公开(公告)号：US20170362458A1

公开(公告)日：2017-12-21

申请号：US14893561

申请日：2014-05-30

申请人： THE UNIVERSITY OF AKRON

发明人： Gang CHENG ,  Bin CAO

IPC分类号： C09D133/14 ,  C08F120/36 ,  C07C227/18 ,  A01N37/12 ,  C07C227/16 ,  C07C227/02 ,  C09D5/14 ,  C07C229/12

CPC分类号： C09D133/14 ,  A01N37/12 ,  C07C227/02 ,  C07C227/16 ,  C07C227/18 ,  C07C229/12 ,  C07C233/38 ,  C08F20/34 ,  C08F20/36 ,  C08F22/385 ,  C08F120/36 ,  C08F220/36 ,  C08F222/385 ,  C09D5/14 ,  C09D133/26 ,  C09D139/00

摘要： Various embodiments of the present invention are directed to switchable carboxybetaine-based polymers, hydrogels, and/or elastomers, along with novel related monomers, crosslinkers, and methods. Under acidic conditions, the materials undergo self-cyclization and can catch and kill bacteria. Under neutral/basic conditions, these materials undergo ring-opening and can release killed bacterial cells and resist protein adsorption and bacterial attachment. These smart polymers, hydrogels and elastomers also show excellent mechanical properties making them highly desirable for many biomedical applications.

公开(公告)号：US20150166876A1

公开(公告)日：2015-06-18

申请号：US14417197

申请日：2013-07-26

申请人： RHODIA OPERATIONS

发明人： Dominique Labarre ,  James Wilson

IPC分类号： C09K8/524 ,  C09K8/528

CPC分类号： C09K8/524 ,  C08F22/385 ,  C08F220/06 ,  C09K8/52 ,  C09K8/528 ,  C09K2208/10 ,  C09K2208/26

摘要： The invention relates to compositions for inhibiting the formation of deposits in underground formations such as oil wells, comprising, in a solvent medium, polymers P resulting from the radical copolymerisation, preferably controlled and in solution, of a mixture including: monomers having an ethylenically unsaturated structure, selected from monomers that form, by polymerisation, a polymer that has an effect of inhibiting the formation of organic and/or inorganic deposits; and polyethylenically unsaturated, cross-linking monomers carrying at least one group that can be cleaved between two ethylene unsaturations, said polymers P being present in the solvent in the form of dispersed nanogels.

摘要翻译： 本发明涉及用于抑制在地下地层（例如油井）中形成沉积物的组合物，其包括在溶剂介质中，由自由基共聚得到的聚合物P，优选受控并在溶液中，混合物包括：具有烯属不饱和单体 选自通过聚合形成具有抑制有机和/或无机沉积物形成的作用的聚合物的单体的结构; 和携带至少一个能够在两个乙烯不饱和键之间切割的基团的多烯属不饱和的交联单体，所述聚合物P以分散的纳米凝胶的形式存在于溶剂中。

公开(公告)号：US20170196778A1

公开(公告)日：2017-07-13

申请号：US15315497

申请日：2015-06-10

申请人： KURARAY NORITAKE DENTAL INC.

发明人： Yamato NOJIRI ,  Mitsuru TAKEI

IPC分类号： A61K6/083

CPC分类号： A61K6/083 ,  A61K6/00 ,  A61K6/0023 ,  A61K6/08 ,  A61K6/087 ,  C08F22/105 ,  C08F22/38 ,  C08F22/385 ,  C08F30/02 ,  C08F216/125 ,  C08F220/20 ,  C08F220/40 ,  C08F222/1006 ,  C08F222/26 ,  C08F236/14 ,  C08F2220/346 ,  C08F2222/1013 ,  C08F2222/102 ,  C08L33/26 ,  C08L33/04 ,  C08L33/14 ,  C08L43/02

摘要： The present invention provides a dental adhesive exhibiting excellent initial bond strength and bond durability to both enamel and dentin. The present invention relates to a dental adhesive containing: an asymmetric acrylamide-methacrylic acid ester compound (a); an acid group-containing (meth)acrylic polymerizable monomer (b); and a water-soluble polymerizable monomer (c). The asymmetric acrylamide-methacrylic acid ester compound (a) is represented by the following general formula (1): where X is an optionally substituted, linear or branched C1 to C6 aliphatic group or an optionally substituted aromatic group, the aliphatic group is optionally interrupted by at least one linking group selected from the group consisting of —O—, —S—, —CO—, —CO—O—, —O—CO—, —NR1—, —CO—NR1—, —NR1—CO—, —CO—O—NR1—, —O—CO—NR1—, and —NR1—CO—NR1—, and R1 is a hydrogen atom or an optionally substituted, linear or branched C1 to C6 aliphatic group.

