公开(公告)号：US12109305B2

公开(公告)日：2024-10-08

申请号：US16303118

申请日：2017-05-26

申请人： Lyndra Therapeutics, Inc.

发明人： Andrew Bellinger ,  Rosemary Kanasty ,  Tyler Grant ,  Nupura Bhise ,  Robert Debenedictis ,  Jung Yang ,  Stephen Zale ,  John Klier

IPC分类号： A61K9/00 ,  A61F5/00 ,  A61K47/34 ,  A61L31/04 ,  A61L31/06 ,  A61L31/16

CPC分类号： A61K9/0065 ,  A61F5/0036 ,  A61K47/34 ,  A61L31/06 ,  A61L31/16 ,  A61L31/048 ,  A61L2300/602 ,  A61L2300/604 ,  A61L31/06 ,  C08L67/04 ,  A61L31/048 ,  C08L29/04

摘要： The invention provides gastric residence systems with specifically tailored architectures and methods for making such systems. The components of the gastric residence systems can be manufactured by three-dimensional printing or by co-extrusion. The ability to construct precise architectures for the systems provides excellent control over drug release, in vivo stability, and residence time of the systems.

公开(公告)号：US20240016976A1

公开(公告)日：2024-01-18

申请号：US18462292

申请日：2023-09-06

申请人： Zetagen Therapeutics, Inc.

发明人： Bryan S. Margulies ,  Nikhil A. Thakur

IPC分类号： A61L27/12 ,  A61L27/54 ,  A61K31/485 ,  A61L27/04 ,  A61L27/24

CPC分类号： A61L27/12 ,  A61L27/54 ,  A61K31/485 ,  A61L27/042 ,  A61L27/24 ,  A61L2300/602 ,  A61L2300/204 ,  A61K2300/00 ,  A61L2300/802 ,  A61L2430/38 ,  A61L2430/02

摘要： A bone graft composition comprising a calcium phosphate putty is provided. A method of repairing a bone defect in a patient by applying the bone graft composition is also provided.

公开(公告)号：US11850333B2

公开(公告)日：2023-12-26

申请号：US17243769

申请日：2021-04-29

申请人： MT Acquisition Holdings LLC

发明人： James P. DeYoung ,  Charles Douglas Taylor ,  James B. McClain ,  Clint Smoke ,  Mike Cole

IPC分类号： A61L31/16 ,  A61L31/10 ,  A61L31/14 ,  A61F2/90 ,  A61L31/06

CPC分类号： A61L31/16 ,  A61F2/90 ,  A61L31/06 ,  A61L31/10 ,  A61L31/148 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L2300/20 ,  A61L2300/216 ,  A61L2300/236 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/426 ,  A61L2300/602 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2420/08

摘要： A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.

公开(公告)号：US20230338626A1

公开(公告)日：2023-10-26

申请号：US18347181

申请日：2023-07-05

申请人： COOK MEDICAL TECHNOLOGIES LLC

发明人： John K. Jackson

IPC分类号： A61L31/16 ,  A61M25/09 ,  A61K31/58 ,  A61K31/436 ,  A61K31/353 ,  A61L31/10 ,  A61L29/16 ,  A61L29/08 ,  A61L27/54 ,  A61L27/44 ,  A61L27/34 ,  A61K31/337 ,  A61L31/08 ,  A61M25/10

CPC分类号： A61L31/16 ,  A61M25/09 ,  A61K31/58 ,  A61K31/436 ,  A61K31/353 ,  A61L31/10 ,  A61L29/16 ,  A61L29/085 ,  A61L27/54 ,  A61L27/44 ,  A61L27/34 ,  A61K31/337 ,  A61L31/08 ,  A61L29/08 ,  A61M25/10 ,  A61L2300/606 ,  H05K999/99 ,  A61M2025/105 ,  A61L2300/61 ,  A61L2300/426 ,  A61L2420/06 ,  A61L2300/416 ,  A61L2300/602

摘要： Various aspects of the present disclosure provide compositions including a water-insoluble therapeutic agent and a gallate-containing compound. Other aspects provide methods of using such compositions.

公开(公告)号：US11771807B2

公开(公告)日：2023-10-03

申请号：US16515946

申请日：2019-07-18

申请人： The Johns Hopkins University

发明人： Sashank Reddy ,  Russell Martin ,  Xiaowei Li ,  Calvin Chang ,  Kevin Colbert ,  Hai-Quan Mao

IPC分类号： A61L27/58 ,  A61L27/54 ,  A61L27/20 ,  A61L27/18 ,  A61L27/44 ,  A61L27/38 ,  A61L27/52 ,  A61M5/19 ,  A61L27/48 ,  A61L27/56 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L27/20 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3895 ,  A61L27/44 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61M5/19 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/622 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/34 ,  A61M2202/08 ,  A61M2202/09 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

摘要： A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

公开(公告)号：US20230256139A1

公开(公告)日：2023-08-17

申请号：US18138588

申请日：2023-04-24

申请人： The General Hospital Corporation

发明人： Jeremy V. Suhardi ,  Ebru Oral ,  Orhun K. Muratoglu ,  Hany Bedair

IPC分类号： A61L27/54 ,  A61L27/34 ,  A61K31/167 ,  A61K31/451 ,  A61L27/48

CPC分类号： A61L27/54 ,  A61L27/34 ,  A61K31/167 ,  A61K31/451 ,  A61L27/48 ,  A61L2300/402 ,  A61L2300/428 ,  A61L2300/602

摘要： The invention related to therapeutic polymeric materials and medical implants containing additives and/or analgesic agents. The invention also relates to methods of making therapeutic polymeric materials and medical implants containing additives and/or analgesic agents. Methods of spatially controlling additive concentrations and release as well as polymeric material morphology are also provided.

