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公开(公告)号：US20240164780A1
公开(公告)日：2024-05-23
申请号：US18241746
申请日：2023-09-01
发明人： Aaron KEHRER , Nathaniel JOHNSON
CPC分类号： A61B17/1128 , A61F2/0077 , A61L27/18 , A61L27/52 , A61L27/58 , A61F2002/0081 , A61F2250/0067 , A61F2250/0097 , A61L2430/32
摘要： Described herein are tissue repair scaffolds having improved features which aid in the installation of the scaffolds. Such features include alignment markers, exterior markers which denote the terminal points of interior channels, and increased sheath thickness.
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公开(公告)号：US11932719B2
公开(公告)日：2024-03-19
申请号：US16972699
申请日：2019-06-06
发明人： Jorge Fernando Jordao Coelho , Ana Clotilde Amaral Loureiro Da Fonseca , Armenio Coimbra Serra , Ana Catarina Da Silva Pinho , Jose Domingos Santos , Ana Colette Pereira De Castro Osorio Mauricio , Ana Rita Caseiro Santos , Silvia Marlene Almeida Santos Pedrosa , Mariana Esteves Vieira Branquinho , Rui Damasio Alvites , Irina Ferraz Amorim Cruz
IPC分类号： C08F299/04 , A61L27/34 , C08K5/05 , A61B17/11
CPC分类号： C08F299/0492 , A61L27/34 , C08K5/05 , A61B17/1128 , C08G2230/00
摘要： A biodegradable based polymers for the production of biodegradable medical applications is provided. The biobased material has a copolymer constituted by dextran modified with glycidyl methacrylate and poly (#-caprolactone) modified with 2-isocyanatoethylmethacrylate, which are combined in different formulations and used to produce membranes, 3-D scaffolds and hollow tubes that can be used as biomedical devices for diverse applications, such as drug delivery systems, tissue engineering scaffolds, repair and regeneration of peripheral nerves, among others.
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公开(公告)号：US20230240682A1
公开(公告)日：2023-08-03
申请号：US18298978
申请日：2023-04-11
申请人： Axsonus LLC
发明人： Jason Bourgeois , Michael L. Wach , Frank Lau
CPC分类号： A61B17/1128 , A61M5/142 , A61N1/205 , A61N1/36071 , A61N1/0551 , A61B5/4041 , A61B17/0218 , A61L2430/32 , A61B17/3468
摘要： To achieve in vivo repair of severed mammalian nerve tissue, a system can be employed to induce distraction neurogenesis. At least a portion of the system can be anchored at an injury site, such as between distal and proximal nerve ends. The system can be attached to the proximal nerve end and can place the nerve under micro-tension for an extended period of treatment. The system may also deliver medication or treatment to encourage neurogenesis and to reduce pain in the subject receiving treatment. After the course of treatment, the device can be removed from the injury site, and the nerve ends rejoined.
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公开(公告)号：US20190090872A1
公开(公告)日：2019-03-28
申请号：US16201011
申请日：2018-11-27
发明人： George D. BITTNER
CPC分类号： A61B17/1128 , A61B2017/00893 , A61B2017/00907 , A61B2017/1132 , A61B2090/0807 , A61M5/00
摘要： The present disclosure is directed to the use of fusogenic compounds such as polyethylene glycol (PEG) in combination with antioxidants, calcium-containing and calcium-free solutions for treating damaged nerves, such as for reconnecting severed nerves.
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公开(公告)号：US20180221043A1
公开(公告)日：2018-08-09
申请号：US15426460
申请日：2017-02-07
申请人： AxoGen Corporation
IPC分类号： A61B17/285
CPC分类号： A61B17/282 , A61B17/1128 , A61B2017/320052 , A61B2090/061 , G01B3/34 , G01B5/08
摘要： A sizing forceps is provided for fixing a nerve in place, measuring the diameter of the nerve, and providing an efficient way to resect the nerve. A sizing forceps can have an upper and lower jaw with one or more aligned notches that form apertures for holding a nerve. The apertures can have predetermined sizes that can be used to measure the diameter of a nerve. A slicing slot in the upper and lower jaw allows a nerve within an aperture to be severed to obtain a non-frayed end.