公开(公告)号：US20150213732A1

公开(公告)日：2015-07-30

申请号：US14684745

申请日：2015-04-13

申请人： Chongqing Haifu Medical Technology Co., Ltd.

发明人： Yunbo Tian ,  Fangwei Ye

IPC分类号： G09B23/28 ,  G01D18/00 ,  C08L33/26

CPC分类号： G09B23/286 ,  A61B17/00 ,  A61B2017/00707 ,  A61B2017/00716 ,  A61N7/02 ,  C08F220/56 ,  C08L33/26 ,  G01D18/00 ,  C08F222/385 ,  C08F22/385

摘要： An intelligent tissue mimicking ultrasonic phantom, which is a temperature-sensitive polymer gel having the following characteristics: acoustic velocity: 1500-1550 m/s; acoustic impedance: (1.50-1.60)×106 Pa·s/m; density: 1.01-1.06 g/cm3; and a denaturation temperature around which there is a reversible phase transformation between the opaque phase and the transparent phase. Said gel can be a polymer of isopropylacrylamide (NIPA). Said ultrasonic phantom has a transparent appearance, and an adjustable thermal denaturation temperature; the thermal denaturation region of the ultrasonic phantom is distinct and has a well-defined boundary; the material of the phantom is stable and deterioration-resistant, and can ensure the consistency of the quality; the phantom is thermal denaturable with the appearance thereof turning white, while the phantom recovers when the heat is removed, such that it can be used repeatedly.

摘要翻译： 一种模仿超声波体模的智能组织，它是具有以下特征的温度敏感性聚合物凝胶：声速：1500-1550m / s; 声阻抗（1.50-1.60）×106Pa·s / m; 密度：1.01-1.06g / cm3; 以及在不透明相和透明相之间存在可逆相变的变性温度。 所述凝胶可以是异丙基丙烯酰胺（NIPA）的聚合物。 所述超声波体模具有透明的外观和可变的热变性温度; 超声模型的热变性区域是不同的，并且具有明确的边界; 体模的材质稳定，耐老化，能保证质量的一致性; 该模体是耐热变性的，其外观为白色，而当热量被去除时，幻影恢复，从而可以重复使用。

公开(公告)号：US20140256837A1

公开(公告)日：2014-09-11

申请号：US14254661

申请日：2014-04-16

申请人： MicroVention, Inc.

发明人： Gregory M. Cruise ,  Michael J. Constant

IPC分类号： C08F22/38

CPC分类号： C08F22/385 ,  A61K9/0024 ,  A61K49/0457 ,  A61L31/145

摘要： Hydrogels are described that expand volumetrically in response to a change in their environment and as well as their methods of manufacture and use.

摘要翻译： 描述了水凝胶，其响应于其环境的变化以及它们的制造和使用方法而以体积方式膨胀。

公开(公告)号：US20130022570A1

公开(公告)日：2013-01-24

申请号：US13581049

申请日：2011-02-24

申请人： Jordan Kopping ,  Kalpesh Biyani ,  Eric Connor ,  Scott Hecker ,  Inez Lees ,  Grace Quaker ,  Faleh Salaymeh ,  Hongmin Zhang ,  David Bergbreiter ,  Paul Mansky ,  YongQi Mu ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao

发明人： Jordan Kopping ,  Kalpesh Biyani ,  Eric Connor ,  Scott Hecker ,  Inez Lees ,  Grace Quaker ,  Faleh Salaymeh ,  Hongmin Zhang ,  David Bergbreiter ,  Paul Mansky ,  YongQi Mu ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao

IPC分类号： C08F226/02 ,  A61P3/06 ,  A61K31/785

CPC分类号： A61K31/785 ,  A61K45/06 ,  C08F20/52 ,  C08F22/385 ,  C08F222/385 ,  C08F226/02 ,  C08F232/08

摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

摘要翻译： 本发明提供了一种有效地从胃肠道结合和除去胆汁盐的交联的胺和酰胺聚合物。 这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

公开(公告)号：US5767211A

公开(公告)日：1998-06-16

申请号：US850028

申请日：1997-05-01

申请人： Zhibin Guan

发明人： Zhibin Guan

IPC分类号： C08F2/38 ,  C08F4/04 ,  C08F4/80 ,  C08F12/34 ,  C08F12/36 ,  C08F22/10 ,  C08F22/38 ,  C08F20/18 ,  C08F20/56

CPC分类号： C08F22/10 ,  C08F12/34 ,  C08F12/36 ,  C08F2/38 ,  C08F22/385

摘要： This invention concerns the synthesis of multi-functional hyperbranched polymers by free radical polymerization of di- or tri-vinyl monomers in the presence of a chain transfer catalyst and a non-peroxide free radical initiator. The low viscosity and high functionality of these polymers make them useful for automotive coatings and for photopolymerization applications.

