公开(公告)号：US12128236B2

公开(公告)日：2024-10-29

申请号：US18179845

申请日：2023-03-07

申请人： Boston Scientific Neuromodulation Corporation

发明人： Bradley L. Hershey ,  Changfang Zhu

IPC分类号： A61N1/36 ,  A61B5/24 ,  A61N1/00 ,  A61B5/00

CPC分类号： A61N1/36139 ,  A61B5/24 ,  A61N1/00 ,  A61N1/36017 ,  A61N1/36021 ,  A61N1/3605 ,  A61N1/36071 ,  A61N1/36128 ,  A61B5/40 ,  A61N1/36125

摘要： An Implantable Pulse Generator (IPG) is disclosed that is capable of sensing a degree to which recruited neurons in a patient's tissue are firing synchronously, and of modifying a stimulation program to promote desynchronicity and to reduce paresthesia. An evoked compound action potential (ECAP) of the recruited neurons is sensed as a measure of synchronicity by at least one non-active electrode. An ECAP algorithm operable in the IPG assesses the shape of the ECAP and determines one or more ECAP shape parameters that indicate whether the recruited neurons are firing synchronously or desynchronously. If the shape parameters indicate significant synchronicity, the ECAP algorithm can adjust the stimulation program to promote desynchronous firing.

公开(公告)号：US20240315627A1

公开(公告)日：2024-09-26

申请号：US18731532

申请日：2024-06-03

申请人： Medtronic Xomed, Inc.

发明人： Matthew L. Cantwell ,  Wenjeng Li ,  Kevin L. McFarlin ,  Anirudhan Narasimhan

IPC分类号： A61B5/24 ,  A61B5/00 ,  A61B5/389 ,  A61B5/394 ,  A61B18/00 ,  A61B18/14 ,  A61N1/00 ,  A61N1/36

CPC分类号： A61B5/24 ,  A61B5/389 ,  A61B5/394 ,  A61B5/4035 ,  A61B5/4041 ,  A61B5/6847 ,  A61B5/7475 ,  A61N1/00 ,  A61N1/36017 ,  A61B5/4893 ,  A61B5/6852 ,  A61B2018/0066 ,  A61B2018/00839 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/0094 ,  A61B18/1442 ,  A61B2018/1452 ,  A61B2018/146 ,  A61B2562/225

摘要： A monitoring system may include a processor and display system for displaying results from the monitoring. A user may be in a sterile field away from the processor and display system and selected input devices. A controller may be physically connected to the monitoring system from the sterile field to allow the user to control the monitoring system.

公开(公告)号：US12083342B2

公开(公告)日：2024-09-10

申请号：US17883332

申请日：2022-08-08

申请人： Galvani Bioelectronics Limited ,  Case Western Reserve University

发明人： Alessandra Giarola ,  Yee-Hsee Hsieh ,  Stephen J. Lewis ,  Arun Sridhar

IPC分类号： A61N1/36 ,  A61B5/00 ,  A61B5/08 ,  A61N1/00 ,  A61N1/05 ,  A61N1/18

CPC分类号： A61N1/3611 ,  A61B5/0826 ,  A61B5/4818 ,  A61N1/00 ,  A61N1/0556 ,  A61N1/18 ,  A61N1/36

摘要： This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.

公开(公告)号：US12070603B2

公开(公告)日：2024-08-27

申请号：US17650492

申请日：2022-02-09

申请人： Boston Scientific Neuromodulation Corporation

发明人： G. Karl Steinke ,  Hemant Bokil ,  Joseph Costello

IPC分类号： A61N1/00 ,  A61N1/05 ,  A61N1/36

CPC分类号： A61N1/36125 ,  A61N1/0553 ,  A61N1/3614 ,  A61N1/36185

摘要： Methods and systems for using sensed evoked neural responses for informing aspects of neurostimulation therapy are disclosed. Electrical signals may be recorded during the provision of electrical stimulation to a patient's neural tissue. The electrical signals may be processed and analyzed using one or more classification criteria to determine if the electrical signals contain a neural response of interest. Examples of such neural responses include evoked neural responses that are oscillatory and/or resonant in nature. If the electrical signals include such responses of interest, one or more features may be extracted from the signals and used as biomarkers for informing aspects of neurostimulation therapy, such as directing lead placement, optimizing stimulation parameters, closed-loop feedback control of stimulation, and the like. Various methods and systems described herein are particularly relevant in the context of multi-site stimulation paradigms, such as coordinated reset neuromodulation.

公开(公告)号：US12005256B2

公开(公告)日：2024-06-11

申请号：US18218951

申请日：2023-07-06

申请人： Boston Scientific Neuromodulation Corporation

发明人： James R. Kozloski ,  Anup Kalia ,  Jeffrey Rogers ,  Sara E. Berger

IPC分类号： A61N1/00 ,  A61N1/02 ,  A61N1/36 ,  G16H20/40

CPC分类号： A61N1/36132 ,  A61N1/025 ,  A61N1/36071 ,  A61N1/36135 ,  A61N1/36175 ,  A61N1/36189 ,  G16H20/40

摘要： Systems and techniques are disclosed to establish programming of an implantable electrical neurostimulation device for treating pain of a human subject, through the use and adjustment of analgesic stimulation parameters based on trust dynamics and trust measurements. In an example, the system to establish programming of the neurostimulation device performs operations that: determine a trust measurement value that is derived from results of at least one commitment made with a human subject, via observable interactions; determine a modification of at least one neurostimulation programming parameter, based on the trust measurement value; and to cause the implantable neurostimulation device to implement the modification of the at least one neurostimulation programming parameter. Further examples are provided to produce and track the trust measurement value, as well as identify a pain susceptibility value and determine a receptiveness to analgesic effects based on these and other trust dynamics.

