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    PROCESS OF PREPARING A HIGH MOLECULAR WEIGHT ESTERIFIED CELLULOSE ETHER
    2.
    发明申请
    PROCESS OF PREPARING A HIGH MOLECULAR WEIGHT ESTERIFIED CELLULOSE ETHER 审中-公开

    公开(公告)号：US20180105607A1

    公开(公告)日：2018-04-19

    申请号：US15569197

    申请日：2016-05-10

    申请人： Dow Global Technologies LLC

    发明人： Oliver Petermann ,  Meinolf Brackhagen

    IPC分类号： C08B13/00 ,  C08B11/20 ,  C08L1/32 ,  A61K47/38

    CPC分类号： C08B13/00 ,  A61K47/38 ,  C08B11/20 ,  C08L1/32

    摘要： An esterified cellulose ether of increased weight average molecular weight is produced in a process for reacting a cellulose ether with an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride, wherein the process comprises the steps of a) preparing a reaction mixture comprising the cellulose ether, the dicarboxylic acid anhydride and a reaction diluent and heating the reaction mixture to a temperature of from 60 C to 110 C prior to, during or after mixing the components of the reaction mixture, and b) adding continuously or in at least three portions the monocarboxylic acid anhydride to the reaction mixture of step a) and completing the reaction.

    LOW-SUBSTITUTED HYDROXYPROPYL CELLULOSE, PRODUCTION METHOD THEREOF, AND SOLID PREPARATION
    4.
    发明申请
    LOW-SUBSTITUTED HYDROXYPROPYL CELLULOSE, PRODUCTION METHOD THEREOF, AND SOLID PREPARATION 审中-公开

    公开(公告)号：US20180100027A1

    公开(公告)日：2018-04-12

    申请号：US15722594

    申请日：2017-10-02

    申请人： SHIN-ETSU CHEMICAL CO., LTD.

    发明人： Yasuyuki HIRAMA ,  Aya TSUCHIYA

    IPC分类号： C08B3/08 ,  C08B3/14

    CPC分类号： C08B3/08 ,  A61K9/146 ,  A61K9/2054 ,  A61K47/38 ,  C08B3/14 ,  C08B11/08 ,  C08B11/193 ,  C08L1/32 ,  C09D101/30 ,  G01N23/20

    摘要： Provided are low-substituted hydroxypropyl cellulose (L-HPC) having a hydroxypropoxy content of from 5 to 16% by weight, and having, on a basis of a dynamic image analysis to divide all particles into fine, spherical, and fibrous particles consisting of long and short fibrous particles, a volume fraction of the long fibrous particles of from 15 to 50% and a volume fraction of the short fibrous particles of from 23 to 60%; and a solid preparation containing the L-HPC. Also provided is a method for producing the L-HPC including the steps: bringing sheet-like or chip-like pulp having a length-weighted average fiber length of from 2.40 to 3.50 mm into contact with an alkali metal hydroxide solution, reacting the resulting alkali cellulose with propylene oxide, and dispersing the resulting reaction product in water containing an acid to partially dissolve it therein, followed by neutralization with an acid to precipitate crude L-HPC.

    ESTERIFIED CELLULOSE ETHERS OF LOW ACETONE-INSOLUBLE CONTENT
    6.
    发明申请
    ESTERIFIED CELLULOSE ETHERS OF LOW ACETONE-INSOLUBLE CONTENT 审中-公开

    公开(公告)号：US20170240654A1

    公开(公告)日：2017-08-24

    申请号：US15503600

    申请日：2015-08-18

    申请人： Dow Global Technologies LLC

    发明人： Oliver Petermann ,  Matthias Knarr ,  Matthias Sprehe

    IPC分类号： C08B13/00 ,  C09D101/32 ,  A61K9/48

    CPC分类号： C08B13/00 ,  A61K9/146 ,  A61K9/2054 ,  A61K9/4816 ,  A61K47/38 ,  C08L1/32 ,  C09D101/32

    摘要： Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and ii) a content of not more than 0.85 weight percent acetone-insoluble esterified cellulose ether particles, when the esterified cellulose ether is present in a mixture of 12.5 weight parts of esterified cellulose ether and 87.5 weight parts of acetone at 21° C., the weight percent acetone-insoluble esterified cellulose ether particles being based on the total weight of the esterified cellulose ether, wherein iii) not more than 14 percent of the acetone-insoluble esterified cellulose ether particles have a particle size of more than 90 micrometers.

    Water-soluble polysaccharide ethers and their use
    10.
    发明授权
    Water-soluble polysaccharide ethers and their use 有权
    水溶性多糖醚及其用途

    公开(公告)号：US09045565B2

    公开(公告)日：2015-06-02

    申请号：US13390733

    申请日：2010-08-17

    申请人： Helmut Ritter ,  Bernd Mueller ,  Dirk-Henning Menz

    发明人： Helmut Ritter ,  Bernd Mueller ,  Dirk-Henning Menz

    IPC分类号： C08B13/00 ,  A61L27/20 ,  C08B11/20 ,  C08L1/32 ,  C09K19/36 ,  C09K19/38 ,  C08B15/00 ,  A61K9/00

    CPC分类号： C08B13/00 ,  A61K9/0051 ,  A61L27/20 ,  C08B11/20 ,  C08B15/00 ,  C08L1/32 ,  C09K19/36 ,  C09K19/3819 ,  C08L1/28

    摘要： The invention relates to modified polysaccharide ethers having a weight-averaged molecular weight of 40,000 to 500,000 g/mole, zero shear viscosity of more than 10 Pa·s, and pseudo-plasticity of more than 20. These modified polysaccharide ethers are obtainable by reacting cellulose-based polysaccharide ether(s) with at least one mesogenic modification agent or modified polysaccharide ethers, obtainable by reacting polysaccharide ether(s) selected from hydroxypropylmethyl cellulose (HPMC), hydroxyethylmethyl cellulose (HEMC), methyl cellulose, and cellulose ethers with methyl and/or ethyl and/or propyl groups and mixtures thereof, with at least one mesogenic modification agent. These substances can be used to produce gel-like to stable aqueous preparations having viscoelastic flow properties, which are suited for use in the human body, particularly within the scope of ophthalmologic procedures.

    摘要翻译： 本发明涉及重均分子量为40,000至500,000g / mol，零剪切粘度大于10Pa·s，假塑性大于20的改性多糖醚。这些改性多糖醚可通过使 通过使选自羟丙基甲基纤维素（HPMC），羟乙基甲基纤维素（HEMC），甲基纤维素和纤维素醚的多糖醚与甲基的纤维素醚反应获得的具有至少一种介晶改性剂或改性多糖醚的纤维素基多糖醚 和/或乙基和/或丙基及其混合物与至少一种介晶改性剂。 这些物质可以用于制备具有粘弹性流动性的稳定的水性制剂，其适用于人体，特别是在眼科手术范围内。