公开(公告)号：US12036330B2

公开(公告)日：2024-07-16

申请号：US18123299

申请日：2023-03-19

Applicant: NURAMI MEDICAL LTD.

Inventor： Nora Nseir Manassa ,  Amir Bahar

IPC: A61L15/26 ,  A61L15/42 ,  A61L15/58 ,  A61L17/12 ,  A61L24/00 ,  A61L24/04 ,  A61L27/18 ,  A61L27/48 ,  A61L27/50 ,  A61L27/56 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  B29C48/00 ,  B29C48/14 ,  B29C65/00 ,  B32B5/02 ,  B32B5/12 ,  B32B5/26 ,  B32B7/02 ,  B32B7/12 ,  B32B37/10 ,  B32B37/14 ,  C08L67/04 ,  D04H1/728 ,  A61F2/00 ,  B29K67/00 ,  B29K667/00 ,  B29L31/00

CPC classification number: A61L15/26 ,  A61L15/42 ,  A61L15/425 ,  A61L15/58 ,  A61L17/12 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/043 ,  A61L27/18 ,  A61L27/48 ,  A61L27/50 ,  A61L27/56 ,  A61L31/041 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  B29C48/0021 ,  B29C48/022 ,  B29C48/142 ,  B29C66/45 ,  B29C66/7315 ,  B32B5/022 ,  B32B5/024 ,  B32B5/12 ,  B32B5/26 ,  B32B7/02 ,  B32B7/12 ,  B32B37/10 ,  B32B37/144 ,  C08L67/04 ,  D04H1/728 ,  A61F2/0063 ,  B29K2067/04 ,  B29K2067/046 ,  B29K2667/04 ,  B29K2667/046 ,  B29K2995/0046 ,  B29L2031/7532 ,  B32B2250/03 ,  B32B2250/20 ,  B32B2250/244 ,  B32B2250/40 ,  B32B2255/02 ,  B32B2255/102 ,  B32B2262/0253 ,  B32B2262/0261 ,  B32B2262/0276 ,  B32B2307/51 ,  B32B2307/542 ,  B32B2307/7265 ,  B32B2367/00 ,  B32B2535/00 ,  C08L2203/02 ,  A61L31/06 ,  C08L67/04 ,  A61L15/26 ,  C08L67/04 ,  A61L27/18 ,  C08L67/04

Abstract: Compositions-of-matter comprising a matrix made of one or more, preferably two or more elastic layers and one or more viscoelastic layer are disclosed. The compositions-of-matter are characterized by high water-impermeability and optionally by self-recovery. Processes of preparing the compositions-of-matter and uses thereof as tissue substitutes or for repairing damaged tissues are also disclosed.

公开(公告)号：US20240157020A1

公开(公告)日：2024-05-16

申请号：US18550874

申请日：2022-03-15

Applicant: The Queen's University of Belfast

Inventor： Shu LI ,  Gavin P. ANDREWS ,  David S. JONES

IPC: A61L17/00 ,  A61L17/04 ,  A61L17/12

CPC classification number: A61L17/005 ,  A61L17/04 ,  A61L17/12 ,  A61L2300/22 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41

Abstract: The invention relates to a suture thread material comprising at least one polymer and at least one eutectic mixture. The polymer can be a biocompatible polymer such as polycaprolactone or PLGA. The eutectic mixture may comprise maleic acid and an antibiotic such as metronidazole. Other eutectic mixtures can be used in suture thread materials to reduce SSis and/or to decrease pain and/or to increase lubricity of sutures. The invention also provides a method for the production of sutures with drug loadings, the method comprising the use of therapeutic deep eutectic solvent (THEDES) technology to significantly increase drug content in suture matrices.

公开(公告)号：US11690623B2

公开(公告)日：2023-07-04

申请号：US14871131

申请日：2015-09-30

Applicant: Cilag GmbH International

Inventor： Frederick E. Shelton, IV ,  Michael J. Vendely ,  Emily A. Schellin ,  Taylor W. Aronhalt ,  Trevor J. Barton ,  Lauren S. Weaner ,  Mark H. Ransick

IPC: A61B17/10 ,  A61B17/072 ,  A61B17/064 ,  B32B5/02 ,  B32B5/10 ,  B32B5/12 ,  B32B5/18 ,  B32B5/24 ,  B32B5/26 ,  B32B3/02 ,  B32B3/08 ,  B32B3/20 ,  B32B3/26 ,  B29C48/16 ,  A61B17/00 ,  A61B17/32 ,  A61B17/08 ,  A61L17/10 ,  A61L17/12 ,  B05D1/00 ,  B05D1/30 ,  D01D5/00 ,  D01D5/18 ,  D04H1/56 ,  B32B7/05 ,  A61B17/068 ,  B29L31/00 ,  B29C44/34 ,  B29C48/05 ,  B29C48/00

