公开(公告)号：US12121432B2

公开(公告)日：2024-10-22

申请号：US18307147

申请日：2023-04-26

Applicant: Verily Life Sciences LLC

Inventor： Daniel B. Otts ,  Stein Kuiper

IPC: A61F2/16 ,  A61L31/02 ,  A61L31/06 ,  A61L31/08 ,  G02B3/14 ,  G02B26/00 ,  G02C7/08 ,  A61F2/48 ,  G02B7/02

CPC classification number: A61F2/1635 ,  A61L31/022 ,  A61L31/06 ,  A61L31/088 ,  G02B3/14 ,  G02B26/005 ,  G02C7/085 ,  A61F2/482 ,  A61F2210/0014 ,  A61F2250/0001 ,  A61F2250/0002 ,  A61F2250/0003 ,  A61F2250/0018 ,  A61F2250/0056 ,  G02B7/02

Abstract: Ophthalmic devices having elastic electrodes are disclosed herein. An example ophthalmic device may be an intraocular lens that includes a support structure, two optical windows, two immiscible fluids, and an elastic electrode. The support structure may have an inner surface defining an aperture with first and second optical windows disposed on opposite sides of the support structure and spanning the aperture. The two immiscible liquids may be disposed in a cavity formed by the aperture and the first and second optical windows, and the elastic electrode may be disposed on the inner surface. The elastic electrode may be formed from an elastic metal alloy having a minimum yield strain of 0.25%.

公开(公告)号：US20240315823A1

公开(公告)日：2024-09-26

申请号：US18261534

申请日：2022-01-17

Applicant: TISSIUM SA

Inventor： Miguel LOPES ,  Maria PEREIRA ,  David MOREAU ,  Elisa BITTON

IPC: A61F2/00 ,  A61L24/00 ,  A61L24/04 ,  A61L31/06 ,  A61L31/14

CPC classification number: A61F2/0063 ,  A61L24/001 ,  A61L24/046 ,  A61L31/06 ,  A61L31/14 ,  A61F2230/0006

Abstract: The present disclosure relates to a novel surgical material comprising mesh and a polymer composition, and its use in treating a hernia and related diseases and conditions. The present disclosure also relates to a method of manufacturing the surgical material.

公开(公告)号：US20240293600A1

公开(公告)日：2024-09-05

申请号：US18571757

申请日：2022-06-21

Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

Inventor： Tammy R. Dugas ,  Cristina Sabliov ,  Carlos Astete

IPC: A61L27/54 ,  A61L27/18 ,  A61L29/06 ,  A61L29/16 ,  A61L31/06 ,  A61L31/16

CPC classification number: A61L27/54 ,  A61L27/18 ,  A61L29/06 ,  A61L29/16 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/624 ,  A61L2400/12

Abstract: The present disclosure provides for compositions, methods of making the composition, and devices (e.g., vascular grafts, self-expandable stents, balloon-expandable stents, and stent-grafts) having the composition disposed thereof. The composition can include a polymer nanoparticle (e.g., charged or uncharged) made of polymers that have one or more types of agents covalently bonded to the polymer. In this regard, the one or more types of agents are not physically encapsulated by the polymer, rather are covalently bonded to the polymer that makes up the polymeric nanoparticle. In another aspect, an agent can also be encapsulated in the polymer of the polymeric nanoparticle. In another embodiment, the composition includes two types of polymeric nanoparticles, where a first polymeric nanoparticle has at least one agent covalently bonded to the polymer of the first polymeric nanoparticle and where the composition can also include a second polymeric nanoparticle encapsulating an agent.

公开(公告)号：US20240261540A1

公开(公告)日：2024-08-08

申请号：US18467589

申请日：2023-09-14

Applicant: Fractyl Health, Inc.

