公开(公告)号：US12121733B2

公开(公告)日：2024-10-22

申请号：US17774032

申请日：2020-11-03

申请人： CELTRO GMBH

发明人： Gerd Teepe

IPC分类号： A61N1/375 ,  A61M37/00 ,  A61N1/362 ,  A61N1/372 ,  A61N1/378 ,  H02J7/00 ,  H02J7/34 ,  H02J50/00 ,  H02J50/10

CPC分类号： A61N1/37512 ,  A61M37/0015 ,  A61N1/362 ,  A61N1/37235 ,  A61N1/3785 ,  H02J7/0013 ,  H02J7/345 ,  H02J50/001 ,  H02J50/10 ,  H02J2207/50 ,  H02J2310/23

摘要： The invention discloses a device for collection of tiny charges in the Nano-Coulomb-range and below, comprising at least one capacitor stack build by n capacitors and 2n switches (nϵN), at least one further capacitor outside the capacitor stack as buffer capacity, at least two additional switches and a DC input source. The n capacitors are dedicated to be sequentially charged by the DC input source one after the other, wherein the 2n switches in the capacitor stack couple the n capacitors sequentially to the DC input source. The at least one further capacitor is dedicated to be charged from the n capacitors of the capacitor stack at once. Furthermore, the invention discloses a method for small charge collection, comprising the steps of sequentially charging the n capacitors of the at least one capacitor stack by coupling one capacitor after the other to the DC input source by selectively closing the switches and discharging the n capacitors of the capacitor stack into at least one further capacitor outside the capacitor stack (nϵN). Additionally, the usage of the device or the method according to the invention to collect charges from sources with electrical potentials of a few millivolts is disclosed.

公开(公告)号：US20240342484A1

公开(公告)日：2024-10-17

申请号：US18632405

申请日：2024-04-11

申请人： William Marsh Rice University ,  WTMC Innovation Factory - Motif Neurotech

发明人： Jacob T. ROBINSON ,  Joshua WOODS ,  Matthew KUHN ,  Kaiyuan YANG ,  Fatima ALRASHDAN ,  Zhanghao YU

IPC分类号： A61N1/36 ,  A61N1/372

CPC分类号： A61N1/36139 ,  A61N1/3615 ,  A61N1/37223 ,  A61N1/37235 ,  A61N1/37264

摘要： Embodiments disclosed herein generally relate to wirelessly monitoring and controlling implantable magnetoelectric devices. Particularly, aspects of the present disclosure are directed to a system that includes an implantable device, a base station, and one or more sensors that are physically connected or wirelessly connected to the base station. The implantable device includes a magnetoelectric film, an electrical circuit coupled to the magnetoelectric film, and one or more electrodes. The base station includes a magnetic field generator and a magnetic transceiver.

公开(公告)号：US12115374B2

公开(公告)日：2024-10-15

申请号：US17569095

申请日：2022-01-05

申请人： Curonix LLC

发明人： Laura Tyler Perryman ,  Patrick Larson ,  Chad Andresen

IPC分类号： A61N1/372 ,  A61N1/02 ,  A61N1/36

CPC分类号： A61N1/37252 ,  A61N1/025 ,  A61N1/36125 ,  A61N1/36146 ,  A61N1/37223 ,  A61N1/37229 ,  A61N1/37235 ,  A61N1/37247 ,  A61N1/36139 ,  A61N1/3727

摘要： A system includes a controller module, which includes a storage device, a controller, a modulator, and one or more antennas. The storage device is stored with parameters defining a stimulation waveform. The controller is configured to generate, based on the stored parameters, an output signal that includes the stimulation waveform, wherein the output signal additionally includes polarity assignments for electrodes in an implantable, passive stimulation device. The modulator modulates a stimulus carrier signal with the output signal to generate a transmission signal. The one or more antennas transmit the transmission signal to the implantable, passive stimulation device such that the implantable, passive stimulation device uses energy in the transmission signal for operation, sets the polarities for the electrodes in the implantable, passive stimulation device based on the encoded polarity assignments, generates electrical pulses using the stimulation waveform, and applies the electrical pulses to excitable tissue.

