METHOD FOR PRODUCING A MODIFIED CATIONIZED POLYSACCHARIDE, MODIFIED CATIONIZED POLYSACCHARIDE AND ITS USE

    公开(公告)号:US20240141075A1

    公开(公告)日:2024-05-02

    申请号:US18281067

    申请日:2022-03-18

    Applicant: KEMIRA OYJ

    CPC classification number: C08B15/06

    Abstract: The invention relates to a method for producing a modified cationized polysaccharide. The method comprises preparing a reaction slurry by mixing of a starting material comprising a polysaccharide, preferably cellulose, and an alkaline liquid medium comprising an organic liquid, allowing the polysaccharide to interact with the alkaline liquid medium in the reaction slurry at a pre-treatment temperature under a pre-determined reaction time, and adjusting the temperature of the reaction slurry to modification temperature, which is less than the boiling point of the alkaline liquid medium. A cationizing agent and an alkylation agent, which comprises an epoxy group, are added to the reaction slurry at the modification temperature, and the polysaccharide is allowed to react with the alkylation agent and the cationizing agent, preferably under inert atmosphere, and obtaining a modified cationized polysaccharide product in solution form. The invention relates also to the modified cationized polysaccharide and its use as flocculation agent.

    Hemostatic material and wound dressing containing same

    公开(公告)号:US11938230B2

    公开(公告)日:2024-03-26

    申请号:US17818551

    申请日:2022-08-09

    Inventor: Kazuhiko Shibata

    Abstract: A hemostatic material is described, which eliminates the risks of conventional chitosan-derived products, such as the onset of shellfish allergy and endotoxin contamination, can be used safely for more people, and has an antibacterial property and a hemostatic function that widely-used hydrogels lack, and a wound dressing containing the same. A hemostatic material containing cationized cellulose and a wound dressing containing the hemostatic are described. At least one of hydroxyl groups of the cationized cellulose is modified with —R2—N+(R3)(R4)(R5).X−, other hydroxyl groups of the cationized cellulose have —H, or —(CH2CH2O)m—H, R2 represents C1-6 alkylene, C2-6 hydroxyalkylene, —(CH2CH2O)1—, or a combination thereof, 1 represents 1 or 2, m represents 1 or 2, and X− may represent an anionic group.

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