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公开(公告)号：US20170173159A1
公开(公告)日：2017-06-22
申请号：US15129505
申请日：2015-03-03
发明人： Neal J. Fetner , David L. Malotky , Jin Zhao , Matthias Knarr , Michael J. Devon , Roland Adden
CPC分类号： A61K47/38 , A61J3/07 , A61K9/2866 , A61K9/4816 , C08B13/00 , C08L1/32
摘要： An aqueous composition useful for producing capsules shells comprises a) at least one dispersed esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and b) from 0.05 to 20 percent of at least one salt of a fatty acid, based on the weight of the dispersed esterified cellulose ether, wherein the median particle size, d50, of the dispersed esterified cellulose ether particles is up to 7 micrometers, such median particle size (d50) being the size at which 50 mass percent of the particles have a smaller equivalent diameter and 50 mass percent have a larger equivalent diameter.
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公开(公告)号：US20180244860A1
公开(公告)日：2018-08-30
申请号：US15755625
申请日：2016-09-12
发明人： Oliver Petermann , Neal J. Fetner
CPC分类号： C08J3/12 , A61J3/077 , A61K9/4866 , A61K47/38 , C08J3/05 , C08J2301/32 , C08K5/098 , C08L1/16 , C08L1/32 , C08L2203/02
摘要： In a water-redispersible polymer powder—the polymer is at least one esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and—the polymer powder comprises from 0.05 to 20 percent of at least one salt of a fatty acid, based on the weight of the esterified cellulose ether(s).
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公开(公告)号：US10383944B2
公开(公告)日：2019-08-20
申请号：US15129505
申请日：2015-03-03
发明人： Neal J. Fetner , David L. Malotky , Jin Zhao , Matthias Knarr , Michael J. Devon , Roland Adden
摘要： An aqueous composition useful for producing capsules shells comprises a) at least one dispersed esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and b) from 0.05 to 20 percent of at least one salt of a fatty acid, based on the weight of the dispersed esterified cellulose ether, wherein the median particle size, d50, of the dispersed esterified cellulose ether particles is up to 7 micrometers, such median particle size (d50) being the size at which 50 mass percent of the particles have a smaller equivalent diameter and 50 mass percent have a larger equivalent diameter.
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公开(公告)号：US10179110B2
公开(公告)日：2019-01-15
申请号：US15308792
申请日：2015-04-28
发明人： Jin Zhao , Roland Adden , Neal J. Fetner , David L. Malotky
摘要： An aqueous composition comprising at least 10 weight percent of a dispersed esterified cellulose ether, based on the total weight of the aqueous composition, wherein the esterified cellulose ether comprises (i) groups of the formula —C(O)—R—COOH or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent aliphatic or aromatic hydrocarbon group, and at least a part of the groups —C(O)—R—COOH are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid, and wherein d90 of the dispersed esterified cellulose ether particles is up to 10 micrometers, d90 being the diameter where 90 mass percent of the particles have a smaller equivalent diameter and the other 10 mass percent have a larger equivalent diameter, is useful for preparing coating dosage forms including tablets, capsules and others, or for the formation of capsules shells.
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公开(公告)号：US10450424B2
公开(公告)日：2019-10-22
申请号：US15746207
申请日：2016-07-08
发明人： Meinolf Brackhagen , Neal J. Fetner , Matthias Knarr , Jin Zhao
摘要： A process for producing an aqueous composition comprising a dispersed esterified cellulose ether comprises the steps of grinding, in the presence of an aqueous diluent an esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a N divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, blending a salt of a fatty acid with the esterified cellulose ether and choosing the amounts of aqueous diluent, esterified cellulose ether and salt of a fatty acid that the produced aqueous composition comprises at least 20 percent of the dispersed esterified cellulose ether and heating the aqueous composition to a temperature of from 37 to 80 C during or after the grinding step.
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公开(公告)号：US20180215880A1
公开(公告)日：2018-08-02
申请号：US15746207
申请日：2016-07-08
发明人： Meinolf Brackhagen , Neal J. Fetner , Matthias Knarr , Jin Zhao
IPC分类号： C08J3/07 , C09D101/32 , C08J3/12
摘要： A process for producing an aqueous composition comprising a dispersed esterified cellulose ether comprises the steps of grinding, in the presence of an aqueous diluent an esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a N divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, blending a salt of a fatty acid with the esterified cellulose ether and choosing the amounts of aqueous diluent, esterified cellulose ether and salt of a fatty acid that the produced aqueous composition comprises at least 20 percent of the dispersed esterified cellulose ether and heating the aqueous composition to a temperature of from 37 to 80 C during or after the grinding step.
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公开(公告)号：US20170181977A1
公开(公告)日：2017-06-29
申请号：US15308792
申请日：2015-04-28
发明人： Jin Zhao , Roland Adden , Neal J. Fetner , David L. Malotky
CPC分类号： A61K9/4816 , B29C41/14
摘要： An aqueous composition comprising at least 10 weight percent of a dispersed esterified cellulose ether, based on the total weight of the aqueous composition, wherein the esterified cellulose ether comprises (i) groups of the formula —C(O)—R—COOH or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent aliphatic or aromatic hydrocarbon group, and at least a part of the groups —C(O)—R—COOH are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid, and wherein d90 of the dispersed esterified cellulose ether particles is up to 10 micrometers, d90 being the diameter where 90 mass percent of the particles have a smaller equivalent diameter and the other 10 mass percent have a larger equivalent diameter, is useful for preparing coating dosage forms including tablets, capsules and others, or for the formation of capsules shells.
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