公开(公告)号：US20240350814A1

公开(公告)日：2024-10-24

申请号：US18574984

申请日：2022-06-07

申请人： Hylomorph AG

发明人： Aldo FERRARI ,  Simone BOTTAN ,  Francesco ROBOTTI ,  Georgios STEFOPOULOS

IPC分类号： A61N1/375 ,  A61L31/04 ,  A61L31/16

CPC分类号： A61N1/37512 ,  A61L31/044 ,  A61L31/16 ,  A61L2300/406

摘要： Method for the preparation of an implantable device, wherein in a first step a non-degradable implantable device is at least partially covered or surrounded by at least one separate layer of material comprising a therapeutically active substance providing for sustained controlled release of said substance under physiological conditions, and wherein in a second step this is inserted into a wet or humid pouch through an opening thereof.

公开(公告)号：US12097308B2

公开(公告)日：2024-09-24

申请号：US16642822

申请日：2018-06-19

申请人： KNU—Industry Cooperation Foundation

发明人： Kwang Ho Lee

IPC分类号： A61L31/14 ,  A61B5/053 ,  A61L31/04 ,  A61L31/08 ,  A61L31/10 ,  B29C64/106 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y70/00 ,  B33Y80/00 ,  C08J7/04 ,  C08J7/044 ,  D01D5/00 ,  B29K83/00 ,  B82Y30/00

CPC分类号： A61L31/146 ,  A61B5/053 ,  A61L31/041 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  B29C64/106 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y70/00 ,  B33Y80/00 ,  C08J7/0423 ,  C08J7/044 ,  D01D5/003 ,  A61B2562/0214 ,  A61B2562/125 ,  A61L2420/02 ,  A61L2420/08 ,  B29K2083/00 ,  B82Y30/00 ,  C08J2383/04 ,  C08J2475/04 ,  D10B2331/10 ,  A61L31/10 ,  C08L75/04

摘要： The present invention relates to a bio-electrode having improved conductivity, flexibility and bio-compatibility, and a method of manufacturing the same. Specifically, the present invention relates to a conductive polymer bio-electrode including nano-porous permeable membrane, based on a bio-compatible polymer material having a plurality of pores and an improved surface area based on a PDMS device having a low mechanical strength and an excellent bio-compatibility, bio-signal transmission patterning, and a gold coating layer and has an excellent bio-compatibility and low rejection response while having a conductivity similar to that of a bio-electrode configured with a metal material of the related art. Therefore, the conductive polymer bio-electrode of the present invention is expected to be able to replace a bio-electrode configured with a metal material by which the bio-signal transmission efficiency is degraded due to a high bio-incompatibility.

公开(公告)号：US20240299632A1

公开(公告)日：2024-09-12

申请号：US18608675

申请日：2024-03-18

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Eric Andrew APPEL ,  Y. Joseph WOO ,  Lyndsay STAPLETON

IPC分类号： A61L31/04 ,  A61L31/14 ,  C08L1/08 ,  C08L67/02

CPC分类号： A61L31/041 ,  A61L31/042 ,  A61L31/145 ,  A61L31/148 ,  C08L1/08 ,  C08L67/025 ,  A61L2300/424 ,  A61L2400/06 ,  C08L2203/02 ,  C08L2205/22

摘要： A method of preventing tissue adhesion includes forming an incision in tissue, applying a hydrogel to tissue through the incision, and closing the incision with the hydrogel therein. The hydrogel includes a polymer non-covalently cross-linked with a plurality of nanoparticles and prevents a formation of adhesions between tissues and/or organs.

公开(公告)号：US20240299197A1

公开(公告)日：2024-09-12

申请号：US18444629

申请日：2024-02-17

申请人： HORIEN BIOCHEMICAL TECHNOLOGY CO.,LTD. ,  ALAN VISION INVESTMENT CORPORATION

发明人： YING-CHIH LIN ,  YUNG-CHEN CHANG

IPC分类号： A61F2/94 ,  A61L31/02 ,  A61L31/04 ,  A61L31/10

CPC分类号： A61F2/94 ,  A61L31/022 ,  A61L31/044 ,  A61L31/10 ,  A61F2210/0004 ,  A61F2210/0009 ,  A61F2230/0041 ,  A61F2230/0091 ,  A61F2240/001 ,  A61F2250/003

