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1.发明申请公开(公告)号：US20190209844A1
公开(公告)日：2019-07-11
申请号：US16238151
申请日：2019-01-02
发明人： Rosana Esteller , Rafael Carbunaru
IPC分类号： A61N1/36
CPC分类号： A61N1/36164 , A61N1/0534 , A61N1/0551 , A61N1/36071 , A61N1/36132 , A61N1/36139 , A61N1/36178 , A61N1/36185 , A61N1/37247 , A61N1/3758
摘要： Medical device systems and methods for providing spinal cord stimulation (SCS) are disclosed. The SCS systems and methods provide therapy below the perception threshold of the patient. The methods and systems are configured to measure neurological responses to stimulation and use the neurological responses as biomarkers to maintain and adjust therapy. An example of neurological responses includes an evoked compound action potential (ECAP).
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公开(公告)号：US20190001124A1
公开(公告)日：2019-01-03
申请号：US16064604
申请日：2016-12-21
申请人： RAINBOW MEDICAL LTD.
发明人： Yossi GROSS , Gideon FOSTICK
CPC分类号： A61N1/306 , A61N1/0551 , A61N1/205 , A61N1/325 , A61N1/326 , A61N1/327 , A61N1/36062 , A61N1/36132 , A61N1/37205 , A61N1/37518
摘要： Apparatus (20) for treating an intervertebral disc (30) of a subject is provided. The apparatus (20) includes at least three intra-pulposus exposed electrode surfaces (40), which are configured to be implanted within a nucleus pulposus (42) of the disc (30), at different respective locations; and one or more extra-pulposus exposed electrode surfaces (44), which are configured to be implanted outside the nucleus pulposus (42), in electrical communication with the disc (30). Control circuitry (50) is configured to (a) configure the intra-pulposus exposed electrode surfaces (40) to be cathodes, and the one or more extra-pulposus exposed electrode surfaces (44) to be one or more anodes, and (b) drive the intra-pulposus exposed electrode surfaces (40) and the one or more extra-pulposus exposed electrode surfaces (44) to electroosmotically drive fluid into the nucleus pulposus (40) to increase pressure in the disc (30).
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公开(公告)号：US20180369591A1
公开(公告)日：2018-12-27
申请号：US16119560
申请日：2018-08-31
发明人： Dongchul Lee , Changfang Zhu
CPC分类号： A61N1/36164 , A61N1/36071 , A61N1/36132 , A61N1/36139 , A61N1/36178 , A61N1/36185 , A61N1/37247
摘要： A neuromodulation system and method of providing sub-threshold therapy to a patient. An anodic perception threshold of super-threshold electrical energy and a cathodic perception threshold of super-threshold electrical energy are determined for a plurality of electrode sets. A ratio between the anodic perception threshold and the cathodic perception threshold is calculated for each of the electrode sets. An effective electrode set is selected based on the ratio between the anodic perception threshold and the cathodic perception threshold.
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公开(公告)号：US20180272142A1
公开(公告)日：2018-09-27
申请号：US15902163
申请日：2018-02-22
CPC分类号： A61N1/37241 , A61B5/04001 , A61B5/4836 , A61B5/6868 , A61B5/7435 , A61N1/025 , A61N1/0534 , A61N1/3605 , A61N1/36125 , A61N1/36128 , A61N1/36132 , A61N1/36139 , A61N1/36185 , G16H20/40
摘要： An example of a system for delivering neurostimulation may include a programming control circuit and a stimulation control circuit. The programming control circuit may be configured to generate stimulation parameters controlling delivery of the neurostimulation according to a stimulation configuration. The stimulation control circuit may be configured to specify the stimulation configuration, and may include volume definition circuitry and stimulation configuration circuitry. The volume definition circuitry may be configured to determine one or more test volumes, determine a clinical effect resulting from the one or more test volumes each being activated by the neurostimulation, and determine a target volume using the determined clinical effect. The stimulation configuration circuitry may be configured to generate the specified stimulation configuration for activating the target volume.
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公开(公告)号：US20180264278A1
公开(公告)日：2018-09-20
申请号：US15920153
申请日：2018-03-13
发明人： Fabio Laghi
CPC分类号： A61N1/37247 , A61N1/0534 , A61N1/36067 , A61N1/36132 , A61N1/36146 , A61N1/37223
摘要： A computing device executes a software program that communicates various deep brain stimulation (DBS) routines to a neurostimulator. The software program generates a graphical user interface (GUI) that receives inputs that are indicative of a patient's response to the various DBS routines. The GUI further includes a representation of each of one or more electrode leads that are connected to the neurostimulator. Based on the patient response inputs, one or more symbols that are indicative of an effectiveness of the stimulation routines are displayed at positions on the lead representations that correspond to parameters of the stimulation routines.