摘要翻译： 本发明涉及通过二链或三乙烯基单体在链转移催化剂和非过氧化物自由基引发剂存在下的自由基聚合来合成多功能超支化聚合物。 这些聚合物的低粘度和高官能度使其可用于汽车涂料和光聚合应用。

公开(公告)号：US20180298133A1

公开(公告)日：2018-10-18

申请号：US15604529

申请日：2017-05-24

申请人： Terumo Corporation

发明人： Steve Plotkin ,  Gregory M. Cruise ,  Edward Michael Keeley ,  Renee Yu ,  Clayton Harris

IPC分类号： C08F220/28 ,  A61L24/06 ,  C08G65/333 ,  C08F220/38 ,  A61K47/32 ,  A61K31/704 ,  A61L24/00

CPC分类号： C08F220/28 ,  A61K9/0019 ,  A61K9/146 ,  A61K9/5026 ,  A61K31/704 ,  A61K47/32 ,  A61L24/0015 ,  A61L24/06 ,  A61L2300/418 ,  C08F22/385 ,  C08F220/38 ,  C08F290/062 ,  C08F2220/282 ,  C08F2220/382 ,  C08G65/33324 ,  Y10T428/2982 ,  C08F220/10

摘要： Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.

公开(公告)号：US10071028B2

公开(公告)日：2018-09-11

申请号：US15315497

申请日：2015-06-10

申请人： KURARAY NORITAKE DENTAL INC.

发明人： Yamato Nojiri ,  Mitsuru Takei

IPC分类号： A61K6/083 ,  C08F216/12 ,  C08F222/26 ,  A61K6/08 ,  C08F222/10 ,  C08F22/38 ,  A61K6/087 ,  C08F220/40 ,  C08F220/34 ,  C08F236/14 ,  C08F220/20 ,  C08F30/02 ,  C08F22/10

CPC分类号： A61K6/083 ,  A61K6/00 ,  A61K6/0023 ,  A61K6/08 ,  A61K6/087 ,  C08F22/105 ,  C08F22/38 ,  C08F22/385 ,  C08F30/02 ,  C08F216/125 ,  C08F220/20 ,  C08F220/40 ,  C08F222/1006 ,  C08F222/26 ,  C08F236/14 ,  C08F2220/346 ,  C08F2222/1013 ,  C08F2222/102 ,  C08L33/26 ,  C08L33/04 ,  C08L33/14 ,  C08L43/02

摘要： The present invention provides a dental adhesive exhibiting excellent initial bond strength and bond durability to both enamel and dentin. The present invention relates to a dental adhesive containing: an asymmetric acrylamide-methacrylic acid ester compound (a); an acid group-containing (meth)acrylic polymerizable monomer (b); and a water-soluble polymerizable monomer (c). The asymmetric acrylamide-methacrylic acid ester compound (a) is represented by the following general formula (1): where X is an optionally substituted, linear or branched C1 to C6 aliphatic group or an optionally substituted aromatic group, the aliphatic group is optionally interrupted by at least one linking group selected from the group consisting of —O—, —S—, —CO—, —CO—O—, —O—CO—, —NR1—, —CO—NR1—, —NR1—CO—, —CO—O—NR1—, —O—CO—NR1—, and —NR1—CO—NR1—, and R1 is a hydrogen atom or an optionally substituted, linear or branched C1 to C6 aliphatic group.

公开(公告)号：US20150166696A1

公开(公告)日：2015-06-18

申请号：US14536394

申请日：2014-11-07

申请人： MicroVention, Inc.

发明人： Steve Plotkin ,  Gregory M. Cruise ,  Edward Michael Keeley ,  Renee Yu ,  Clayton Harris

IPC分类号： C08F22/38

CPC分类号： C08F22/385 ,  A61K9/0019 ,  A61K9/146 ,  A61K9/5026 ,  A61K31/704 ,  C08F290/062 ,  Y10T428/2982 ,  C08F220/10

摘要： Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.

摘要翻译： 描述聚合物颗粒栓塞及其制备方法。 颗粒栓塞可用作栓塞剂。