公开(公告)号：US20240299615A1

公开(公告)日：2024-09-12

申请号：US18702663

申请日：2022-04-11

申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

发明人： Seung Woo CHO ,  Yi Sun CHOI ,  Ji Hoon JEON

IPC分类号： A61L24/00 ,  A61K9/06 ,  A61K45/06 ,  A61K47/18 ,  A61K47/38 ,  A61L24/08 ,  A61L27/20 ,  A61L27/38 ,  A61L27/52 ,  C08B15/06 ,  C08B15/10 ,  C08J3/075 ,  C08J3/24 ,  C08L1/08

CPC分类号： A61L24/0031 ,  A61K9/06 ,  A61K45/06 ,  A61K47/18 ,  A61K47/38 ,  A61L24/08 ,  A61L27/20 ,  A61L27/3834 ,  A61L27/52 ,  C08B15/06 ,  C08B15/10 ,  C08J3/075 ,  C08J3/24 ,  C08L1/08 ,  A61L2400/04 ,  C08J2301/08 ,  C08L2203/02 ,  C08L2312/00

摘要： A hydrogel including phenol derivative-modified cellulose, a use thereof, and a preparation method therefor are described. Physical properties of the hydrogel can be modulated by adjusting concentrations of and oxidation conditions for the phenol derivative-modified cellulose. In addition, the hydrogel of the present invention can find applications in various fields due to its properties, such as hemostasis, blood coagulation acceleration, tissue adhesion, cell culture, cell transplantation, drug delivery, etc.

公开(公告)号：US12054653B2

公开(公告)日：2024-08-06

申请号：US17327944

申请日：2021-05-24

申请人： Massachusetts Institute of Technology

发明人： Xuanhe Zhao ,  Hyunwoo Yuk ,  Xiaoyu Chen

IPC分类号： C09J7/32 ,  A61L24/00 ,  C08K5/00 ,  C09J7/20 ,  C09J105/00 ,  C09J109/04 ,  C09J125/08 ,  C09J129/04 ,  C09J133/06 ,  C09J133/10 ,  C09J133/26 ,  C09J151/00 ,  C09J175/00 ,  C09J181/08

CPC分类号： C09J7/32 ,  A61L24/0031 ,  C08K5/0025 ,  C09J7/20 ,  C09J105/00 ,  C09J109/04 ,  C09J125/08 ,  C09J129/04 ,  C09J133/064 ,  C09J133/066 ,  C09J133/10 ,  C09J133/26 ,  C09J151/003 ,  C09J175/00 ,  C09J181/08 ,  C09J2301/10 ,  C09J2301/306 ,  C09J2301/502 ,  C09J2405/00 ,  C09J2429/00 ,  C09J2433/00 ,  C09J2451/00 ,  C09J2475/00

摘要： An adhesive material that provides fast and robust adhesion on wet surfaces, where the adhesion formed is detachable on-demand. The adhesive material is formed of one or more hydrophilic polymers or copolymers grafted with one or more amine coupling groups via a plurality of cleavable physical bonds and/or cleavable covalent bonds and one or more cross linkers. Application of the adhesive material on a wet surface causes the adhesive material to absorb liquid to thereby swell the adhesive material to form a layer of hydrogel, resulting in the formation of temporary crosslinks followed by covalent crosslinks with the surface. Introducing a triggering agent cleaves the cleavable physical bonds and/or cleavable covalent bonds to allow for non-traumatic detachment of the adhesive material from the surface.

公开(公告)号：US20240156644A1

公开(公告)日：2024-05-16

申请号：US18381401

申请日：2023-10-18

申请人： HOLLISTER INCORPORATED

发明人： JAN WOHLGEMUTH ,  METTE MAACK ,  CARSTEN RIKHOF ,  PETER SKOV ,  KRISTOFFER NIELSEN ,  PER LADEFOGED ,  KENNETH NIELSEN ,  MICHAEL TAYLOR ,  RICHARD MURAHATA

IPC分类号： A61F13/0246 ,  A61F5/443 ,  A61F13/0203 ,  A61L15/58 ,  A61L15/60 ,  A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  C08L23/18 ,  C08L33/02 ,  C08L53/02 ,  C09J123/20 ,  C09J123/22 ,  C09J133/02

CPC分类号： A61F13/0253 ,  A61F5/443 ,  A61F13/0203 ,  A61L15/585 ,  A61L15/60 ,  A61L24/0031 ,  A61L24/043 ,  A61L26/0052 ,  A61L26/008 ,  C08L23/18 ,  C08L33/02 ,  C08L53/02 ,  C09J123/20 ,  C09J123/22 ,  C09J133/02 ,  C08L2205/16 ,  C08L2205/22

摘要： Provided are buffered adhesive compositions comprising a high molecular weight non-neutralized polymeric acid and a high molecular weight partially neutralized polymeric acid and products such as wound dressings and ostomy skin barriers incorporating the compositions.

