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    Tissue adhesive membrane and preparation method thereof
    1.
    发明授权
    Tissue adhesive membrane and preparation method thereof 有权

    公开(公告)号：US12090245B2

    公开(公告)日：2024-09-17

    申请号：US18144859

    申请日：2023-05-09

    Applicant: SOUTH CHINA UNIVERSITY OF TECHNOLOGY

    Inventor： Xuetao Shi ,  Wei Yang

    IPC: A61L24/06 ,  C08G83/00 ,  C08L29/04 ,  A61L24/00

    CPC classification number: A61L24/06 ,  C08G83/008 ,  C08L29/04 ,  A61L24/0015 ,  C08G2170/00 ,  C08L2203/02 ,  C08L2203/162

    Abstract: A tissue adhesive membrane and a preparation method thereof are provided. The tissue adhesive membrane includes a supramolecular polymer and an enhancer; the supramolecular polymer is prepared by copolymerization of lipoic acid and a biocompatible stabilizer; and the enhancer includes at least one selected from the group consisting of a cationic compound, a cationic polymer, and a metal particle. The tissue adhesive membrane of the present invention can achieve rapid adhesion, seal wounds continuously and effectively, and maintain long-lasting mechanical strength. The components of the tissue adhesive membrane come from natural components of animals and plants, have good biocompatibility, and possess the functions of antibacterial and inhibiting inflammation. The tissue adhesive membrane of the present invention is a hydrophobic adhesive membrane where hydrogen bonding and high surface energy can provide strong adhesion energy and no adverse active groups that may cause irritation or discomfort are contained.

    IN SITU SOLIDIFYING INJECTABLE COMPOSITIONS WITH TRANSIENT CONTRAST AGENTS AND METHODS OF MAKING AND USING THEREOF
    9.
    发明公开
    IN SITU SOLIDIFYING INJECTABLE COMPOSITIONS WITH TRANSIENT CONTRAST AGENTS AND METHODS OF MAKING AND USING THEREOF 审中-公开

    公开(公告)号：US20240042093A1

    公开(公告)日：2024-02-08

    申请号：US18268786

    申请日：2021-12-22

    Applicant: FLUIDX MEDICAL TECHNOLOGY, INC.

    Inventor： Russell J. Stewart ,  Joshua JONES ,  Shawn FOJTIK ,  Jessica KARZ

    IPC: A61L24/00 ,  A61L24/06

    CPC classification number: A61L24/0015 ,  A61L24/06 ,  A61L2300/106 ,  A61L2300/44 ,  A61L2400/06

    Abstract: Described herein are injectable compositions composed of one or more polycationic polyelectrolytes and anionic counterions, one or more one polyanionic polyelectrolytes and cationic counterions, and a transient contrast agent. The injectable compositions have an ion concentration that is sufficient to prevent association of the polycationic polyelectrolytes and the polyanionic poly-electrolytes in water. Upon introduction of the composition into a subject, a solid is produced in situ. The transient contrast agent diffuses out of the solid over hours or days providing temporary contrast and does not remain in the subject unlike permanent contrast agents. This feature provides sufficient time for the clinician to perform medical procedures prior to the diffusion of the contrast agent out of the solid. The viscosity of the injectable compositions can be varied depending upon the application of the injectable composition. By varying the molecular weight, charge densities, and/or concentrations of the polycationic and polyanionic salts, it is possible to produce injectable compositions having a useful range of viscosities.

    Absorbable bone wax and preparation method thereof
    10.
    发明授权
    Absorbable bone wax and preparation method thereof 有权

    公开(公告)号：US11890392B2

    公开(公告)日：2024-02-06

    申请号：US17267024

    申请日：2019-12-20

    Applicant: GUANGZHOU BEOGENE BIOTECHNOLOGY CO., LTD.

    Inventor： Yong Lan ,  Yu Liu ,  Yu Chen

    IPC: A61L24/00 ,  A61L24/02 ,  A61L24/06 ,  C08L87/00 ,  C08L3/02

    CPC classification number: A61L24/0042 ,  A61L24/0015 ,  A61L24/02 ,  A61L24/06 ,  C08L3/02 ,  C08L87/005 ,  A61L2300/104 ,  A61L2300/204 ,  A61L2400/04 ,  A61L2430/02

    Abstract: Disclosed is absorbable bone wax and a preparation method thereof. The preparation method comprises the steps of: 1) mixing polyoxypropylene polyoxyethylene block copolymer (PEG-PPG-PEG) and polyoxypropylene polyoxyethylene random copolymer (PEG-PPG), and stirring evenly under heating to obtain a liquid mixture; 2) under mechanical stirring and heating condition, adding hemostatic starch microspheres to the liquid mixture obtained in step 1) to obtain a uniformly-mixed liquid; and 3) adding a bone repair material to the uniformly-mixed liquid obtained in step 2), and mixing uniformly to obtain a mixed solution, then pouring the mixed solution into a mold or sub-packaged bottle, and leaving at room temperature for solidifying and shaping to give the absorbable bone wax. The absorbable bone wax of the present invention can achieve the effect of rapid hemostasis, changing the relatively single hemostasis method with traditional bone wax which only depends on physical sealing.

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