公开(公告)号：US20240307681A1

公开(公告)日：2024-09-19

申请号：US18672957

申请日：2024-05-23

Applicant: Wisconsin Alumni Research Foundation ,  Mayo Foundation for Medical Education and Research

Inventor： Justin Williams ,  Kip Ludwig ,  Erika Ross

IPC: A61N1/05 ,  A61N1/04 ,  A61N1/36 ,  A61N1/375

CPC classification number: A61N1/056 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/0536 ,  A61N1/0551 ,  A61N1/36025 ,  A61N1/36034 ,  A61N1/36053 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/36175 ,  A61N1/37516

Abstract: The present invention provides materials and methods for using electrical stimulation to treat a mammal having a proteinopathy (e.g., neurodegenerative diseases) or at risk of developing a proteinopathy are provided. For example, the present invention provides materials and methods for modulating glymphatic clearance (e.g., enhancing glymphatic clearance) of pathogenic proteins.

公开(公告)号：US11957910B2

公开(公告)日：2024-04-16

申请号：US17473406

申请日：2021-09-13

Applicant: California Institute of Technology ,  University of Louisville Research Foundation, Inc. ,  The Regents of the University of California

Inventor： Victor Reggie Edgerton ,  Roland R. Roy ,  Yury Gerasimenko ,  Joel W. Burdick ,  Susan J. Harkema ,  Jonathan Hodes ,  Yu-Chong Tai ,  Mandheerej S. Nandra ,  Claudia A. Angeli ,  Thomas Anthony Desautels

IPC: A61N1/00 ,  A61H1/02 ,  A61N1/05 ,  A61N1/36 ,  A63B21/00 ,  A63B22/02 ,  A63B69/00

CPC classification number: A61N1/36103 ,  A61H1/0237 ,  A61H1/0274 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/36003 ,  A63B21/00181 ,  A61N1/3616 ,  A63B22/0235 ,  A63B69/0064 ,  A63B2213/004 ,  A63B2220/805 ,  A63B2230/60 ,  F04C2270/0421

Abstract: Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having a spinal cord injury, a brain injury, or a neurological neuromotor disease are described.

公开(公告)号：US20230398357A1

公开(公告)日：2023-12-14

申请号：US18238155

申请日：2023-08-25

Applicant: CHECKPOINT SURGICAL, INC.

Inventor： Kevin SCANLAN ,  Eric R. WALKER ,  Leonard M. COSENTINO

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/04

CPC classification number: A61N1/36103 ,  A61N1/0551 ,  A61N1/36167 ,  A61N1/0464 ,  A61N1/36017

Abstract: A stimulation device includes an adaptor component. The adaptor component couples a percutaneous lead to the stimulation device. The stimulation device may apply a stimulation signal to target tissue via the adaptor. A surgeon may place the stimulation device in a container and the adaptor component may be disposed outside of the container. Methods describe prolonged stimulation of target tissue via a stimulation device. The prolonged stimulation may be applied during and after a surgical procedure.

公开(公告)号：US11839766B2

公开(公告)日：2023-12-12

申请号：US17098183

申请日：2020-11-13

Applicant: ONWARD MEDICAL N.V.

Inventor： Mathieu Scheltienne ,  Edoardo Paoles ,  Jeroen Tol ,  Jurriaan Bakker

IPC: A61N1/36 ,  A61N1/05 ,  A61B34/10 ,  G16H20/40 ,  G16H30/20 ,  A61B90/00 ,  A61B17/00

CPC classification number: A61N1/36062 ,  A61B34/10 ,  A61N1/0551 ,  A61N1/36067 ,  A61N1/36175 ,  G16H20/40 ,  G16H30/20 ,  A61B2017/00039 ,  A61B2017/00044 ,  A61B2034/104 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2090/373 ,  A61B2090/374 ,  A61B2090/3762 ,  A61N1/36103

Abstract: A neuromodulation system comprising:



at least one input means for inputting patient data into the neuromodulation system;
at least one model calculation and building means for building a patient model, the patient model describing the anatomy and/or physiology and/or pathophysiology and the real and/or simulated reaction of the patient on a provided and/or simulated neuromodulation;
at least one computation means for using the patient model (M) and calculating the impact of the provided and/or simulated neuromodulation.




The present invention further relates to a method for providing neuromodulation.

公开(公告)号：US11819687B2

公开(公告)日：2023-11-21

申请号：US16615210

申请日：2018-05-24

Applicant: Case Western Reserve University

Inventor： Tina L. Vrabec ,  Kevin L. Kilgore ,  Niloy Bhadra ,  Laura Shaw ,  David Roberts ,  Narendra Bhadra

IPC: A61N1/05 ,  A61N1/20 ,  A61N1/36

CPC classification number: A61N1/0551 ,  A61N1/20 ,  A61N1/36067 ,  A61N1/36103

Abstract: Systems and methods that deliver a continuous partial nerve conduction block are described. A waveform generator can configure one or more direct current (DC) waveforms to provide a continuous partial nerve conduction block. One or more electrodes can deliver the one or more DC waveforms to provide the partial block to the neural structure. Feedback can be provided to the waveform generator related to the partial block. The feedback includes monitoring a property associated with the partial block and altering a parameter associated with the one or more direct current waveforms in response to the property associated with the partial block.