公开(公告)号：US20240335662A1

公开(公告)日：2024-10-10

申请号：US18746503

申请日：2024-06-18

申请人： Nyxoah SA

发明人： Roi Moshe TSUKRAN

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61N1/372

CPC分类号： A61N1/3611 ,  A61N1/0548 ,  A61N1/3615 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36178 ,  A61N1/36192 ,  A61N1/37235

摘要： Disclosed herein is a method for electrical nerve (510) stimulation, the method comprising: generating an electrical stimulation pattern (100) comprising a plurality of successive pulse trains (110), wherein each pulse train (110) has a pulse train amplitude (111); delivering the electrical stimulation pattern (100) to a subject's hypoglossal nerve (510) with a stimulator (300) having at least one electrode (310); modulating the electrical stimulation pattern (100), wherein modulation of the electrical stimulation pattern (100) comprises gradually increasing the pulse train amplitude (111) from one pulse train (110) to a successive pulse train (110) at stimulation onset (101) until a determined target stimulation amplitude (130) is reached; characterized in that modulation of the electrical stimulation pattern (100) further comprises decreasing the target stimulation amplitude (130) to a defined step-down amplitude (140) within each pulse train (110) after the target stimulation amplitude (130) was reached.

公开(公告)号：US20240278021A1

公开(公告)日：2024-08-22

申请号：US18651413

申请日：2024-04-30

申请人： Advanced Neuromodulation Systems, Inc.

发明人： Daran DeShazo ,  Gavin L. Rade

IPC分类号： A61N1/372 ,  A61B5/367 ,  A61N1/36 ,  A61N1/362 ,  A61N1/378 ,  A61N1/38 ,  A61N1/39 ,  A61N2/00

CPC分类号： A61N1/37235 ,  A61N1/37223 ,  A61N1/378 ,  A61B5/367 ,  A61N1/36038 ,  A61N1/36053 ,  A61N1/36062 ,  A61N1/36082 ,  A61N1/362 ,  A61N1/38 ,  A61N1/39622 ,  A61N2/006

摘要： An implantable medical device (IMO) includes one or more stimulation engines (SEs) and selectively connectable output switching circuitry for driving a plurality of output nodes associated with a respective plurality of electrodes of the IMO's lead system when implanted in a patient. The output switching circuitry may be configured to facilitate self-test mode (STM) functionality in the IMO (e.g., when it is in a hermetically sealed package) by using a dual mode switch in series with a stimulation engine selection switch with respect to each output node in the output switching circuitry under mode selection control.

公开(公告)号：US20240238519A1

公开(公告)日：2024-07-18

申请号：US18622294

申请日：2024-03-29

申请人： Medtronic, Inc.

发明人： Martin T. Gerber ,  John C. Rondoni

IPC分类号： A61M5/172 ,  A61N1/36 ,  A61N1/372 ,  G16H20/10 ,  G16H20/30 ,  G16H40/20 ,  G16H40/63 ,  G16H50/50 ,  A61M5/142

CPC分类号： A61M5/1723 ,  A61N1/36034 ,  A61N1/36185 ,  A61N1/37235 ,  A61N1/37247 ,  A61N1/37264 ,  G16H20/10 ,  G16H20/30 ,  G16H40/20 ,  G16H40/63 ,  G16H50/50 ,  A61M5/14276 ,  A61M2205/054 ,  A61M2210/0693 ,  A61N1/36003 ,  A61N1/36007 ,  A61N1/36071 ,  A61N1/36082

摘要： Techniques for modeling therapy fields for therapy delivered by medical devices are described. Each therapy field model is based on a set of therapy parameters and represents where therapy will propagate from the therapy system delivering therapy according to the set of therapy parameters. Therapy field models may be useful in guiding the modification of therapy parameters. As one example, a processor compares an algorithmic model of a therapy field to a reference therapy field and adjusts at least one therapy parameter based on the comparison. As another example, a processor adjusts at least one therapy parameter to increase an operating efficiency of the therapy system while substantially maintaining the modeled therapy field.