Inventor： Harith Rajagopalan ,  Jay Caplan ,  R. Maxwell Flaherty ,  J. Christopher Flaherty

IPC: A61M25/00 ,  A61F5/00 ,  A61K31/728 ,  A61K33/42 ,  A61K35/33 ,  A61K35/35 ,  A61K45/06 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  A61L31/16 ,  A61M31/00 ,  A61N1/30

CPC classification number: A61M25/0084 ,  A61F5/0013 ,  A61F5/0076 ,  A61K31/728 ,  A61K33/42 ,  A61K35/33 ,  A61K35/35 ,  A61K45/06 ,  A61L31/043 ,  A61L31/048 ,  A61L31/06 ,  A61L31/145 ,  A61L31/16 ,  A61M25/00 ,  A61M25/0082 ,  A61M31/00 ,  A61F2005/0016 ,  A61M2025/0089 ,  A61M2025/0096 ,  A61N1/306

Abstract: A system for treating a patient comprises a delivery device and injectate. The delivery device comprises an elongate shaft with a distal portion and at least one delivery element positioned on the elongate shaft distal portion. The delivery device is constructed and arranged to deliver the injectate through the at least one delivery element and into tissue to create a therapeutic restriction in the gastrointestinal tract. Methods of creating a therapeutic restriction are also provided.

公开(公告)号：US20240226394A1

公开(公告)日：2024-07-11

申请号：US18609954

申请日：2024-03-19

Applicant: Foundry Therapeutics, Inc.

Inventor： Honglei Wang ,  Jingnan Luo

IPC: A61L31/16 ,  A61K31/496 ,  A61K31/65 ,  A61L27/54 ,  A61L27/58 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  A61N1/375 ,  A61P31/00

CPC classification number: A61L31/16 ,  A61K31/496 ,  A61K31/65 ,  A61L27/54 ,  A61L27/58 ,  A61L31/041 ,  A61L31/06 ,  A61L31/148 ,  A61N1/375 ,  A61P31/00 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/602

Abstract: There is provided a controlled-release antibiotic socket for securely holding an implantable medical device that is made from: at least one film having at least one polymer layer, where the at least one film is formed into the socket; at least one antibiotic agent; and at least one opening in the socket, where the at least one polymer layer comprises a biodegradable elastomeric polymeric material; and the at least one antibiotic agent is dispersed within at least one of the at least one polymer layers and/or, when the film comprises at least two polymer layers, the at least one antibiotic agent is disposed as a separate layer between two polymer layers. Also disclosed is the film used to make the socket and uses of both the socket and film.

公开(公告)号：US20240206912A1

公开(公告)日：2024-06-27

申请号：US18392762

申请日：2023-12-21

Applicant: Bolton Medical, Inc.

Inventor： Bryan Vancheri

IPC: A61B17/34 ,  A61L31/02 ,  A61L31/06

CPC classification number: A61B17/3496 ,  A61B17/3468 ,  A61L31/022 ,  A61L31/06 ,  A61B2017/00477

Abstract: A dilator tip assembly of an endoprosthetic delivery device includes a mounting component of an endoprosthetic delivery device, the dilator tip being mountable on a distal end of the mounting component and defining a luminal conduit having a longitudinal axis and a chamfered proximal end, the luminal conduit including a luminal lateral groove. A circlip mountable on the mounting component at the mounting component lateral groove secures the mounting component to the dilator tip by occupying both the mounting component lateral groove of the mounting component and the luminal lateral groove of the dilator tip.

公开(公告)号：US12016977B2

公开(公告)日：2024-06-25

申请号：US16753355

申请日：2018-10-05

Applicant: DSM IP Assets B.V.

Inventor： Noel L. Davison ,  Henricus Johannes Arts ,  Aylvin Jorge Angelo Athanasius Dias ,  Anne Marie Persson ,  Ruud Jozef Regina Wilhelmus Peters

IPC: A61L31/08 ,  A61L17/04 ,  A61L17/14 ,  A61L27/18 ,  A61L27/32 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  C08L75/04

CPC classification number: A61L31/086 ,  A61L17/04 ,  A61L17/145 ,  A61L27/18 ,  A61L27/32 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  C08L75/04 ,  A61L2420/02 ,  A61L2430/02 ,  A61L2430/38

Abstract: The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 μm in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.