公开(公告)号：US11998751B2

公开(公告)日：2024-06-04

申请号：US17110904

申请日：2020-12-03

申请人： SORIN CRM SAS

发明人： Elodie Marie ,  Luca Vitali

IPC分类号： A61B5/00 ,  A61B5/287 ,  A61B5/29 ,  A61B5/318 ,  A61N1/00 ,  A61N1/37

CPC分类号： A61N1/3712 ,  A61B5/287 ,  A61B5/29 ,  A61B5/318

摘要： A method for processing a cardiac signal represented as a function of time includes providing a number n of different threshold levels Ni, with i=1 to n and n being greater than or equal to three; detecting, from a given time T and per threshold level Ni, at least two successive intersections of the cardiac signal with the threshold level Ni, considering a crossing per increasing and/or decreasing value of the cardiac signal with the threshold level Ni; and determining at least one statistical parameter for the cardiac signal from the intersections of the cardiac signal with the at least three different threshold levels Ni. The method may be implemented by a subcutaneous active implantable medical device having a control circuit configured to process a cardiac signal.

公开(公告)号：US11944833B2

公开(公告)日：2024-04-02

申请号：US17078507

申请日：2020-10-23

申请人： Medtronic, Inc.

发明人： Andrew Fried ,  Janet Creaser ,  Prathyusha Marri ,  Charles Nowell ,  Robert Schulzetenberg

IPC分类号： A61N1/00 ,  A61N1/08 ,  A61N1/36 ,  A61N1/372 ,  A61N1/378

CPC分类号： A61N1/3787 ,  A61N1/08 ,  A61N1/36128 ,  A61N1/37247

摘要： Systems and methods for improved user experience with rechargers for implantable medical devices. An external charging device for providing power to a rechargeable implantable device can determine a firmware state of the external charging device during recharging of the rechargeable implantable device, display a searching indication using a light indicator when the firmware state is determined to be in a searching state, display a charging indication using the light indicator when the firmware state is determined to be a charging state, and display an error indication using the light indicator when the firmware state is determined to be an error state. An optional user device application can provide complementary graphical user interfaces according to the firmware states.

公开(公告)号：US11931566B1

公开(公告)日：2024-03-19

申请号：US18484999

申请日：2023-10-11

申请人： ENERGY MINING Co., Ltd.

发明人： Hyun Moon Park ,  Young Min Cho ,  Jang Mook Jeong

IPC分类号： A61N1/00 ,  A61N1/05 ,  A61N1/375

CPC分类号： A61N1/0558 ,  A61N1/3754

摘要： The present invention relates to an implantable nerve stimulation device, which includes: a body part which is formed of a metal that ultrasonic waves can be transmitted, and includes a stimulation surface and a charging surface facing each other; a header part which is made of a non-metal and is located at one end of the body part; a cover which includes a stimulation electrode, a hinge part rotatably coupled to one side of the stimulation surface, and a coupling part detachably coupled to the other side of the stimulation surface, is positioned above the stimulation surface to interpose a nerve between the electrode and the stimulation surface; and power generation elements which are located inside the body part and are electrically connected to the electrode.

公开(公告)号：US20240065621A1

公开(公告)日：2024-02-29

申请号：US18499080

申请日：2023-10-31

申请人： ZIPLINE MEDICAL, INC.

发明人： Amir Belson ,  Edward C. Driscoll, JR. ,  Eric Storne ,  Alan Schaer

IPC分类号： A61B5/00 ,  A61B5/01 ,  A61B5/11 ,  A61B5/145 ,  A61B17/08 ,  A61F7/00 ,  A61H23/00 ,  A61H23/02 ,  A61M31/00 ,  A61N1/00 ,  A61N5/06 ,  A61N7/00

CPC分类号： A61B5/4848 ,  A61B5/0015 ,  A61B5/01 ,  A61B5/1118 ,  A61B5/1121 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/6832 ,  A61B5/746 ,  A61B17/08 ,  A61B17/085 ,  A61F7/007 ,  A61H23/00 ,  A61H23/02 ,  A61H23/0245 ,  A61M31/002 ,  A61N1/00 ,  A61N5/0616 ,  A61N5/0624 ,  A61N7/00 ,  A61B2017/00022

摘要： A wound or incision closure apparatus comprises a first and second panel. Each of the panels comprises a bottom adhesive layer, a medial substrate layer, and an upper load distribution layer which connect the two panels. A sensory or therapeutic element is disposed adjacent, within, or between two or more of the layers. The sensory or therapeutic element can provide sensing and/or therapy for the incision and/or monitor the incision so that the therapy can be customized and updated.

公开(公告)号：US11872389B2

公开(公告)日：2024-01-16

申请号：US17058611

申请日：2019-12-13

申请人： BARUN GONGHAK CO., LTD.

发明人： Jinkee Hong ,  Sangmin Lee

IPC分类号： A61N1/00 ,  A61N1/04 ,  A61N1/40

CPC分类号： A61N1/0468 ,  A61N1/0492 ,  A61N1/40

摘要： The present invention relates to a stimulation apparatus for applying electrical stimulation to a subject for stimulation application. Specifically, a stimulation apparatus according to the present invention comprises: a stimulation part comprising a first conductive member and a first surface which comes into contact with a subject for stimulation application and to which an alternating electric field transmitted from the subject for stimulation application upon contact is input; a conductive part comprising a second conductive member and positioned away from the stimulation part; and a connecting member for electrically connecting the stimulation part and conductive part.