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公开(公告)号：US11771807B2
公开(公告)日：2023-10-03
申请号：US16515946
申请日：2019-07-18
Applicant: The Johns Hopkins University
Inventor： Sashank Reddy , Russell Martin , Xiaowei Li , Calvin Chang , Kevin Colbert , Hai-Quan Mao
IPC: A61L27/58 , A61L27/54 , A61L27/20 , A61L27/18 , A61L27/44 , A61L27/38 , A61L27/52 , A61M5/19 , A61L27/48 , A61L27/56 , B82Y5/00 , B82Y30/00 , B82Y40/00
CPC classification number: A61L27/58 , A61L27/18 , A61L27/20 , A61L27/3808 , A61L27/3834 , A61L27/3895 , A61L27/44 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61M5/19 , A61L2300/412 , A61L2300/414 , A61L2300/602 , A61L2300/604 , A61L2300/622 , A61L2400/06 , A61L2400/12 , A61L2430/34 , A61M2202/08 , A61M2202/09 , B82Y5/00 , B82Y30/00 , B82Y40/00
Abstract: A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.
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公开(公告)号：US20200030496A1
公开(公告)日：2020-01-30
申请号：US16515946
申请日：2019-07-18
Applicant: The Johns Hopkins University
Inventor： Sashank Reddy , Russell Martin , Xiaowei Li , Calvin Chang , Kevin Colbert , Hai-Quan Mao
Abstract: A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.
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公开(公告)号：US20160354509A1
公开(公告)日：2016-12-08
申请号：US15117715
申请日：2015-02-10
Applicant: THE JOHNS HOPKINS UNIVERSITY
Inventor： Michael Parlato , Pratik Patel , Kevin Colbert , Ashish Nimgaonkar , Pankaj Pasricha
IPC: A61L24/04
CPC classification number: A61L24/043 , A61K9/7007 , A61L24/06 , A61L24/08 , C08L33/02 , C08L5/08
Abstract: Devices for and methods of treatment of metabolic syndromes are disclosed. Namely, the presently disclosed devices and methods are provided for affecting the function of the gastrointestinal endocrine system in key regions of the gut, thereby, producing therapeutic effects on obesity, diabetes and other metabolic syndromes. In some embodiments, the devices include multilayered bioadhesive patches delivered orally by dissolvable ingestible capsule, wherein various mechanisms are provided for anchoring the bioadhesive patches to the duodenal mucosa.
Abstract translation: 公开了代谢综合征的治疗方法和方法。 也就是说，提供了目前公开的装置和方法，用于影响胃肠内分泌系统在肠道关键区域的功能，从而产生对肥胖，糖尿病和其他代谢综合征的治疗作用。 在一些实施方案中，所述装置包括通过可溶解的可摄取胶囊口服递送的多层生物粘附性贴片，其中提供了用于将生物粘附性贴片锚定到十二指肠粘膜的各种机制。
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公开(公告)号：US20200069846A1
公开(公告)日：2020-03-05
申请号：US16515819
申请日：2019-07-18
Applicant: The Johns Hopkins University
Inventor： Russell Martin , Hai-Quan Mao , Sashank Reddy , Kevin Colbert
Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.
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公开(公告)号：US20180228863A1
公开(公告)日：2018-08-16
申请号：US15750460
申请日：2016-08-05
Applicant: The Johns Hopkins University
Inventor： Thomas Jozefiak , Michael Parlato , Pratik Patel , Kevin Colbert , Ashish Nimgaonkar , Pankaj Pasricha
CPC classification number: A61K38/02 , A61K9/0095 , A61K9/06 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K9/50 , A61K31/722 , A61K31/79 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38
Abstract: The present invention provides compositions and methods for treatment of metabolic syndromes. Namely, the presently disclosed compositions and methods are provided for affecting the function of the gastrointestinal endocrine system in key regions of the gut, thereby, producing therapeutic effects on obesity, diabetes and other metabolic disorders. The compositions include components for forming luminal barriers within the gastrointestinal tract of a subject where the barrier is created in-situ via interaction of resident mucin with the mucin-interacting agent.