公开(公告)号：US12006395B2

公开(公告)日：2024-06-11

申请号：US15540201

申请日：2015-12-31

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD

Inventor： Daniel Cohn

IPC: C08G18/42 ,  A61K47/34 ,  A61L15/26 ,  A61L17/10 ,  A61L17/12 ,  A61L27/18 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  C08G18/48 ,  C08G18/73 ,  C08G18/74 ,  C08G18/76 ,  C08G63/664 ,  C08G63/685 ,  C08G63/91 ,  C08L67/04

CPC classification number: C08G18/42 ,  A61L15/26 ,  A61L17/10 ,  A61L17/12 ,  A61L27/18 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  C08G18/4277 ,  C08G18/4825 ,  C08G18/73 ,  C08G18/74 ,  C08G18/76 ,  C08G63/664 ,  C08G63/685 ,  C08G63/6852 ,  C08G63/91 ,  C08G63/912 ,  A61K47/34 ,  C08G2220/00 ,  C08G2230/00 ,  A61L27/18 ,  C08L67/04 ,  A61L27/18 ,  C08L71/02 ,  A61L27/34 ,  C08L71/02 ,  A61L27/34 ,  C08L67/04 ,  A61L31/06 ,  C08L67/04 ,  A61L31/06 ,  C08L71/02 ,  A61L31/10 ,  C08L71/02 ,  A61L31/10 ,  C08L67/04 ,  A61L15/26 ,  C08L67/04 ,  A61L15/26 ,  C08L71/02 ,  A61L17/10 ,  C08L71/02

Abstract: The invention provides a class of polymeric materials being ABA tri-block or AB di-block, comprised of biodegradable segments and poly(propylene oxide) (PPO) segment and uses thereof.

公开(公告)号：US11999130B2

公开(公告)日：2024-06-04

申请号：US17355261

申请日：2021-06-23

Applicant: Zeus Industrial Products, Inc.

Inventor： James M. Lindsey ,  John Richard Campanelli ,  Elizabeth A. Foley ,  Bruce L. Anneaux ,  Justin A. Marro

IPC: B32B27/36 ,  A61L31/06 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  B29C55/26 ,  B32B1/08 ,  B29K67/00 ,  B29L31/00

CPC classification number: B32B1/08 ,  A61L31/06 ,  A61L31/129 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  B29C55/26 ,  B32B27/36 ,  B29K2067/046 ,  B29K2995/0053 ,  B29K2995/006 ,  B29L2031/7534 ,  B32B2307/514 ,  B32B2307/7163 ,  Y10T428/1328 ,  Y10T428/1352 ,  Y10T428/139 ,  A61L31/129 ,  C08L67/04 ,  A61L31/06 ,  C08L67/04

Abstract: Methods for preparing oriented polymer tubes, such as biodegradable polymer tubes suitable for in vivo use, are provided herein. The disclosed methods provide alternatives to the typical extrusion/expansion methods by which oriented polymeric tubes for such uses are commonly produced. Advantageously, the disclosed methods can provide more homogeneous molecular orientation of crystallizable polymers within the tube walls, which can endow such polymeric tubes with enhanced strength (e.g., resistance to compression) and toughness.

公开(公告)号：US11975124B2

公开(公告)日：2024-05-07

申请号：US17312377

申请日：2019-12-09

Applicant: INEO-TECH SDN BHD

Inventor： Sebastien Treilhes ,  Pierre Hoerner

IPC: A61L31/04 ,  A61B42/10 ,  A61L31/06 ,  A61L31/14 ,  C08L11/00 ,  C08L53/02

CPC classification number: A61L31/049 ,  A61B42/10 ,  A61L31/041 ,  A61L31/048 ,  A61L31/06 ,  A61L31/141 ,  A61L2420/06 ,  A61L2420/08 ,  C08L11/00 ,  C08L53/02

Abstract: Provided are multilayer synthetic rubber compositions formed from a layer of a styrene block copolymer composition and a layer of one or more synthetic elastomers, such as polychloroprene, polyisoprene, nitrile rubber, styrene butadiene rubber, butyl rubber and polyurethane. The multilayer compositions find use in the manufacture of thin walled articles, for example gloves, particularly medical or industrial gloves.