公开(公告)号：US20240279695A1

公开(公告)日：2024-08-22

申请号：US17298464

申请日：2019-12-03

Applicant: The Regents of the University of California

Inventor： Bradley S. Moore ,  Jonathan R. Chekan ,  Shaun M. K. McKinnie

IPC: C12P17/18 ,  C12N9/02 ,  C12N9/10

CPC classification number: C12P17/188 ,  C12N9/0071 ,  C12N9/1085 ,  C12Y114/11 ,  C12Y205/01

Abstract: Provided herein are compounds of Formulas (la), (lb), (II) to (VIII), and salts thereof, and methods of making the same. Also provided herein are recombinant proteins useful in the production of compounds disclosed herein, polynucleotides encoding the same, and cells comprising the same.

公开(公告)号：US20250027127A1

公开(公告)日：2025-01-23

申请号：US18692695

申请日：2022-09-15

Applicant: The Regents of the University of California

Inventor： Trevor N. Purdy ,  Bradley S. Moore

IPC: C12P17/10 ,  C12N9/02 ,  C12P7/42

Abstract: The disclosure relates to a method of making at least one cannabinoid comprising contacting at least one berberine bridge enzyme like (BBE-like) oxidase with at least one substrate, wherein the substrate comprises a cannabinoid precursor. The cannabinoid precursor can include cannabigerolic acid dihydrotetrachlorizine, prechlorizidine, cannabigerorcinic acid, grifolic acid, or a combination thereof.