公开(公告)号：US12233103B2

公开(公告)日：2025-02-25

申请号：US18298263

申请日：2023-04-10

Applicant: IO BIOTECH APS

Inventor： Mads Hald Andersen ,  Per Thor Straten

IPC: A61K38/20 ,  A61K38/19 ,  A61K39/00 ,  A61K45/06 ,  C12N9/02

Abstract: The invention relates to the field of prophylaxis and therapy of cancer. Provided is a Indoleamine 2,3-dioxygenase (IDO) or peptide fragments hereof that are capable of eliciting anti-cancer immune responses. Specifically, the invention relates to the use of IDO or peptides derived herefrom or IDO specific T-cells for treatment of cancer. The invention thus relates to an anti-cancer vaccine which optionally may be used in combination with other immunotherapies and to IDO specific T-cells adoptively transferred or induced in vivo by vaccination as a treatment of cancer. The invention also provides that the medicaments herein provided may be used in combination with cancer chemotherapy treatment. The invention further provides the prophylaxis and therapy of infections by the same means as described above. The use of IDO and immunogenic peptide fragments hereof in cancer and infection treatment, diagnosis and prognosis is also provided.

公开(公告)号：US12221641B2

公开(公告)日：2025-02-11

申请号：US17285888

申请日：2019-10-14

Applicant: AMYRIS, INC.

Inventor： Gale A. Wichmann ,  Wenzong Li ,  Sean Lund ,  Shaina J. Jackson ,  Chantal V. Garcia De Gonzalo ,  Hailley Warbington ,  Yi Xiong ,  Svetlana Alekseyevna Borisova

IPC: C12P19/56 ,  C12N1/18 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12R1/865

Abstract: Provided herein are compositions and methods for improved production of steviol glycosides in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding a Stevia rebaudiana kaurenoic acid hydroxylase. In some embodiments, the host cell further comprises one or more heterologous nucleotide sequence encoding further enzymes of a pathway capable of producing one or more steviol glycosides in the host cell. The compositions and methods described herein provide an efficient route for the heterologous production of steviol glycosides, including but not limited to, rebaudioside D and rebaudioside M.

公开(公告)号：US20250043234A1

公开(公告)日：2025-02-06

申请号：US18250594

申请日：2021-10-28

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER

Inventor： Iftach YACOBY ,  Tamar ELMAN ,  Oren BEN ZVI ,  Chris Philip SCHWIER ,  Thi Thu Hoai HO ,  Michael HIPPLER

IPC: C12N1/12 ,  C12N9/02 ,  C12P3/00 ,  C12R1/89

Abstract: The present invention is in the field of molecular hydrogen (H2) bio-production, particularly, the present invention provides genetically modified photosynthetic microalgae producing hydrogen in complete growth medium under ambient, continuous growth conditions at cost-effective amounts and to a process for hydrogen production using genetically modified photosynthetic microalga.

公开(公告)号：US12216122B2

公开(公告)日：2025-02-04

申请号：US16879611

申请日：2020-05-20

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Heather Dawn Agnew ,  Bert Tsunyin Lai ,  Anders Eliasen

IPC: G01N33/573 ,  C07K1/06 ,  C07K5/08 ,  C07K5/10 ,  C07K7/06 ,  C12N9/02 ,  G01N33/68 ,  G01N33/534

Abstract: The present application provides stable heterobiligands made up of peptide-based IDO1 ligands and small molecule inhibitors of IDO1 and methods of use of the heterobiligands as detection, imaging, diagnostic, and therapeutic agents. The application further provides methods of manufacturing IDO1 heterobiligands, capture agents, and imaging agents.

公开(公告)号：US12215375B2

公开(公告)日：2025-02-04

申请号：US17332459

申请日：2021-05-27

Applicant: Promega Corporation

Inventor： Brock Binkowski ,  Lance P. Encell ,  Mary Hall ,  Matthew B. Robers ,  Michael R. Slater ,  Keith V. Wood ,  Monika G. Wood

IPC: C12N9/02 ,  C07D487/04 ,  C12N15/52 ,  C12Q1/66

Abstract: An isolated polynucleotide encoding a modified luciferase polypeptide and substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one amino acid substitution at a position corresponding to an amino acid in SEQ ID NO: 1. The OgLuc variant polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the corresponding polypeptide of the wild-type Oplophorus luciferase.

