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1.发明授权公开(公告)号：US11834524B2
公开(公告)日：2023-12-05
申请号：US17828152
申请日：2022-05-31
发明人： Jue Wang , Yaru Wu , Meiqin Zhu
CPC分类号： C08B37/003 , A61K8/73 , A61K47/36
摘要： The application discloses a method for preparing chitin highly dispersible in aqueous phase and prepared chitin. After chitin is ground, dissolved, modified with glycidol and purified, a final product glycidol chitin is obtained. The glycidol chitin prepared according to this method has good solubility in purified water, and the concentration can reach 100 mg/mL, which is obviously different from common insoluble or poorly soluble chitin derivatives. Glycidol chitin may have a wide range of application prospects in biomedicine, cosmetics, absorbable materials, and other related aspects.
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公开(公告)号：US20220081492A1
公开(公告)日：2022-03-17
申请号：US17106194
申请日：2020-11-30
摘要： Provided are a chitin whisker-enhanced hyaluronic acid cell scaffold and a preparation method thereof. Components of the cell scaffold include chitin whiskers and cross-linked hyaluronic acid. The chitin whisker-enhanced hyaluronic acid cell scaffold is obtained by dispersing chitin whiskers into deionized water using ultrasound, followed by addition of hyaluronic acid and uniform mixing to obtain an aqueous solution, adjusting a pH value of the aqueous solution to be in a range of 4.0 to 6.0, subjecting the aqueous solution to a cross-linking reaction, dialyzing a reaction product in a phosphate buffer solution, and freeze drying a resulting product. The chitin whisker-enhanced hyaluronic acid cell scaffold and the preparation method thereof can increase a mechanical property and a resistance to degradation of a scaffold material and expand an application scope of hyaluronic acid cell scaffolds.
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公开(公告)号：US20170182203A1
公开(公告)日：2017-06-29
申请号：US15201597
申请日：2016-07-04
发明人： Zhiguo Zhang , Yange Suo , Wei Huang , Weiqing Sun
CPC分类号： A61L24/0036 , A61L24/08 , A61L2400/04 , C08B15/04 , C08L1/04
摘要： Disclosed is a method for preparing an oxidized cellulose hemostatic product, including using a sodium hydroxide solution with the concentration of 1 to 5% to pre-process a cellulose product; after removing lignins or impurities on the fiber surface, using an alkaline solution to activate the fiber surface further; after the activating treatment, using demin-water for washing until it is neutral and drying the obtained cellulose product in air to obtain a raw material; using a sodium hydroxide solution with the concentration of 5 to 20% as a solvent; adding the cellulose product, carbamide and ZnO that are 3 to 10%, 2% and 2% of the sodium hydroxide solution respectively.
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4.发明公开公开(公告)号：US20240238479A1
公开(公告)日：2024-07-18
申请号：US18135733
申请日：2023-04-17
发明人： Qingzhi Deng , Zhihong Zhang , Yufei Xiong , Wei Huang , Quan Zhang , Bair Zu
IPC分类号： A61L27/26
CPC分类号： A61L27/26 , A61L2400/06 , A61L2430/34
摘要： The present disclosure provides a collagen and sodium hyaluronate cross-linked composite filler for injection and a preparation method thereof. The collagen and sodium hyaluronate cross-linked composite filler is obtained by a cross-linking reaction of collagen and sodium hyaluronate with a 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) cross-linking system. As the EDC/NHS is used as a cross-linking agent in the present disclosure, the resulting product has no biological toxicity, so that the injury caused by a final product to an injection site and the human body is reduced. Meanwhile, due to intramolecular and intermolecular cross-linking, the degradation rate of the collagen and the sodium hyaluronate is reduced, and the retention time of the two in the body is prolonged. Therefore, the collagen and sodium hyaluronate cross-linked composite filler for injection in the present disclosure can be used in plastic surgery in the medical industry.
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5.发明公开公开(公告)号：US20230312763A1
公开(公告)日：2023-10-05
申请号：US17828152
申请日：2022-05-31
发明人： Jue Wang , Yaru Wu , Meiqin Zhu
CPC分类号： C08B37/003 , A61K47/36 , A61K8/73
摘要： The application discloses a method for preparing chitin highly dispersible in aqueous phase and prepared chitin. After chitin is ground, dissolved, modified with glycidol and purified, a final product glycidol chitin is obtained. The glycidol chitin prepared according to this method has good solubility in purified water, and the concentration can reach 100 mg/mL, which is obviously different from common insoluble or poorly soluble chitin derivatives. Glycidol chitin may have a wide range of application prospects in biomedicine, cosmetics, absorbable materials, and other related aspects.
