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1.发明公开公开(公告)号：US20240033514A1
公开(公告)日：2024-02-01
申请号：US18482926
申请日：2023-10-09
Applicant: Case Western Reserve University
Inventor： Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore , Scott Lempka , Jesse Wainright , Tina Vrabec , Manfred Franke
IPC: A61N1/36
CPC classification number: A61N1/36071 , A61N1/36057 , A61N1/36021 , A61N1/36175 , A61N1/0551
Abstract: One aspect of the present disclosure is a system including a waveform generator, a controller, and an electrical contact. The waveform generator is for generating an electrical nerve conduction block (ENCB). The controller is coupled with the waveform generator. The controller is configured to receive an input comprising at least one parameter to adjust the ENCB. The electrical contact is coupled with the waveform generator. The electrical contact is configured to be placed into contact with a nerve. The electrical contact comprises a high charge capacity material that prevents formation of damaging electro-chemical products at a charge delivered by the ENCB. The electrical contact is configured to deliver the ENCB to the nerve to block transmission of a signal related to a pain through the nerve.
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公开(公告)号：US11318300B2
公开(公告)日：2022-05-03
申请号：US16347671
申请日：2017-11-03
Applicant: Case Western Reserve University
Inventor： Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore , Scott Lempka , Tina Vrabec , Manfred Franke
Abstract: Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.
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公开(公告)号：US20210275802A1
公开(公告)日：2021-09-09
申请号：US17319180
申请日：2021-05-13
Applicant: Case Western Reserve University
Inventor： Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore , Scott Lempka , Jesse Wainright , Tina Vrabec , Manfred Franke
Abstract: Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.
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公开(公告)号：US09694181B2
公开(公告)日：2017-07-04
申请号：US14969826
申请日：2015-12-15
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore , Scott Lempka , Jesse Wainright , Tina Vrabec , Manfred Franke
CPC classification number: A61N1/36071 , A61N1/0551 , A61N1/06 , A61N1/20 , A61N1/36057 , A61N1/36067 , A61N1/36103 , A61N1/3615 , A61N1/36171 , A61N1/37247
Abstract: Described herein are methods of treating various neurological disorders using electrical nerve conduction block (ENCB) without causing electrochemical damage. Examples of the various neurological disorders can include pain, muscle spasticity, hyperhidrosis, vertigo, sialorrhea, or the like. The methods can include placing an electrode contact in electrical communication with a nerve that transmits a signal related to the neurological disorder. The method also includes applying an ENCB to the nerve through the electrode contact. The electrode contact can include a high charge capacity material that prevents formation of damaging electrochemical reaction products at a charge delivered by the ENCB. The method also includes blocking transmission of the signal related to the neurological disorder through the nerve with the ENCB to treat the neurological disorder.
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公开(公告)号：US11033734B2
公开(公告)日：2021-06-15
申请号：US16266236
申请日：2019-02-04
Applicant: Case Western Reserve University
Inventor： Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore , Scott Lempka , Jesse Wainright , Tina Vrabec , Manfred Franke
Abstract: Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.
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Patent Agency Ranking
公开(公告)号：US10195434B2
公开(公告)日：2019-02-05
申请号：US15344959
申请日：2016-11-07
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore , Scott Lempka , Jesse Wainright , Tina Vrabec , Manfred Franke
Abstract: Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.
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公开(公告)号：US20170050024A1
公开(公告)日：2017-02-23
申请号：US15344959
申请日：2016-11-07
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore , Scott Lempka , Jesse Wainright , Tina Vrabec , Manfred Franke
CPC classification number: A61N1/36071 , A61N1/0456 , A61N1/0551 , A61N1/0556 , A61N1/06 , A61N1/20 , A61N1/205 , A61N1/36017 , A61N1/36021 , A61N1/36062 , A61N1/36125 , A61N1/3615 , A61N1/36171
Abstract: Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.
Abstract translation: 本文描述了使用电神经传导阻滞（ENCB）治疗疼痛的系统和方法。 与其他疼痛治疗方法相反，ENCB可建立直接阻断神经活动，从而消除疼痛。 另外，ENCB可以在不引起电化学损伤的情况下进行施用。 示例性方法可以包括：将至少一个电极接触件放置在与受试者的脊髓区域电连通中; 通过所述至少一个电极接触将电神经传导阻滞（ENCB）施加到所述区域中的神经; 并用ENCB阻断神经活动，以减少受试者的疼痛或其他不希望的感觉。
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公开(公告)号：US11291832B2
公开(公告)日：2022-04-05
申请号：US16397141
申请日：2019-04-29
Applicant: Case Western Reserve University
Inventor： Cameron McIntyre , Nicholas Maling , Scott Lempka
Abstract: Embodiments discussed herein facilitate identification of a target area within a region of a brain for stimulation via one or more BS (Brain Stimulation) electrodes. One example embodiment comprises generating, based on radiological imaging of a region of a brain of a patient and BS electrode lead(s), a patient-specific anatomical model of the region and lead(s); populating the patient-specific anatomical model with neuron models based on associated neuronal densities of at least one of the region or one or more sub-regions of the region; constructing a patient-specific local field potential (LFP) model of the region based on the patient-specific anatomical model and location(s)/orientation(s) of the one or more BS electrode leads; and identifying, via the patient-specific LFP model of the region, a target area within the region for at least one of monitoring or treatment of a medical condition via the one or more BS electrode leads.
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公开(公告)号：US20200001071A1
公开(公告)日：2020-01-02
申请号：US16397141
申请日：2019-04-29
Applicant: Case Western Reserve University
Inventor： Cameron McIntyre , Nicholas Maling , Scott Lempka
Abstract: Embodiments discussed herein facilitate identification of a target area within a region of a brain for stimulation via one or more BS (Brain Stimulation) electrodes. One example embodiment comprises generating, based on radiological imaging of a region of a brain of a patient and BS electrode lead(s), a patient-specific anatomical model of the region and lead(s); populating the patient-specific anatomical model with neuron models based on associated neuronal densities of at least one of the region or one or more sub-regions of the region; constructing a patient-specific local field potential (LFP) model of the region based on the patient-specific anatomical model and location(s)/orientation(s) of the one or more BS electrode leads; and identifying, via the patient-specific LFP model of the region, a target area within the region for at least one of monitoring or treatment of a medical condition via the one or more BS electrode leads.
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公开(公告)号：US20190269921A1
公开(公告)日：2019-09-05
申请号：US16347671
申请日：2017-11-03
Applicant: Case Western Reserve University
Inventor： Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore , Scott Lempka , Tina Vrabec , Manfred Franke
Abstract: Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.
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