公开(公告)号：US20250034599A1

公开(公告)日：2025-01-30

申请号：US18745084

申请日：2024-06-17

Applicant: Wisconsin Alumni Research Foundation

Inventor： Chris Todd Hittinger ,  Trey Sato ,  Sae-Byuk Lee

IPC: C12P7/10 ,  C10L1/02 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/92

Abstract: An engineered yeast strain capable of efficient fermentation of xylose to ethanol, and methods of making and using the strain, are provided

公开(公告)号：US12209258B2

公开(公告)日：2025-01-28

申请号：US17434436

申请日：2019-04-17

Applicant: ASYMCHEM LIFE SCIENCE (TIANJIN) CO., LTD.

Inventor： Hao Hong ,  Gage James ,  Jiangping Lu ,  Na Zhang ,  Yulei Ma ,  Yibing Cheng ,  Huiyan Mu

IPC: C12N9/02 ,  C12N1/20 ,  C12N15/00 ,  C12N15/70 ,  C12N15/81 ,  C12P7/26 ,  C12P17/18

Abstract: Disclosed are a monooxygenase mutant and use thereof. An amino acid sequence of a monooxygenase mutant is an amino acid sequence obtained by mutating an amino acid sequence as shown in SEQ ID NO: 1. Mutation includes at least one of the following mutation sites: site 49, site 60, site 61, site 144, site 145, site 146, site 147, site 167, site 169, site 189, site 246, site 247, site 280, site 284, site 285, site 286, site 287, site 328, site 330, site 332, site 382, site 427, site 428, site 429, site 430, site 431, site 432, site 433, site 434, site 435, site 436, site 438, site 441, site 493, site 494, site 508, site 509, site 510, site 511, site 512, and site 513 sites and the like.

公开(公告)号：US12209245B2

公开(公告)日：2025-01-28

申请号：US16671036

申请日：2019-10-31

Applicant: The Regents of the University of California

Inventor： Ethan Mirsky ,  Karsten Temme ,  Christopher A. Voigt ,  Dehua Zhao

IPC: C12N15/63 ,  C07K14/255 ,  C07K14/26 ,  C12N9/02 ,  C12N15/52 ,  C12N15/67 ,  C12N15/74 ,  G16B25/00 ,  G16B30/00 ,  G16B30/10 ,  G16B30/20

Abstract: Methods for making synthetic gene clusters are described.

公开(公告)号：US12209236B2

公开(公告)日：2025-01-28

申请号：US17058612

申请日：2019-05-24

Applicant: DANISCO US INC.

Inventor： Celia Emily Gaby Payen

IPC: C12N1/16 ,  C12N9/02 ,  C12N15/52 ,  C12P1/02 ,  C12P7/06

Abstract: Described are compositions and methods relating to modified yeast that overexpress fumarate reductase. The yeast cells have an increased fermentation rate compared to their parental cells. Such yeast cells ae particularly useful for large-scale ethanol production from starch substrates where an increased rate of ethanol production is desirable.

公开(公告)号：US20250027127A1

公开(公告)日：2025-01-23

申请号：US18692695

申请日：2022-09-15

Applicant: The Regents of the University of California

Inventor： Trevor N. Purdy ,  Bradley S. Moore

IPC: C12P17/10 ,  C12N9/02 ,  C12P7/42

Abstract: The disclosure relates to a method of making at least one cannabinoid comprising contacting at least one berberine bridge enzyme like (BBE-like) oxidase with at least one substrate, wherein the substrate comprises a cannabinoid precursor. The cannabinoid precursor can include cannabigerolic acid dihydrotetrachlorizine, prechlorizidine, cannabigerorcinic acid, grifolic acid, or a combination thereof.