摘要： A biodegradable double-J stent and a method of manufacturing a biodegradable double-J stent are provided. The stent comprises a main tube, a first retaining tube, and a second retaining tube, each fabricated from a biodegradable material. The first and second retaining tubes are curl-shaped and are connected to two ends of the main tube, respectively. The method of manufacturing a biodegradable double-J stent comprises the steps of: (a) providing a tube made of a biodegradable material; and (b) bending two ends of the tube to render the two ends curl-shaped and keeping a middle segment between the two ends straight. The two curl-shaped ends define a first retaining tube and a second retaining tube, respectively, and the middle segment defines a main tube. The biodegradable double-J stent precludes a ureteral obstruction which might otherwise occur with conventional double-J stents not removed in a timely manner.

公开(公告)号：US20240299154A1

公开(公告)日：2024-09-12

申请号：US18670257

申请日：2024-05-21

申请人： ZHEJIANG UNIVERSITY

发明人： Xiujun CAI ,  Zhongyu WU ,  Mingyu CHEN ,  Diyu HUANG ,  Yifan WANG ,  Lei SHI ,  Weijian DAI ,  Yanli MA

IPC分类号： A61F2/04 ,  A61L31/04

CPC分类号： A61F2/04 ,  A61L31/04 ,  A61F2002/045 ,  A61F2230/0069 ,  A61F2250/0059 ,  A61F2250/0069

摘要： A method of an intestinal protective ostomy with the use of a degradable intestinal diversion device and an intubation includes steps of: preparing the degradable intestinal complete diversion device; after cutting off the terminal ileum intestine, measuring the diameter of the intestine, and then selecting a degradable intestinal diversion device of appropriate specifications according to the diameter of the intestine; when diverting, placing the device in the intestinal cavity, and fixing the ileum on the device with a thread at the convex ring; inserting the stoma drainage tube in the proximal ileum where the device is placed against the direction of intestinal peristalsis; and disintegrating and discharging the device with the contents of the intestine. The invention used with a drainage tube realizes complete intestinal diversion without secondary operations of stoma reintroduction.

公开(公告)号：US20240293653A1

公开(公告)日：2024-09-05

申请号：US18661731

申请日：2024-05-13

申请人： TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES ,  Beijing CAS Microneedle Technology Ltd.

发明人： Yunhua Gao ,  Mengzhen Xing

IPC分类号： A61M37/00 ,  A61L31/04 ,  A61L31/14

CPC分类号： A61M37/0015 ,  A61L31/048 ,  A61L31/145 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053

摘要： A hydrogel microneedle patch based on a three-dimensional framework structure is provided and includes a hydrogel microneedle. A raw material of the hydrogel microneedle includes polyvinyl alcohol and aqueous dispersion of acrylic resin. the hydrogel microneedle is obtained by uniformly mixing and molding of the aqueous dispersion of acrylic resin and the polyvinyl alcohol. The hydrogel microneedle patch has good strength, excellent swelling property and puncture property. In addition, a preparation method and an application of hydrogel microneedle patch are also provided.

公开(公告)号：US20240262942A1

公开(公告)日：2024-08-08

申请号：US18624492

申请日：2024-04-02

申请人： Celanese International Corporation

发明人： Christina Schmid ,  Rainer Walkenhorst

IPC分类号： C08F10/02 ,  A61B17/122 ,  A61B90/98 ,  A61C8/00 ,  A61F5/00 ,  A61F6/14 ,  A61J15/00 ,  A61K47/32 ,  A61K49/12 ,  A61K49/22 ,  A61L27/16 ,  A61L29/04 ,  A61L31/04 ,  A61M25/10 ,  A61N1/36 ,  B29C45/00 ,  B29K23/00 ,  B29K105/00 ,  B29L31/00

CPC分类号： C08F10/02 ,  A61K47/32 ,  A61K49/126 ,  A61K49/22 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  B29C45/0001 ,  A61B17/122 ,  A61B90/98 ,  A61C8/0016 ,  A61F5/005 ,  A61F6/14 ,  A61J15/00 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/20 ,  A61L2430/22 ,  A61L2430/24 ,  A61L2430/30 ,  A61L2430/38 ,  A61M25/10 ,  A61N1/36038 ,  A61N1/3605 ,  B29K2023/0675 ,  B29K2105/0052 ,  B29L2031/753 ,  B29L2031/7532

摘要： A high molecular weight polyethylene polymer is formulated so that the polymer is capable of being injection molded. The polyethylene polymer has a Viscosity Number of greater than about 400 ml/g and has a melt flow rate of greater than about 0.9 g/10 min. The polyethylene polymer is of high purity and is particularly well suited for producing medical products.