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Patent Agency Ranking
公开(公告)号：US20240269351A1
公开(公告)日：2024-08-15
申请号：US18237744
申请日：2023-08-24
Applicant: The Johns Hopkins University
Inventor： Sashank Reddy , Russell Martin , Xiaowei Li , Calvin Chang , Kevin Colbert , Hai-Quan Mao
IPC: A61L27/58 , A61L27/18 , A61L27/20 , A61L27/38 , A61L27/44 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61M5/19 , B82Y5/00 , B82Y30/00 , B82Y40/00
CPC classification number: A61L27/58 , A61L27/18 , A61L27/20 , A61L27/3808 , A61L27/3834 , A61L27/3895 , A61L27/44 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61M5/19 , A61L2300/412 , A61L2300/414 , A61L2300/602 , A61L2300/604 , A61L2300/622 , A61L2400/06 , A61L2400/12 , A61L2430/34 , A61M2202/08 , A61M2202/09 , B82Y5/00 , B82Y30/00 , B82Y40/00
Abstract: A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.
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公开(公告)号：US20210402064A1
公开(公告)日：2021-12-30
申请号：US17054161
申请日：2019-05-09
Applicant: The Johns Hopkins University
Inventor： Russell Martin , Sashank Reddy , Kevin Colbert , Hai-Quan Mao
Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.
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公开(公告)号：US20210402061A1
公开(公告)日：2021-12-30
申请号：US17054156
申请日：2019-05-09
Applicant: The Johns Hopkins University
Inventor： Sashank Reddy , Russell Martin , Xiaowei Li , Calvin Chang , Kevin Colbert , Hai-Quan Mao
Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.
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公开(公告)号：US11090354B2
公开(公告)日：2021-08-17
申请号：US15750460
申请日：2016-08-05
Applicant: The Johns Hopkins University
Inventor： Thomas Jozefiak , Michael Parlato , Pratik Patel , Kevin Colbert , Ashish Nimgaonkar , Pankaj Pasricha
IPC: A61K38/00 , A61K38/02 , A61K31/722 , A61K31/79 , A61K47/32 , A61K9/00 , A61K9/08 , A61K47/36 , A61K47/38 , A61K47/34 , A61K9/16 , A61K9/20 , A61K9/50 , A61K47/26 , A61K9/06 , A61K9/48
Abstract: The present invention provides compositions and methods for treatment of metabolic syndromes. Namely, the presently disclosed compositions and methods are provided for affecting the function of the gastrointestinal endocrine system in key regions of the gut, thereby, producing therapeutic effects on obesity, diabetes and other metabolic disorders. The compositions include components for forming luminal barriers within the gastrointestinal tract of a subject where the barrier is created in-situ via interaction of resident mucin with the mucin-interacting agent.
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公开(公告)号：US20180236127A1
公开(公告)日：2018-08-23
申请号：US15962911
申请日：2018-04-25
Applicant: THE JOHNS HOPKINS UNIVERSITY
Inventor： Michael Parlato , Pratik Patel , Kevin Colbert , Ashish Nimgaonkar , Pankaj Pasricha
CPC classification number: A61L24/043 , A61K9/7007 , A61L24/06 , A61L24/08 , C08L33/02 , C08L5/08
Abstract: Devices for and methods of treatment of metabolic syndromes are disclosed. Namely, the presently disclosed devices and methods are provided for affecting the function of the gastrointestinal endocrine system in key regions of the gut, thereby, producing therapeutic effects on obesity, diabetes and other metabolic syndromes. In some embodiments, the devices include multilayered bioadhesive patches delivered orally by dissolvable ingestible capsule, wherein various mechanisms are provided for anchoring the bioadhesive patches to the duodenal mucosa.
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