公开(公告)号：US11786729B2

公开(公告)日：2023-10-17

申请号：US17347865

申请日：2021-06-15

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

IPC: A61N1/36 ,  A61N1/08 ,  H04L67/565 ,  H04L67/568 ,  G06F13/38 ,  H04L49/90 ,  H04L49/901 ,  A61N1/05 ,  A61N1/372

CPC classification number: A61N1/3606 ,  A61N1/36135 ,  A61N1/36146 ,  G06F13/385 ,  H04L49/90 ,  H04L49/901 ,  H04L67/565 ,  H04L67/568 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/37252 ,  Y02D10/00

Abstract: Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

公开(公告)号：US11779762B2

公开(公告)日：2023-10-10

申请号：US17117228

申请日：2020-12-10

Applicant: Case Western Reserve University

Inventor： Niloy Bhadra ,  Narendra Bhadra ,  Kevin L. Kilgore ,  Scott Lempka ,  Jesse Wainright ,  Tina Vrabec ,  Manfred Franke

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/06 ,  A61N1/20

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/06 ,  A61N1/20 ,  A61N1/36021 ,  A61N1/36057 ,  A61N1/36103 ,  A61N1/36125 ,  A61N1/36171 ,  A61N1/36175

Abstract: One aspect of the present disclosure is a system including a waveform generator, a controller, and an electrical contact. The waveform generator is for generating an electrical nerve conduction block (ENCB). The controller is coupled with the waveform generator. The controller is configured to receive an input comprising at least one parameter to adjust the ENCB. The electrical contact is coupled with the waveform generator. The electrical contact is configured to be placed into contact with a nerve. The electrical contact comprises a high charge capacity material that prevents formation of damaging electro-chemical products at a charge delivered by the ENCB. The electrical contact is configured to deliver the ENCB to the nerve to block transmission of a signal related to a pain through the nerve.

公开(公告)号：US11738203B2

公开(公告)日：2023-08-29

申请号：US17009635

申请日：2020-09-01

Applicant: EPIC Neuro, Inc.

Inventor： James William Phillips

IPC: A61N1/378 ,  A61N1/36 ,  A61N1/18 ,  A61N1/05

CPC classification number: A61N1/3787 ,  A61N1/0531 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36075 ,  A61N1/36103 ,  A61N1/36139 ,  A61N1/36171 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/36082

Abstract: A method and device is described, which provides electrical stimulation to the brain of a person, where the device comprises an external portion and at least one implantable portion. The external portion provides the energy source for stimulation to the implantable portions. The implantable portions provide at least two conductive paths through the skull and use the skull's high impedance to generate a current loop with the focus of stimulation lying in the current path.

公开(公告)号：US20230226363A1

公开(公告)日：2023-07-20

申请号：US18000021

申请日：2021-06-11

Applicant: UNIVERSIDADE DO PORTO - REITORIA ,  MECHANOBIONICS LDA

Inventor： Jose Alberto PEIXOTO MACHADO DA SILVA ,  Joaquim Gabriel MAGALHAES MENDES ,  Jorge Serafim SOBRADO MARINHO

IPC: A61N1/378 ,  A61N1/36 ,  A61C8/00 ,  A61N1/05

CPC classification number: A61N1/3785 ,  A61N1/36103 ,  A61C8/0093 ,  A61N1/0556

Abstract: A sensory unit for implant-supported dental implants or prostheses. The main unit is composed of two or more subunits, or devices. One of the units is placed in the region of the implant head, and will have the function of transforming the mechanical forces into an electrical signal. It can also be placed in the masticatory region of implant supported bridges or overdenture, to perform the same function, i.e., transforming mechanical loads into an electrical signal. A second unit, will receive by a wired or wireless electronic communication the electrical signal, and will convert it into a neurological stimulus perceived sensorially by the sensory endings of the trigeminal nerve, unilaterally, or bilaterally. This second unit will be arranged in the submucosa, in the vicinity of the nerve ending, taking advantage of the anatomical depressions or recesses in the region, and will establish a gradient of neurological stimulation towards the nerve ending.

公开(公告)号：US20230146775A1

公开(公告)日：2023-05-11

申请号：US18154280

申请日：2023-01-13

Applicant: The Board of Regents, The University of Texas System

Inventor： Christa McIntyre RODRIGUEZ ,  Navzer Dara ENGINEER ,  Michael P. KILGARD

IPC: A61M21/00 ,  A61N1/36 ,  G09B23/28

CPC classification number: A61M21/00 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36053 ,  A61N1/36092 ,  A61N1/36096 ,  A61N1/361 ,  A61N1/36103 ,  G09B23/28 ,  A61M21/02

Abstract: A therapy method (for a patient having post-traumatic stress disorder (PTSD)) includes: providing an exposure event, to the patient, which is related to a traumatic event that contributed to the PTSD; and, during a therapy session which includes the exposure event, applying vagus nerve stimulation (VNS). A therapy method (for a patient having a given disorder, e.g., a phobia disorder or an obsessive-compulsive disorder (OCD) or an addiction disorder) includes: providing a therapy event (e.g., an extinction event for a phobia disorder), to the patient, which is related to one or more things that contributed to the given disorder; and during a therapy session which includes the therapy event, applying VNS.