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公开(公告)号：US10577432B2
公开(公告)日：2020-03-03
申请号：US15574497
申请日：2016-05-26
摘要： Provided is a method of making methylcellulose-type ether in powder form, said method comprising (a) providing a solution of said methylcellulose-type ether in water, and (b) then separating said methylcellulose-type ether from said water to produce dried methylcellulose-type ether, with the proviso that either (i) step (b) produces said methylcellulose-type ether in powder form, or (ii) after step (b), said method additionally comprises a step (c) of subjecting said dried methylcellulose-type ether to mechanical stress to produce said methylcellulose-type ether in powder form.
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公开(公告)号：US10450424B2
公开(公告)日：2019-10-22
申请号：US15746207
申请日：2016-07-08
发明人： Meinolf Brackhagen , Neal J. Fetner , Matthias Knarr , Jin Zhao
摘要： A process for producing an aqueous composition comprising a dispersed esterified cellulose ether comprises the steps of grinding, in the presence of an aqueous diluent an esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a N divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, blending a salt of a fatty acid with the esterified cellulose ether and choosing the amounts of aqueous diluent, esterified cellulose ether and salt of a fatty acid that the produced aqueous composition comprises at least 20 percent of the dispersed esterified cellulose ether and heating the aqueous composition to a temperature of from 37 to 80 C during or after the grinding step.
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公开(公告)号：US10377835B2
公开(公告)日：2019-08-13
申请号：US15550094
申请日：2016-03-08
发明人： Oliver Petermann , Matthias Knarr
摘要： 1. An esterified cellulose ether which i) comprises groups of the formula —C(O)—R—COOH or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group, ii) has a weight average molecular weight Mw of up to 70,000 Dalton, iii) has a degree of neutralization of the groups —C(O)—R—COOH of not more than 0.4, and iv) has a solubility in water of at least 2.0 weight percent at 2° C., is useful for preparing enteric capsules.
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公开(公告)号：US20180215880A1
公开(公告)日：2018-08-02
申请号：US15746207
申请日：2016-07-08
发明人： Meinolf Brackhagen , Neal J. Fetner , Matthias Knarr , Jin Zhao
IPC分类号： C08J3/07 , C09D101/32 , C08J3/12
摘要： A process for producing an aqueous composition comprising a dispersed esterified cellulose ether comprises the steps of grinding, in the presence of an aqueous diluent an esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a N divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, blending a salt of a fatty acid with the esterified cellulose ether and choosing the amounts of aqueous diluent, esterified cellulose ether and salt of a fatty acid that the produced aqueous composition comprises at least 20 percent of the dispersed esterified cellulose ether and heating the aqueous composition to a temperature of from 37 to 80 C during or after the grinding step.
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公开(公告)号：US09216191B2
公开(公告)日：2015-12-22
申请号：US14350819
申请日：2012-10-11
IPC分类号： A61K31/717 , A61K31/7016 , C08B11/02 , A61P3/04 , A23L1/308 , A23L1/00 , A23L1/0534 , A23L1/09 , A23L1/29 , A61K31/7004 , A61K31/702
CPC分类号： A61K31/717 , A23L5/00 , A23L7/00 , A23L9/00 , A23L29/262 , A23L29/30 , A23L33/125 , A23L33/21 , A23L33/24 , A23L33/30 , A23P10/20 , A23V2002/00 , A61K31/7004 , A61K31/7016 , A61K31/702 , A23V2200/228 , A23V2250/28 , A23V2250/51088 , A23V2250/60 , A23V2200/332
摘要： A flowable or spoonable medicament, food, food ingredient or food supplement is useful for inducing satiety. It comprises (a) one or more mono-, di- and/or oligosaccharides and (b) a methylcellulose, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is from 0.17 to 0.36, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.
