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1.发明公开公开(公告)号：US20230264023A1
公开(公告)日：2023-08-24
申请号：US18310935
申请日：2023-05-02
Inventor： Michael P. KILGARD , Navzer ENGINEER , David Michael PIERCE , Robert L. RENNAKER
CPC classification number: A61N1/36067 , A61N1/36053 , A61N1/37235 , A61N1/37247 , A61N1/36092 , A61N1/361 , G09B23/28 , A61N1/36103 , A61N1/36003 , A61N1/36178 , A61N1/36139 , A61N1/37217 , A61N2/006 , A61N7/00 , A61N1/36132 , A61B5/1124
Abstract: A motor-deficit-therapeutic method (for treatment of a patient who has hemiparesis) includes: providing, to the patient afflicted with a hemiparesis, a neurostimulator configured to stimulate a vagus nerve of the patient using electrical, magnetic, optical, acoustic or mechanical stimulation; and initiating stimulation of the vagus nerve by the neurostimulator so that at least a portion of the stimulation occurs at least during performance by the patient of a motor therapy session which is hemiparesis-therapeutic, thereby improving the patient's hemiparesis.
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公开(公告)号：US20170143550A1
公开(公告)日：2017-05-25
申请号：US15422958
申请日：2017-02-02
Inventor： Michael P. KILGARD , Navzer ENGINEER , David Michael PIERCE
CPC classification number: A61F11/00 , A61B5/128 , A61N1/0551 , A61N1/36036 , A61N1/36053 , A61N1/36092 , A61N1/361 , A61N1/36132 , A61N1/36167 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/37247 , G09B23/28 , H04R25/75
Abstract: A method of treating tinnitus comprising measuring a patient's hearing, determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing, programming a clinical controller with the measurements of the patient's hearing, selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency, setting an appropriate volume for each of the plurality of tones, repetitively playing each of the plurality of therapeutic tones, and pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.
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3.发明申请METHODS, SYSTEMS, AND DEVICES FOR TREATING TINNITUS WITH VNS PAIRING 审中-公开用VNS配对处理TINNITUS的方法，系统和装置公开(公告)号：US20150051659A1
公开(公告)日：2015-02-19
申请号：US14527370
申请日：2014-10-29
Inventor： Michael P. KILGARD , Navzer ENGINEER , David Michael PIERCE
CPC classification number: A61F11/00 , A61B5/128 , A61N1/0551 , A61N1/36036 , A61N1/36053 , A61N1/36092 , A61N1/361 , A61N1/36132 , A61N1/36167 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/37247 , G09B23/28 , H04R25/75
Abstract: A method of treating tinnitus comprising measuring a patient's hearing, determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing, programming a clinical controller with the measurements of the patient's hearing, selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency, setting an appropriate volume for each of the plurality of tones, repetitively playing each of the plurality of therapeutic tones, and pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.
Abstract translation: 一种治疗耳鸣的方法，包括测量患者的听力，使用患者听力的测量来确定患者的听力损失和患者的耳鸣频率，使用患者听力的测量来编制临床控制器，选择多个治疗音调，其中 治疗音被选择为患者耳鸣频率之上或之下的至少八度八度以上，为多个音调中的每一个设置适当的音量，重复播放多个治疗音中的每一个，并配对迷走神经刺激脉冲 训练每个演奏的治疗音，从而减少患者耳鸣的感觉。
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公开(公告)号：US20230040112A1
公开(公告)日：2023-02-09
申请号：US17968021
申请日：2022-10-18
Inventor： Michael P. KILGARD , Navzer ENGINEER , David PIERCE
Abstract: A method (of treating a patient who has tinnitus) includes: providing to the patient a series of tones including at least a single tone which is at least a half-octave outside a tinnitus frequency of the patient; and applying vagus nerve stimulation to the patient to induce a period of plasticity in a cortex of the patient that is transitory and that represents a transitory opportunity for learning to occur; and wherein the at least a single tone occurs during the transitory opportunity for learning.
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公开(公告)号：US20150343222A1
公开(公告)日：2015-12-03
申请号：US14809781
申请日：2015-07-27
Inventor： Michael P. KILGARD , Larry CAULLER , Navzer ENGINEER , Christa McIntyre Rodriguez , Will ROSELLINI
CPC classification number: A61N1/36167 , A61F11/00 , A61M21/00 , A61M21/02 , A61M2021/0016 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61M2021/0077 , A61M2205/3515 , A61M2230/06 , A61M2230/08 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/50 , A61M2230/60 , A61M2230/65 , A61N1/36014 , A61N1/36053 , A61N1/36067 , A61N1/36082 , A61N1/36092 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N5/0618 , A61N5/0622 , G09B19/00 , G09B19/003 , G09B23/28 , H04R25/75
Abstract: Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.