公开(公告)号：US12036330B2

公开(公告)日：2024-07-16

申请号：US18123299

申请日：2023-03-19

申请人： NURAMI MEDICAL LTD.

发明人： Nora Nseir Manassa ,  Amir Bahar

IPC分类号： A61L15/26 ,  A61L15/42 ,  A61L15/58 ,  A61L17/12 ,  A61L24/00 ,  A61L24/04 ,  A61L27/18 ,  A61L27/48 ,  A61L27/50 ,  A61L27/56 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  B29C48/00 ,  B29C48/14 ,  B29C65/00 ,  B32B5/02 ,  B32B5/12 ,  B32B5/26 ,  B32B7/02 ,  B32B7/12 ,  B32B37/10 ,  B32B37/14 ,  C08L67/04 ,  D04H1/728 ,  A61F2/00 ,  B29K67/00 ,  B29K667/00 ,  B29L31/00

CPC分类号： A61L15/26 ,  A61L15/42 ,  A61L15/425 ,  A61L15/58 ,  A61L17/12 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/043 ,  A61L27/18 ,  A61L27/48 ,  A61L27/50 ,  A61L27/56 ,  A61L31/041 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  B29C48/0021 ,  B29C48/022 ,  B29C48/142 ,  B29C66/45 ,  B29C66/7315 ,  B32B5/022 ,  B32B5/024 ,  B32B5/12 ,  B32B5/26 ,  B32B7/02 ,  B32B7/12 ,  B32B37/10 ,  B32B37/144 ,  C08L67/04 ,  D04H1/728 ,  A61F2/0063 ,  B29K2067/04 ,  B29K2067/046 ,  B29K2667/04 ,  B29K2667/046 ,  B29K2995/0046 ,  B29L2031/7532 ,  B32B2250/03 ,  B32B2250/20 ,  B32B2250/244 ,  B32B2250/40 ,  B32B2255/02 ,  B32B2255/102 ,  B32B2262/0253 ,  B32B2262/0261 ,  B32B2262/0276 ,  B32B2307/51 ,  B32B2307/542 ,  B32B2307/7265 ,  B32B2367/00 ,  B32B2535/00 ,  C08L2203/02 ,  A61L31/06 ,  C08L67/04 ,  A61L15/26 ,  C08L67/04 ,  A61L27/18 ,  C08L67/04

摘要： Compositions-of-matter comprising a matrix made of one or more, preferably two or more elastic layers and one or more viscoelastic layer are disclosed. The compositions-of-matter are characterized by high water-impermeability and optionally by self-recovery. Processes of preparing the compositions-of-matter and uses thereof as tissue substitutes or for repairing damaged tissues are also disclosed.

公开(公告)号：US20240226389A1

公开(公告)日：2024-07-11

申请号：US18390157

申请日：2023-12-20

申请人： Board Of Regents, The University Of Texas System

发明人： Sarah Mayes ,  Christine E. Schmidt

IPC分类号： A61L31/04 ,  A61K31/192 ,  A61K31/195 ,  A61L31/14 ,  A61L31/16

CPC分类号： A61L31/041 ,  A61K31/192 ,  A61K31/195 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2300/62

摘要： A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.

公开(公告)号：US12023420B2

公开(公告)日：2024-07-02

申请号：US15734027

申请日：2019-06-05

申请人： UNIVERSITÉ PAUL SABATIER TOULOUSE III ,  CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS ,  INSERM-INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

发明人： Christophe Cognard ,  Olivier Eichwald ,  Cédric Garcia ,  Nofel Merbahi ,  Bernard Payrastre ,  Pierre Sie ,  Aurélie Tokarski ,  Ivan Vukasinovic ,  Mohammed Yousfi

IPC分类号： A61L31/10 ,  A61L31/02 ,  A61L31/04

CPC分类号： A61L31/10 ,  A61L31/022 ,  A61L31/047 ,  A61L2420/02

摘要： The present invention relates to a vascular stent, deployed or non-deployed, the surface of which is coated by a film comprising at least one protein, to a process for coating of the surface of a vascular stent with a film comprising at least one protein and to a device for carrying out the process according to the invention.