公开(公告)号：US11707557B2

公开(公告)日：2023-07-25

申请号：US17591806

申请日：2022-02-03

申请人： COOK MEDICAL TECHNOLOGIES LLC

发明人： John K. Jackson

IPC分类号： A61L31/16 ,  A61K31/58 ,  A61K31/436 ,  A61L31/10 ,  A61L29/16 ,  A61L29/08 ,  A61L27/54 ,  A61L27/44 ,  A61L27/34 ,  A61K31/337 ,  A61L31/08 ,  A61M25/09 ,  A61K31/353 ,  A61M25/10

CPC分类号： A61L31/16 ,  A61K31/337 ,  A61K31/353 ,  A61K31/436 ,  A61K31/58 ,  A61L27/34 ,  A61L27/44 ,  A61L27/54 ,  A61L29/08 ,  A61L29/085 ,  A61L29/16 ,  A61L31/08 ,  A61L31/10 ,  A61M25/09 ,  A61M25/10 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/61 ,  A61L2420/06 ,  A61M2025/105 ,  H05K999/99

摘要： Various aspects of the present disclosure provide compositions including a water-insoluble therapeutic agent and a gallate-containing compound. Other aspects provide methods of using such compositions.

公开(公告)号：US11684574B2

公开(公告)日：2023-06-27

申请号：US16308889

申请日：2017-06-29

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Morgan Virginia Fedorchak ,  Jeffrey Krawiec ,  Steven R. Little ,  Katherine Lorentz ,  David A. Vorp ,  Justin Weinbaum

IPC分类号： A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  A61K9/107 ,  A61K9/00 ,  A61K9/16 ,  A61K35/15 ,  A61K35/28 ,  A61K35/34 ,  A61K35/39 ,  C12N5/071

CPC分类号： A61K9/1075 ,  A61K9/0004 ,  A61K9/1647 ,  A61K35/15 ,  A61K35/28 ,  A61K35/34 ,  A61K35/39 ,  A61L27/507 ,  A61L27/56 ,  A61L27/58 ,  C12N5/0691 ,  A61L2300/602 ,  A61L2300/62 ,  C12N2533/40

摘要： Provided herein is a drug delivery device and composition, such as a particle, comprising conditioned medium. Also provided herein is a method of preparing polymeric particles for release of conditioned medium. Further, a tissue growth scaffold comprising particles for release of conditioned medium is provided.

公开(公告)号：US20230149603A1

公开(公告)日：2023-05-18

申请号：US17986604

申请日：2022-11-14

申请人： Novaflux Inc.

发明人： Mohamed Emam Labib ,  Lucas Lawrence Franz ,  Seo Yean Sohn

IPC分类号： A61L31/04 ,  A61K31/496 ,  A61K31/65 ,  A61K9/00 ,  A61K47/32 ,  A61K47/10 ,  A61K47/34 ,  A61L29/16 ,  A61L31/16 ,  A61L29/04

CPC分类号： A61L31/041 ,  A61K31/496 ,  A61K31/65 ,  A61K9/0024 ,  A61K47/32 ,  A61K47/10 ,  A61K47/34 ,  A61L29/16 ,  A61L31/16 ,  A61L29/049 ,  A61L2300/602 ,  A61L2300/41 ,  A61L2300/404 ,  A61L2300/216 ,  A61L2300/204

摘要： A drug-releasing polymer composition is disclosed. It may include a major component, which may be ethylene vinyl acetate, and may further include at least one or two release-modifying materials, and may further include at least one or two drugs. The release-modifying materials may be polyethylene glycol and polycaprolactone. The drugs may be minocycline and rifampin. There may be an interaction such that in the presence of two different release-modifying materials, drug release may be greater than with either release-modifying material alone. There may be an interaction such that in the presence of two drugs, drug release may be greater than with either drug alone, and antibacterial performance may be enhanced. Release durations as long as two months are possible. In addition, the composition can be provided on a medical device that is configured for implanting in body tissue for an extended time period.

公开(公告)号：US20190193109A1

公开(公告)日：2019-06-27

申请号：US16290109

申请日：2019-03-01

申请人： Nanocopoeia, Inc.

发明人： Robert A. Hoerr ,  John V. Carlson

IPC分类号： B05D1/06 ,  B05D1/36 ,  A61L27/34 ,  B05D7/00 ,  B05D1/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  B05B5/025 ,  B05D1/04

CPC分类号： B05D1/06 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/624 ,  A61L2400/12 ,  A61L2420/02 ,  A61L2420/06 ,  B05B5/025 ,  B05B5/03 ,  B05B5/08 ,  B05B7/061 ,  B05D1/04 ,  B05D1/34 ,  B05D1/36 ,  B05D7/54 ,  B05D2258/00 ,  B05D2451/00 ,  B05D2401/32

摘要： A nanoparticle coated hydrogel may be formed by a method of electrospraying nanoparticles on to a surface includes providing a drug and polymer combination in solvent to an inner capillary of a coaxial dual capillary spray nozzle. A coating with a drug that releases over time may be provided. Open and closed matrixes may be selectively formed to help modify time release periods.