公开(公告)号：US11964071B2

公开(公告)日：2024-04-23

申请号：US17831392

申请日：2022-06-02

申请人： NANYANG TECHNOLOGICAL UNIVERSITY ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD

发明人： Terry W. J. Steele ,  Daniel Mandler

IPC分类号： A61B17/00 ,  A61L24/00 ,  A61L24/04 ,  A61L24/08 ,  H01B1/12

CPC分类号： A61L24/001 ,  A61B17/00491 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/04 ,  A61L24/08 ,  H01B1/124 ,  A61B2017/005 ,  A61L2300/216 ,  A61L2400/00

摘要： Electrochemically initiated bioadhesive compositions comprising biocompatible polymers containing derivatives of diazonium, arylsulfonium, or diaryliodonium in general, and to their use in tissue fixation, in particular.

公开(公告)号：US11911531B2

公开(公告)日：2024-02-27

申请号：US17381481

申请日：2021-07-21

申请人： Trio Healthcare Ltd

发明人： Lloyd Pearce ,  Stewart Lee

IPC分类号： A61L24/00 ,  C08K5/56 ,  C08L33/02 ,  C08L83/04

CPC分类号： A61L24/0094 ,  A61L24/0031 ,  A61L24/0073 ,  A61L2400/14 ,  C08K5/56 ,  C08L33/02 ,  C08L83/04 ,  C08L2203/02 ,  A61L24/0073 ,  C08L83/04

摘要： A skin compatible component attachable to mammalian skin. The component is formed as a silicone matrix comprising a polyorganosiloxane derived silicone polymer and moisture control particulate distributed within the polymer network being configured to absorb moisture from the skin. The skin compatible component may be utilised as an ostomy wafer or flange to secure an ostomy appliance to the skin and in particular peri-skin.

公开(公告)号：US11904067B2

公开(公告)日：2024-02-20

申请号：US16846293

申请日：2020-04-11

申请人： Massachusetts Institute of Technology

发明人： Xuanhe Zhao ,  Hyunwoo Yuk

IPC分类号： A61L24/00 ,  A61B5/00 ,  A61B5/11 ,  A61K9/70 ,  A61L24/04 ,  B32B9/02 ,  B32B29/00 ,  A61F13/00

CPC分类号： A61L24/0031 ,  A61B5/1102 ,  A61B5/68335 ,  A61K9/7084 ,  A61L24/043 ,  B32B9/02 ,  B32B29/002 ,  A61B2562/0261 ,  A61F2013/00676 ,  B32B2307/7163 ,  B32B2307/748 ,  B32B2405/00 ,  B32B2535/00 ,  A61L24/043 ,  C08L33/08 ,  A61L24/043 ,  C08L33/10 ,  A61L24/043 ,  C08L5/08

摘要： Dry adhesive materials, particularly in the form of a film or tape, for adhering one or more wet surfaces comprising: (i) one or more hydrophilic polymers; (ii) one or more amine coupling groups, and (iii) one or more cross linkers. The dry adhesive material, when placed in contact with the one or more wet surfaces, absorbs liquid from the one or more wet surfaces, swells to form temporary crosslinking with the wet surface, and forms covalent crosslinking with the one or more wet surfaces.

公开(公告)号：US20240009139A1

公开(公告)日：2024-01-11

申请号：US18228476

申请日：2023-07-31

申请人： JENARRON THERAPEUTICS LIMITED

发明人： Paul Anthony McCarron ,  Ryan Gerald Loughlin

IPC分类号： A61K9/70 ,  A61P23/02 ,  A61K9/06 ,  A61K31/196 ,  A61K31/451 ,  A61K47/32 ,  A61L24/00 ,  A61L24/06 ,  C08J3/075

CPC分类号： A61K9/7084 ,  C08J2331/04 ,  A61K9/06 ,  A61K9/703 ,  A61K31/196 ,  A61K31/451 ,  A61K47/32 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  C08J3/075 ,  A61L2300/402 ,  A61L2400/04 ,  C08J2329/04 ,  A61P23/02