摘要翻译： 可流动或可匙取的药物，食物，食物成分或食物补充剂可用于诱导饱腹感。 它包含（a）一种或多种单糖，二糖和/或寡糖和（b）甲基纤维素，其中甲基纤维素具有通过1-4键连接的脱水葡萄糖单元，其中脱水葡萄糖单元的羟基被甲基取代，使得s23 / s26为0.17至0.36，其中s23为脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和3-位上的两个羟基仅被甲基取代，并且其中s26是脱葡萄糖单元的摩尔分数 其中在脱水葡萄糖单元的2位和6位只有两个羟基被甲基取代。
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6.发明申请COMPOSITION COMPRISING AN ORGANIC LIQUID DILUENT AND A CELLULOSE ETHER OF VERY LOW VISCOSITY 审中-公开包含有机液体稀释剂的组合物和非常低粘度的纤维素醚公开(公告)号：US20150209436A1
公开(公告)日：2015-07-30
申请号：US14413080
申请日：2013-07-12
发明人： Meinolf Brackhagen , Nicholas S. Grasman , Mark J. Hall , Steven J. Guillaudeu , Robert L. Schmitt , Matthias Knarr
IPC分类号： A61K47/38 , A61K31/343 , A61K31/4166 , A61K9/14
CPC分类号： A61K47/38 , A61K9/10 , A61K9/146 , A61K9/1652 , A61K9/2866 , A61K31/343 , A61K31/4166 , C08L1/284
摘要： A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa·s and optionally one or more adjuvants.
摘要翻译： 包含有机液体稀释剂和至少一种具有高达2.33mPa·s的非离子纤维素醚的非离子纤维素醚的液体组合物，其在20℃下以2重量％的水溶液测量，在 延长时间 液体组合物可用于通过喷雾干燥制备包含至少一种纤维素醚中的至少一种活性成分的固体分散体。 或者，可以通过共混和挤出至少一种活性成分，至少一种粘度高达2.33mPa·s的纤维素醚和任选的一种或多种佐剂来制备固体分散体。
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公开(公告)号：US10526421B2
公开(公告)日：2020-01-07
申请号：US15503600
申请日：2015-08-18
摘要： Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and ii) a content of not more than 0.85 weight percent acetone-insoluble esterified cellulose ether particles, when the esterified cellulose ether is present in a mixture of 12.5 weight parts of esterified cellulose ether and 87.5 weight parts of acetone at 21° C., the weight percent acetone-insoluble esterified cellulose ether particles being based on the total weight of the esterified cellulose ether, wherein iii) not more than 14 percent of the acetone-insoluble esterified cellulose ether particles have a particle size of more than 90 micrometers.
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8.发明申请公开(公告)号：US20190209693A1
公开(公告)日：2019-07-11
申请号：US16357687
申请日：2019-03-19
发明人： Meinolf Brackhagen , Nicholas S. Grasman , Mark J. Hall , Steven J. Guillaudeu , Robert L. Schmitt , Matthias Knarr
IPC分类号： A61K47/38 , A61K9/10 , A61K31/4166 , A61K31/343 , A61K9/16 , C08L1/28 , A61K9/28 , A61K9/14
CPC分类号： A61K47/38 , A61K9/10 , A61K9/146 , A61K9/1652 , A61K9/2866 , A61K31/343 , A61K31/4166 , C08L1/284
摘要： A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa»s and optionally one or more adjuvants.
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公开(公告)号：US20180072818A1
公开(公告)日：2018-03-15
申请号：US15550094
申请日：2016-03-08
发明人： Oliver Petermann , Matthias Knarr
CPC分类号： C08B13/00 , A23P10/30 , A23P20/105 , A61K9/4816 , A61K9/4833 , A61K9/4866 , A61K47/38 , C08L1/32 , C09D101/32
摘要： 1. An esterified cellulose ether which i) comprises groups of the formula —C(O)—R—COOH or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group, ii) has a weight average molecular weight Mw of up to 70,000 Dalton, iii) has a degree of neutralization of the groups —C(O)—R—COOH of not more than 0.4, and iv) has a solubility in water of at least 2.0 weight percent at 2° C., is useful for preparing enteric capsules.
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公开(公告)号：US20180071396A1
公开(公告)日：2018-03-15
申请号：US15550096
申请日：2016-03-08
发明人： Oliver Petermann , Matthias Knarr
CPC分类号： A61K47/38 , A61K9/10 , A61K9/146 , A61K9/2866 , A61K9/4816 , A61K9/4891
摘要： An aqueous composition comprising an esterified cellulose ether being at least partially dissolved in an aqueous liquid, wherein the esterified cellulose ether comprises groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group is produced in a process which comprises the step of a) mixing the esterified cellulose ether with the aqueous liquid, and b) maintaining or adjusting the degree of neutralization of the groups —C(O)—R—COOH of the esterified cellulose ether at or to less than 0.45 and setting the temperature of the mixture of the esterified cellulose ether and the aqueous liquid to less than 10 C to at least partially dissolve the esterified cellulose ether in the aqueous liquid.
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