公开(公告)号：US20240191209A1

公开(公告)日：2024-06-13

申请号：US18484993

申请日：2023-10-11

Applicant: Universidade do Porto - Reitoria

Inventor： Paula Maria DAS NEVES FERREIRA DA SILVA ,  Pedro Jorge Fonseca MADUREIRA

IPC: C12N9/02 ,  A01K67/0275 ,  A61K39/00 ,  A61K39/085 ,  A61K39/09 ,  A61K39/095 ,  A61K39/104 ,  A61K39/108 ,  C07K16/40

CPC classification number: C12N9/0008 ,  A01K67/0275 ,  A61K39/0258 ,  A61K39/0266 ,  A61K39/085 ,  A61K39/092 ,  A61K39/095 ,  A61K39/104 ,  C07K16/40 ,  C12Y102/01012 ,  A01K2217/00 ,  A61K2039/505 ,  A61K2039/55 ,  A61K2039/57 ,  C07K2317/76

Abstract: The invention provides peptides derived from a ubiquitous protein, and nucleic acids encoding such peptides. The invention extends to various uses of these peptides and nucleic acids, for example, as antigens for use in vaccines per se and in the generation of antibodies for use in therapeutic drugs for the prevention, amelioration or treatment of infections caused by sepsis-inducing bacteria. The invention particularly benefits immunocompromised hosts such as neonates, babies, children, women of fertile age, pregnant women, foetuses, the elderly and diabetics.

公开(公告)号：US20230226363A1

公开(公告)日：2023-07-20

申请号：US18000021

申请日：2021-06-11

Applicant: UNIVERSIDADE DO PORTO - REITORIA ,  MECHANOBIONICS LDA

Inventor： Jose Alberto PEIXOTO MACHADO DA SILVA ,  Joaquim Gabriel MAGALHAES MENDES ,  Jorge Serafim SOBRADO MARINHO

IPC: A61N1/378 ,  A61N1/36 ,  A61C8/00 ,  A61N1/05

CPC classification number: A61N1/3785 ,  A61N1/36103 ,  A61C8/0093 ,  A61N1/0556

Abstract: A sensory unit for implant-supported dental implants or prostheses. The main unit is composed of two or more subunits, or devices. One of the units is placed in the region of the implant head, and will have the function of transforming the mechanical forces into an electrical signal. It can also be placed in the masticatory region of implant supported bridges or overdenture, to perform the same function, i.e., transforming mechanical loads into an electrical signal. A second unit, will receive by a wired or wireless electronic communication the electrical signal, and will convert it into a neurological stimulus perceived sensorially by the sensory endings of the trigeminal nerve, unilaterally, or bilaterally. This second unit will be arranged in the submucosa, in the vicinity of the nerve ending, taking advantage of the anatomical depressions or recesses in the region, and will establish a gradient of neurological stimulation towards the nerve ending.

公开(公告)号：US11834684B2

公开(公告)日：2023-12-05

申请号：US17331536

申请日：2021-05-26

Applicant: Universidade do Porto—Reitoria

Inventor： Paula Maria Das Neves Ferreira Da Silva ,  Pedro Jorge Fonseca Madureira

IPC: C12N9/02 ,  A01K67/027 ,  A61K39/108 ,  A61K39/085 ,  A61K39/09 ,  A61K39/095 ,  A61K39/104 ,  C07K16/40 ,  A61K39/00

CPC classification number: C12N9/0008 ,  A01K67/0275 ,  A61K39/0258 ,  A61K39/0266 ,  A61K39/085 ,  A61K39/092 ,  A61K39/095 ,  A61K39/104 ,  C07K16/40 ,  C12Y102/01012 ,  A01K2217/00 ,  A61K2039/505 ,  A61K2039/55 ,  A61K2039/57 ,  C07K2317/76

Abstract: The invention provides peptides derived from a ubiquitous protein, and nucleic acids encoding such peptides. The invention extends to various uses of these peptides and nucleic acids, for example, as antigens for use in vaccines per se and in the generation of antibodies for use in therapeutic drugs for the prevention, amelioration or treatment of infections caused by sepsis-inducing bacteria. The invention particularly benefits immunocompromised hosts such as neonates, babies, children, women of fertile age, pregnant women, foetuses, the elderly and diabetics.

公开(公告)号：US11066652B2

公开(公告)日：2021-07-20

申请号：US15313327

申请日：2015-06-12

Applicant: UNIVERSIDADE DO PORTO—REITORIA

Inventor： Paula Maria Das Neves Ferreira Da Silva ,  Pedro Jorge Fonseca Madureira

IPC: C12N9/02 ,  A01K67/027 ,  A61K39/108 ,  A61K39/085 ,  A61K39/09 ,  A61K39/095 ,  A61K39/104 ,  C07K16/40 ,  A61K39/00

Abstract: The invention provides peptides derived from a ubiquitous protein, and nucleic acids encoding such peptides. The invention extends to various uses of these peptides and nucleic acids, for example, as antigens for use in vaccines per se and in the generation of antibodies for use in therapeutic drugs for the prevention, amelioration or treatment of infections caused by sepsis-inducing bacteria. The invention particularly benefits immunocompromised hosts such as neonates, babies, children, women of fertile age, pregnant women, foetuses, the elderly and diabetics.

公开(公告)号：US20170191040A1

公开(公告)日：2017-07-06

申请号：US15313327

申请日：2015-06-12

Applicant: UNIVERSIDADE DO PORTO - REITORIA

Inventor： Paula Maria DAS NEVES FERREIRA DA SILVA ,  Pedro Jorge Fonseca MADUREIRA

IPC: C12N9/02 ,  C07K16/40 ,  A61K39/095 ,  A61K39/108 ,  A61K39/085 ,  A61K39/104 ,  A01K67/027 ,  A61K39/09

CPC classification number: C12N9/0008 ,  A01K67/0275 ,  A01K2217/00 ,  A61K39/0258 ,  A61K39/0266 ,  A61K39/085 ,  A61K39/092 ,  A61K39/095 ,  A61K39/104 ,  A61K2039/505 ,  A61K2039/55 ,  A61K2039/57 ,  C07K16/40 ,  C07K2317/76 ,  C12Y102/01012

Abstract: The invention provides peptides derived from a ubiquitous protein, and nucleic acids encoding such peptides. The invention extends to various uses of these peptides and nucleic acids, for example, as antigens for use in vaccines per se and in the generation of antibodies for use in therapeutic drugs for the prevention, amelioration or treatment of infections caused by sepsis-inducing bacteria. The invention particularly benefits immunocompromised hosts such as neonates, babies, children, women of fertile age, pregnant women, foetuses, the elderly and diabetics.