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公开(公告)号：US20180140742A1
公开(公告)日：2018-05-24
申请号：US15519283
申请日：2015-10-16
申请人： SCHOOL JURIDICAL PERSON KITASATO INSTITUTE , ATREE, INC. , NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY , NIPPI, INCORPORATED
发明人： Kentaro UCHIDA , Gen INOUE , Hisako FUJIMAKI , Masashi TAKASO , Taro SAKU , Yoshihiro ISOBE , Osamu MATSUSHITA , Takehiko MIMA , Nozomu NISHI , Shunji HATTORI , Keisuke TANAKA , Takayuki OGURA
CPC分类号： A61L27/3675 , A61B17/1128 , A61B2017/1132 , A61F2/0077 , A61F2002/0068 , A61L27/227 , A61L27/24 , A61L27/3604 , A61L27/3695 , A61L27/50 , A61L27/54 , A61L2300/414 , A61L2430/32 , C12N2501/115
摘要： 1) A graft material for nerve regeneration characterizing by comprising collagen-based materials containing collagen having an orientation. 2) A method for producing a graft material for nerve regeneration comprising a step of immersing the collagen-based materials containing collagen having an orientation in a solution containing a collagen-binding site-containing growth factor comprising a receptor agonist peptide and a collagen-binding peptide and binding the collagen-binding site-containing growth factor to the collagen. 3) A kit for producing a graft material for nerve regeneration characterized by comprising collagen-based materials containing collagen having an orientation, and a collagen-binding site-containing growth factor comprising a receptor agonist peptide and a collagen-binding peptide.
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公开(公告)号：US20180133372A1
公开(公告)日：2018-05-17
申请号：US15573270
申请日：2016-05-11
CPC分类号： A61L27/56 , A61B17/1128 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/52 , A61L27/58 , A61L2400/08 , A61L2430/32 , C08L5/08 , C08L89/06
摘要： The present disclosure provides magnetically templated tissue scaffolds, methods of making the magnetically templated tissue scaffolds, and various methods of employing the scaffolds for tissue growth and repair in vitro and in vivo, including peripheral nerve repair.
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公开(公告)号：US09950099B2
公开(公告)日：2018-04-24
申请号：US14768826
申请日：2014-02-18
CPC分类号： A61L31/16 , A61B17/1128 , A61B17/12 , A61B2017/00893 , A61L27/3878 , A61L31/041 , A61L2300/432
摘要： In one aspect, nerve growth inhibition devices are described herein. In some embodiments, a nerve growth inhibition device described herein comprises a tube having a proximal end and a distal end. A matrix material is disposed in the tube, and the matrix material comprises one or more microchannels. The proximal end of the tube comprises an opening operable to receive nerve tissue, the distal end of the tube is sealed, and the microchannels of the matrix material extend from the proximal end of the tube toward the distal end of the tube.
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公开(公告)号：US20180042629A1
公开(公告)日：2018-02-15
申请号：US15556893
申请日：2016-03-11
发明人： Nicholas B. LANGHALS , Cynthia Anne CHESTEK , Paul S. CEDERNA , Albert SHIH , Melanie G. URBANCHEK , Grant H. KRUGER , Jeffrey Stephen PLOTT , Jordan T. KREDA
IPC分类号： A61B17/295 , A61B17/34 , A61B17/3205
CPC分类号： A61B17/295 , A61B17/1128 , A61B17/29 , A61B17/3205 , A61B17/32053 , A61B17/3417 , A61B17/3468 , A61B2017/00353 , A61B2017/00438 , A61B2017/00969 , A61B2090/062
摘要： The present disclosure provides a mechanically-actuated tool for cutting a tissue graft having a hollow core and methods for use thereof. A portion of a biological structure, such as a nerve, is attached to the hollow core to form an implantable neural graft assembly. The tool has a cutter mechanism and a grasper mechanism. The grasper mechanism has one or more component(s) that open and close via an actuation mechanism, like a handle, and rotate via a controller component, like a rotatable wheel. The cutter mechanism may be a cutting tube component that harvests the tissue graft. The tool may also have an ejector mechanism to remove the tissue graft as part of the implantable neural graft assembly. Such devices and methods are particularly suitable for treating neuromas and other neural regeneration procedures.
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公开(公告)号：US09877725B2
公开(公告)日：2018-01-30
申请号：US13515211
申请日：2010-12-10
申请人： Georg Bretthauer , Selman Uranues
发明人： Georg Bretthauer , Selman Uranues
CPC分类号： A61B17/1128 , A61N1/0551 , A61N1/36103
摘要： The invention relates to a neural prosthesis, a neural prosthesis for use in the treatment of severed nerves and to a method for producing a neural prosthesis. Said neural prosthesis comprises a coupling element receptacle and at least one coupling element having a first and a second coupling section, wherein the coupling element is fixed by the coupling element receptacle, and wherein the first coupling section can be arranged on a first nerve region and the second coupling section on a second nerve region so that both nerve regions can be coupled by means of the neural prosthesis.
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