier function through simple mixing of a polymer material, serving as a physical barrier in its anti-adhesion effect, and a solvent, and remains in the body for a certain period of time, then decomposes, absorbs, and is excreted. The anti-adhesion composition does not interfere with the healing of the wound after surgery, and exhibits an excellent effect of convenient application to the surgical site.

公开(公告)号：US11986561B2

公开(公告)日：2024-05-21

申请号：US17499221

申请日：2021-10-12

申请人： THE PENN STATE RESEARCH FOUNDATION ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Jian Yang ,  Kytai T. Nguyen ,  Zhiwei Xie

IPC分类号： A61L15/22 ,  A61L15/26 ,  A61L15/28 ,  A61L15/42 ,  A61L15/44 ,  A61L15/64 ,  A61L31/04 ,  A61L31/06 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  C08L67/04

CPC分类号： A61L15/225 ,  A61L15/26 ,  A61L15/28 ,  A61L15/425 ,  A61L15/44 ,  A61L15/64 ,  A61L31/042 ,  A61L31/06 ,  A61L31/129 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  C08L67/04 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/414 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2300/624 ,  A61L31/06 ,  C08L71/02 ,  A61L31/042 ,  C08L1/26 ,  A61L31/042 ,  C08L5/08 ,  A61L31/129 ,  C08L67/04 ,  A61L31/129 ,  C08L71/02 ,  A61L31/129 ,  C08L1/26 ,  A61L31/129 ,  C08L5/08 ,  A61L15/28 ,  C08L5/08 ,  A61L15/28 ,  C08L1/26 ,  A61L15/26 ,  C08L71/02

摘要： In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation.

公开(公告)号：US20240123124A1

公开(公告)日：2024-04-18

申请号：US18535139

申请日：2023-12-11

申请人： HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  AZRIELI COLLEGE OF ENGINEERING JERUSALEM

发明人： Yoav MINTZ ,  Nikolai KUNICHER ,  Tali TAVOR RE'EM

IPC分类号： A61L31/04 ,  A61F2/00 ,  A61K31/734 ,  A61K33/14

CPC分类号： A61L31/042 ,  A61F2/0063 ,  A61K31/734 ,  A61K33/14 ,  A61F2002/0072

摘要： Disclosed herein are devices/kits and methods for reducing, treating, preventing or eliminating post-operative adhesions in an intervention/target site within a body of a subject. The method comprises the steps of: introducing an applicator, configured for applying an anti-adhesive composition, into an intervention/target site within a body of a subject; applying the anti-adhesive composition onto the intervention/target site; and extracting the applicator from the body of the subject, wherein the method is performed during or following an interventional procedure.

公开(公告)号：US20240082456A1

公开(公告)日：2024-03-14

申请号：US18513436

申请日：2023-11-17

申请人： Medtronic Xomed, Inc.

发明人： Ethan G. Sherman ,  Wei Chen ,  Denise E. Guenther

IPC分类号： A61L24/00 ,  A61F13/20 ,  A61K9/00 ,  A61L2/00 ,  A61L15/22 ,  A61L24/04 ,  A61L24/08 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16 ,  B65B55/16 ,  B65B63/08

CPC分类号： A61L24/0042 ,  A61F13/2005 ,  A61K9/0043 ,  A61L2/0029 ,  A61L15/225 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/043 ,  A61L24/08 ,  A61L31/042 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  B65B55/16 ,  B65B63/08 ,  A61L2202/24 ,  A61L2300/232 ,  A61L2300/404 ,  A61L2400/04

摘要： An implantable article comprising a dissolvable sponge derived from the mixture of chitosan, a first polysaccharide and a second polysaccharides. The polysaccharides have different number average molecular weight characteristics to enable the control of the mechanical features of the sponge.

公开(公告)号：US20240033492A1

公开(公告)日：2024-02-01

申请号：US18130490

申请日：2023-04-04

申请人： Allergan, Inc.

发明人： Justin J. Schwab ,  Michael Augarten ,  Zachary Dominguez ,  Ethan Franklin ,  Edwin J. Kayda ,  Jason Metzner

IPC分类号： A61M37/00 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16

CPC分类号： A61M37/0015 ,  A61L31/042 ,  A61L31/148 ,  A61L31/16 ,  A61M2037/0023 ,  A61L2300/414 ,  A61L2300/428 ,  A61M2037/0046 ,  A61M2037/0061

摘要： A layered microneedle device can have successively stacked layers that each include microneedles and perforations positioned between the microneedles. The layers can be stacked to permit microneedles of a lower layer to extend through the perforations of an upper layer. Thus, microneedles of successively stacked layers can extend away from individual layers in a common direction.

公开(公告)号：US20240000473A1

公开(公告)日：2024-01-04

申请号：US18468853

申请日：2023-09-18

申请人： Boston Scientific Scimed, Inc.

发明人： Shawn Ryan ,  Samuel Raybin ,  Matthew B. Hollyer

IPC分类号： A61B17/32 ,  A61L31/14 ,  A61L31/04 ,  A61B17/00 ,  A61M5/19 ,  A61M5/28 ,  A61B17/34 ,  G01R33/00 ,  H01F27/34

CPC分类号： A61B17/320016 ,  A61L31/148 ,  A61L31/042 ,  A61B17/00234 ,  A61M5/19 ,  A61M5/285 ,  A61B17/3478 ,  G01R33/0011 ,  G01R33/0017 ,  H01F27/346 ,  A61B18/14

摘要： The present disclosure relates to the field of medical devices generally and specifically, to endoscopic systems and methods for resection of malignant and pre-malignant lesions within the gastrointestinal (GI) tract. In particular, the present disclosure relates to systems and methods for delivering injectable compositions between tissue layers (e.g., between the muscularis and submucosa layers) to elevate and stabilize the lesion for fast and efficient resection.

公开(公告)号：US20230414844A1

公开(公告)日：2023-12-28

申请号：US17899612

申请日：2022-08-31

申请人： Hangzhou Singclean Medical Products Co., Ltd

发明人： Zhihong Zhang ,  Qingzhi Deng ,  Yufei Xiong ,  Wei Huang

IPC分类号： A61L31/14 ,  A61L31/04

CPC分类号： A61L31/145 ,  A61L31/042 ,  A61L31/048

摘要： The present disclosure discloses a cross-linked hydrogel microneedle for transdermal drug delivery and a method for preparing the same. The preparation method includes the following steps: mixing a polyvinyl alcohol solution and a hyaluronic acid solution; freeze-thawing the mixed solution in a mold to obtain a gel with no fluidity; and demolding the gel and further performing irradiation cross-linking to obtain the cross-linked hydrogel microneedle. The preparation method described in the present disclosure overcomes the problem of poor stability that exists in the preparation by a freeze-thaw method and the problem of easy introduction of air bubbles that exists in the preparation by an irradiation method, and can increase the yield of the microneedles, which is conducive to mass production. The prepared microneedles can be transported and stored for a long time and have wide application prospects.