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公开(公告)号：US20220064436A1
公开(公告)日：2022-03-03
申请号：US17197022
申请日：2021-03-09
IPC分类号： C08L67/04
摘要： Provided is a gradient injection containing a mixture of polymer microspheres. The injection is a freeze-dried powder composed of a filler, cross-linked sodium hyaluronate microspheres, poly-L-lactic acid (PLLA) microspheres, and an excipient. The powder can be mixed with sterile water and then used for injection cosmetology. A triple gradient effectiveness is provided by mixing the filler, the cross-linked sodium hyaluronate microspheres, and the PLLA microspheres to improve the subcutaneous capacity of human skin and repair skin wrinkles, folds, scars, and aging. The gradient injection is also suitable for repairing large-volume facial fat loss without adverse reactions such as nodules and granulomas.
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公开(公告)号：US12121907B1
公开(公告)日：2024-10-22
申请号：US18523848
申请日：2023-11-29
发明人： Yang Fu , Lingling Lyu , Jue Wang , Wei Huang
摘要： A cyclical and continuous device and method for wet sieving of polysaccharide granules are provided. The device includes a first dosing tank, a second dosing tank connected to the first dosing tank by a first circulation pump, a first suction filtration tank connected to the second dosing tank by a second circulation pump, and a second suction filtration tank connected to the first dosing tank by a third circulation pump. An overflow port provided on a side wall of the second dosing tank is higher than a feed port of the first dosing tank. A sieve of a mesh filter for coarse powder is disposed in the first dosing tank. A sieve of a mesh filter for fine powder is disposed in the second dosing tank. A stirring device is disposed in both the first dosing tank and the second dosing tank.
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8.发明公开公开(公告)号：US20230414844A1
公开(公告)日：2023-12-28
申请号：US17899612
申请日：2022-08-31
发明人： Zhihong Zhang , Qingzhi Deng , Yufei Xiong , Wei Huang
CPC分类号： A61L31/145 , A61L31/042 , A61L31/048
摘要： The present disclosure discloses a cross-linked hydrogel microneedle for transdermal drug delivery and a method for preparing the same. The preparation method includes the following steps: mixing a polyvinyl alcohol solution and a hyaluronic acid solution; freeze-thawing the mixed solution in a mold to obtain a gel with no fluidity; and demolding the gel and further performing irradiation cross-linking to obtain the cross-linked hydrogel microneedle. The preparation method described in the present disclosure overcomes the problem of poor stability that exists in the preparation by a freeze-thaw method and the problem of easy introduction of air bubbles that exists in the preparation by an irradiation method, and can increase the yield of the microneedles, which is conducive to mass production. The prepared microneedles can be transported and stored for a long time and have wide application prospects.
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公开(公告)号：US20230098334A1
公开(公告)日：2023-03-30
申请号：US17681991
申请日：2022-02-28
发明人： Feifei Wu , Zhongyi Chen , Wanjun Jiang , Jie Li , Shitu Ma , Mengjun Hu
IPC分类号： C08B37/08
摘要： The invention discloses a thiolated chitosan and a preparation method thereof, which is chitosan co-modified by hydroxybutyl and sulfhydryl. The preparation method includes the following steps: firstly, hydroxybutyl is introduced into a chitosan molecular chain, and then sulfhydryl is introduced as a sulfhydryl moiety by a condensation reaction between free amino of hydroxybutyl chitosan and carboxyl of L-cysteine. An aqueous solution of the thiolated chitosan of the invention is in a solution state at low temperature, and can be flow-injected. When the temperature rises to around 37° C., a hydrogel can be formed. Due to the introduction of sulfhydryl, the antioxidant ability and tissue adhesion ability of the material are increased. The thiolated chitosan prepared according to the method may have wide application prospects in an aspect such as tissue engineering, drug delivery systems, cell culture, cosmetics, etc.
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公开(公告)号：US20220296781A1
公开(公告)日：2022-09-22
申请号：US17335039
申请日：2021-05-31
发明人： Qiang Zhang , Mengjun Hu , Feifei Wu , Wei Huang , Weiqing Sun
摘要： The present application provides an injectable temperature-sensitive composite hydrogel containing adipose-derived mesenchymal stem cells, and a preparation method and application thereof. The present application includes: preparing hydroxypropyl chitin from chitin through modification, preparing a composite with collagen and sodium hyaluronic, constructing the injectable temperature-sensitive composite hydrogel, loading adipose-derived mesenchymal stem cells of New Zealand rabbit and Genipin, and finally forming in-situ the injectable temperature-sensitive composite hydrogel containing adipose-derived mesenchymal stem cells at the physiological temperature. The hydrogel prepared in the present application is of a three-dimensional porous structure, which is conducive to transferring of nutrients and metabolic waste, so as to provide an excellent microenvironment for the growth of cells, helping maintain survival rate and biological activity of the adipose-derived mesenchymal stem cells, and promoting differentiation of the adipose-derived mesenchymal stem cells into cartilage tissue, while having high mechanical strength, and thus can be widely used in cartilage tissue engineering.
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