公开(公告)号：US12036414B2

公开(公告)日：2024-07-16

申请号：US15342167

申请日：2016-11-03

申请人： Medtronic, Inc.

发明人： William F. Kaemmerer ,  Siddharth Dani ,  Allison T. Connolly

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61N1/372

CPC分类号： A61N1/36185 ,  A61N1/0534 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36075 ,  A61N1/36096 ,  A61N1/36139 ,  A61N1/37247 ,  A61N1/37235

摘要： In one example, a method includes selecting, by one or more processors and based on a representation of sensed electrical signals for a particular patient and a plurality of representations of sensed electrical signals for a plurality of other patients, a combination of electrodes of a plurality of combinations of one or more implantable electrodes for delivery of electrical stimulation to the particular patient.

公开(公告)号：US20240226558A1

公开(公告)日：2024-07-11

申请号：US18612591

申请日：2024-03-21

申请人： Boston Scientific Neuromodulation Corporation

发明人： Que T. Doan ,  Jianwen Gu ,  Ismael Huertas Fernandez ,  Rosana Esteller ,  Michael A. Moffitt

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61N1/06 ,  A61N1/372

CPC分类号： A61N1/36062 ,  A61N1/0551 ,  A61N1/36021 ,  A61N1/36071 ,  A61N1/36185 ,  A61N1/37247 ,  A61N1/06 ,  A61N1/36132 ,  A61N1/37235 ,  A61N1/37252

摘要： Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain. Beneficially, sub-perception stimulation at such low frequencies significantly lowers power consumption in the patient's neurostimulator.

公开(公告)号：US20240173551A1

公开(公告)日：2024-05-30

申请号：US18549313

申请日：2022-03-10

申请人： The Regents of the University of California

发明人： Aydin Babakhani

IPC分类号： A61N1/36 ,  A61N1/02 ,  A61N1/372 ,  A61N1/378

CPC分类号： A61N1/36139 ,  A61N1/025 ,  A61N1/37235 ,  A61N1/37252 ,  A61N1/37288 ,  A61N1/3787

摘要： Systems and methods for wirelessly powered biomedical treatment systems with closed-loop wireless implantable treatment devices for recording and stimulation are described. In an embodiment, a treatment system, includes: at least one implantable treatment device implantable in a location with respect to a body part, where the at least one implantable treatment device includes: an energy harvesting circuit configured to harvest ambient energy, a sensing circuit configured to sense bioelectrical signals, an stimulator circuit coupled to a set of electrodes to deliver energy, and a communication circuit configured to control the stimulation delivery circuit to deliver energy via at least one electrode from the set of electrodes in response to wireless control signals received from an external controller.

公开(公告)号：US20240139527A1

公开(公告)日：2024-05-02

申请号：US18558555

申请日：2022-05-18

申请人： BIOTRONIK SE & Co. KG

发明人： Brian M. TAFF ,  Kurt SWENSON ,  Dean BERGSTROM ,  Julian MERLIN

IPC分类号： A61N1/372

CPC分类号： A61N1/37252 ,  A61N1/37235 ,  A61N1/365

摘要： The invention is directed to a communication system for a wireless message transfer between an implantable medical device (IMD) and an external device. A communication system is disclosed that effectively throttles/manages messages in a limited resource communication scheme, wherein the IMD is configured to monitor the health status of a patient and/or configured to deliver a therapy signal to the patient, wherein the IMD comprises a processor and a transceiver module configured to bi-directionally exchange the messages with the external device, wherein the processor adopts at least a predefined active state and a predefined processing state, wherein the processor of the IMD is configured to produce response messages in order to send these response messages from the transceiver module to the external device. The invention is further directed to a respective communication method, computer program product and computer readable data carrier.