摘要： The present invention relates to a sterile gel formulation suitable for use in filling a wound cavity and delivering an active ingredient thereto, the gel further having a pH range of 4.5 to 8.5, low bioadhesive strength and cohesive integrity and being formed from a polymer selected from among the group consisting of poly(vinyl) alcohol (PVA) polymer and a PVA-polyvinyl acetate copolymer, a cross-linker being a salt form of boron that produces borate ions in aqueous solution, at least one compound which has a beneficial effect as an active ingredient in the wound and at least one modulator, the modulator being a low molecular weight species that is capable of binding borate or PVA in aqueous solution through a mono-diol or di-diol formation and reduces the pH of PVA-borate hydrogels; wherein the gel is heat and/or gamma sterilised and contains less than 5% acetic acid and the polymer has a degree of hydrolysis of between 98% and 100% and a molecular weight of from 100,000 to 300,000 Daltons.

公开(公告)号：US20230390451A1

公开(公告)日：2023-12-07

申请号：US18044681

申请日：2021-08-11

申请人： SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY

发明人： Yuxiao LAI ,  Yuanchi ZHANG ,  Wei ZHANG

IPC分类号： A61L24/08 ,  A61L24/02 ,  A61L24/00 ,  A61L24/06 ,  A61L24/10

CPC分类号： A61L24/08 ,  A61L24/02 ,  A61L24/0031 ,  A61L24/06 ,  A61L24/104

摘要： Provided are a biomedical tape, a preparation method thereof and use thereof. The biomedical tape comprises a hydrogel carrier in dry state and a functional nanomaterial encapsulated within the hydrogel carrier in dry state, and the hydrogel carrier in dry state comprises a thin film body of hyaluronic acid hydrogel and a dopamine-modified polyacrylic acid permeated into a surface of the thin film body of hyaluronic acid hydrogel. The preparation method for the biomedical tape comprises: preparing a hyaluronic acid hydrogel with the functional nanomaterial dispersed therein, and drying and curing the hydrogel to form a film to obtain the thin film body of hyaluronic acid hydrogel; and preparing a dopamine-modified polyacrylic acid solution, and permeating the solution into a surface of the thin film body of hyaluronic acid hydrogel by coating to obtain the biomedical tape.

公开(公告)号：US20230372582A1

公开(公告)日：2023-11-23

申请号：US18363760

申请日：2023-08-02

申请人： SHANGHAI LINGEL MEDICAL TECHNOLOGY CO., LTD.

发明人： Yiqing ZHANG ,  Yu SUN

IPC分类号： A61L26/00 ,  A61L31/14 ,  A61L24/00 ,  A61L24/04 ,  A61L31/04 ,  C08G65/333 ,  C08G69/50 ,  C08G63/91

CPC分类号： A61L26/008 ,  A61L31/145 ,  A61L24/0031 ,  A61L24/043 ,  A61L26/0052 ,  A61L31/041 ,  C08G65/33396 ,  C08G69/50 ,  C08G63/912 ,  A61L2400/04

摘要： This invention provides the preparation and applications of a degradable dual-component hydrogel. The hydrogel is prepared by mixing component A, component B and solvent; Component A is an o-phthalaldehyde modified degradable polymer; Component B is a water-soluble molecule, a water-soluble synthetic polymer, or a polysaccharide that contains one or more types of the groups selected from primary amine, hydrazine, hydrazide, hydroxylamine and sulfhydryl, with the number of groups not less than 2. This invention achieves the regulation for hydrogel degradability by introducing degradable structures into the polymer skeleton of component A, and obtains hydrogels with rapid degradation. This invention thus solve the dilemma of materials—confronting either the problems of undegradable poly (ethylene glycol) skeleton or the potential risks of the degradable bioproducts introduced—used for preparing the dual-component hydrogel.

公开(公告)号：US20230372576A1

公开(公告)日：2023-11-23

申请号：US18229369

申请日：2023-08-02

申请人： MicroVention, Inc.

发明人： Aaron Baldwin

IPC分类号： A61L24/06 ,  A61L24/00 ,  A61L31/14 ,  A61L31/18

CPC分类号： A61L24/06 ,  A61L24/0031 ,  A61L24/001 ,  A61L31/14 ,  A61L31/145 ,  A61L31/18 ,  A61L2430/36

摘要： Described herein are polymers and associated methods to occlude structures and malformations of the vasculature with polymers with delayed controlled rates of expansion. Methods of forming such devices are also disclosed.