CPC classification number: A61B17/105 ,  A61B17/00491 ,  A61B17/068 ,  A61B17/0644 ,  A61B17/072 ,  A61B17/07207 ,  A61B17/07292 ,  A61B17/08 ,  A61B17/32 ,  A61L17/105 ,  A61L17/12 ,  B05D1/007 ,  B05D1/30 ,  B29C48/16 ,  B32B3/02 ,  B32B3/08 ,  B32B3/20 ,  B32B3/266 ,  B32B5/024 ,  B32B5/026 ,  B32B5/10 ,  B32B5/12 ,  B32B5/18 ,  B32B5/245 ,  B32B5/26 ,  B32B7/05 ,  D01D5/0023 ,  D01D5/18 ,  D04H1/565 ,  A61B2017/00004 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/00831 ,  A61B2017/00862 ,  A61B2017/00893 ,  A61B2017/00955 ,  A61B2017/00964 ,  A61B2017/0725 ,  A61B2017/07214 ,  A61B2017/07221 ,  A61B2017/07228 ,  A61B2017/07235 ,  A61B2017/07242 ,  A61B2017/07257 ,  A61B2017/07271 ,  A61B2017/07278 ,  A61B2017/07285 ,  A61L2420/02 ,  B29C44/3453 ,  B29C44/358 ,  B29C48/0012 ,  B29C48/0022 ,  B29C48/05 ,  B29L2031/753 ,  B29L2031/7546 ,  B32B2250/03 ,  B32B2250/40 ,  B32B2307/50 ,  B32B2307/54 ,  B32B2307/72 ,  B32B2307/732 ,  B32B2307/736 ,  B32B2535/00 ,  D10B2331/041 ,  D10B2509/00

Abstract: Methods for forming an implantable layer onto a staple cartridge are disclosed.

公开(公告)号：US20180078255A1

公开(公告)日：2018-03-22

申请号：US15825960

申请日：2017-11-29

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Gregory Dumanian

IPC: A61B17/06 ,  A61L17/00 ,  A61B17/04 ,  A61B17/00

CPC classification number: A61B17/06166 ,  A61B17/06 ,  A61B2017/00526 ,  A61B2017/0412 ,  A61B2017/0417 ,  A61B2017/0461 ,  A61B2017/0464 ,  A61B2017/06009 ,  A61B2017/0608 ,  A61B2017/061 ,  A61B2017/06185 ,  A61L17/00 ,  A61L17/04 ,  A61L17/12 ,  A61L17/145 ,  Y10T29/49826

Abstract: A medical device includes a surgical needle, an elongated suture, and an intervening segment. The elongated suture has a first end proximate to the needle and a second end located away from the needle. The elongated suture also includes a plurality of fibers defining a mesh wall between the first and second ends. A plurality of pores extend through the mesh wall, at least some which are in the macroporous size range of greater than 200 microns for facilitating tissue integration when introduced into a body. The intervening segment is disposed between and connected to either or both ends of the elongated suture and the needle. The intervening segment includes one or more fibers of the plurality of fibers and has a cross-sectional dimension smaller than a cross-sectional dimension of the mesh wall such that the intervening segment facilitates indirect attachment of the elongated macroporous mesh suture to the needle.

公开(公告)号：US09867910B2

公开(公告)日：2018-01-16

申请号：US14753346

申请日：2015-06-29

Applicant: Warsaw Orthopedic, Inc.

Inventor： Danielle L. Clay

IPC: A61L17/00 ,  A61L31/00 ,  A61B17/04 ,  A61K9/00 ,  A61L31/16 ,  A61B17/06 ,  A61K47/34 ,  A61K9/70 ,  A61K31/4168 ,  A61L31/08 ,  A61L31/12 ,  A61L31/14 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61L17/12 ,  A61B17/11 ,  A61B17/00

CPC classification number: A61L31/16 ,  A61B17/04 ,  A61B17/06166 ,  A61B17/1128 ,  A61B2017/00893 ,  A61K9/0024 ,  A61K9/70 ,  A61K31/4168 ,  A61K47/34 ,  A61L17/005 ,  A61L17/12 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61L31/08 ,  A61L31/125 ,  A61L31/148 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2400/16

Abstract: Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine in a fiber at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate fiber formulations are provided within biodegradable polymers, this pain relief can be continued for at least three days.

公开(公告)号：US20170119936A1

公开(公告)日：2017-05-04

申请号：US15318350

申请日：2015-06-12

Applicant: FORT WAYNE METALS RESEARCH PRODUCTS CORP

Inventor： Jeremy E. Schaffer ,  Adam J. Griebel

IPC: A61L31/10 ,  A61B17/06 ,  A61F2/01 ,  A61L31/02 ,  A61F2/86

CPC classification number: A61L31/10 ,  A61B17/06166 ,  A61B17/064 ,  A61B2017/00004 ,  A61F2/01 ,  A61F2/86 ,  A61F2002/016 ,  A61F2210/0004 ,  A61F2250/003 ,  A61L17/12 ,  A61L31/022 ,  A61L31/148 ,  C08L67/04

Abstract: A composite wire product includes a biodegradable parent material which forms the bulk of the cross-sectional area of the wire, and a central fiber or filament of a slower-degrading or non-biodegradable material runs throughout the length of the wire. This central filament promotes the mechanical integrity of an intraluminal appliance or other medical device made from the wire product throughout the biodegradation process by preventing non-absorbed parent material from dislodging from the central filament. Thus, the present wire design enables the creation of medical devices that are designed to improve in flexibility toward a more natural state over the course of healing, while also controlling for the possibility of non-uniform in vivo erosion.