Abstract translation: 用于配对训练的系统，方法和装置包括时间控制，以便可以同时提供训练和神经刺激。 配对训练可能包括治疗，康复和性能增强训练神经的刺激，如影响皮质下区域的迷走神经，如基底细胞，基因座或杏仁核诱导脑中的可塑性，增强各种疗法的作用，如 那些用于治疗耳鸣，中风，创伤性脑损伤和创伤后应激障碍。
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Patent Agency Ranking
公开(公告)号：US20150051656A1
公开(公告)日：2015-02-19
申请号：US14527253
申请日：2014-10-29
Inventor： Michael P. KILGARD , Navzer ENGINEER , David Michael PIERCE
CPC classification number: A61F11/00 , A61B5/128 , A61N1/0551 , A61N1/36036 , A61N1/36053 , A61N1/36092 , A61N1/361 , A61N1/36132 , A61N1/36167 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/37247 , G06F19/00 , G09B23/28 , H04R25/75
Abstract: A method of treating tinnitus comprising measuring a patient's hearing, determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing, programming a clinical controller with the measurements of the patient's hearing, selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency, setting an appropriate volume for each of the plurality of tones, repetitively playing each of the plurality of therapeutic tones, and pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.
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公开(公告)号：US20150018893A1
公开(公告)日：2015-01-15
申请号：US14500325
申请日：2014-09-29
Inventor： Michael P. KILGARD , Larry CAULLER , Nazer ENGINEER , Christa McIntyre Rodriguez , Will ROSSELLINI
CPC classification number: A61N1/36167 , A61F11/00 , A61M21/00 , A61M21/02 , A61M2021/0016 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61M2021/0077 , A61M2205/3515 , A61M2230/06 , A61M2230/08 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/50 , A61M2230/60 , A61M2230/65 , A61N1/36014 , A61N1/36053 , A61N1/36067 , A61N1/36082 , A61N1/36092 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N5/0618 , A61N5/0622 , G09B19/00 , G09B19/003 , G09B23/28 , H04R25/75
Abstract: Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.
Abstract translation: 用于配对训练的系统，方法和装置包括时间控制，以便可以同时提供训练和神经刺激。 配对培训可能包括治疗，康复和绩效增强培训。 影响神经的神经刺激，如影响皮层下的区域，如核碱基，脑脊髓或杏仁核，诱导脑中的可塑性，增强各种疗法的作用，例如用于治疗耳鸣，中风，创伤性脑损伤 和创伤后应激障碍。
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公开(公告)号：US20230146775A1
公开(公告)日：2023-05-11
申请号：US18154280
申请日：2023-01-13
Inventor： Christa McIntyre RODRIGUEZ , Navzer Dara ENGINEER , Michael P. KILGARD
CPC classification number: A61M21/00 , A61N1/36017 , A61N1/36025 , A61N1/36053 , A61N1/36092 , A61N1/36096 , A61N1/361 , A61N1/36103 , G09B23/28 , A61M21/02
Abstract: A therapy method (for a patient having post-traumatic stress disorder (PTSD)) includes: providing an exposure event, to the patient, which is related to a traumatic event that contributed to the PTSD; and, during a therapy session which includes the exposure event, applying vagus nerve stimulation (VNS). A therapy method (for a patient having a given disorder, e.g., a phobia disorder or an obsessive-compulsive disorder (OCD) or an addiction disorder) includes: providing a therapy event (e.g., an extinction event for a phobia disorder), to the patient, which is related to one or more things that contributed to the given disorder; and during a therapy session which includes the therapy event, applying VNS.
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公开(公告)号：US20170224994A1
公开(公告)日：2017-08-10
申请号：US15496766
申请日：2017-04-25
Inventor： Michael P. KILGARD , Larry CAULLER , Navzer ENGINEER , Christa McIntyre Rodriguez , Will ROSELLINI
CPC classification number: A61N1/36167 , A61F11/00 , A61M21/00 , A61M21/02 , A61M2021/0016 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61M2021/0077 , A61M2205/3515 , A61M2230/06 , A61M2230/08 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/50 , A61M2230/60 , A61M2230/65 , A61N1/36014 , A61N1/36053 , A61N1/36067 , A61N1/36082 , A61N1/36092 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N5/0618 , A61N5/0622 , G09B19/00 , G09B19/003 , G09B23/28 , H04R25/75
Abstract: Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.
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10.发明申请公开(公告)号：US20150094785A1
公开(公告)日：2015-04-02
申请号：US14560735
申请日：2014-12-04
Inventor： Michael P. KILGARD , Navzer ENGINEER , David Michael PIERCE , Robert L. RENNAKER
CPC classification number: A61N1/36067 , A61B5/1124 , A61N1/36003 , A61N1/36053 , A61N1/36092 , A61N1/361 , A61N1/36103 , A61N1/36132 , A61N1/36139 , A61N1/36178 , A61N1/37217 , A61N1/37235 , A61N1/37247 , A61N2/006 , A61N7/00 , A61N2007/0026 , G06F19/00 , G09B23/28
Abstract: A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.
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