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公开(公告)号：US20180256897A1
公开(公告)日：2018-09-13
申请号：US15975542
申请日：2018-05-09
CPC分类号： A61N1/36132 , A61N1/0551 , A61N1/36071 , A61N1/36139 , A61N1/36142 , A61N1/37247
摘要： An example of a system may include electrodes on at least one lead configured to be operationally positioned for use in modulating neural tissue. The neural tissue may include at least one of dorsal horn tissue, dorsal root tissue or dorsal column tissue. The system may include an implantable device including a neural modulation device and a controller. The neural modulation device may be configured to use at least some of the electrodes to generate a modulation field to deliver sub-perception modulation to the neural tissue. The sub-perception modulation may have an intensity below a patient-perception threshold. The patient-perception threshold may be a boundary below which a patient does not sense generation of the modulation field. The controller may be configured to control the neural modulation device to generate the modulation field, and automatically adjust the modulation field in response to a patient input.
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7.发明申请公开(公告)号：US20180236237A1
公开(公告)日：2018-08-23
申请号：US15962354
申请日：2018-04-25
申请人： PACESETTER, INC.
发明人： Alexander Kent , Edward Karst , Gene A. Bornzin
CPC分类号： A61N1/36132 , A61B5/0533 , A61B5/225 , A61B5/4824 , A61B5/4836 , A61B2562/046 , A61N1/0551 , A61N1/36021 , A61N1/36062 , A61N1/36071 , A61N1/36135 , A61N1/37247 , A63B21/4035 , G06F3/015
摘要： The present disclosure provides a grip sensor for quantifying pain experienced by a patient during spinal cord stimulation (SCS). The grip sensor includes an electronics enclosure, an annular outer shell substantially surrounding the electronics enclosure and sized to be held by the patient, a pressure sensor embedded in the outer shell and communicatively coupled to the electronics enclosure, the pressure sensor configured to measure a grip strength of the patient as SCS is applied to the patient, and a plurality of galvanic skin response sensors communicatively coupled to the electronics enclosure and configured to measure an electrical impedance of the skin of the patient as SCS is applied to the patient.
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公开(公告)号：US20180229046A1
公开(公告)日：2018-08-16
申请号：US15544515
申请日：2016-01-19
发明人： John Louis Parker , Mark Staples
CPC分类号： A61N1/37217 , A61B5/0028 , A61B5/0031 , A61B5/04001 , A61B5/686 , A61B5/7475 , A61B2560/0487 , A61N1/0526 , A61N1/36132 , A61N1/37211
摘要： Communications along a neural pathway are provided. The neural pathway is stimulated at a first location, in order to evoke neural responses which propagate along the neural pathway, the neural responses being modulated with data. At a second location spaced apart from the first location along the neural pathway the evoked neural responses are sensed. The sensed neural responses are then demodulated to retrieve the data. The stimulation could comprise peripheral sensory stimulation, and the second location could be at an implanted electrode array.
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公开(公告)号：US20180214701A1
公开(公告)日：2018-08-02
申请号：US15882549
申请日：2018-01-29
发明人： Tianhe Zhang , Changfang Zhu , Que T. Doan
CPC分类号： A61N1/36164 , A61N1/0551 , A61N1/36062 , A61N1/36071 , A61N1/36132 , A61N1/36139 , A61N1/36185 , A61N1/36189 , A61N1/37247
摘要： An example of a system to program a neuromodulator to deliver neuromodulation to a neural target using a plurality of electrodes may comprise a programming control circuit configured to determine target energy allocations for the plurality of electrodes based on at least one target pole to provide a target sub-perception modulation field, and normalize the target sub-perception modulation field, including determine a time domain scaling factor to account for at least one property of a neural target or of a neuromodulation waveform, and apply the time domain scaling factor to the target energy allocations.
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公开(公告)号：US20180193653A1
公开(公告)日：2018-07-12
申请号：US15865805
申请日：2018-01-09
发明人： Hemant Bokil
CPC分类号： A61N1/36178 , A61N1/0534 , A61N1/0551 , A61N1/36132 , A61N1/36146 , A61N1/37211
摘要： This document discusses medical device for coupling to a plurality of implantable electrodes. The medical device includes a therapy circuit configured to deliver electrical neurostimulation energy to the plurality of implantable electrodes; and a control circuit operatively coupled to the therapy circuit. The control circuit is configured to: initiate delivery of bursts of pulses of the electrical neurostimulation energy to the plurality of the implantable electrodes, wherein pulses within a burst include an intra-pulse period; change a combination of electrodes used to deliver the bursts of pulses according to an inter-burst period between bursts; and change the inter-burst period during the delivery of the electrical neuromodulation energy.
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