公开(公告)号：US20160302788A1

公开(公告)日：2016-10-20

申请号：US15083845

申请日：2016-03-29

Applicant: Boston Scientific Scimed, Inc.

Inventor： Peter J. Pereira ,  Jonathan Zoll

IPC: A61B17/06 ,  A61B17/04

CPC classification number: A61B17/06166 ,  A61B17/0469 ,  A61B2017/005 ,  A61B2017/00955 ,  A61B2017/00964 ,  A61B2017/0619 ,  A61F2/0045 ,  A61F2/0063 ,  A61L17/08 ,  A61L17/12 ,  A61L17/145

Abstract: This disclosure concerns suburethral and pelvic support structures which utilize tissue soldering materials instead of, or in addition to, traditional tissue anchors and suture knots. It further concerns methods of treating patients that includes implanting these structures and activating the tissue soldering materials to attach the structures to a tissue in the body of the patient.

Abstract translation: 本公开涉及使用组织焊接材料代替传统组织锚和缝线结或除传统组织锚和缝线结之外的尿道和骨盆支撑结构。 它还涉及治疗患者的方法，包括植入这些结构并激活组织焊接材料以将结构附接到患者体内的组织。

公开(公告)号：US09296145B2

公开(公告)日：2016-03-29

申请号：US14068226

申请日：2013-10-31

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic ,  Kenneth Keilman ,  Dennis D. Jamiolkowski

IPC: A61B17/04 ,  B29C47/00 ,  D01D5/098 ,  A61B17/06 ,  A61L17/12 ,  B29C47/86 ,  B29C47/88 ,  B29K73/00 ,  B29L31/00

CPC classification number: B29C47/0014 ,  A61B17/04 ,  A61B17/06166 ,  A61L17/12 ,  B29C47/0004 ,  B29C47/0061 ,  B29C47/0064 ,  B29C47/0066 ,  B29C47/0088 ,  B29C47/862 ,  B29C47/8805 ,  B29C47/8895 ,  B29K2073/00 ,  B29K2995/0056 ,  B29K2995/006 ,  B29L2031/726 ,  B29L2031/731 ,  B29L2031/753 ,  D01D5/098

Abstract: Novel absorbable monofilament sutures and fibers having unique and improved properties are disclosed including mid-term strength retention post-implantation. Also disclosed is a novel method of manufacturing absorbable monofilament sutures and fibers. The sutures and fibers are extruded from poly(p-dioxanone-co-glycolide) copolymers.

Abstract translation: 公开了新颖的可吸收单丝缝合线和具有独特且改善的性质的纤维，包括植入后的中期强度保留。 还公开了制造可吸收的单丝缝合线和纤维的新方法。 缝合线和纤维从聚（对二恶烷酮 - 共 - 乙交酯）共聚物挤出。

公开(公告)号：US20150322596A1

公开(公告)日：2015-11-12

申请号：US14490680

申请日：2014-09-19

Applicant: Jui-Yu Lin

Inventor： Jui-Yu Lin

IPC: D02G3/44 ,  D02G3/36 ,  D02G3/04

CPC classification number: A61L17/10 ,  A61L17/12 ,  A61L2420/08 ,  D02G3/045 ,  D02G3/36 ,  D02G3/448 ,  D02G3/449

Abstract: A composite thread including a core thread and at least one wrapping film is provided. The wrapping film wraps the core thread uniformly. The composite thread is mainly formed by the biodegradable material, and has improved biocompatibility which is suitable to be used in the surgery. A manufacture process thereof is also provided.

Abstract translation: 提供了包括芯线和至少一个包装膜的复合线。 包装膜均匀地包裹芯线。 复合线主要由生物降解材料形成，具有改善的生物相容性，适用于手术。 还提供了其制造方法。

公开(公告)号：US09066853B2

公开(公告)日：2015-06-30

申请号：US13741475

申请日：2013-01-15

Applicant: Warsaw Orthopedic, Inc.

Inventor： Danielle L. Clay

IPC: A61B17/06 ,  A61B17/068 ,  A61B17/00 ,  A61K9/00 ,  A61B17/04 ,  A61K47/34 ,  A61K9/70 ,  A61K31/4168 ,  A61B17/11

CPC classification number: A61L31/16 ,  A61B17/04 ,  A61B17/06166 ,  A61B17/1128 ,  A61B2017/00893 ,  A61K9/0024 ,  A61K9/70 ,  A61K31/4168 ,  A61K47/34 ,  A61L17/005 ,  A61L17/12 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61L31/08 ,  A61L31/125 ,  A61L31/148 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2400/16

Abstract: Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine in a fiber at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate fiber formulations are provided within biodegradable polymers, this pain relief can be continued for at least three days.

Abstract translation: 提供长时间有效的疼痛治疗。 通过在目标部位或其附近的纤维中施用有效量的可乐定，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节 疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物内提供合适的纤维制剂时，该疼痛缓解可持续至少三天。