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公开(公告)号：US11865342B2
公开(公告)日：2024-01-09
申请号：US17890327
申请日：2022-08-18
CPC分类号： A61N1/36071 , A61N1/048 , A61N1/0456 , A61N1/0556 , A61N1/20
摘要： Slurry electrodes can deliver direct current (DC) nerve conduction block to neural tissue. Such slurry electrodes can include an ionically conductive membrane having a first side and a second side. Slurry electrodes can also include a mechanism that is configured to encapsulate a slurry against the first side of the ionically conductive membrane. The slurry can include an ionically conductive material and a plurality of electrically conducting high surface area particles. The mechanism and the first side of the ionically conductive membrane make up a housing for the slurry. Slurry electrodes can also include a connector configured to establish an electrical connection between the slurry and the DC generator.
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公开(公告)号：US11628299B2
公开(公告)日：2023-04-18
申请号：US16341511
申请日：2017-10-17
发明人： Tina Vrabec , Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore
摘要： The present disclosure relates to subcutaneous direct current (DC) nerve conduction block. A subcutaneous electrode can be implanted under a subject's skin between the subject's skin and a neural structure within the subject's body. The subcutaneous electrode can be coupled to a current generator. A DC can be configured by the current generator and delivered through the subcutaneous electrode to block conduction in the neural structure. The subcutaneous electrode eliminates an effect of an impedance of the subject's skin on the DC. The DC can be returned to the current generator by a return electrode.
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公开(公告)号：US11191974B2
公开(公告)日：2021-12-07
申请号：US16614951
申请日：2018-05-24
摘要： A capacity-expanding separated interface nerve electrode (SINE) can be used to deliver a nerve conduction block to one or more nerves. The SINE can include a source electrode coupled to a waveform generator. The source electrode can deliver an electrical neuromodulation signal (e.g., a direct current (DC) signal) to an ionically conductive medium. The SINE can also include a vessel holding the ionically conductive medium, which can include a material that facilitates a transformation of the electrical neuromodulation signal to an ionic neuromodulation signal with a high charge capacity. The SINE can also include a nerve interface that can deliver the ionic neuromodulation signal to a nerve. The SINE can be used in combination with a return electrode that is also coupled to the waveform generator.
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公开(公告)号：US20200001073A1
公开(公告)日：2020-01-02
申请号：US16565841
申请日：2019-09-10
发明人： Niloy Bhadra , Kevin L. Kilgore , Narendra Bhadra , Jesse Wainright , Tina Vrabec , Manfred Franke
摘要： Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.
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公开(公告)号：US20180085587A1
公开(公告)日：2018-03-29
申请号：US15827076
申请日：2017-11-30
发明人： Kevin L. Kilgore , Niloy Bhadra
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/20 , A61N1/205 , A61N1/32 , A61N1/36057 , A61N1/36067 , A61N1/36071 , A61N1/36103 , A61N1/3615 , A61N1/36167
摘要： A method of blocking signal transmission through a nerve with reduced onset activity includes applying an HFAC to an axon of a nerve to block the transmission of signals through the axon. The method may also include applying a direct current (DC) to the axon, increasing the amplitude of the DC over time to a predetermined amplitude, applying the HFAC, and then decreasing the DC. The method may also include temporarily reducing the amplitude of the HFAC to permit the transmission of signals through the axon and subsequently increasing the amplitude to block transmission without triggering an onset response. The method may also include temporarily applying an unbalanced charge to the nerve and then balancing the charge over time.
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6.发明授权Therapy delivery devices and methods for non-damaging neural tissue conduction block 有权治疗传递装置和方法用于非破坏性神经组织传导阻滞公开(公告)号：US09387322B2
公开(公告)日：2016-07-12
申请号：US14408017
申请日：2013-06-14
发明人： Niloy Bhadra , Kevin L. Kilgore , Narendra Bhadra , Jesse Wainright , Tina Vrabec , Manfred Franke
CPC分类号： A61N1/0556 , A61N1/06 , A61N1/20 , A61N1/36064 , A61N1/36067 , A61N1/36071
摘要： Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.
摘要翻译： 通过神经组织阻断信号传导的装置和方法。 方法的一个步骤包括将治疗递送装置放置成与神经组织电连通。 治疗递送装置包括具有高电荷容量材料的电极接触。 可以将多相直流（DC）应用于神经组织而不损伤神经组织。 多相DC包括阴极DC相和阳极DC相，其共同产生神经阻滞并减少由治疗递送装置递送的电荷。 DC输送可以与高频交流（HFAC）模块组合，以产生提供有效，安全，长期阻挡的系统，而不会引发发作响应。
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公开(公告)号：US20240082571A1
公开(公告)日：2024-03-14
申请号：US18514470
申请日：2023-11-20
发明人： Tina L. Vrabec , Kevin L. Kilgore , Niloy Bhadra , Laura Shaw , David Roberts , Narendra Bhadra
CPC分类号： A61N1/0551 , A61N1/20 , A61N1/36067 , A61N1/36103
摘要： Systems and methods that deliver a continuous partial nerve conduction block are described. A waveform generator can configure one or more direct current (DC) waveforms to provide a continuous partial nerve conduction block. One or more electrodes can deliver the one or more DC waveforms to provide the partial block to the neural structure. Feedback can be provided to the waveform generator related to the partial block. The feedback includes monitoring a property associated with the partial block and altering a parameter associated with the one or more direct current waveforms in response to the property associated with the partial block.
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公开(公告)号：US20230086695A1
公开(公告)日：2023-03-23
申请号：US17991045
申请日：2022-11-21
发明人： Niloy Bhadra , Kevin L. Kilgore , Narendra Bhadra , Jesse Wainright , Tina Vrabec , Manfred Franke
摘要： Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.
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公开(公告)号：US20200001078A1
公开(公告)日：2020-01-02
申请号：US16341511
申请日：2017-10-17
发明人： Tina Vrabec , Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore
摘要： The present disclosure relates to subcutaneous direct current (DC) nerve conduction block. A subcutaneous electrode can be implanted under a subject's skin between the subject's skin and a neural structure within the subject's body. The subcutaneous electrode can be coupled to a current generator. A DC can be configured by the current generator and delivered through the subcutaneous electrode to block conduction in the neural structure. The subcutaneous electrode eliminates an effect of an impedance of the subject's skin on the DC. The DC can be returned to the current generator by a return electrode.
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公开(公告)号：US10441782B2
公开(公告)日：2019-10-15
申请号：US16106092
申请日：2018-08-21
发明人： Niloy Bhadra , Kevin L. Kilgore , Narendra Bhadra , Jesse Wainright , Tina Vrabec , Manfred Franke
摘要： Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.
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